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Next-Generation Prosthetic Hand:from Biomimetic to Biorealistic

Research 2021年第1期2021卷 222-225页

作者： Ning Lan Manzhao Hao Chuanxin MNiu He Cui Yu Wang Ting Zhang peng fang Chih-hong Chou Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghaiChina Laboratory of Neurorehabilitation Engineering School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Rehabilitation Medicine Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Center for Excellence in Brain Science and Intelligent Technology Chinese Academy of SciencesShanghaiChina School of Biological Science and Medical Engineering Beihang UniversityBeijingChina Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina i-lab Key Laboratory of Multifunctional Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenChina

Integrating a prosthetic hand to amputees with seamless neural compatibility presents a grand challenge to neuroscientists and neural engineers for more than half *** anatomical structure or appearance of human hand does not lead to improved neural connectivity to the sensorimotor system of *** functions of modern prosthetic hands do not match the dexterity of human hand due primarily to lack of sensory awareness and compliant ***,progress in restoring sensory feedback has marked a significant step forward in improving neural continuity of sensory information from prosthetic hands to ***,little effort has been made to replicate the compliant property of biological muscle when actuating prosthetic ***,a full-fledged biorealistic approach to designing prosthetic hands has not been contemplated in neuroprosthetic *** this perspective article,we advance a novel view that a prosthetic hand can be integrated harmoniously with amputees only if neural compatibility to the sensorimotor system is *** ongoing research supports that the next-generation prosthetic hand must incorporate biologically realistic actuation,sensing,and reflex functions in order to fully attain neural compatibility.

关键词： neural compatibility primarily

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Fast charge transfer kinetics in Sv-ZnIn_(2)S_(4)/Sb_(2)S_(3)S-scheme heterojunction photocatalyst for enhanced photocatalytic hydrogen evolution

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Rare Metals 2024年第2期43卷 533-542页

作者： Wei Li Jia-Jun Li Zhi-Fei Liu Hong-Yu Ma peng-Fei fang Rui Xiong Jian-Hong Wei Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan430072China

Constructing a S-scheme heterojunction with tight interface contact and fast charge transfer is beneficial to improving the photocatalytic hydrogen evolution ***,a unique one-dimensional(1D)/two-dimensional(2D)S-scheme heterojunction containing 1D Sb_(2)S_(3) nanorods and 2D ZnIn_(2)S_(4) with affluent sulfur vacancies(denoted as Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3)) was *** introduced sulfur vacancy can promote the effective adsorption of H+for the following interfacial hydrogen-evolution ***,the larger contact area and stronger electron interaction between Sb_(2)S_(3) and ZnIn_(2)S_(4) effectively inhibits the recombination of photo-generated electron–hole pairs and abridges the migration distance of *** a result,the optimal Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) sample achieves H_(2) evolution activity of 2741.3 mol·h^(−1)·g^(−1),which is 8.6 times that of pristine ZnIn_(2)S_(4) and 3.0 times that of the Sv-ZnIn_(2)S_(4) *** on the experimental result,the photo-reactivity S-scheme mechanism of hydrogen evolution from water splitting with Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) is *** work provides an effective method for developing S-scheme heterojunction composites of transition metal sulfide with high hydrogen evolution performance.

关键词： ZnIn_(2)S_(4) nanosheets S-scheme heterojunction Sulfur vacancy Charge transfer and separation Photocatalytic H_(2)evolution

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Bis(7)-Tacrine, a Promising Anti-Alzheimer's Agent,Attenuates Glutamate-Induced Cell Injury in Primary Cultured Cerebrocortical Neurons of Rats

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Wuhan University Journal of Natural Sciences 2001年第3期6卷 737-741页

作者： Zhang Bai fang,peng fang fang,Zhang Jiang zhou,Wu Dong cheng  Biochemistry Department, School of Medicine, Wuhan University, Wuhan 430071, China Biochemistry Department School of Medicine Wuhan University Wuhan China

The effects of bis(7) tacrine, a novel dimeric acetylcholinesterase (AChE) inhibitor, on glutamate induced cell injury were investigated in primary cerebral cortical neurons of rats. Exposure of cultured neurons (12 days after plating) to 0.5 mmol/L glutamate for 30 min resulted in significant cell damage. Pretreatment with bis(7) tacrine (0.03 1.0 μmol/L) reduced the glutamate induced neurotoxicity in a concentration dependent manner and the maximal response was seen at 1 μmol/L with approximately 30% protection. A receptor binding assay showed that bis(7) tacrine can completely displace MK 801 binding to rat cortical membrane with an IC 50 of 0.57 μmol/L. These findings suggest that bis(7) tacrine can directly interact with N methyl D aspartate receptor channel complex, which may contribute to the inhibitor's protective effects against glutamate induced excitotoxicity. Thus, it is possible that anti glutamate/anti AChE synergism is responsible for potentially better Alzheimer's therapy of bis(7) tacrine relative to tacrine.

关键词： bis(7) tacrine tacrine cholinesterase inhibitor glutamate primary neuronal cell culture

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Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids:A case report

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World Journal of Clinical Cases 2023年第5期11卷 1144-1151页

作者： peng-fang Tang Long-Chuan Xu Wen-Ting Hong Hong-Ying Shi Department of Rheumatology Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Pathology Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Immunology Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Tocilizumab is a humanized monoclonal antibody against the interleukin-6(IL-6)receptor that is commonly used to treat large vessel vasculitis and antineutrophil cytoplasmic antibody-related small vessel ***,tocilizumab in combination with glucocorticoids for successfully treating granulomatosis with polyangiitis(GPA)has rarely been *** SUMMARY Here,we report a 40-year-old male patient who suffered GPA for 4 *** was treated with multiple rounds of drugs,including cyclophosphamide,Tripterygium wilfordii,mycophenolate mofetil,and belimumab,with no *** addition,he exhibited persistently high IL-6 *** tocilizumab treatment,his symptoms improved,and his inflammatory marker levels returned to *** Tocilizumab may be effective for treating GPA.

关键词： Tocilizumab Granulomatosis with polyangiitis Antineutrophil cytoplasmic antibody Case report

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Values of spleen-preserving distal pancreatectomy in well-differentiated non-functioning pancreatic neuroendocrine tumors:a comparative study

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Gastroenterology Report 2022年第1期10卷 513-518页

作者： Xi-Tai Huang Jin-Zhao Xie Jian-peng Cai peng fang Chen-Song Huang Wei Chen Li-Jian Liang Xiao-Yu Yin Department of Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background The feasibility of spleen-preserving distal pancreatectomy(SPDP)to treat well-differentiated non-functioning pancreatic neuroendocrine tumors(NF-pNETs)located at the body and/or tail of the pancreas remains *** pancreatectomy with splenectomy(DPS)has been widely applied in the treatment of NF-pNETs;however,it may increase the post-operative *** study aimed to evaluate whether SPDP is inferior to DPS in post-operative outcomes and survivals when being used to treat patients with NF-pNETs in our *** Clinicopathological features of patients with NF-pNETs who underwent curative SPDP or DPS at the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between January 2010 and January 2022 were ***-term outcomes and 5-year survivals were compared between patients undergoing SPDP and those undergoing *** Sixty-three patients(SPDP,27;DPS,36)with well-differentiated NF-pNETs were *** patients had grade 1/2 *** identifying patients with T1–T2 NF-pNETs(SPDP,27;DPS,15),there was no disparity between the SPDP and DPS groups except for tumor size(median,1.4 vs 2.6 cm,P=0.001).There were no differences in operation time(median,250 vs 295 min,P=0.478),intraoperative blood loss(median,50 vs 100 mL,P=0.145),post-operative major complications(3.7%vs 13.3%,P=0.287),clinically relevant post-operative pancreatic fistula(22.2%vs 6.7%,P=0.390),or post-operative hospital stays(median,9 vs 9 days,P=0.750)between the SPDP and DPS ***–Meier curve showed no significant differences in the 5-year overall survival rate(100%vs 100%,log-rank P>0.999)or recurrence-free survival(100%vs 100%,log-rank P>0.999)between patients with T1–T2 NF-pNETs undergoing SPDP and those undergoing *** In patients with T1–T2 well-differentiated NF-pNETs,SPDP could achieve comparable post-operative outcomes and prognosis compared with DPS.

关键词： pancreatic neuroendocrine tumor distal pancreatectomy spleen preservation prognosis

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Tenofovir amibufenamide vs tenofovir alafenamide for treating chronic hepatitis B:A real-world study

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World Journal of Gastroenterology 2023年第44期29卷 5907-5918页

作者： Wen-Ting peng Chuan Jiang Fei-Lan Yang Nian-Qi Zhou Ke-Yu Chen Jin-Qing Liu Shi-fang peng Lei Fu Department of Infectious Diseases Xiangya Hospital Central South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND The efficacy and safety profile of tenofovir amibufenamide(TMF)in chronic hepatitis B(CHB)patients is not *** To compare the efficacy and safety of TMF and tenofovir alafenamide(TAF)over a 48-wk period in patients with *** A total of 215 subjects meeting the inclusion criteria were enrolled and divided into two groups:TMF group(n=106)and the TAF group(n=109).The study included a comparison of virological response(VR):Undetectable hepatitis B virus DNA levels,alanine transaminase(ALT)normalization rates,renal function parameters,and blood lipid *** At 24 and 48 wk,VR rates for the TMF group were 53.57%and 78.57%,respectively,compared with 48.31%and 78.65%for the TAF group(P>0.05).The VR rates were also similar in both groups among patients with low-level viremia,both hepatitis B e antigen(HBeAg)-positive and HBeAg-negative *** TMF cohort showed ALT normalization and renal safety profiles similar to the TAF *** was a notable increase in total cholesterol levels in the TAF group(P=0.045),which was not observed in the TMF group(P>0.05).In patients with liver cirrhosis,both groups exhibited comparable VR and ALT normalization rates and renal safety ***,the fibrosis 4 score at 48 wk showed a significant reduction in the TAF group as compared to the TMF group within the liver cirrhosis *** Our study found TMF is as effective as TAF in treating CHB and has a comparable safety ***,TAF may be associated with worsening lipid profiles.

关键词： Alanine transaminase normalization Chronic hepatitis B Renal safety Virological response Blood lipid Tenofovir

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Two Sympathetic Homologous CMEs on 2002 May 22

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Chinese Journal of Astronomy and Astrophysics 2005年第3期5卷 265-272页

作者： Jian-XiaCheng Chengfang peng-FeiChen Ming-DeDing DepartmentofAstronomy NanjingUniversityNanjing210093

Sympathetic coronal mass ejections (CMEs) usually occur in different active regions connected by interconnecting magnetic loops, while homologous CMEs occur within the same active region with an almost the same background magnetic field, and so are similar in shapes. Two sympathetic CMEs erupted within 3 hours on 2002 May 22, originating from the same active region, AR 9948. Their multi-wavelength data were collected and analyzed. It is suggested that emerging flux triggered the occurrence of the first CME and the corresponding flare, the reconnection inflow of which in turn triggered the eruption of the second CME. Based on the fact that the two sympathetic CMEs have many similarities, in their shapes, their low-lying dimming areas, etc., we tentatively propose, for the first time, the phenomenon of sympathetic homologous CMEs.

关键词： filament flares CMEs

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Identification and Purification of an Allergic Glycoprotein from Ginkgo biloba Kernel

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Agricultural Sciences in China 2011年第4期10卷 631-641页

作者： YANG Jian-ting WU Cai-e LI Ying-ying JIA Shao-qian FAN Gong-jian peng fang-ren Department of Forest Resource and Environment Nanjing Forest University Nanjing 210037 P.R.China College of Food and Drug Anhui Science and Technology University Fengyang 233100 P.R. China

Glycoprotein from Ginkgo biloba kernel may be allergic. In this paper, the allergic proteins were identified with Western blotting, and the 32 kDa glycoprotein was purified with ion exchange chromatography and gel chromatography. With Western blotting, there were 3 allergic proteins with molecular weight 21, 32, and 36 kDa. With SDS-PAGE analysis and measurements of the protein and sugar contents, the isolation and purification technology of 32 kDa was confirmed. Ginkgo crude protein extract was precipitated with ammonium sulphate （saturation gradient： 40-80%）. The precipitate was purified by chromatography with DEAE-cellulose 52, then chromatography with Sephadex G-200 and the target glycoprotein was finally obtained. The analysis results showed the molecule of the glycoprotein was 32.12 kDa and the ratio of protein to sugar was 20.56：1. In conclusion, the purification method could be used in preparation of the glycoprotein, and the study could provide a basis for the further research of the glycoprotein.

关键词： Ginkgo biloba kernel glycoprotein allergy identification purification

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Traditional herbal formula Sini Powder extract produces antidepressantlike effects through stress-related mechanisms in rats

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Chinese Journal of Natural Medicines 2016年第8期14卷 590-598页

作者： WEI Shan-Shan YANG He-Jin Huang Jia-Wen LU Xue-Ping peng Ling-fang WANG Qing-Guo School of Basic Medicine Beijing University of Chinese Medicine Department of Drug Screening Yunnan Institute of Materia Medica

Sini Powder(SP), a traditional Chinese herbal formula, has long been used to treat depression in patients, although the underlying mechanisms remain to be elucidated. In the present study, we found that rats treated with SP extract for 7 days showed a significant increase in swimming time and reduction in immobility time in forced swimming test in a dose-dependent manner, without changes in locomotion. These effects could be attributed to SP's modulation of the hypothalamus-pituitary-adrenal axis, because a single pretreatment of SP extract could rescue increased serum corticosterone and plasma adrenocorticotropin levels induced by acute elevated platform stress. A single pretreatment of SP extract could also elevate the m RNA expression of hippocampal glucocorticoid receptors. In conclusion, our results suggest that SP extract may act as an anti-stress medication to produce antidepressant-like effects.

关键词： Sini Powder extract Antidepressant-like Hypothalamic-pituitary-adrenal axis Glucocorticoid receptor

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Two Types of New Conserved Quantities and Mei Symmetry of Mechanical Systems in Phase Space

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Communications in Theoretical Physics 2007年第12期48卷 993-995页

作者： WANG peng fang Jian-Hui DING Ning College of Physics Science and Technology,China University of Petroleum,Dongying 257061,China College of Physics Science and Technology China University of Petroleum Dongying 257061 China

In this paper,two types of new conserved quantities directly deduced by Mei symmetry in phase space *** conditions under which Mei symmetry can directly lead to the two types of new conserved quantities andthe forms o... 详细信息

关键词： phase space Mei symmetry conserved quantity

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