Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids:A case report

作     者：Peng-Fang Tang Long-Chuan Xu Wen-Ting Hong Hong-Ying Shi 

作者机构：Department of RheumatologySecond Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of PathologySecond Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of ImmunologySecond Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第5期

页      面：1144-1151页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Tocilizumab Granulomatosis with polyangiitis Antineutrophil cytoplasmic antibody Case report 

摘      要：BACKGROUND Tocilizumab is a humanized monoclonal antibody against the interleukin-6(IL-6)receptor that is commonly used to treat large vessel vasculitis and antineutrophil cytoplasmic antibody-related small vessel vasculitis.However,tocilizumab in combination with glucocorticoids for successfully treating granulomatosis with polyangiitis(GPA)has rarely been reported.CASE SUMMARY Here,we report a 40-year-old male patient who suffered GPA for 4 years.He was treated with multiple rounds of drugs,including cyclophosphamide,Tripterygium wilfordii,mycophenolate mofetil,and belimumab,with no improvement.In addition,he exhibited persistently high IL-6 levels.After tocilizumab treatment,his symptoms improved,and his inflammatory marker levels returned to normal.CONCLUSION Tocilizumab may be effective for treating GPA.