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重症肺部感染相关脓毒症预后不良的预测模型及其预测效能

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中华医院感染学杂志 2024年第9期34卷 1286-1289页

作者：周江伟韩贝贝隋海洋李志超张鹏飞忽新刚三门峡市中心医院急诊科河南三门峡472000 河南省人民医院呼吸科河南郑州450000

目的构建重症肺部感染相关脓毒症预后不良的预测模型,并评估模型的预测效能。方法收集2018年4月-2021年2月三门峡市中心医院收治的165例重症肺部感染相关脓毒症患者临床资料,其中28 d治疗后生存58例(预后良好组)、死亡107例(预后不良组)... 详细信息

目的构建重症肺部感染相关脓毒症预后不良的预测模型,并评估模型的预测效能。方法收集2018年4月-2021年2月三门峡市中心医院收治的165例重症肺部感染相关脓毒症患者临床资料,其中28 d治疗后生存58例(预后良好组)、死亡107例(预后不良组),采用Logistics回归分析法构建预后不良的预测模型,Hosmer-Lemeshow检验评估模型的拟合度,受试者工作特征(ROC)曲线评估模型的预测效能。结果与预后良好组比较,预后不良组患者合并急性肾损伤占比较高(P<0.05);白细胞计数、尿素氮、血肌酐、总胆红素、谷草转氨酶、谷丙转氨酶、C-反应蛋白、降钙素原、急性生理学与慢性健康状况Ⅱ(APACHEⅡ)评分、全身感染相关性器官功能衰竭评价(SOFA)评分均升高(P<0.05);前白蛋白及24 h乳酸清除率降低(P<0.05);Logistic回归分析结果显示,合并急性肾损伤及APACHEⅡ评分、SOFA评分均为重症肺部感染相关脓毒症预后不良独立危险因素(P<0.05),24 h乳酸清除率为独立保护因素(P<0.05);多元Logistic回归方程获得重症肺部感染相关脓毒症预后不良的预测模型,Hosmer-Lemeshow检验显示模型拟合度较好(χ^(2)=12.691,P=0.124),ROC曲线分析显示模型的预测效能较高[曲线下面积(AUC)值为0.881,95%CI:0.814~0.949]。结论应用Logistic回归分析法构建预测模型能综合评估重症肺部感染相关脓毒症的不良预后,模型拟合度满意,预测效能较高,可为脓毒症诊疗提供指导数据。

关键词：重症肺部感染脓毒症预后预测模型 Logistics回归分析预测效能

A smart MnO_(2)-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion

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Acta Pharmaceutica Sinica B 2021年第3期11卷 823-834页

作者： peng liu xin Xie Miao liu Shuo hu Jinsong Ding Wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China School of Pharmaceutical Sciences Gannan Medical UniversityGanzhou 341000China Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic ***,tumor is pathologically featured with extreme hypoxia together with the adaptable overexpression of anti-oxidants,such as glutathione(GSH),which greatly restricts the therapeutic ***,a combinatorial strategy was designed to simultaneously relieve tumor hypoxia by self-oxygenation and reduce intracellular GSH level to sensitize chemo-photodynamic *** our system,a novel multifunctional nanosystem based on MnO_(2)-doped graphene oxide(GO)was developed to co-load cisplatin(Cis Pt)and a photosensitizer(Ce6).With Mn O_(2)doping,the nanosystem was equipped with intelligent functionalities:(1)catalyzes the decomposition of H_(2)O_(2)into oxygen to relieve the tumor hypoxia;(2)depletes GSH level in tumor cells,and(3)concomitantly generates Mn^(2+)to proceed Fenton-like reaction,all of which contribute to the enhanced anti-tumor ***,the surface hyaluronic acid(HA)modification could facilitate the targeted delivery of the nanosystem into tumor cells,thereby resulting in amplified cellular toxicity,as well as tumor growth inhibition in nude mice *** work sheds a new light on the development of intelligent nanosystems for synergistic combination therapy via regulating tumor microenvironment.

关键词： Cisplatin Nanoparticles Photosensitizer Tumor microenvironment Oxygenation GSH depletion Nanozyme Targeting

TVS三步法系统超声评估深部子宫内膜异位症的价值初探

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中国临床医学影像杂志 2024年第5期35卷 343-346页

作者：张红彬孟欣雨田捧王润丽张峰栗河舟郑州大学第三附属医院河南郑州450052

目的:应用经阴道超声(TVS)三步法系统超声评估深部子宫内膜异位症(DIE)的诊断价值。方法:57例疑似DIE患者在我院接受手术。所有患者在手术前接受TVS三步法系统超声评估,术前详细询问病史、准确记录病灶的部位、大小及特征性超声表现,将... 详细信息

目的:应用经阴道超声(TVS)三步法系统超声评估深部子宫内膜异位症(DIE)的诊断价值。方法:57例疑似DIE患者在我院接受手术。所有患者在手术前接受TVS三步法系统超声评估,术前详细询问病史、准确记录病灶的部位、大小及特征性超声表现,将结果与手术和(或)组织学进行对照。结果:根据病变发生部位、大小的不同,TVS三步法系统超声评估DIE的敏感度为55.3%~99.7%,特异度为84.7%~96.6%。结论:TVS三步法在检测DIE的位置、范围及深度方面具有价值,有助于在术前对DIE患者进行全面评估。

关键词：子宫内膜异位症超声检查,多普勒,彩色

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住宅厨房的通风优化模拟

武汉理工大学学报 2024年第7期46卷 91-97页

作者：张露黄军心周亮周军莉康鑫彭杨东桂树强彭建斌武汉理工大学土木工程与建筑学院武汉430070 中冶武勘工程技术有限公司武汉430080

基于实际住宅厨房和烹饪过程,建立物理模型并进行厨房环境CFD模拟,模拟结果与实测结果吻合很好。提出基于专用空调设备、双排风口油烟机和空气幕的厨房环境优化策略,对优化前后环境进行数值模拟对比分析。结果表明:优化后夏季备菜阶段... 详细信息

基于实际住宅厨房和烹饪过程,建立物理模型并进行厨房环境CFD模拟,模拟结果与实测结果吻合很好。提出基于专用空调设备、双排风口油烟机和空气幕的厨房环境优化策略,对优化前后环境进行数值模拟对比分析。结果表明:优化后夏季备菜阶段的平均温度下降15.7%,烹饪阶段平均温度下降20%,人体周围CO_(2)平均浓度接近380 ppm,人体呼吸区域油烟平均浓度接近0 ppm;优化后冬季备菜阶段的平均温度上升了65.4%,烹饪阶段平均温度上升了136%,人体呼吸区CO_(2)平均浓度不到500 ppm,人体呼吸区域油烟平均浓度接近0 ppm。

关键词：住宅厨房热舒适空气幕室内空气质量 CFD

Microwave absorption properties of SiC@SiO2@Fe3O4 hybrids in the 2–18 GHz range

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International Journal of Minerals,Metallurgy and Materials 2017年第7期24卷 804-813页

作者： peng zhou Jun-hong Chen Meng liu peng Jiang Bin li xin-mei Hou National Engineering Research Center for Advanced Rolling Technology University of Science and Technology Beijing Beijing 100083 China School of Material Science and Engineering University of Science and Technology Beijing Beijing 100083 China Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Beijing 100083 China

To enhance the microwave absorption performance of silicon carbide nanowires（SiCNWs）, SiO_2 nanoshells with a thickness of approximately 2 nm and Fe_3O_4 nanoparticles were grown on the surface of SiCNWs to form SiC@SiO_2@Fe_3O_4 hybrids. The microwave absorption performance of the SiC@SiO_2@Fe_3O_4 hybrids with different thicknesses was investigated in the frequency range from 2 to 18 GHz using a free-space antenna-based system. The results indicate that SiC@SiO_2@Fe_3O_4 hybrids exhibit improved microwave absorption. In particular, in the case of an SiC@SiO_2 to iron（III） acetylacetonate mass ratio of 1：3, the microwave absorption with an absorber of 2-mm thickness exhibited a minimum reflection loss of-39.58 d B at 12.24 GHz. With respect to the enhanced microwave absorption mechanism, the Fe_3O_4 nanoparticles coated on SiC@SiO_2 nanowires are proposed to balance the permeability and permittivity of the materials, contributing to the microwave attenuation.

关键词： silicon carbide nanowires hybrids microwave absorption mechanism impedance match

Scan of the endogenous retrovirus sequences across the swine genome and survey of their copy number variation and sequence diversity among various Chinese and Western pig breeds

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Zoological Research 2022年第3期43卷 423-441页

作者： Jia-Qi Chen Ming-peng Zhang xin-Kai Tong Jing-Quan li zhou Zhang Fei huang hui-peng Du Meng zhou hua-Shui Ai Lu-Sheng huang State Key Laboratory for Swine Genetic Improvement and Production Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

In pig-to-human xenotransplantation,the transmission risk of porcine endogenous retroviruses(PERVs)is of great ***,the distribution of PERVs in pig genomes,their genetic variation among Eurasian pigs,and their evolutionary history remain *** scanned PERVs in the current pig reference genome(assembly Build 11.1),and identified 36 long complete or near-complete PERVs(lc PERVs)and 23 short incomplete PERVs(si PERVs).Besides three known PERVs(PERV-A,-B,and-C),four novel types(PERV-JX1,-JX2,-JX3,and-JX4)were detected in this *** to evolutionary analyses,the newly discovered PERVs were more ancient,and PERV-Bs probably experienced a bottleneck~0.5 million years ago(Ma).By analyzing63 high-quality porcine whole-genome resequencing data,we found that the PERV copy numbers in Chinese pigs were lower(32.0±4.0)than in Western pigs(49.1±6.5).Additionally,the PERV sequence diversity was lower in Chinese pigs than in Western *** the lc PERV copy numbers,PERV-A and-JX2 in Western pigs were higher than in Chinese ***,Bama Xiang(BMX)pigs had the lowest PERV copy number(27.8±5.1),and a BMX individual had no PERV-C and the lowest PERV copy number(23),suggesting that BMX pigs were more suitable for screening and/or modification as xenograft ***,we identified 451 PERV transposon insertion polymorphisms(TIPs),of which 86 were shared by all 10 Chinese and Western pig *** findings provide systematic insights into the genomic distribution,variation,evolution,and possible biological function of PERVs.

关键词： PERVs Chinese and Western pigs Copy number variation Evolutionary history Biological function prediction

A discussion on vacuum polarization correction to the cross-section of e^+e^-→γ~*/ψ →μ^+μ^-

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Chinese Physics C 2019年第1期43卷 24-35页

作者： Hong-Dou Jin li-peng zhou Bing-xin Zhang Hai-Ming hu University of Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Sciences

Vacuum polarization is a part of the initial-state radiative correction for the cross-section of e^+e^- annihilation processes. In the energy region in the vicinity of narrow resonances J/ψ and ψ(3686), the vacuum polarization contribution from the resonant component has a significant effect on the line-shape of the lepton pair production cross-section. This paper discusses some basic concepts and describes an analytical calculation of the cross-section of e^+e^-→γ*/ψ→μ+μ-considering the single and double vacuum polarization effect of the virtual photon propagator. Moreover, it presents some numerical comparisons with the traditional treatments.

关键词： electron-positron annihilation resonance vacuum polarization cross-section

Molecular interaction mechanism in the separation of a binary azeotropic system by extractive distillation with ionic liquid

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Green Energy & Environment 2021年第3期6卷 329-338页

作者： Hong li Guanlun Sun Dongyang li li Xi peng zhou xingang li Ji Zhang xin Gao School of Chemical Engineering and Technology National Engineering Research Center of Distillation TechnologyCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin300072China Department of Chemical Engineering McMaster UniversityHamiltonOntarioL8S 4L7Canada

Ionic liquids(ILs)have shown excellent performance in the separation of binary azeotropes through extractive distillation[1].But the role of the ionic liquid in azeotropic system is not well *** this paper,COSMO-RS model was applied to screen an appropriate IL to separate the binary azeotrope of ethyl acetate(EA)and ethanol and 1-octyl-3-methylimidazolium tetrafluoroborate([OMIM][BF4])was *** Quantum Mechanics(QM)calculations and molecular dynamics(MD)simulation are performed to study the interactions between the solvent molecules and[OMIM][BF4],in order to investigate the separation mechanism at the molecular *** nature of the interactions is studied through the reduced density gradient(RDG)function and quantum theory of Atom in Molecule(QTAIM).Hydrogen bonds and van der Waals interactions are the key interactions in the *** results of MD simulations indicate that the introduction of ILs has a prominent effect on the interaction between the solvent molecules,especially on reducing the number of hydrogen bonds among the solvent *** radial distribution function(RDF)reveals that the interaction between the cation and solvent molecules will increase while the concentration of ILs *** paper provides important information for understanding the role of ILs in the separation of the azeotropic system,which is valuable to the development of new entrainers.

关键词： Ionic liquids Azeotrope Density functional theory Separation Extractive distillation

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重庆市中晚熟马铃薯品种综合品质分析与评价

现代农业科技 2024年第6期 43-48页

作者：周见陈加伦彭艳唐鑫黄振霖重庆市农业技术推广总站重庆401121 石柱土家族自治县武陵山研究院重庆石柱409100

为了进一步丰富重庆市马铃薯品种资源,连续2年分别在低、中、高海拔地区对10个马铃薯品种的形态特征、抗病性、产量性状、品质性状进行分析评价。结果表明:2年的试验结果趋势相对一致,不同品种之间产量具有明显差异;综合皮色、肉色、薯... 详细信息

为了进一步丰富重庆市马铃薯品种资源,连续2年分别在低、中、高海拔地区对10个马铃薯品种的形态特征、抗病性、产量性状、品质性状进行分析评价。结果表明:2年的试验结果趋势相对一致,不同品种之间产量具有明显差异;综合皮色、肉色、薯形、产量、商品薯率、品质性状,初步确定渝马铃薯5号、中薯19号可作为加工品种,中薯48号、希森6号可作为鲜食品种。

关键词：马铃薯产量品质重庆市

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