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Science Bulletin 2019年第6期64卷 385-390页

作者： Guo-peng zhan Chuan-De State Key Laboratory of Silicon Materials Center for Chemistry of High-Performance&Novel MaterialsDepartment of ChemistryZhejiang University

Reducing energy barriers of chemical reactions is the never-ending endeavor of *** by the high reactivity of primary cells,we develop a nanosized fuel cell catalyst(denoted as nanomicrocell catalyst),consisting of integrated electrode pairs,conductive matrices and electrolytes,to improve the chemical ***,the anodes are Pd species which is combining with the electron-rich N atoms in B-and-N co-doped carbon dots;the cathodes are electron-deficient B atoms;and the conductive matrices are B-and-N co-doped carbon dots which are connecting with the electrode *** to the reactivity of primary cells,the catalytic properties of the nanomicrocell catalyst in hydrogenation of benzaldehyde are depending on the properties of electrode pairs,conductive matrices and *** unique catalytic properties are attributed to the different substrate adsorption capability and catalytic properties of paired electrodes,and the easy migration of electrons and charge carriers,which could improve the synergetic effect between paired active ***,this work may open up a new window for designed synthesis of advanced catalysts which could highly lower the energy barriers of chemical reactions.

关键词： Nanomicrocell catalysts Conductive matrices Electrode pairs Electrolytes Primary cells

Targeting the entry step of SARS-CoV-2:a promising therapeutic approach

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1607-1608页

作者： Jing Li peng zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesShandong UniversityJi’nan 250012China

A very recent study published in Cell by Hoffmann and coworkers identifies the key proteins exploited by SARS-CoV-2 to invade cells,and finds some effective therapeutic strategies that can block cell *** findings shou... 详细信息

关键词： therapeutic invasion overcome

Ultrathin polyamide nanofiltration membrane prepared by triazine-based porous organic polymer as interlayer for dye removal

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Chinese Journal of Chemical Engineering 2023年第5期57卷 193-201页

作者： Yongbo Liu Zhihao Si Cong Ren Hanzhu Wu peng zhan Yuqing peng Peiyong Qin National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Membrane Science and Technology College of ChemicalEngineeringBeijing University of Chemical TechnologyBeijing 100029China

Separation membrane with high flux is generally encouraged in industrial application,because of the tremendous needs for decreasing membrane areas,usage costs and space *** most effective and direct method for obtaining the high flux is to decrease membrane ***(PA)nanofiltration membrane is conventionally prepared by the direct interfacial polymerization(IP)on substrate surface,and results in a thick PA *** this work,we proposed a strategy that constructing triazine-based porous organic polymer(TRZ-POP)as the interlayer to prepare the ultrathin PA nanofiltration ***-POP is firstly deposited on the polyethersulfone substrate,and then the formed TRZ-POP provides more adhesion sites towards PA based on its high specific surface *** chemical bonding between terminal amine group of TRZ-POP and the amide group of PA further improves the binding force,and strengthens the stability of PA *** importantly,the high porosity of TRZPOP layer causes the higher polymerization of initial PA owning to the stored sufficient amino monomer;and H-bonding interaction between amine groups of TRZ-POP and piperazine(PIP)can astrict the release of ***,IP process is controlled,and the thinnest thickness of prepared PA layer is only<15 *** expected,PA/TRZ-POP membrane shows a more excellent water flux of 1414 L·m^(-2)·h^(-1)·MPa^(-1)than that of the state-of-the-art nanofiltration membranes,and without sacrificing dye *** build of TRZPOP interlayer develops a new method for obtaining a high-flux nanofiltration membrane.

关键词： Polyamide Nanofiltration Interfacial polymerization Triazine-based porous organic polymer

Preparation of Polyimide/BaTiO_3/Ag Nanocomposite Films via in situ Technique and Study of Their Dielectric Behavior

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Chinese Journal of Polymer Science 2014年第4期32卷 424-431页

作者： Jia-yu zhan Guo-feng Tian zhan-peng Wu Sheng-li Qi 武德珍 State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing Building Materials Academy of Science Research/State Key Laboratory of Solid Waste Reuse for Building Materials

Triphase polyimide nanocomposite films were fabricated using barium titanate （BaTiO3） with high dielectric constant and silver （Ag） with high conductivity as fillers. In situ method was utilized to obtain the homogeneous dispersion of nanoparticles. The in situ polymerization of polyimide precursor-poly（amic acid） was performed in the presence of BaTiO3 particles. Silver compound 1,1,1-trifluoro-2,4-pentadionato silver（I） was added into the BaTiO3 containing poly（amic acid） solution to achieve silver nanoparticles via in situ self metallization technique. The thermally induced reduction converted silver （I） to metallic silver with concomitant imidization of poly（amic acid） to polyimide. Both BaTiO3 and silver nanoparticles were uniformly dispersed in the polyimide substrate. The dependence of dielectric behavior on the BaTiO3 and Ag contents was studied. The incorporation of small amount of silver nanoparticles greatly increased dielectric constant of composite films.

关键词： Polyimide Silver Barium titanate Nanocomposites Dielectrics.

SMIP-30,a potent and selective PPM1A inhibitor with potential to treat tuberculosis

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4519-4521页

作者： Shujing Xu Xinyong Liu peng zhan Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesShandong UniversityJi'nan 250012China

Recently,a collaborative research led by Weibo Yang and Jim Sun1 published in Cell Chemical Biology identified a potent and selective small molecule inhibitor(SMIP-30)for human protein phosphatase Mg^(2+)/Mn^(2+)-dependent 1 A(PPM1A).They applied this chemical probe to determine the autophagy receptor p62 as a new substrate of PPM1A.

关键词： PPM1A Tuberculosis Drug discovery Compound library

Intra-family Income Redistribution and Its Dynamic Changes among the Elderly in China:2002-2018

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China & World Economy 2021年第5期29卷 84-104页

作者： Hanrui Jia peng zhan Business School Beijing Normal UniversityChina Research Fellow Institute for Common Prosperity and DevelopmentZhejiang UniversityChina

This paper studies the impact of household income redistribution on income inequality among the elderly from 2002 to 2018. It defines shared income and measures how each family member's contributions affect income inequality among the elderly. The study has three major findings. First, from 2013 to 2018, the role of household shared income in reducing income inequality among the elderly increased. Second, the proportion of shared income contributed by children was the highest overall, reaching 11.0 percent nationwide and even 17.9 percent in rural areas in 2018. The contribution of shared income to inequality was also higher among the rural elderly. Grandchildren under 16 largely received shared income from the elderly, and the income transferred by the male elderly to their wives was obvious. Third, changes in family structure narrowed the inequality gap among the elderly in the periods 2002–2013 and 2013–2018.

关键词： family structure income inequality for the elderly inequality decomposition intra-family income redistribution

Decontamination efficiency and root structure change in the plant-intercropping model in vertical-flow constructed wetlands

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Frontiers of Environmental Science & Engineering 2013年第6期7卷 906-912页

作者： Yonghua CHEN Xiaofu WU Mingli CHEN Kelin LI Jing peng peng zhan Research Center of Environment Science and Engineering Central South University of Forestry and Technology Changsha 4 10004 China

Subtropical climatic conditions can contribute to the death of the aerial parts of constructed wetland plants in winter. This presents a barrier to the widespread application of constructed wetland and is an issue that urgently needs to be solved. Three contrasting experi- ments, the plant-intercropping model （A）, the warm- seasonal plant model （B）, and the non-plant model （C）, were studied in terms of their efficiency in removing pollutants, and the change in root structure of plants in the plant-intercropping model within the vertical-flow con- structed wetlands. The results indicate that model A was able to solve the aforementioned problem. Overall, average removal rates of three pollutants （CODcr, total nitrogen （TN） and total phosphorous （TP）） using model A were significantly higher than those obtained using models B and C （P 〈 0.01）. Moreover, no significant differences in removal rates of the three pollutants were detected between A and B during the higher temperature part of the year （P〉 0.05）. Conversely, removal rates of the three pollutants were found to be significantly higher using model A than those observed using model B during the lower temperature part of the year （P 〈 0.01）. Furthermore, the morphologies and internal structures of plant roots further demonstrate that numerous white roots, whose distribution in soil was generally shallow, extend further under model A. The roots of these aquatic plants have an aerenchyma structure composed of parenchyma cells, therefore, roots of the cold-seasonal plants with major growth advantages used in A were capable of creating a more favorable vertical-flow constructed wetlands media- microenvironment. In conclusion, the plant-intercropping model （A） is more suitable for use in the cold environment experienced by constructed wetland during winter.

关键词： vertical-flow constructed wetlands plantintercropping model warm seasonal plant model

Jun12682,a potent SARS-CoV-2 papain-like protease inhibitor with exceptional antiviral efficacy in mice

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4189-4192页

作者： Mianling Yang Meehyein Kim peng zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi’nan 250012China Infectious Diseases Therapeutic Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea

Recently,a collaborative research study published in Science,led by Jun Wang,Xufang Deng,Eddy Arnold,and Francesc Xavier Ruiz1,identified a series of potent small molecule inhibitors that specifically target SARS-CoV-2 papain-like protease(PL^(pro)).The study demonstrated nanomolar PL^(pro) inhibitory potency with K_(i) values ranging from 13.2 to 88.2 nmol/*** employing a structure-based drug design strategy,the researchers discovered an exceptionally promising compound,named Jun12682,that effectively targets both the newly discovered ubiquitin Val70(Val70^(Ub))-binding site and the known blocking loop(BL2)groove near the S4 subsite of PL^(pro).Furthermore,studies on the mechanism of action revealed that Jun12682 inhibits the deubiquitinating and deISGylating activities of PLpro,which are crucial for antagonizing the host’s innate immune response upon viral *** biology studies confirmed the“two-pronged”binding mode of Jun12682,aligning perfectly with their drug design ***,Jun12682 exhibited potent antiviral activity against SARS-CoV-2 and its variants,including nirmatrelvir-resistant mutants,in Caco-2 cells(EC_(50):0.44-2.02 μmol/L).It is noteworthy that its oral administration significantly improved survival rates and alleviated both lung virus loads and histopathological lesions in a lethal SARS-CoV-2 mouse *** conclusion。

关键词： SARS-CoV-2 Papain-like protease Broad-spectrum Anti-drug resistance Drug candidate

Local density of states around two nonmagnetic impurities in cuprate superconductors

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Frontiers of physics 2011年第3期6卷 309-312页

作者： zhan-peng HUANG Xia-xia WAN Feng YUAN College of Physics Science Qingdao University Qingdao 266071 China

The local density of states （LDOS） around two nonmagnetic impurities which are located at different sites is studied within the two-dimensional t-J-U model. The order parameters are determined in a self-consistent way with the Gutzwiller projected mean-field approximation and the Bogoliubov-de Gennes theory. When the two impurities are located one or two sites away, we find the supercon- ductivity coherence peaks are more strongly suppressed and the zero-energy peak （ZEP） has split into two peaks. Whereas when the two impurities are located next to each other, the ZEP vanished, and LDOS does not change a lot compared with the case away from the impurities.

关键词： local density of states (LDOS) nonmagnetic impurities Gutzwiller approximation

Large-area surface-enhanced Raman scattering-active substrates fabricated by femtosecond laser ablation

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Science China(Physics,Mechanics & Astronomy) 2013年第9期56卷 1806-1809页

作者： ZHU ZhiQing YAN ZhenDong zhan peng WANG ZhenLin School of Physics and National Laboratory of Solid State Microstructures Nanjing University

A rapid and simple approach to fabricate large-area surface-enhanced Raman scattering-active(SERS-active) substrates is *** substrates are fabricated by using femtosecond laser(fs-laser) direct writing on Silicon wafers,followed by thin-film coating of metal such as *** substrates are demonstrated to exhibit signal homogeneity and good enhancement ability for *** maximum enhancement factor(EF) up to 3×10 7 of such SERS substrates for rhodamine 6G(R6G) at 785 nm excitation wavelength was *** technique could demonstrate a functional microchip with SERS capability of signal homogeneity,high sensitivity and chemical stability.

关键词： surface-enhanced Raman scattering femtosecond laser ablation metal microstructure