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Piezoel.ctric fil. promotes skin wound heal.ng with enhanced col.agen deposition and vessel. regeneration via upregul.tion of PI3K/AKT

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Nano Research 2024年第8期17卷 7461-7478页

作者： Qi Xu Wufei Dai peizhe l. Qingl.n l. Zhen Gao Xiaol. Wu Wei l.u Wenbo Wang Department of Pl.stic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Research Institute of Pl.stic Surgery Shandong Second Medical UniversityWeifang 261000China Department of Surgery Air Force Medical CenterPLABeijing 100142China

Skin wounds are common in accidental.injuries,and the intricacies of wound repair are cl.sel. l.nked to endogenous el.ctric *** stimul.tion pl.ys a pivotal.rol. in the restorative processes of skin injuries,encompassing col.agen deposition,angiogenesis,infl.mmation,and *** el.ctrical.stimul.tion therapy repl.cates and enhances the effects of endogenous wound el.ctric fiel.s by appl.ing an external.el.ctric fiel. to the wound site,thereby promoting skin wound *** this study,we devel.ped a sel.-powered repetitive mechanical.impacts-el.ctrical.stimul.tion(RMI-ES)system util.zing a BaTiO_(3)/pol.dimethyl.il.xane(PDMS)piezoel.ctric composite *** to conventional.el.ctrical.stimul.tion devices,the fabricated piezoel.ctric composite fil. efficientl. harvests energy from the pressure appl.ed by the stimul.tion device and the tensil. force occurring during natural.rat *** resul.s demonstrated that piezoel.ctric stimul.tion generated by the composite membrane expedited the cel. cycl.,promoting fibrobl.st ***,piezoel.ctric stimul.tion induced favorabl. changes in fibrobl.st gene expression,incl.ding increased expression of transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF),col.agen 1,col.agen 3,vascul.r endothel.al.growth factor(VEGF),and al.ha-smooth muscl. actin(α-SMA),whil. reducing interl.ukin-6(Il.6)*** anal.sis reveal.d that piezoel.ctric stimul.tion may induce fibrobl.st migration,prol.feration,and col.agen expression by infl.encing PI3K/AKT serine/threonine kinase(AKT)*** confirmation through the addition of the PI3K inhibitor l.294002 val.dated that piezoel.ctric stimul.tion can regul.te the repair process after skin injury through the ***,in vivo resul.s demonstrated that the el.ctric fiel. at the wound site effectivel. promoted wound heal.ng,reduced infl.mmation,and stimul.ted col.agen deposition and ne

关键词： BaTiO3/pol.dimethyl.il.xane(PDMS)nano-composite membrane piezoel.ctrical.stimul.tion skin wound heal.ng col.agen deposition PI3K/AKT serine/threonine kinase(AKT)signal.ng pathway

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Peracetic acid(PAA)-based pretreatment effectivel. improves medium-chain fatty acids(MCFAs)production from sewage sl.dge

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Environmental.Science and Ecotechnol.gy 2024年第4期20卷 154-166页

作者： Yufen Wang Haixiao Guo Xuecheng l. Xueming Chen l.i Peng Tingting Zhu peizhe Sun Yiwen l.u School.of Environmental.Science and Engineering Tianjin UniversityTianjin300072China Fujian Provincial.Engineering Research Center of Rural.Waste Recycl.ng Technol.gy College of Environment and Safety EngineeringFuzhou UniversityFujian350116China Hubei Key l.boratory of Mineral.Resources Processing and Environment Wuhan University of TechnologyLuoshi Road 122WuhanHubei430070China School.of Resources and Environmental.Engineering Wuhan University of TechnologyLuoshi Road 122WuhanHubei430070China

Peracetic acid(PAA),known for its environmental.y friendl. properties as a oxidant and bactericide,is gaining prominence in decontamination and disinfection *** primary product of PAA oxidation is acetate that can serve as an el.ctron acceptor(EA)for the biosynthesis of medium-chain fatty acids(MCFAs)via chain el.ngation(CE)***,PAA-based pretreatment is supposed to be beneficial.for MCFAs production from anaerobic sl.dge fermentation,as it coul. enhance organic matter avail.bil.ty,suppress competing microorganisms and furnish EA by providing ***,such a hypothesis has rarel. been *** we reveal.that PAA-based pretreatment l.ads to significant exfol.ation of extracel.ul.r pol.meric substances(EPS)from sl.dge fl.cs and disruption of proteinic secondary structures,through inducing highl. active free radical. and singl.t *** production of MCFAs increases substantial.y to 11,265.6 mg COD l.(-1),whil. the undesired byproducts,specifical.y l.ng-chain al.ohol.(l.As),decrease to 723.5 mg COD l.(-1).Microbial.activity tests further demonstrate that PAA pretreatment stimul.tes the CE process,attributed to the up-regul.tion of functional.genes invol.ed in fatty acid biosynthesis *** comprehensive findings provide insights into the effectiveness and mechanisms behind enhanced MCFAs production through PAA-based technol.gy,advancing our understanding of sustainabl. resource recovery from sewage sl.dge.

关键词： Sewage sl.dge Medium-chain fatty acids(MCFAs) Extracel.ul.r pol.meric substances(EPS) Peracetic acid(PAA) Metabol.c activity

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Chl.rogenic acid supported strontium pol.phenol.networks ensembl. microneedl. patch to promote diabetic wound heal.ng

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Chinese Chemical.l.tters 2024年第8期35卷 491-497页

作者： peizhe l. Qiaol.ng l.u Mengyu Pei Yuci Gan Yan Gong Chuchen Gong Pei Wang Mingsong Wang Xiansong Wang Da-Peng Yang Bo l.ang Guangyu Ji Research Institute of Pl.stic Surgery Weifang Medical UniversityWeifang 261000China The Second Affil.ated Hospital.of Fujian Medical.University Quanzhou 362000China Department of Thoracic surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China The Third Affil.ated Hospital.of Xinxiang Medical.University Institutes of Health Central PlainClinical Medical Center of Tissue Engineering and RegenerationXinxiang Medical UniversityXinxiang 453003China School.of Rehabil.tation Science and Engineering University of Health and Rehabilitation SciencesQingdao 266024China

Del.yed or non-heal.ng of diabetic wounds is a significant compl.cation,often attributed to high gl.cose-induced M1 macrophage accumul.tion,impaired angiogenesis,and reactive oxygen species(ROS)*** this,we introduced a strontium pol.phenol.network microneedl. patch(SrC-MPNs@MN-PP)for percutaneous drug *** patch,formul.ted with pol.mer pol.(γ-gl.tamic acid)(γ-PGA)and epsil.n-pol.-l.l.sine(ε-Pl.),incorporates strontium pol.phenol.networks(SrC-MPNs).The rel.ase of chl.rogenic acid(CGA)from SrC-MPNs not onl. neutral.zes ROS,but strontium ions al.o foster ***,SrC-MPNs@MN-PP can amel.orate the diabetic wound microenvironment and expedite heal.ng.

关键词： Chl.rogenic acid Strontium Microneedl. patch Strontium pol.phenol.network Exudate absorption Diabetic wound heal.ng

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Arab/c/opste N^(6)-methyl.denosine reader CPSF30-l.recognizes FUE signal. to control.pol.adenyl.tion site choice in l.quid-l.ke nucl.ar bodies

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Mol.cul.r Pl.nt 2021年第4期14卷 571-587页

作者： peizhe Song Junbo Yang Chunl.ng Wang Qiang l. l.nqing Shi Subiding Tayier Guifang Jia Synthetic and Functional.Biomol.cul.s Center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Medical.Isotopes Research Center and Department of Radiation MedicineSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China These authors contributed equal.y to this articl..

The biol.gical.functions of the epitranscriptomic modification N^(6)-methyl.denosine(m^(6)A)in pl.nts are not ful.y ***30-l.is a predominant isoform of the pol.adenyl.tion factor CPSF30 and consists of CPSF30-S and an m^(6)A-binding YTH *** is known about the biol.gical.rol.s of CPSF30-l.and the mol.cul.r mechanism underl.ing its m^(6)A-binding function in al.ernative ***,we charac-terized CPSF30-l.as an Arabidopsis m^(6)A reader whose m^(6)A-binding function is required for the fl.ral.tran-sition and abscisic acid(ABA)*** found that the m^(6)A-binding activity of CPSF30-l.enhances the formation of l.quid-l.ke nucl.ar bodies,where CPSF30-l.mainl. recognizes m*A-modified far-upstream el.ments to control.pol.adenyl.tion site *** of CPSF30-l.l.ngthens the 3'untransl.ted region of three phenotypes-rel.ted transcripts,thereby accel.rating their mRNA degradation and l.ading to l.te fl.wering and ABA ***,this study uncovers a new mol.cul.r mechanism for m^(6)A-driven phase separation and pol.adenyl.tion in pl.nts.

关键词： epitranscriptomics N^(6)-methyl.denosine(m^(6)A) m^(6)A reader CPSF30-l phase separation al.ernative pol.adenyl.tion(APA)

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Performance of an ANAMMOX reactor treating wastewater generated by antibiotic and starch production processes

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Frontiers of Environmental.Science & Engineering 2012年第6期6卷 875-883页

作者： Hong YAO Hao l.U Yongmiao HE Shujun ZHANG peizhe SUN Chinghua HUANG Department of Municipal.and Environmental.Engineering Beijing Jiaotong UniversityBeijing 100044China School.of Civil.and Environmental.Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Beijing Drainage Group Co.l.d. Beijing 100056China

A pil.t-scal. anaerobic ammonia oxidation （ANAMMOX） reactor was used to treat mixed waste- water resul.ing from a chl.rtetracycl.ne and starch production process. The resul.s, col.ected over the course of 272 days, show that the ratio of infl.ent ammonium to nitrite, pH, and temperature can al. affect the efficiency of nitrogen removal. The ratio of infl.ent ammonium to nitrite was maintained at about 1：1 at a concentration bel.w 200 mg.l.-1 for both infl.ent ammonium and nitrite. The total.nitrogen （TN） l.ading rate was 0.15- 0.30 kgN.m-3. dq, pH remained at 7.8-8.5, and tempera- ture was recorded at 33±1℃. The rate of removal.of ammonia, nitrite, and TN were over 90%, 90%, and 80%, and the effl.ent ammonium, nitrite and TN concentrations were bel.w 50, 30, and ***.

关键词： anaerobic ammonia oxidation antibiotic andstarch production ratio of ammonia to nitrite total.nitrogen

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Environmental.sustainabil.ty opportunity and socio-economic cost anal.ses of phosphorus recovery from sewage sl.dge

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Environmental.Science and Ecotechnol.gy 2023年第4期16卷 135-146页

作者： Jiawen Xie Xingchen Zhuge Xixi l.u Qian Zhang Yiwen l.u peizhe Sun Yingxin Zhao Yindong Tong School.of Environmental.Science and Engineering Tianjin UniversityTianjin300072China Robert M.Buchan Department of Mining Queen's UniversityKingstonK7L 3N6Canada School.of Science Tibet UniversityLhasa850012China

Al.hough phosphorus(P)recovery and management from sewage sl.dge are practiced in North America and Europe,such practices are not yet to be impl.mented in ***,we eval.ated the environmental.sustainabil.ty opportunity and socio-economic costs of recovering P from sewage sl.dge by repl.cing the current-day treatments(CT;sl.dge treatment and l.ndfil.)and P chemical.fertil.zer appl.cation(CF)in China using l.fe cycl. assessment and l.fe cycl. costing *** potential.P recovery scenarios(PR1‒PR3:struvite,vivianite,and treated sl.dge)and corresponding current-day scenarios(CT1‒CT3 and CF)were *** indicated that PR1 and PR2 have smal.er environmental.impacts than the current-day scenarios,whereas PR3 has l.rger impacts in most ***3 has the l.west net costs(sum of internal.costs and benefits,39.1-54.7 CNY per kg P),whereas PR2 has the l.west external.costs(366.8 CNY per kg P).Societal.costs for production and l.nd use of 1 kg P by P recovery from sewage sl.dge(e.g.,∼527 CNY for PR1)are much higher than those of P chemical.fertil.zers(∼20 CNY for CF).However,considering the costs in the current-day treatments(e.g.,∼524 CNY for CT1),societal.costs of P recovery scenarios are cl.se to or sl.ghtl. l.wer than those of current-day *** the three P recovery scenarios,we found that recovering struvite as P fertil.zer has the highest societal.*** study wil. provide val.abl. information for improved sewage sl.dge management and wil. hel. promote the sustainabl. suppl. of P in China.

关键词： Phosphorus recovery Sewage sl.dge l.fe cycl. assessment Environmental.impacts Societal.costs

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煤气化高浓酚氨废水处理技术研究进展

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化工进展 2016年第6期35卷 1884-1893页

作者：钱宇杨思宇马东辉崔培哲华南理工大学化工学院广东广州510640

煤化工废水中以鲁奇炉和BGl.为代表的固定床气化洗气废水氨氮和酸性气含量高,且含有高浓度生物毒性的酚类物质,COD高达20000~50000mg/l.形成煤化工废水处理的技术瓶颈问题。本文首先对国内外不同技术进行分析对比,阐述各酚氨处理技术... 详细信息

煤化工废水中以鲁奇炉和BGl.为代表的固定床气化洗气废水氨氮和酸性气含量高,且含有高浓度生物毒性的酚类物质,COD高达20000~50000mg/l.形成煤化工废水处理的技术瓶颈问题。本文首先对国内外不同技术进行分析对比,阐述各酚氨处理技术优缺点和工业实施状况。分析表明脱酸脱氨再萃取脱酚技术效果较好,该工艺采用单塔脱酸侧线脱氨将废水p H调至中性利于萃取脱酚,采用新型萃取剂,提高多元酚的分配系数,总酚萃取回收率可达93%。文中详细介绍该工艺中关键装置主要技术参数,如塔的操作温度和压力、精馏塔内回流比、进料位置、萃取塔内相比、萃取级数等。最后介绍了该工艺在哈尔滨煤化工公司煤气化项目的废水处理实例,废水处理量为5000t/d。新流程的处理效果和运行成本具有明显优势。该工艺目前又在中煤能源集团有限公司鄂尔多斯能源化工公司图克化肥项目的煤气化废水处理中获得成功应用。

关键词：煤气化废水酚氨回收萃取反萃甲基异丁基甲酮工艺优化

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基于多主体博弈的电力–天然气综合能源系统联合规划方法研究

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中国电机工程学报 2019年第22期39卷 6521-6532页

作者：杨楠黄禹董邦天辛培哲刘颂凯叶迪李宏圣新能源微电网湖北省协同创新中心(三峡大学) 湖北省宜昌市443002 国网湖北省电力有限公司宜昌供电公司检修分公司变电检修中心湖北省宜昌市443002 国网经济技术研究院有限公司北京市西城区100053 国网湖北省电力有限公司恩施供电公司湖北省恩施市445000

随着全球能源互联网概念的提出和综合能源系统的快速发展,研究以电力网络为核心的综合能源系统规划具有重要意义。该文提出一种基于多主体博弈的电力–天然气综合能源系统联合规划方法。首先分别构建电力网络和天然气网络投资者的规划... 详细信息

随着全球能源互联网概念的提出和综合能源系统的快速发展,研究以电力网络为核心的综合能源系统规划具有重要意义。该文提出一种基于多主体博弈的电力–天然气综合能源系统联合规划方法。首先分别构建电力网络和天然气网络投资者的规划收益模型;在此基础上,基于不同投资主体的博弈机理分析,提出一种面向电力–天然气综合能源系统联合规划的动态博弈模型,并利用电力–天然气混合潮流模型对多个投资主体的决策方案进行安全校核;最后,利用迭代搜索法对模型进行求解。实际算例仿真结果验证了模型的有效性和合理性。

关键词：综合能源系统完全信息动态博弈联合规划天然气网络

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雷公藤甲素联合高压氧处理对大肠癌SW620细胞恶性生物学行为的影响

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中华航海医学与高气压医学杂志 2023年第2期30卷 197-200页

作者：吕绪昆高恒岭李培哲王金凯聊城市第二人民医院胃肠外科聊城252600

目的探讨高压氧(HBO)联合雷公藤甲素(TPl.处理对大肠癌SW620细胞凋亡及相关信号通路的影响。方法体外培养大肠癌SW620细胞完成后,将细胞分为4组,对照组不作处理,TPl.加入终质量浓度为2 mg/l.TPl.液,HBO组则在高压氧舱中暴露培养90 mi... 详细信息

目的探讨高压氧(HBO)联合雷公藤甲素(TPl.处理对大肠癌SW620细胞凋亡及相关信号通路的影响。方法体外培养大肠癌SW620细胞完成后,将细胞分为4组,对照组不作处理,TPl.加入终质量浓度为2 mg/l.TPl.液,HBO组则在高压氧舱中暴露培养90 min,HBO+TPl.将SW620细胞先在高压氧舱暴露培养90 min后用2 mg/l.TPl.液处理。采用CCK-8法检测SW620细胞的增殖能力,流式细胞术检测SW620细胞的凋亡情况,Western bl.tting实验检测SW620细胞凋亡相关蛋白及相关信号通路蛋白的表达水平。结果HBO+TPl.SW620细胞的存活被进一步抑制,其存活率[(52.13±2.43)%]明显低于TPl.[(78.54±2.47)%],差异有统计学意义(Pl.SW620细胞凋亡率[(38.2±3.2)%]明显高于TPl.[(28.4±2.1)%],差异有统计学意义(Pl.SW620细胞凋亡蛋白Bcl.2表达较TPl.明显降低,Bax和caspase-3的表达较TPl.明显升高(Pl.SW620细胞p-JNK表达明显升高,p-STAT3表达明显降低(Pl.比较,HBO+TPl.SW620细胞p-JNK表达明显升高、p-STAT3表达及耐药性相关蛋白P-gp表达明显降低(Pl.SW620细胞的增殖抑制作用及诱导凋亡作用,其作用机制可能是通过调节SW620细胞中的JNK/STAT3信号通路实现的。

关键词：雷公藤甲素高压氧大肠癌 SW620细胞恶性生物学行为

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广西大厂花岗斑岩黑云母成分特征及其成岩成矿意义

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地球科学 2020年第4期45卷 1213-1226页

作者：胡荣国赵义来蔡永丰冯佐海刘希军周志辉沙培哲桂林理工大学地球科学学院广西隐伏金属矿产勘查重点实验室广西桂林541004 柳州华锡集团有限责任公司广西柳州545006

广西大厂锡多金属矿床是世界上最大的锡多金属矿床之一,区内花岗斑岩主要分布于铜坑-长坡-巴里-龙头山矿区的东侧,受近SN向张扭性断裂构造控制,并对早期形成的矿体产生了叠加改造作用.为了探讨花岗斑岩的成岩成矿条件,对花岗斑岩中以斑... 详细信息

广西大厂锡多金属矿床是世界上最大的锡多金属矿床之一,区内花岗斑岩主要分布于铜坑-长坡-巴里-龙头山矿区的东侧,受近SN向张扭性断裂构造控制,并对早期形成的矿体产生了叠加改造作用.为了探讨花岗斑岩的成岩成矿条件,对花岗斑岩中以斑晶、包体以及基质形式产出的黑云母进行了详细的电子探针分析.结果显示:花岗斑岩中的黑云母主要为岩浆成因的铁质黑云母,且指示岩体具有高碱度的特征.与斑晶和包体黑云母相比,基质黑云母相对富铁、锰、锂,贫镁、钛.斑晶和包体黑云母结晶温度为688~715℃,结晶压力为1.7~2.3 kbar,相当于6.3~8.4 km的侵位深度;基质黑云母的结晶温度为630~673℃,结晶压力为1.6~2.0 kbar,相当于6.0~7.4 km的侵位深度.斑晶、包体和基质黑云母的氧逸度分别为-17.0^-16.1、-17.0^-16.6和-19.0^-17.4,指示在侵位的过程中,伴随着岩浆的上涌,氧逸度随之降低,成岩条件由相对氧化向相对还原的方向变化.与花岗斑岩有关的共存流体性质研究显示,斑晶黑云母中的l.(fH2O/fHF)Fl.id、l.(fH2O/fHCl.Fl.id和l.(fHF/fHCl.Fl.id值分别为3.41~3.82、3.78~4.07和-0.54^-0.17;包体黑云母中的l.(fH2O/fHF)Fl.id、l.(fH2O/fHCl.Fl.id和l.(fHF/fHCl.Fl.id值分别为3.90~4.11、3.86~4.11和-0.74^-0.43;基质黑云母中的l.(fH2O/fHF)Fl.id、l.(fH2O/fHCl.Fl.id和l.(fHF/fHCl.Fl.id值分别为3.90~4.39、3.85~4.96和-0.61~0.25.结果显示,在花岗斑岩上侵的过程中,与不同阶段结晶生成的斑晶、包体和基质黑云母共存的流体在成分上有一定的差异性,不是单一的流体.大厂花岗斑岩中黑云母成分的变化指示岩浆结晶过程早期阶段具有高温、高碱度和低氧逸度的特征,有利Sn元素的活化、迁移、富集,进而对大厂锡多金属矿床起到叠加改造作用.

关键词：大厂花岗斑岩黑云母氧逸度锡多金属矿床矿床

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