Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing

作     者：Peizhe Li Qiaoling Liu Mengyu Pei Yuci Gan Yan Gong Chuchen Gong Pei Wang Mingsong Wang Xiansong Wang Da-Peng Yang Bo Liang Guangyu Ji Peizhe Li;Qiaoling Liu;Mengyu Pei;Yuci Gan;Yan Gong;Chuchen Gong;Pei Wang;Mingsong Wang;Xiansong Wang;Da-Peng Yang;Bo Liang;Guangyu Ji

作者机构：Research Institute of Plastic SurgeryWeifang Medical UniversityWeifang 261000China The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000China Department of Thoracic surgeryShanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China The Third Affiliated Hospital of Xinxiang Medical UniversityInstitutes of Health Central PlainClinical Medical Center of Tissue Engineering and RegenerationXinxiang Medical UniversityXinxiang 453003China School of Rehabilitation Science and EngineeringUniversity of Health and Rehabilitation SciencesQingdao 266024China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第8期

页      面：491-497页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China(No.31971271) The Natural Science Foundation of Fujian Province of China(No.2022J01794) The Science and Technology Plan Project of Quanzhou(No.2021N033S) 

主　　题：Chlorogenic acid Strontium Microneedle patch Strontium polyphenol network Exudate absorption Diabetic wound healing 

摘      要：Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)*** this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug *** patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-l-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster ***,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.