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Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT

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Nano Research 2024年第8期17卷 7461-7478页

作者： Qi Xu Wufei Dai peizhe li Qinglin li Zhen Gao Xiaoli Wu Wei liu Wenbo Wang Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Research Institute of Plastic Surgery Shandong Second Medical UniversityWeifang 261000China Department of Surgery Air Force Medical CenterPLABeijing 100142China

Skin wounds are common in accidental injuries,and the intricacies of wound repair are closely linked to endogenous electric *** stimulation plays a pivotal role in the restorative processes of skin injuries,encompassing collagen deposition,angiogenesis,inflammation,and *** electrical stimulation therapy replicates and enhances the effects of endogenous wound electric fields by applying an external electric field to the wound site,thereby promoting skin wound *** this study,we developed a self-powered repetitive mechanical impacts-electrical stimulation(RMI-ES)system utilizing a BaTiO_(3)/polydimethylsiloxane(PDMS)piezoelectric composite *** to conventional electrical stimulation devices,the fabricated piezoelectric composite film efficiently harvests energy from the pressure applied by the stimulation device and the tensile force occurring during natural rat *** results demonstrated that piezoelectric stimulation generated by the composite membrane expedited the cell cycle,promoting fibroblast ***,piezoelectric stimulation induced favorable changes in fibroblast gene expression,including increased expression of transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF),collagen 1,collagen 3,vascular endothelial growth factor(VEGF),and alpha-smooth muscle actin(α-SMA),while reducing interleukin-6(IL-6)*** analysis revealed that piezoelectric stimulation may induce fibroblast migration,proliferation,and collagen expression by influencing PI3K/AKT serine/threonine kinase(AKT)*** confirmation through the addition of the PI3K inhibitor LY294002 validated that piezoelectric stimulation can regulate the repair process after skin injury through the ***,in vivo results demonstrated that the electric field at the wound site effectively promoted wound healing,reduced inflammation,and stimulated collagen deposition and ne

关键词： BaTiO3/polydimethylsiloxane(PDMS)nano-composite membrane piezoelectrical stimulation skin wound healing collagen deposition PI3K/AKT serine/threonine kinase(AKT)signaling pathway

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Multifunctional Peptide-Melanin Hybrid Nanodots with Robust Anti-Cutaneous Photoaging Activity

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Journal of Analysis and Testing 2024年第3期8卷 395-401页

作者： peizhe li Qiming Zhu Baozhu Wang Shanshan He Qi Xu Kaiyan li Yongmiao Shen Miao Su Zhijun Zhang Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang Province School of Chemistry and Chemical EngineeringZhejiang Sci-Tech UniversityHangzhou310018China College of Textile Science and Engineering(International Silk Institute) Zhejiang Sci-Tech UniversityHangzhou310018China Shanghai Beautyart Biotechnology Co. LtdShanghai200438China Shengzhou Innovation Research Institute of Zhejiang Sci-Tech University Shengzhou312400China

Skin aging is a systematic and complex process,mainly including intrinsic aging caused by time change and extrinsic aging caused by environmental *** caused by ultraviolet(UV)irradiation is the principle extrinsic factor of skin aging,which can directly or indirectly cause damage to DNA and other biomolecules,generate reactive oxygen species(ROS),and induce a decrease in collagen synthesis and other adverse ***,to address the causative factors and multiple side effects of skin photoaging,we constructed multifunctional peptide-melanin hybrid nanodots(PMHDs)to achieve multifaceted synergistic anti-skin aging by using melanin-like nanodots(MDs)and functional peptides as active *** them,the peptide has the activity of promoting collagen synthesis,while the MDs have the function of absorbing UV light and scavenging free ***,the MDs also act as a carrier to increase the cellular uptake of the *** anti-photoaging effects of the PMHDs were systematically verified in a multidimensional manner at the biochemical,cellular and small animal levels,respectively.

关键词： aging Skin ultraviolet

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Near-Infrared light-Activatable Melanized Paclitaxel Nano-Self-Assemblies for Synergistic Anti-tumor Therapy

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Journal of Analysis and Testing 2023年第3期7卷 204-214页

作者： Qiming Zhu peizhe li Qiwen Huang Xinpei Ding Nan Wang Weijun Yao Maozhong Miao Zhijun Zhang Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang Province School of Chemistry and Chemical EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China Shaoxing Keqiao Research Institute of Zhejiang Sci-Tech University Shaoxing 312000China Shengzhou Innovation Research Institute of Zhejiang Sci-Tech University Shengzhou 312400China

Building self-assembly nanostructures is an important way to overcome the limitations of paclitaxel in tumor ***,this strategy is also faced with challenges,such as difficulties in efficient release and the potential for drug ***,we developed a near-infrared light-activatable melanized paclitaxel self-assembly nanoparticles for synergistic anti-tumor *** this strategy,paclitaxel dimer prodrugs were synthesized and paclitaxel nanoparticles were obtained through ***,the paclitaxel dimer nanoparticles were capped with polydopamine(PDA,melanoidin)and human serum albumin(HSA).The disulfide bonds in paclitaxel dimeric prodrug specifically respond to high concentrations of glutathione(GSH)and reactive oxygen species(ROS)in tumor *** enhances the biocompatibility of the drug molecules and imparts near-infrared photothermal conversion capability to the *** the in vitro and in vivo experiments demonstrated that this paclitaxel nanoprodrug exhibited enhanced tumor therapeutic efficacy under near-infrared light irradiation.

关键词： Paclitaxel nano-self-assemblies Synergistic anti-tumor therapy Photothermal eff ect Melanoidins Nearinfrared light-activatable

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Exploring the Scientific Research Collaboration Network in Sustainability Science in China

Exploring the Scientific Research Collaboration Network in S...

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第三十九届中国控制会议

作者： peizhe li School of Business Shan Dong University of Political science and Law College of Economics and Management Nanjing University of Aeronautics and Astronautics

Sustainable development has been one of the main hotspots of Chinese research studies in recent years. Examining the scientific research collaboration network will help explore the current collaboration situation and development trends, particularly in the field of sustainability science. Based on the method of social network analysis, the author collaboration network, keyword co-occurrence network, and institutional collaboration network were constructed using the China HowNet database, and the structure and characteristics of the collaboration networks were analyzed. The results show that the co-authorship rates in sustainability science vary greatly, the overall cooperation is still relatively loose, and there are many small groups disconnected within the overall network. The collaboration network can be characterized as being small-world and scale-free, and the nodes with greater influence act as the center of the collaboration network, affecting the academic exchanges and scientific research work in the network.

关键词： sustainable development authors key words institution social network analysis

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Effects of biofertilizer and water-saving irrigation interactions on the leaf photosynthesis and plant growth of tomatoes

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 177-185页

作者： Danyan Chen Yuchun Ai peizhe li Yue Dong Hailing li Changyi Wang Xiaorui Jiang Shilong li Yan Shen Aijun Dai Yuanyuan Feng College of Horticulture Jinling Institute of TechnologyNanjing 210038China Co-Innovation Center for Sustainable Forestry in Southern China College of Forestry and GrasslandCollege of Soil and Water ConservationNanjing Forestry UniversityNanjing 210037China Institute of Agricultural Resources and Environment Jiangsu Academy of Agricultural SciencesNanjing 210014China Agriculture Exchange and Cooperation Center of Shandong Province Jinan 250100China Murdoch Applied Innovation Nanotechnology Research Group College of ScienceHealthEngineering and EducationMurdoch UniversityPerthWA 5150Australia

Irrigation and fertilizer interaction is an efficient cultivation management strategy for facility ***,the effects of irrigation and fertilizer management on tomato growth and its physiological factors remain *** this study,two irrigation patterns(W1,conventional irrigation;W2,water-saving irrigation)and four fertilizer application patterns(CF,chemical fertilizer;BOF,biological organic fertilizer;NPK,nutrient compound fertilizer;BOF+NPK)were selected to observe the effects of their interaction on cherry tomato plant growth,leaf photosynthesis and fruit quality through pot *** results showed that W2 treatments promoted plant height growth compared to W1 under the same fertilizer ***,irrigation and fertilizer management had significant effects on net photosynthetic rate,intercellular oxidation concentration,stomatal conductance and transpiration rate at the first sequence flowering and fruiting *** maximum tomato plant height(99.0 cm)was achieved under the irrigation and fertilizer pattern of BOF and W2,along with the highest fruit yield of 1.98 kg/plant,which was approximately 31.1%higher than the minimum yield under the combined CF and W2 *** W2 treatments,the application of either NPK or BOF increased the soluble sugar content of *** structural equation models showed that the soil alkali hydrolyzed nitrogen could directly significantly affect the yield and soluble *** findings suggest that optimization of irrigation-fertilizer interactions positively regulates tomato growth,providing an efficient model for tomato irrigation and fertilizer management and a reference for sustainable development of facility agriculture.

关键词： irrigation-fertilization interaction cherry tomato plant height leaf photosynthesis fruit yield and quality

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Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing

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Chinese Chemical Letters 2024年第8期35卷 491-497页

作者： peizhe li Qiaoling liu Mengyu Pei Yuci Gan Yan Gong Chuchen Gong Pei Wang Mingsong Wang Xiansong Wang Da-Peng Yang Bo liang Guangyu Ji Research Institute of Plastic Surgery Weifang Medical UniversityWeifang 261000China The Second Affiliated Hospital of Fujian Medical University Quanzhou 362000China Department of Thoracic surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China The Third Affiliated Hospital of Xinxiang Medical University Institutes of Health Central PlainClinical Medical Center of Tissue Engineering and RegenerationXinxiang Medical UniversityXinxiang 453003China School of Rehabilitation Science and Engineering University of Health and Rehabilitation SciencesQingdao 266024China

Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)*** this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug *** patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-l-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster ***,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.

关键词： Chlorogenic acid Strontium Microneedle patch Strontium polyphenol network Exudate absorption Diabetic wound healing

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Analysis on the Evolution of Strategic Emerging Industry Innovation Network Based on Improved Local World Model

Analysis on the Evolution of Strategic Emerging Industry Inn...

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第40届中国控制会议

作者： peizhe li Shanshan Pei School of Business Shan Dong University of Political science and Law College of Economics and Management Nanjing University of Aeronautics and Astronautics

Strategic emerging industry is the leading industry of national economy, so it is of great significance to study its dynamic evolution law to promote the healthy development of strategic emerging industry. From the perspective of industry university research innovation of strategic emerging industries, this paper constructs an improved local world model for the evolution of strategic emerging industries by adding attraction and exit mechanism on the basis of local world network, and reveals the influence of various parameters on the innovation network of strategic emerging industries and its evolution law through MATLAB simulation. The results show that: the industry university research innovation network of strategic emerging industries is scale-free, the node degree obeys the power-law distribution, has larger average aggregation coefficient and smaller average path length, and the improved local world model can better describe the topological structure and evolution characteristics of strategic emerging industry innovation network.

关键词： strategic emerging industries innovation complex network local world evolution model attraction

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产学研视角下高技术产业成长系统动力学研究

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复杂系统与复杂性科学 2020年第2期17卷 76-85页

作者：李培哲南京航空航天大学经济与管理学院南京210016 山东政法学院商学院济南250014

为探索高技术产业成长的内在机理和规律,以产学研为视角,运用系统动力学方法构建了高技术产业成长系统动力学模型并进行模拟仿真,分析了影响高技术产业成长的关键因素及其影响程度。结果表明:企业R&D经费投入、人才政策支持力度和科技... 详细信息

为探索高技术产业成长的内在机理和规律,以产学研为视角,运用系统动力学方法构建了高技术产业成长系统动力学模型并进行模拟仿真,分析了影响高技术产业成长的关键因素及其影响程度。结果表明:企业R&D经费投入、人才政策支持力度和科技中介服务能力等对新产品销售收入有较为显著的正影响,人才政策支持力度和企业R&D经费投入对专利数量的正影响较为显著;综合来看,企业R&D经费投入与科技人才投入是影响高技术产业成长的主要因素。

关键词：高技术产业复杂系统成长系统动力学仿真

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网络结构、知识基础与企业创新绩效

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复杂系统与复杂性科学 2022年第2期19卷 31-38页

作者：李培哲菅利荣山东政法学院商学院济南250014 南京航空航天大学经济与管理学院南京210016

为探究网络结构、知识基础等对企业创新绩效的影响,基于社会网络的视角构建产学研合作创新网络,并运用负二项回归模型进行实证分析。结果表明:产学研创新网络中心性对企业创新绩效有显著正向影响,网络结构洞与企业创新绩效没有呈现出显... 详细信息

为探究网络结构、知识基础等对企业创新绩效的影响,基于社会网络的视角构建产学研合作创新网络,并运用负二项回归模型进行实证分析。结果表明:产学研创新网络中心性对企业创新绩效有显著正向影响,网络结构洞与企业创新绩效没有呈现出显著的倒U型关系,知识基础对企业创新绩效具有显著正向影响,知识基础与网络中心性的交互作用对企业创新绩效有显著负向影响,知识基础与结构洞的交互作用对企业创新绩效有正向影响但不显著。

关键词：产学研合作网络结构创新绩效社会网络分析

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基于社会网络视角的科研合作网络结构及特性分析--以战略性新兴产业领域为例

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技术经济 2020年第6期39卷 34-43,53页

作者：李培哲南京航空航天大学经济与管理学院南京210016 山东政法学院商学院济南250014

战略性新兴产业是近几年新出现的研究热点,对其科研合作网络的研究,有助于探究该领域的科研合作现状与发展趋势。基于社会网络分析方法,以中国知网(CNKI)作为数据来源,构建了战略性新兴产业领域作者合作网络、关键词共现网络、作者-关... 详细信息

战略性新兴产业是近几年新出现的研究热点,对其科研合作网络的研究,有助于探究该领域的科研合作现状与发展趋势。基于社会网络分析方法,以中国知网(CNKI)作为数据来源,构建了战略性新兴产业领域作者合作网络、关键词共现网络、作者-关键词耦合网络及机构合作网络,对合作网络的结构及特性等进行了分析。结果表明:战略性新兴产业领域论文合著率基本呈上升趋势,但该领域整体合作仍较为松散,存在较多的小团体;合作网络具有小世界和无标度特性,具有较大影响力的节点作为合作网络的中心,影响着网络内的学术交流和科研工作的开展。

关键词：战略性新兴产业作者关键词社会网络分析

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