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‘海黄’牡丹芳樟醇合酶基因PsTPS14的克隆及功能验证

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园艺学报 2024年第6期51卷 1273-1283页

作者：王佩云李子昂白杨杨萍尹承芃李传荣张馨文宋秀华山东农业大学园艺科学与工程学院山东泰安271018 山东农业大学林学院山东泰安271018

以芳香型牡丹品种‘海黄’(Paeonia×lemoinei‘High Noon’)为材料,根据转录组测序所得片段,克隆得到PsTPS14基因,该结构基因的完整CDS序列长903 bp,共编码300个氨基酸。氨基酸序列分析发现该蛋白具有较高的保守性,有1个保守结构域Terp... 详细信息

以芳香型牡丹品种‘海黄’(Paeonia×lemoinei‘High Noon’)为材料,根据转录组测序所得片段,克隆得到PsTPS14基因,该结构基因的完整CDS序列长903 bp,共编码300个氨基酸。氨基酸序列分析发现该蛋白具有较高的保守性,有1个保守结构域Terpene_cyclase_plant_C1。PsTPS14在‘海黄’牡丹半开期花瓣中表达量最高,与其花香挥发物释放规律一致。亚细胞定位分析表明PsTPS14主要定位于叶绿体中。利用瞬时表达方法将PsTPS14过表达载体注射到烟草叶片和淡香型牡丹‘凤丹’切花花瓣中,通过GC–MS方法可检测到烟草叶片和‘凤丹’花瓣中芳樟醇的释放,同时PsTPS14高表达,且芳樟醇合酶含量及其活性明显升高。研究结果表明PsTPS14在植物体内调控芳樟醇的合成。

关键词：牡丹芳樟醇芳樟醇合酶基因基因克隆功能验证

Laboratory-based Surveillance and Clinical Profile of Sporadic HEV Infection in Shanghai,China

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Virologica Sinica 2021年第4期36卷 644-654页

作者： Jie Lu Qing Li Jiayuan Jiang Ziqiang Li peiyun wang Zike Sheng Rongtao Lai Huijuan Zhou Wei Cai Hui wang Qing Guo Honglian Gui Qing Xie Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghai 200025China

The study aimed to describe the epidemiological,virological and clinical features of sporadic HEV infection in eastern China.A total of 6112 patient sera were tested for anti-HEV IgG or anti-HEV IgM during one consecutive year(between August 2018 and July 2019).HEV RNA presence was evaluated by RT-PCR and HEV sequences were phylogenetically *** features of confirmed HEV-infected patients were *** sero-positivity rate of anti-HEV IgG maintained stable around 40%,while an obvious winter spike of anti-HEV IgM prevalence was observed.A total of 111 patients were confirmed of HEV viremia by molecular *** 4d was *** analyses suggest that certain strains circulate across species and around the *** with confirmed current HEV infection had a high median age(58 years)and males were predominant(62.2%).Most patients presented with jaundice(75.7%)and anorexia(68.0%).Significantly elevated levels of liver enzymes and bilirubin were ***,the baseline bilirubin level was positively correlated with illness ***-existing HBV carriage may deteriorate *** clinical burden caused by locally acquired HEV infection is *** should be enforced especially during the transition period from winter to *** with higher level of bilirubin at disease onset had slower recovery from HEV infection.

关键词： Hepatitis E virus(HEV) Seroprevalence Genotyping Epidemiology Surveillance

Uncertainty-Aware Physical Simulation of Neural Radiance Fields for Fluids

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1143-1163页

作者： Haojie Lian Jiaqi wang Leilei Chen Shengze Li Ruochen Cao Qingyuan Hu peiyun Zhao Key Laboratory of In-Situ Property-Improving Mining of Ministry of Education Taiyuan University of TechnologyTaiyuan030024China Henan International Joint Laboratory of Structural Mechanics and Computational Simulation College of Architectural and Civil EngineeringHuanghuai UniversityZhumadian463000China National Innovation Institute of Defense Technology Academy of Military ScienceBeijing100091China School of Software Taiyuan University of TechnologyJinzhong030600China School of Science Jiangnan UniversityWuxi214122China

This paper presents a novel framework aimed at quantifying uncertainties associated with the 3D reconstruction of smoke *** approach reconstructs color and density fields from 2D images using Neural Radiance Field(NeRF)and improves image quality using frequency *** NeRF model is obtained via joint training ofmultiple artificial neural networks,whereby the expectation and standard deviation of density fields and RGB values can be evaluated for each *** addition,customized physics-informed neural network(PINN)with residual blocks and two-layer activation functions are utilized to input the density fields of the NeRF into Navier-Stokes equations and convection-diffusion equations to reconstruct the velocity *** velocity uncertainties are also evaluated through ensemble *** effectiveness of the proposed algorithm is demonstrated through numerical *** presentmethod is an important step towards downstream tasks such as reliability analysis and robust optimization in engineering design.

关键词： Uncertainty quantification neural radiance field physics-informed neural network frequency regularization twolayer activation function ensemble learning

IL-24 armored CAR19-T cells show enhanced antitumor activity and persistence

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Signal Transduction and Targeted Therapy 2021年第2期6卷 232-234页

作者： Qian Hu Yuxuan Zhang peiyun wang Miaojin Zhou Zhiqing Hu Cong Liu Mujun Liu Lingqian Wu Xionghao Liu Desheng Liang Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunanChina Hunan Key Laboratory of Basic and Applied Hematology School of Life SciencesCentral South UniversityChangshaHunanChina

Dear Editor,Nowadays,two autologous CAR19-T drugs,Tisagenlecleucel(Kymriah^(TM))and axicabtagene ciloleucel(Yescarta^(TM)),have been approved for the treatment of B cell leukemia and lymphoma and achieved unprecedented ***,about 10-20%of B-ALL patients receiving CAR19-T drugs didn't achieve complete remission(CR),while 30~50%of patients achieved CR would relapse mainly within 1 ***,the high CR rate of CAR19-T therapy for B-ALL can't be recaptured in other B-NHLs,'such as Burkitt's lymphoma(BL).Therefore,there is an urgent need to improve the therapeutic efficacy of CAR19-T cells.3.

关键词： drugs CAR lymphoma

温经浴袋熏洗辅助治疗寒凝血瘀型类风湿关节炎33例临床研究

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江苏中医药 2024年第8期56卷 44-47页

作者：王佩云邱帅辉张芳馨韩啸宇李琴段亚姣王保国王振亚曹奕安徽中医药大学研究生院安徽合肥230038 安徽中医药大学第二附属医院安徽合肥230061

目的:观察温经浴袋熏洗辅助治疗寒凝血瘀型类风湿关节炎(RA)的临床疗效。方法:将66例寒凝血瘀型RA患者随机分为治疗组与对照组,每组33例。对照组予来氟米特口服,治疗组在对照组治疗的基础上加用温经浴袋熏洗,2组疗程均为12周。观察并比... 详细信息

目的:观察温经浴袋熏洗辅助治疗寒凝血瘀型类风湿关节炎(RA)的临床疗效。方法:将66例寒凝血瘀型RA患者随机分为治疗组与对照组,每组33例。对照组予来氟米特口服,治疗组在对照组治疗的基础上加用温经浴袋熏洗,2组疗程均为12周。观察并比较2组患者治疗前后晨僵时间、压痛关节计数(TJC)、肿胀关节计数(SJC)、中医证候评分、临床疾病活动指数(CDAI)及类风湿因子(RF)、超敏C反应蛋白(hs-CRP)、红细胞沉降率(ESR)、血清钙离子(Ca^(2+))、D-二聚体(D-D)等指标的变化情况,疗程结束后评估2组患者临床疗效。结果:治疗后2组患者晨僵时间、TJC、SJC及CDAI均较本组治疗前明显降低(P<0.01),治疗组明显低于对照组(P<0.05)。治疗后2组患者hs-CRP、ESR、D-D水平均较本组治疗前明显降低(P<0.01),血清Ca^(2+)水平均较本组治疗前明显升高(P<0.01),治疗组上述指标改善程度均明显优于对照组(P<0.05)。治疗后2组患者关节刺痛、关节肿胀、关节压痛、关节屈伸不利、晨僵等中医证候单项评分及总分均较本组治疗前明显降低(P<0.01),治疗组明显低于对照组(P<0.05)。治疗组中医证候总有效率为87.88%,明显高于对照组的69.70%(P<0.05)。治疗期间2组患者均未出现与治疗药物及治疗方法相关的不良反应。结论:在常规治疗的基础上加用温经浴袋熏洗可显著缓解寒凝血瘀型RA患者临床症状,降低炎症水平,减少骨破坏以及改善局部血液循环,提高临床疗效,且安全性高,其机制可能与其对hs-CRP、ESR、D-D以及血清Ca^(2+)水平的调节作用有关,需做进一步研究。

关键词：类风湿关节炎温经浴袋中药熏洗外治法寒凝血瘀临床疗效

A Defense Planning Model for a Power System Against Coordinated Cyber-physical Attack

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Protection and Control of Modern Power Systems 2024年第5期9卷 84-95页

作者： peiyun Li Jian Fu Kaigui Xie Bo Hu Yu wang Changzheng Shao Yue Sun Wei Huang State Key Laboratory of Power Transmission Equipment&System Secu-rity and New Technology Chongqing UniversityChongqing 400044China State Grid Chengdu Power Supply Com-pany State Grid Sichuan Electric Power Co.Ltd.Chengdu 610041China China Yangtze Power Co. LtdYichang 443002China

This paper proposes a tri-level defense planning model to defend a power system against a coor-dinated cyber-physical attack(CCPA).The defense plan considers not only the standalone physical attack or the cyber attack,but also coordinated *** defense strategy adopts coordinated generation and transmission expansion planning to defend against the *** the process of modeling,the upper-level plan represents the perspective of the planner,aiming to minimize the critical load shedding of the planning system after the *** load resources available to planners are extended to flex-ible loads and critical *** middle-level plan is from the viewpoint of the attacker,and aims at generating an optimal CCPA scheme in the light of the planning strategy determined by the upper-level plan to maximize the load shedding caused by the *** optimal operational behavior of the operator is described by the lower-level plan,which minimizes the load shedding by defending against the *** tri-level model is analyzed by the column and constraint generation algorithm,which de-composes the defense model into a master problem and *** studies on a modified IEEE RTS-79 system are performed to demonstrate the economic effi-ciency of the proposed *** Terms—Coordinated cyber-physical attack,flexible load,column-and-constraint generation,defense planning,robust optimization.

关键词： Coordinated cyber-physical attack flexible load column-and-constraint generation defense planning robust optimization.

Expediting *OH accumulation kinetics on metal-organic frameworks-derived CoOOH with CeO2 “accelerator” for electrocatalytic 5-hydroxymethylfurfural oxidation valorization

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Journal of Energy Chemistry 2024年第11期 721-732页

作者： peiyun Zhou Haokun Pan Guangtong Hai Xiang Liu Xiubing Huang Ge wang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule & Structure Construction School of Materials Science and Engineering University of Science and Technology Beijing Department of Chemistry Tsinghua University Institute of Zhejiang University-Quzhou Zhejiang University

In this work,nickel foam supported CeO2-modified CoBDC（BDC stands for terephthalic acid linker）metal-organic frameworks（NF/CoBDC@CeO2） are prepared by hydrothermal and subsequent impregnation methods,which can be further transformed to NF/CoOOH@CeO2by reconstruction during the electrocatalytic *** obtained NF/CoOOH@CeO2exhibits excellent performance in electrocatalytic oxidation of 5-hydroxymethylfurfural（HMF） because the introduction of CeO2can optimize the electronic structure of the heterointerface and accelerate the accumulation of**** requires only a potential of 1.290 VRHEto provide a current density of 50 mA cm-2in 1.0 M KOH+50 mM HMF,which is 222 mV lower than that required in 1,0 M KOH(1.512 VRHE).In addition,density-functional theory calculation results demonstrate that CeO2biases the electrons to the CoOOH side at the heterointerface and promotes the adsorption of*OH and*HMF on the catalyst surface,which lower the reaction energy barrier and facilitate the electrocata lytic oxidation process.

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Sensitively and selectively removal of Hg(Ⅱ) from aqueous solution by supported ionic liquidmaterial

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Sensitively and selectively removal of Hg(Ⅱ) from aqueous s...

图像分析与传感器融合的室内导航定位系统设计及实践

河南省化学会2016年学术年会

作者： Liping Zhou Meng Cheng Chunlai Wu peiyun wang Jing Fan School of Environment Henan normal University Henan Key Laboratory for Environmental Pollution Control Key Laboratory for Yellow River Water Environmental and Pollution Control Ministry of Education

In this work, a new supported ionic liquid material was prepared via chemically functionalized chlorine methyl polystyrene resin with N-methylimidazolium. The material has been used for Hg(Ⅱ) removal form water solution. The effect of factors on quantitatively adsorption of Hg(Ⅱ) was systematically investigated,such as p H value of solution, equilibrium time, temperature of the solution, the amount of the adsorbent and the effect of the common co-existing ions. Under the optimum conditions, the material can be directly used for Hg(Ⅱ) adsorption without the addition of extraction agents. The maximum adsorption capacity obtained from Langmuir isotherm was as high as 633.6 mg·g, which is higher than most of other adsorbents. Concentrations of Hg(Ⅱ) at 0.97 μg·L can be efficiently removed. Additionally, the common co-existing ions did not interfere the adsorption of Hg(Ⅱ) on the material. Kinetics for the adsorption of Hg(Ⅱ) by the material was analyzed by pseudo second order model. In addition, the mechanism for Hg(Ⅱ) adsorption was also proposed.

关键词： ionic liquids supported chlorine methyl polystyrene resin Hg(Ⅱ) removal

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北京测绘 2022年第10期36卷 1321-1326页

作者：王培云华芯拓远(天津)科技有限公司天津300457

面对当前公共建筑愈发复杂庞大,居民对陌生环境下室内定位导航的需求日益高涨。传统基于无线网络传感器的方法在网络系统未知场所不适用,惯性传感器定位导航方法需要先验环境支持。因此,提出了一种基于双目图像分析与传感器融合的室内... 详细信息

面对当前公共建筑愈发复杂庞大,居民对陌生环境下室内定位导航的需求日益高涨。传统基于无线网络传感器的方法在网络系统未知场所不适用,惯性传感器定位导航方法需要先验环境支持。因此,提出了一种基于双目图像分析与传感器融合的室内导航定位方法。通过角点检测、视觉残差计算、高斯球方向检测实现图像处理,使用紧耦合策略将视觉数据与惯导数据融合,采用边缘化先验法消除无关标量。基于相关原理设计室内导航定位系统,经过在工作室内测试,该系统能够良好建立起虚拟地图并提供相对准确的导航和定位服务,误差可达分米级。为陌生环境下的室内导航提供了一种新方法。

关键词：导航定位图像处理立体视觉惯导融合紧耦合