Laboratory-based Surveillance and Clinical Profile of Sporadic HEV Infection in Shanghai,China

作     者：Jie Lu Qing Li Jiayuan Jiang Ziqiang Li Peiyun Wang Zike Sheng Rongtao Lai Huijuan Zhou Wei Cai Hui Wang Qing Guo Honglian Gui Qing Xie Jie Lu;Qing Li;Jiayuan Jiang;Ziqiang Li;Peiyun Wang;Zike Sheng;Rongtao Lai;Huijuan Zhou;Wei Cai;Hui Wang;Qing Guo;Honglian Gui;Qing Xie

作者机构：Department of Infectious DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Clinical Research InstituteShanghai Jiao Tong University School of MedicineShanghai 200025China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2021年第36卷第4期

页      面：644-654页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This study was funded by grants from the National Natural Science Foundation of China(No.81501733) the Shanghai Municipal Key Clinical Specialty(shslczdzk01103) Key Projects in the National Science&Technology Pillar Program during the Thirteenth Five-year Plan Period(2017ZX10203201-008,2018ZX09201016-003-001,2017ZX10202202-005-004) 

主　　题：Hepatitis E virus(HEV) Seroprevalence Genotyping Epidemiology Surveillance 

摘      要：The study aimed to describe the epidemiological,virological and clinical features of sporadic HEV infection in eastern China.A total of 6112 patient sera were tested for anti-HEV IgG or anti-HEV IgM during one consecutive year(between August 2018 and July 2019).HEV RNA presence was evaluated by RT-PCR and HEV sequences were phylogenetically *** features of confirmed HEV-infected patients were *** sero-positivity rate of anti-HEV IgG maintained stable around 40%,while an obvious winter spike of anti-HEV IgM prevalence was observed.A total of 111 patients were confirmed of HEV viremia by molecular *** 4d was *** analyses suggest that certain strains circulate across species and around the *** with confirmed current HEV infection had a high median age(58 years)and males were predominant(62.2%).Most patients presented with jaundice(75.7%)and anorexia(68.0%).Significantly elevated levels of liver enzymes and bilirubin were ***,the baseline bilirubin level was positively correlated with illness ***-existing HBV carriage may deteriorate *** clinical burden caused by locally acquired HEV infection is *** should be enforced especially during the transition period from winter to *** with higher level of bilirubin at disease onset had slower recovery from HEV infection.