检索结果-南通市图书馆

Decreased invasion ability of hypotaurine synthesis deficient glioma cells was partially due to hypomethylation of Wnt5a promoter

引用

BIOCELL 2017年第1期41卷 27-32页

作者： Hong TIAN peiyu cong Ruiqun QI Xinghua GAO Xin LIU Hongsheng LIU Fengping SHAN Department of Immunology School of Basic Medical ScienceChina Medical University77 Puhe RoadShenyang North New AreaShenyangLiaoning110122P.R.China Oncology Department The 4th People’s Hospital of Shenyang20 Huanghe South StreetShengyangLiaoning110122P.R.China Department of neurosurgery Dalian Municipal Central Hospital826 Xinan RoadDalianLiaoning116023P.R.China Department of Dermatology Key Laboratory of Immunodermatology No.1 Hospital of China Medical University155 Nanjing RoadHeping DistrictShenyangLiaoning110001P.R.China Department of Dermatology No.1 Hospital of China Medical University92 North Second RoadHeping DistrictShenyangLiaoning110001P.R.China The First Affiliated Hospital of Jinzhou Medical University 2 Wuduan Renmin StreetJinzhouLiaoning121001 P.R.China Heart ICU Affiliated Hospital of Jining Medical College79 Guhuai RoadJiningShangdong272000P.R.China

Glioma is one of the lethal central nervous system *** infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues,resulting in inevitable recurrence after surgery *** do not metastasize,so to prevent the residual tumor from proliferating or invading is a key *** report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’*** a hypotaurine synthesis deficient U251 cell line,we proved that the cells invasion ability was *** expression profile analysis exhibited that knocking down one of the key enzymes of hypotaurine synthesis,2-aminoethanethiol dioxygenase(ADO),significantly affected the extracellular matrix-receptor *** that process,Wnt5a expression was severely upregulated by decreased intracellular ADO *** cultured at the presence of hypotaurine showed a decrease in intracellular Wnt5a protein and mRNA *** phenotype was due to hypermethylation of Wnt5a promoter,which was most likely the result of hypotaurine’s inhibiting demethylases ***,this study demonstrated that hypotaurine synthesis deficient U251 cells were prone to epigenetic modification and Wnt5a seemed to be a tumor suppressor under that *** tumor suppression effect is warranted to be reevaluated in real tumor samples and the relevant evidence might contribute to develop new glioma interference strategies.

关键词： Glioma Wnt5a Hypotaurine Tumor invasiveness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Reconstruction of a Large Defect after Excision of Infiltrative Squamous Cell Carcinoma in the Scalp and Occipital Region: A Case Report

引用

Proceedings of Anticancer Research 2024年第2期8卷 36-41页

作者： Chi Zhang Tiehui Zhang peiyu cong Hongzhu Lv Chengzhi Cui Department of Neurosurgery Dalian Central HospitalDalian 116000China

Squamous cell carcinoma(SCC)of the scalp is the second most prevalent skin cancer,following basal cell ***,it has the capability to infiltrate the skull,dura mater,and even brain *** cornerstone of treatment is the surgical removal of the lesion,with a particular focus on the depth of invasion,which is directly correlated with recurrence ***-surgical strategies may involve immediate or delayed cranial bone reconstruction and repair of scalp defects using either artificial dermis or skin *** the case presented,a substantial defect necessitated more than a single flap for primary ***,a single pedicle double-island flap was designed for reconstructing the occipital *** to increased tension on the flap following cranial bone repair,the bone repair was temporarily *** care included adjuvant chemotherapy and radiotherapy to mitigate the risk of SCC recurrence.

关键词： Squamous cell carcinoma Intracranial invasion Single pedicle double-island flap Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metastatic intracranial large-cell neuroendocrine carcinoma:a study of two cases

引用

Oncology and Translational Medicine 2018年第6期4卷 255-258页

作者： Xiaozhen Zhan Weidong Wu Xinmin Wang Kezhen Wang Jiyong Leng Chengzhi Cui peiyu cong Department of Neurosurgery Dalian Municipal Central HospitalDalian 116033China Dalian Medical University Dalian 116044China

Objective The occurrence of large-cell neuroendocrine carcinoma(LCNEC), a kind of neuroendocrine tumor(NET), in the cranium is extremely rare. Here we report two such cases and review the literature in order to improve the diagnosis and treatment of intracranial *** We report two cases of metastatic intracranial LCNEC. In case 1, the patient was diagnosed with lung carcinoma and underwent chemotherapy. Brain metastases were found six months later. The lung and intracranial lesions in case 2 were found at the same time. Results Intracranial multiple-tumor resection was performed in case 1 and the patient died 2 months later. Case 2 patient underwent surgery followed by chemotherapy with etoposide and carboplatin. Six months postoperatively, a recurrence lesion was found in the left cerebellar hemisphere. The patient was treated surgically. At present, a year after the diagnosis, the patient is still *** NETs of the intracranial region are extremely rare, and hence, most of our knowledge is based on lung NETs, and standard treatment strategies for intracranial NETs remain unclear. Our patients had different survival times probably due to different treatments, indicating that effective surgical resection and subsequent multi-agent chemotherapy should be administered to promote long-term survival of intracranial LCNEC patients.

关键词： large cell neuroendocrine carcinoma intracranial neuroendocrine tumor prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Olfactory schwannoma:a case report

引用

Oncology and Translational Medicine 2018年第6期4卷 259-262页

作者： Weidong Wu Xiaozhen Zhan Kezhen Wang Chengzhi Cui Kai Xu peiyu cong Department of Neurosurgery Dalian Municipal Central HospitalDalian 116033China Dalian Medical University Dalian 116044China

Objective Intracranial schwannomas are frequently located in the VIII cranial nerve, followed by the V and VII cranial nerves, but are quite rare in the olfactory cranial nerves. Here, we report a case of an olfactory schwannoma and review the literature to improve the diagnosis and treatment of olfactory schwannoma. Methods We report a case of olfactory schwannoma in a 51-year-old Chinese man who experienced dizziness and no other *** Magnetic resonance imaging(MRI) showed a neoplastic mass located on the anterior cranial base to the right of the midline and near the cribriform plate and sphenoidal plane. The lesion travelled through the cribriform plate into the nasal cavity. This mass was initially thought to be an olfactory groove meningioma. We performed a craniotomy for surgical excision, and the tumor was completely resected, and the skull base was reconstructed at the same time. There were no complications during surgery, and the patient recovered well. The histopathological diagnosis was a *** Olfactory schwannomas are extremely rare and similar to olfactory ensheating cell tumors, and the immunohistochemical staining of leukocyte antigen 7(Leu7/CD57) can be used to identify them. Although the standard treatment of olfactory schwannoma remains unclear, in all reports, most patients can have excellent prognosis after an effective surgical resection.

关键词： olfactory schwannoma anterior skull base schwannoma schwannoma diagnosis treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

磨辊轧距自动调节系统

引用

粮食与饲料工业 1999年第9期 7-9页

作者：丛培玉叶坚国家粮食储备局郑州科学研究设计院 450052

1 概述随着我国改革开放的深入,人民生活水平的不断提高,人们对面包、烘烤、速冻食品及甜食品的需求量也不断增加.因而,市场对面粉的产品结构要求发生了很大的变化,要求企业能够根据市场的需求,尽快调整产品结构,生产适销对路的产品.但... 详细信息

1 概述随着我国改革开放的深入,人民生活水平的不断提高,人们对面包、烘烤、速冻食品及甜食品的需求量也不断增加.因而,市场对面粉的产品结构要求发生了很大的变化,要求企业能够根据市场的需求,尽快调整产品结构,生产适销对路的产品.但是,由于受原料的限制,面粉厂经常变换小麦品种,这就给操作带来一定的困难,即使操作人员具有较高的水平,也很难准确地找到最佳的技术参数,或准确地设定这些参数,因此,势必影响面粉的质量、产量和出粉率,影响企业的经济效益.

关键词：面粉磨粉机自动调节系统磨辊轧距

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gamma oscillations and their role in orchestrating balance and communication following stroke

引用

Neural Regeneration Research 2025年第2期20卷 477-478页

作者： Montana Samantzis cong Wang Matilde Balbi Queensland Brain Institute The University of QueenslandBrisbaneQLDAustralia Engineering Research Centre of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina

Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s *** method differs from pharmacological approaches by tapping into the neuronal population dynamics that underlie the homeostatic processes in the brain that are crucial for the recovery of ***,induced gamma-range oscillations have been used to improve cerebral blood flow,motor function,and synaptic plasticity in a mouse model of focal stroke,highlighting the broad potential of recruiting intrinsic recovery processes for the treatment of neurological *** open questions,such as the frequency specificity of the benefits,will shed light on the intrinsic processes involved and allow clinicians to optimize recovery after stroke.

关键词： protective specificity Alzheimer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo Hong-Bo Jin cong-Feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

引用

Science China Earth Sciences 2025年第1期68卷 74-93页

作者： Ye YANG Steven A.BINNIE Sheng XU cong-Qiang LIU Tibor J.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

关键词： 10Be-derived denudation rate Climate change Tectonic uplift Topographic gradient Asian mountains

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Enhancing Deepfake Detection:Proactive Forensics Techniques Using Digital Watermarking

引用

Computers, Materials & Continua 2025年第1期82卷 73-102页

作者： Zhimao Lai Saad Arif cong Feng Guangjun Liao Chuntao Wang School of Automation Guangdong University and TechnologyGuangzhou510006China School of Immigration Administration(Guangzhou) China People’s Police UniversityGuangzhou510663China Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa31982Saudi Arabia Cyber Police Division Guangzhou Public Security BureauGuangzhou510030China School of Forensic Science and Technology Guangdong Police CollegeGuangzhou510320China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou510642China

With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly *** paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking *** detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic *** contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake *** offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal ***,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking *** systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.

关键词： Deepfake proactive forensics digital watermarking traceability detection techniques

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

引用

China Foundry 2025年

作者： Gang Huang Qian Dang cong-cong Su Jing Zhao Chi Zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern University School of Materials Science and Engineering Shenyang University of Technology

The grain size of TiAl alloy castings prepared by traditional casting process is coarse, thus showing poor mechanical properties. In this study, a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was introduced. This research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings, employing both experimental approaches and ProCast simulation methodologies. The findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed grains. Under the condition of pouring temperature of 1,600 °C, rotation speed of 800 r·min-1and pouring time of 6 s, the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa, and the tensile strength at 800 °C reaches 705 MPa, which is significantly higher than that of traditional as-cast Ti-Al alloy.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：