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数字经济对区域新产品开发绩效的影响——来自省级面板数据的证据

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开发研究 2024年第4期 41-49页

作者：王建军孙佩佩河南财经政法大学工商管理学院郑州450016

基于2013—2022年中国30个省份的面板数据,实证检验数字经济对区域新产品开发绩效的影响。研究发现,数字经济对区域新产品开发绩效具有显著的促进作用,且经过内生性检验和多种稳健性检验后这一结论仍然成立。异质性分析结果表明,数字经... 详细信息

基于2013—2022年中国30个省份的面板数据,实证检验数字经济对区域新产品开发绩效的影响。研究发现,数字经济对区域新产品开发绩效具有显著的促进作用,且经过内生性检验和多种稳健性检验后这一结论仍然成立。异质性分析结果表明,数字经济对区域新产品开发绩效的驱动效应存在地区异质性和城市化水平异质性,首先,数字经济显著提高了东部和西部地区的新产品开发绩效,但对中部地区的促进作用不显著;其次,相比低城市化水平地区,数字经济对高城市化水平地区新产品开发绩效的作用效果更显著。进一步研究表明,数字经济通过促进探索式创新提高区域新产品开发绩效。因此,政府应该加大对基础设施建设的投资力度,设立专项基金支持创新项目,并提供相关的培训和技术支持,因地制宜地进行城市规划,制定发展政策,提升区域新产品开发绩效。

关键词：数字经济新产品开发绩效利用式创新探索式创新

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中医治疗桥本氏甲状腺炎研究进展

中国中医药现代远程教育 2024年第10期22卷 167-169页

作者：孙沛沛朱建敏山东中医药大学第一临床医学院山东济南250000 山东中医药大学附属医院乳腺甲状腺外科山东济南250000

综述中医治疗桥本氏甲状腺炎(HT)的研究进展,在检索近年来文献的基础上,从HT的病因病机、内治法、外治法、内外治结合方面,探讨中医治疗HT的优势。中医通过整体分析、辨证论治等手段在改善甲状腺激素水平、甲状腺抗体滴度水平、甲状腺... 详细信息

综述中医治疗桥本氏甲状腺炎(HT)的研究进展,在检索近年来文献的基础上,从HT的病因病机、内治法、外治法、内外治结合方面,探讨中医治疗HT的优势。中医通过整体分析、辨证论治等手段在改善甲状腺激素水平、甲状腺抗体滴度水平、甲状腺肿大程度及生活质量上均有一定作用,且安全性高,因此在治疗HT时可充分发挥中医的优势。

关键词：桥本氏甲状腺炎中医药疗法综述

Successive formation of secondary pores via feldspar dissolution in deeply buried feldspar-rich clastic reservoirs in typical petroliferous basins and its petroleum geological significance

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Science China Earth Sciences 2022年第9期65卷 1673-1703页

作者： Yingchang CAO Guanghui YUAN Yanzhong WANG Nianmin ZAN Zihao JIN Keyu LIU Kelai XI Yihan WEI peipei sun Key Laboratory of Deep Oil and Gas China University of PetroleumQingdao 266580China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Clastic rock reservoirs in petroliferous basins are generally rich in feldspars. Feldspar dissolution has developed widely in clastic reservoirs, and the resulting secondary pores are crucial in deeply buried reservoirs. Based on a study of the diagenesis of clastic reservoirs in the Bohai Bay Basin, Tarim Basin, and Pearl River Mouth Basin and physical and numerical simulation experiments of fluid-rock interactions, this paper proposed a successive formation model of secondary pores via feldspar dissolution in deeply buried clastic reservoirs, considering the global research progresses in feldspar dissolution in clastic rocks. Feldspar dissolution can occur from shallow open systems to deep-ultra deep closed systems in petroliferous basins, resulting in the successive formation of secondary pores at different diagenetic stages. The successive mechanism includes three aspects. The first aspect is the succession of corrosive fluids that dissolve minerals. Meteoric freshwater dominates at the Earth’s surface and the early diagenetic A stage. Subsequently, organic acids and COformed via kerogen maturation dominate at the early diagenetic B stage to the middle diagenetic stage. COand organic acids formed via hydrocarbon oxidation in hydrocarbon reservoirs dominate at the middle diagenetic B stage to the late diagenetic stage. The second aspect is the successive formation processes of secondary pores via feldspar dissolution. Large-scale feldspar secondary pores identified in deep reservoirs include secondary pores formed at shallow-medium depths that are subsequently preserved into deep layers, as well as secondary pores formed at deep depths. Existing secondary pores in deeply buried reservoirs are the superposition of successively feldspar dissolution caused by different acids at different stages. The third aspect is a successive change in the feldspar alteration pathways and porosity enhancement/preservation effect. Open to semi-open diagenetic systems are developed

关键词： Petroliferous basin Deep to ultra-deep layers Clastic reservoirs Acid generation via thermal evolution Feldspar dissolution Successive formation of secondary pores

Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides

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Science China Chemistry 2014年第8期57卷 1176-1182页

作者： DU BingNan sun peipei Jiangsu Key Laboratory of Biofunctional Materials College of Chemistry and Materials Science Nanjing Normal University Jiangsu Collaborative Innovation Center of Biomedical Functional Materials

The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide(TBHP) as the oxidant, the reaction provided N,N-dialkylamides or N-alkylamides with moderate yields via multiple sp3 C-H bonds activation of methylarenes in aqueous and metal-free conditions.

关键词：烷基酰胺氧化偶联顺序耦合 SP3 碘催化合成反应条件氢过氧化物

Evolution characteristics and exploration targets of Permian clastic rock reservoirs in Bohai Bay Basin,East China

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Petroleum Exploration and Development 2023年第5期50卷 1077-1091页

作者： CAO Yingchang sun peipei ZHOU Lihong YUAN Guanghui LIU Huimin LOU Da WU Zhiping JIN Qiang JIANG Youlu National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580China Laboratory for Marine Mineral Resources Evaluation and Exploration Technology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China PetroChina Dagang Oilfield Company Tianjin 300280China Sinopec Shengli Oilfield Company Dongying 257001China

Based on core observation, thin section examination, fluid inclusions analysis, carbon and oxygen isotopic composition analysis, and other approaches, the structural and burial evolution histories were investigated, and the diagenetic evolution process and genetic/development models were systematically discussed of the Upper Paleozoic Permian clastic rock reservoirs in the Bohai Bay Basin, East China. The Bohai Bay Basin underwent three stages of burial and two stages of uplifting in the Upper Paleozoic. Consequently, three stages of acid dissolution generated by the thermal evolution of kerogen, and two stages of meteoric freshwater leaching occurred. Dissolution in deeply buried, nearly closed diagenetic system was associated with the precipitation of authigenic clay and quartz, leading to a limited increase in storage space. Different structural uplifting–subsidence processes of tectonic zones resulted in varying diagenetic–reservoir-forming processes of the Permian clastic reservoirs. Three genetic models of reservoirs are recognized. The Model I reservoirs with pores formed in shallow strata and buried in shallow to medium strata underwent two stages of exposure to long-term open environment and two stages of meteoric freshwater leaching to enhance pores near the surface, and were shallowly buried in the late stage, exhibiting the dominance of secondary pores and the best physical properties. The Model Ⅱ reservoirs with pores formed in shallow strata and preserved due to modification after deep burial experienced an early exposure-open to late burial-closed environment, where pore types were modified due to dissolution, exhibiting the dominance of numerous secondary solution pores in feldspar and the physical properties inferior to Model I. The Model Ⅲ reservoirs with pores formed after being regulated after multiple periods of burial and dissolution experienced a dissolution of acidic fluids of organic origin under a near-closed to closed environment, exhibiti

关键词： Bohai Bay Basin Permian clastic rock diagenetic evolution reservoir-forming mechanism secondary pore

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大港探区南部二叠系致密砂岩储层特征及成因

沉积学报 2024年第4期42卷 1447-1459页

作者：孙沛沛操应长远光辉周立宏靳子濠吴智平付立新张飞鹏陈长伟深层油气全国重点实验室中国石油大学(华东)山东青岛266580 青岛海洋科学与技术试点国家实验室海洋矿产资源评价与探测技术功能实验室山东青岛266071 中国石油大港油田公司天津300280

【目的】大港探区南部二叠系致密砂岩获高产油气流,但其储层特征与成因机制尚不明确。【方法】综合利用岩心观察、薄片鉴定、阴极发光分析、扫描电镜观察、流体包裹体分析、碳氧同位素与氢氧同位素组成分析、电子探针及原位激光剥蚀等... 详细信息

【目的】大港探区南部二叠系致密砂岩获高产油气流,但其储层特征与成因机制尚不明确。【方法】综合利用岩心观察、薄片鉴定、阴极发光分析、扫描电镜观察、流体包裹体分析、碳氧同位素与氢氧同位素组成分析、电子探针及原位激光剥蚀等技术方法,结合埋藏演化史和油气充注史,对大港探区南部王官屯、乌马营地区二叠系深层砂岩储层进行研究。【结果】大港南区二叠系砂岩以高成分成熟度的石英砂岩、亚岩屑砂岩为特征,优质储层储集空间以次生粒间孔及高岭石晶间微孔为主。在构造运动的控制下,储层经历早期开放体系大气水淋滤溶蚀作用和晚期封闭体系烃源岩生酸溶蚀作用。优质储层的发育受多种因素控制,高成熟度的中粗砂岩是优质储层形成的物质基础,早期地层抬升剥蚀导致的大气淡水淋滤作用形成大量次生孔隙是优质储层发育的关键,早期烃类充注抑制胶结作用有利于次生孔隙的保存。【结论】地质历史时期为大气水淋滤注水区,而现今位于斜坡带—洼陷带的深埋储层,为下步有利勘探目标。该模式的建立对渤海湾盆地其他地区二叠系储层的钻前预测具有借鉴意义。

关键词：成因机制成岩演化砂岩储层二叠系大港探区南部

Effects of Different Raw Materials and Additions on Wave Transparency of Alumina Fiber Products

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China's Refractories 2024年第1期33卷 40-43页

作者： WANG Jia sun Xiaofei XU Jianfeng XU peipei Sinosteel Luoyang Institute of Refractories Research Co. Ltd.Luoyang 471039China

Fiber products for microwave kilns were prepared using alumina fibers with alumina contents of 72 mass%and 80 mass%,and calcined alumina powder(4-6μm)as the main raw materials,silica sol as the binder,and cationic starch as the *** of different raw materials and their additions on the wave transparency of fiber products were *** results show that as the alumina fiber(72%)addition increases,the heating rate of the samples first decreases and then increases,and the corresponding wave transparency of the sample first increases and then *** the alumina fibers addition is 40 mass%and the alumina powder addition is 30 mass%,the prepared microwave kiln lining material has a higher mullite content,which improves the wave transparency of the *** sample prepared from alumina fibers with an alumina content of 80%has a suitable glass-mullite phase ratio,performs lower overall dielectric constant and good wave transparency,and is a suitable lining material for microwave kilns.

关键词： alumina fibers microwave kiln wave transparency

Antihypertensive effects of whey protein hydrolysate involve reshaping the gut microbiome in spontaneously hypertension rats

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Food Science and Human Wellness 2024年第4期13卷 1974-1986页

作者： peipei Dou Xiaoyi Li Xiaoxiao Zou Kai Wang Lei Yao Zhuo sun Hui Hong Yongkang Luo Yuqing Tan Key Laboratory of Functional Dairy College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Hebei Dongkang Dairy Co. Ltd.Shijiazhuang 052160China

Novel angiotensin-converting enzyme(ACE)inhibitory peptides were identified from whey protein hydrolysates(WPH)in vitro in our previous study and the antihypertensive abilities of WPH in vivo were further investigated in the current *** indicated that WPH significantly inhibited the development of high blood pressure and tissue injuries caused by *** inhibited ACE activity(20.81%,P<0.01),and reduced renin concentration(P<0.05),thereby reducing systolic blood pressure(SBP)(12.63%,P<0.05)in spontaneously hypertensive *** increased Akkermansia,Bacteroides,and Lactobacillus abundance promoted high short chain fatty acid content in feces after WPH *** changes jointly contributed to low blood *** heart weight and cardiomyocyte injuries(hypertrophy and degeneration)were alleviated by *** proteomic results revealed that 19 protein expressions in the heart mainly associated with the wingless/integrated(Wnt)signaling pathway and Apelin signaling pathway were altered after WPH ***,WPH alleviated serum oxidative stress,indicated by the decreased malondialdehyde content(P<0.01),enhanced total antioxidant capacity(P<0.01)and superoxide dismutase activity(P<0.01).The current study suggests that WPH exhibit promising antihypertensive abilities in vivo and could be a potential alternative for antihypertensive dietary supplements.

关键词： Whey protein hydrolysate Antihypertension Short chain fatty acids Gut microbiome

可见光诱导对映选择性和化学发散性三组分自由基串联反应

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有机化学 2023年第10期43卷 3661-3663页

作者：刘平孙培培南京师范大学化学与材料科学学院南京210023

在新药发现的过程中,传统的目标导向合成难以满足快速构建结构多样化的小分子化合物库的要求.发散性合成(Chemodivergent Synthesis)利用相同的原料,通过控制反应中间过程,可以化学选择性地合成出多种不同类型的分子[1].自由基是高活性... 详细信息

在新药发现的过程中,传统的目标导向合成难以满足快速构建结构多样化的小分子化合物库的要求.发散性合成(Chemodivergent Synthesis)利用相同的原料,通过控制反应中间过程,可以化学选择性地合成出多种不同类型的分子[1].自由基是高活性的反应物种,在发散性合成中有很大的潜在应用价值,然而,自由基的高活性往往导致其在发散性合成中的化学选择性难于控制.

关键词：化学选择性发散性结构多样化小分子化合物目标导向串联反应对映选择性难于控制