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U-SEQUENCE AND PERIOD-TRIPLING PHENOMENA IN A FORCED NONLINEAR CSCILLATOR

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Chinese Physics Letters 1985年第5期2卷 213-216页

作者： WU Shu-xian pei liu-qing GUO Fen Department of Electronics Beijing Normal UniversityBeijing

Experiments on a nonlinear oscillator reveal the same periodic structure as that in one-dimensional unimodal maps and a simple method is found to assign words from a symbolic dynamics of two letters to the periods observed in *** paper gives plentiful patterns of U-sequence,including period-tripling patterns R*RL,RL*RL and RL^(2)**** analysis gives a confirmation of the patterns.

关键词： patterns. assign symbolic

The Mechanism on Cyclization, Debenzylation and Oxidation of 1-[1-(Benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one

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Chinese Chemical Letters 2006年第6期17卷 769-772页

作者： Shi Liang HUANG Yi LUO Zhi Shu HUANG Xian Zhang BU pei qing liu Lin MA Yue Ming LI Albert S. C. CHAN Lian Quan GU School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 School of Pharmaceutical Science Sun Yat-Sen University Guangzhou 510275 Department of Applied Bioiogy ＆ Chemical Technology The Hong Kong Polytechnic University Kowloon Hong Kong

1-[1-（Benzyloxy）-3-methylnaphthalen-4-yloxy]propan-2-one （la） took place a cyclization, debenzylation and oxidation to form 9-substitued benzo[de]chromene-7,8-dione （2a） and 5-benzyl-9-substitued benzo[de]chrome... 详细信息

关键词： Mansonone F cyclization selenium dioxide sigmatropic rearrangement.

Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling

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Acta Pharmacologica Sinica 2019年第8期40卷 1067-1075页

作者： Jun-Jian Wang June X.Zou Hong Wang Zhi-Jian Duan Hai-Bin Wang Peng Chen pei-qing liu Jian-Zhen Xu Hong-Wu Chen School of Pharmaceutical Sciences Sun Yat-Sen University Department of Biochemistry and Molecular Medicine School of MedicineUniversity of California First Affiliated Hospital of Guangzhou University of Chinese Medicine Computational Systems Biology Lab Shantou University Medical College Comprehensive Cancer Center University of CaliforniaDavisSchool of Medicine

Triple-negative breast cancer(TNBC)is a heterogeneous disease with a poor prognosis due to the lack of an effective targeted *** lysine methyltransferases(KMTs)have emerged as attractive drug targets for cancer ***,the function of the majority of KMTs in TNBC has remained largely *** the current study,we found that KMT nuclear receptor binding SET domain protein 2(NSD2)is overexpressed in TNBC tumors and that its overexpression is associated with poor survival of TNBC ***2 regulates TNBC cell survival and invasion and is required for tumorigenesis and tumor ***,NSD2 directly controls the expression of EGFR and ADAM9,a member of the ADAM(a disintegrin and metalloproteinase)family that mediates the release of growth factors,such as *** its methylase activity,NSD2 overexpression stimulates EGFR-AKT signaling and promotes TNBC cell resistance to the EGFR inhibitor ***,our results identify NSD2 as a major epigenetic regulator in TNBC and provide a rationale for targeting NSD2 alone or in combination with EGFR inhibitors as a targeted therapy for TNBC.

关键词： NSD2 Cell survival Cell invasion Histone methyltransferase Triple-negative breast cancer EGFR

制备工艺对(Ba0.85Ca0.15)(Ti0.9Zr0.1)O3无铅压电陶瓷结构与性能的影响

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无机材料学报 2017年第3期32卷 299-304页

作者：龙佩青刘希涛易志国中国科学院福建物质结构研究所中国科学院光电材料化学与物理重点实验室福州350002

采用液相混合与固相烧结相结合的方法制备了(Ba_(0.85)Ca_(0.15))(Ti_(0.9)Zr_(0.1))O_3(BCTZ)无铅压电陶瓷,系统研究了烧结保温时间对其相结构、介电、压电和铁电性能的影响以及电学性能随温度的变化。研究结果表明:制备的陶瓷样品具... 详细信息

采用液相混合与固相烧结相结合的方法制备了(Ba_(0.85)Ca_(0.15))(Ti_(0.9)Zr_(0.1))O_3(BCTZ)无铅压电陶瓷,系统研究了烧结保温时间对其相结构、介电、压电和铁电性能的影响以及电学性能随温度的变化。研究结果表明:制备的陶瓷样品具有单一的四方钙钛矿结构。当烧结温度为1540℃时,随着保温时间的延长,样品晶粒尺寸变大,居里温度(Tc)升高,压电性能提高,电致伸缩性能下降。当保温时间为24 h时,BCTZ陶瓷综合性能最为优异:Tc^90℃,tanδ<0.05,kp^0.46,d33~540 p C/N,Ps^17μC/cm^2。陶瓷电学性能随温度变化测试结果又表明,BCTZ陶瓷的电学性能具有很强的温度依赖性,随着温度的升高其电学性能逐渐下降。

关键词： BCTZ 无铅压电陶瓷制备工艺热稳定性

SIRT3： a potential target for CHF？

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中国药理学与毒理学杂志 2018年第4期32卷 329-329页

作者： Zhong-bao YUE Jia YOU Zhuo-ming LI Shao-rui CHEN pei-qing liu Department of Pharmacology and Toxicology School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou 510006 China

Pathological cardiac hypertrophy is a maladaptive response in a variety of organic heart disease(OHD),which is characterized by mitochondrial dysfunction that results from disturbed energy ***3,a mitochondria-localized sirtuin,regulates global mitochondrial lysine acetylation and preserves mitochondrial ***,the mechanisms by which SIRT3 regulates cardiac hypertrophy remains to be further *** this study,we firstly demonstrated that expression of SIRT3 was decreased in AngiotensionⅡ(AngⅡ)-treated cardiomyocytes and in hearts of AngⅡ-induced cardiac hypertrophic *** addition,SIRT3 overexpression protected myocytes from hypertrophy,whereas SIRT3 silencing exacerbated Ang II-induced cardiomyocyte *** particular,SIRT3-KO mice exhibited significant cardiac ***,we identified NMNAT3(nicotinamide mononucleotide adenylyltransferase 3),the rate-limiting enzyme for mitochondrial NAD biosynthesis,as a new target and binding partner of ***,SIRT3 physically interacts with and *** NMNAT3,thereby enhancing the enzyme activity of NMNAT3 and contributing to SIRT3-mediated anti-hypertrophic ***,NMNAT3 regulates the activity of SIRT3 via synthesis of *** *** together,these findings provide mechanistic insights into the negative regulatory role of SIRT3 in cardiac *** 3(SIRT3),a mitochondrial deacetylase that may play an *** role in regulating cardiac function and a potential target for

关键词：心肌肥厚心脏病治疗方法临床分析

基于慕课的“大学计算机基础”课程教学改革实践及反思

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科教文汇 2017年第9期 72-73,76页

作者：李培刘擎西安邮电大学计算机学院陕西西安710121

"大学计算机基础"这门课程作为一门非常重要的公共基础课,一直以来都是各大高校进行课程改革的重点。我们团队在教学方面结合慕课平台改变了传统了授课模式,结合更具课程特色和过程监控的考核方式,在试点班级中取得较好的教学效果。同时... 详细信息

"大学计算机基础"这门课程作为一门非常重要的公共基础课,一直以来都是各大高校进行课程改革的重点。我们团队在教学方面结合慕课平台改变了传统了授课模式,结合更具课程特色和过程监控的考核方式,在试点班级中取得较好的教学效果。同时,在这次成功的经验上,我们进行了深入的反思,提出了进一步的改革方案,以期进一步提高该课程的教学效果。

关键词：慕课阶段考核过程监控

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电子信息类专业课程体系结构的一种框架

广西师范大学学报（自然科学版） 2005年第1期23卷 111-114页

作者：裴留庆姚力孟丽艳北京师范大学信息科学学院北京100875

电子信息类学科属于技术科学.该学科在20世纪经历了4次技术重点的重大转移,这些转移对该学科的教学内容和人才培养方式都产生了显著影响.21世纪,电子信息类专业人才的培养在基础知识、基本技能和基本素质诸方面都将有重大变化.在总结国... 详细信息

电子信息类学科属于技术科学.该学科在20世纪经历了4次技术重点的重大转移,这些转移对该学科的教学内容和人才培养方式都产生了显著影响.21世纪,电子信息类专业人才的培养在基础知识、基本技能和基本素质诸方面都将有重大变化.在总结国内外相近专业教育教学经验的基础上,提出了一种将本科生和硕士生专业教育相互衔接的"大本科"教育理念,建议了一种新的课程体系结构框架.由通用自然科学基础、技术基础和专业技术课程构成了专业课堂教学类课程体系;由基础实验、技术基础实验和专题性实验构成了实验类教学体系.专业技术类课程和专题性实验课程是本科生和硕士生相衔接的教学平台.

关键词：通信与信息系统基础知识大本科教育课程体系

Suppression of lysosomal function by small molecules can induce autophagy via mTORC1 inhibition

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Suppression of lysosomal function by small molecules can ind...

Mechanism on Novel Rutaecarpine Analogue Potently Reducing Lipid Accumulation in Adipocytes

细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： Min Li pei-qing liu Xiao-Yun Chen,School of Medicine Bilon Khambu,School of Medicine Hao Zhang,School of Medicine Xiao-Ming Yin,School of Medicine School of Pharmaceutical Sciences Department of Pharmacology and ToxicologySun Yet-Sen University School of Medicine Department of Pathology and Laboratory MedicineIndiana University

Autophagy is an evolutionarily conserved lysosome-dependent degradative process that intracellular material is degraded to fuel starving cells and eliminate intracellular *** accumulation of autophagosomes could be due to both induction of autophagy and inhibition of autophagosome *** first investigate that niclosamide acts not only as an autophagy inducer detected by

关键词： Autophagy Lysosome inhibitor Lysosome membrane permeabilization mTORC1

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Mechanism on Novel Rutaecarpine Analogue Potently Reducing L...