Suppression of lysosomal function by small molecules can induce autophagy via mTORC1 inhibition
作者单位：School of Pharmaceutical SciencesDepartment of Pharmacology and ToxicologySun Yet-Sen University School of MedicineDepartment of Pathology and Laboratory MedicineIndiana University
会议名称：《细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉》
会议日期：2013年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
关 键 词：Autophagy Lysosome inhibitor Lysosome membrane permeabilization mTORC1
摘 要：Autophagy is an evolutionarily conserved lysosome-dependent degradative process that intracellular material is degraded to fuel starving cells and eliminate intracellular *** accumulation of autophagosomes could be due to both induction of autophagy and inhibition of autophagosome *** first investigate that niclosamide acts not only as an autophagy inducer detected by