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Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults

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Journal of Geriatric Cardiology 2022年第10期19卷 753-760,I0002页

作者： li WANG Tian-Yu CAO Jin-Qiao li Cong-Cong DING jun-pei li Hua-Bo YING li-Shun liU Xiao HUANG Department of Nephrology the Fourth Hospital of Harbin Medical UniversityHarbinChina Biological Anthropo-logy University of California Santa BarbaraCaliforniaUSA Department of Urology Surgery Graduate School of the Fourth Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology the Second Affiliated Hospi-tal of Nanchang UniversityNanchangChina Institute of Biomedicine Anhui Medical UniversityHefeiChina Instit-ute of Biomedical and Health Engineering Graduate School at ShenzhenTsinghua UniversityShenzhenChina Shen-zhen Evergreen Medical Institute ShenzhenChina

BACKGROUND While studies have suggested the association between triglyceride-glucose(TyG)index,a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood *** study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure(cSBP).METHODS A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this *** was measured noninvasively using an A-Pulse CASPro *** index was calculated as ln[fasting triglycerides(mg/dL)×fasting glucose(mg/dL)/2].Smoothing curve and multivariate linear regression models[beta coefficient(β)with 95%CI]were applied to analyze the association between TyG index and *** analyses were conducted to explore potential modifications to such a *** The overall mean TyG index is 8.8±0.7,and the total mean cSBP is 131.3±12.8 *** index was observed to be independently and positively associated with cSBP among the total population(β=0.92,95%CI:0.53–1.31,P<0.001),and participants who do not use antihypertensive drugs(β=1.03,95%CI:0.46–1.60,P<0.001),which is in accordance with the result of the smoothing *** association between TyG index and cSBP appears robust in all tested *** TyG index is positively and independently associated with cSBP among hypertensive *** study result suggests that TyG index might serve as an effective marker for vascular function.

关键词： hypertensive elevated systolic

Maternal Perfluorinated Compound Exposure and Risk of Early Pregnancy Loss: A Nested Case-control Study

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Biomedical and Environmental Sciences 2022年第2期35卷 174-179页

作者： MI Xin liN Shi Qi ZHANG Xiao Fen li Jia Jia pei li jun JIN Feng liAO Qi XIE li Min WEI li Cong HAO Chan Juan ZHANG Ya Wei li Wei Shunyi Women’s and Children’s Hospital of Beijing Children’s Hospital Beijing 101300China Institute of Population Research/China Center on Population Health and Development Peking UniversityBeijing 100871China

Early pregnancy loss,defined as a nonviable intrauterine pregnancy occurring before 12 weeks of gestation,is estimated to affect 25%of clinically diagnosed pregnancies[1].Several demographic,lifestyle,and environmental risk factors have been reported to associate with the risk of early pregnancy loss,yet the causes of most early pregnancy losses remain elusive;thus,further studies are *** compounds(PFCs)are a class of widespread environmental pollutants that can adversely affect human reproductive *** are inevitably exposed to PFCs through diet,water,air and dust.A wealth of epidemiological and toxicological research using a variety of animal models has warned of the persistence,bioaccumulation,and toxicity of PFCs[2].

关键词： pregnancy viable Early

Stuart-Landau时滞系统非共振双Hopf分岔

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振动工程学报 2005年第1期18卷 24-29页

作者：裴利军徐鉴同济大学航空航天与力学学院教育部固体力学重点实验室上海200092

在 Stuart- L andau系统中 ,通过系统每个变量到自身的时滞反馈 ,建立 Stuart- L andau时滞模型 ,研究时滞和反馈增益对该系统联合作用的影响规律。确定在时滞和反馈增益系数两参数表明的空间中系统平凡解的线性稳定性条件 ,利用 Hopf... 详细信息

在 Stuart- L andau系统中 ,通过系统每个变量到自身的时滞反馈 ,建立 Stuart- L andau时滞模型 ,研究时滞和反馈增益对该系统联合作用的影响规律。确定在时滞和反馈增益系数两参数表明的空间中系统平凡解的线性稳定性条件 ,利用 Hopf分岔定理得到系统出现 1∶ 2双 Hopf分岔的充分必要条件。借助中心流形和规范型方法 ,将系统约化到四维中心流形。从理论上预测由时滞和反馈增益导致的双 Hopf分岔点附近的动力学行为 ,得到双Hopf分岔引起的各种不同拓扑结构的周期解的解析形式 ,数值模拟与理论分析结果完全一致。结果表明 :时滞和反馈增益不仅可以使系统的运动进入所谓的“静默区”,而且可以导致非共振双 Hopf分岔和它产生的不同拓扑结构的周期运动和多稳态周期运动。

关键词：非共振 Hopf分岔时滞系统平凡解 Landau系统两参数充分必要条件拓扑结构反馈变量

Case series of COVID-19 patients from the Qinghai-Tibetan Plateau Area in China

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World Journal of Clinical Cases 2021年第24期9卷 7032-7042页

作者： Ji-Jie li Hui-Qiong Zhang pei-jun li Zhi-Lan Xin Ai-Qi Xi Zhuo-Ma Yue-He Ding Zheng-Ping Yang Si-Qing Ma Department of Respiratory Medicine Qinghai Province Fourth People’s HospitalXining 810000Qinghai ProvinceChina Qinghai Provincial Center for Disease Control and Prevention Xining 810000Qinghai ProvinceChina Qinghai Province Fourth People's Hospital Xining 810000Qinghai ProvinceChina Department of Intensive Medicine The First People's Hospital of Qinghai ProvinceXining 810000Qinghai ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)is a serious infection caused by the new coronavirus severe acute respiratory syndrome coronavirus *** disease was first identified in December 2019 and has caused significant morbidity and mortality *** To explore the clinical characteristics and treatments for COVID-19 in the Qinghai-Tibetan Plateau Area in *** We retrospectively analyzed the blood cell counts(neutrophils and lymphocytes),blood gas analysis,and thoracic computed tomography changes of patients from Qinghai Province before,during,and after treatment(January 23,2020 to February 21,2020).In addition,we summarized and analyzed the information of critical *** data were analyzed using SPSS 17.0(SPSS Inc.,Chicago,IL,United States).The quantitative and count variables are represented as the mean±SD and n(%),*** The main symptoms and signs of patients with COVID-19 were fever,dry cough,cough with phlegm,difficulty breathing,and respiratory distress with a respiration rate≥30 times/min,finger oxygen saturation≤93%in the resting state,and oxygenation index less than 200 but greater than 100(after altitude correction).Eighteen patients with COVID-19,of whom three were critical,and the others were in a mild condition,were *** main manifestations included fever,dry cough,and *** patients developed difficulty breathing and had a *** were eventually cured and *** examinations showed one case with reduced white cell count(6%)(linical diagnosis and treatment for COVID-19 in the Tibetan plateau area.

关键词： Qinghai Plateau COVID-19 Blood cell Pneumonia Case series

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具有非线性控制的Chua电路的混沌同步

物理学报 2010年第9期59卷 5985-5989页

作者：付士慧裴利军郑州大学数学系郑州450001

Chua电路是一个非光滑系统.本文通过广义哈密顿系统和观测器方法,将具有非线性控制的Chua电路的混沌同步问题转化成研究具有非线性控制的光滑系统的零解稳定性;进而利用滑模控制对该光滑系统的零解稳定性进行了研究,从而使得Chua电路达... 详细信息

Chua电路是一个非光滑系统.本文通过广义哈密顿系统和观测器方法,将具有非线性控制的Chua电路的混沌同步问题转化成研究具有非线性控制的光滑系统的零解稳定性;进而利用滑模控制对该光滑系统的零解稳定性进行了研究,从而使得Chua电路达到了混沌同步.最后,将上述方法应用到具体系统,数值结果也表明其正确性.

关键词： Chua电路混沌同步广义哈密顿系统滑模控制

Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice

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Neural Regeneration Research 2023年第3期18卷 568-576页

作者： Lu-Yao li Qi Wang Lu Deng Zhen lin Jing-Jing lin Xin-Ye Wang Tian-Yang Shen Yi-Hui Zheng Wei lin pei-jun li Xiao-Qin Fu Zhen-Lang lin Department of Pharmacy The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Neonatology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Geriatrics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Orthopedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Neurology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Recent studies have shown that chlorogenic acid(CGA),which is present in coffee,has protective effects on the nervous ***,its role in neonatal hypoxic-ischemic brain injury remains *** this study,we established a newborn mouse model of hypoxic-ischemic brain injury using a modified Rice-Vannucci method and performed intraperitoneal injection of *** found that CGA intervention effectively reduced the volume of cerebral infarct,alleviated cerebral edema,restored brain tissue structure after injury,and promoted axon growth in injured brain ***,CGA pretreatment alleviated oxygen-glucose deprivation damage of primary neurons and promoted neuron *** addition,changes in ferroptosis-related proteins caused by hypoxic-ischemic brain injury were partially reversed by ***,CGA intervention upregulated the expression of the key ferroptosis factor glutathione peroxidase 4 and its upstream glutamate/cystine antiporter related factors SLC7A11 and *** summary,our findings reveal that CGA alleviates hypoxic-ischemic brain injury in neonatal mice by reducing ferroptosis,providing new ideas for the treatment of neonatal hypoxic-ischemic brain injury.

关键词： chlorogenic acid ferroptosis glutathione peroxidase 4 lipid peroxidation neonatal hypoxic-ischemic brain injury neurons neuroprotection oxidative stress oxygen-glucose deprivation system Xc^(-)

Anti-inflammatory effects of acupuncture in the treatment of chronic obstructive pulmonary disease

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Journal of Integrative Medicine 2023年第6期21卷 518-527页

作者： lin-hong Jiang pei-jun li Ying-qi Wang Mei-ling Jiang Xiao-yu Han Yi-die Bao Xin-liao Deng Wei-bing Wu Xiao-dan liu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Exercise and Health Shanghai University of SportShanghai 200438China Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghai 201203China Institute of Rehabilitation Medicine Shanghai Academy of Traditional Chinese MedicineShanghai 201203China

Numerous randomised controlled trials have suggested the positive effects of acupuncture on chronic obstructive pulmonary disease(COPD).However,the underlying therapeutic mechanisms of acupuncture for COPD have not been clearly summarized *** is central to the development of *** this review,we elucidate the effects and underlying mechanisms of acupuncture from an antiinflammatory perspective based on animal *** smoke combined with lipopolysaccharide is often used to establish animal models of *** can be an effective intervention to improve inflammation in COPD,and Feishu(BL13)and Zusanli(ST36)can be used as basic acupoints in COPD animal *** acupuncture types can regulate different types of inflammatory cytokines;meanwhile,different acupuncture types and acupoint options have similar effects on modulating the level of inflammatory *** particular,acupuncture exerts anti-inflammatory effects by inhibiting the release of inflammatory cells,inflammasomes and inflammatory *** main underlying mechanism through which acupuncture improves inflammation in COPD is the modulation of relevant signalling pathways:nuclear factor-κB(NF-κB)(e.g.,myeloid differentiation primary response 88/NF-κB,toll-like receptor-4/NF-κB,silent information regulator transcript-1/NF-κB),mitogen-activated protein kinase signalling pathways(extracellular signal-regulated kinase 1/2,p38 and c-jun NH2-terminal kinase),cholinergic anti-inflammatory pathway,and dopamine D2 receptor *** current synthesis will be beneficial for further research on the effect of acupuncture on COPD inflammation.

关键词： Acupuncture Chronic obstructive pulmonary disease Anti-inflammatory effects Mechanisms Animal study

模态分解法在非恒同耦合系统同步研究中的推广

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物理学报 2010年第1期59卷 164-170页

作者：裴利军邱本花郑州大学数学系郑州450001

通过改变耦合函数将模态分解法进行了推广,应用于非恒同耦合系统同步的研究.详细研究了周期吸引子、概周期吸引子等非恒同耦合系统的同步,得到了同步的局部渐近稳定性条件.并进行了数值模拟,发现同步时动力学现象丰富.概周期吸引子耦合... 详细信息

通过改变耦合函数将模态分解法进行了推广,应用于非恒同耦合系统同步的研究.详细研究了周期吸引子、概周期吸引子等非恒同耦合系统的同步,得到了同步的局部渐近稳定性条件.并进行了数值模拟,发现同步时动力学现象丰富.概周期吸引子耦合系统会出现稳定的周期、概周期同步解,由于耦合周期吸引子耦合系统会出现多个稳定的周期同步解,且其吸引域差别较大,均出现了同步的多值性.同时也验证了该方法的正确性.

关键词：模态分解非恒同耦合动力系统同步概周期吸引子

Individual and joint effects of borderline ankle-brachial index and high plasma total homocysteine on all-cause death in hypertensive adults

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Journal of Geriatric Cardiology 2022年第7期19卷 522-530页

作者： jun-pei li Tian-Yu CAO Xiao-Yuan ZHA Yun YU Zi-Heng TAN Zai-Hua CHENG Hua-Bo YING Wei ZHOU lin-Juan ZHU Tao WANG li-Shun liU Hui-Hui BAO Xiao HUANG Xiao-Shu CHENG Department of Cardiology the Second Affiliated Hospital of Nanchang UniversityNanchangChina University of California Santa BarbaraCAUSA Rancheng Community Health Service Center WuyuanChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityNan-changChina Graduate School at Shenzhen Tsinghua UniversityShenzhenChina

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(<0.9),borderline ABI(0.91-0.99)was once commonly **... 详细信息

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(line ABI(0.91-0.99)was once commonly *** study aims to explore the independent and joint effect of tHcy level and borderline ABI on all-cause death in hypertensive *** This study included 10,538 participants from China H-type Hypertension Registry *** was described into two groups:normal ABI(1.00-1.40)and borderline *** level was also divided into two groups:line ABI and high tHcy level has significantly higher altitude and larger increasing rate over follow-up period compare to other *** those with borderline ABI,participants with high tHcy had higher death risk than those with low tHcy,nevertheless,no significant different between borderline and normal ABI among those with low tHcy *** Borderline ABI and tHcy level both have independent predictive value on all-cause *** combined group of borderline ABI and high tHcy has highest risk factor of outcomes,which suggested the mutual additive value of border-line ABI and *** attention should be given to the importance of borderline ABI in hypertensive population,especially with elevated tHcy level.

关键词： hypertensive death ankle