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Comparative effectiveness of several adjuvant therapies after hepatectomy for hepatocellular carcinoma patients with microvascular invasion

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 554-570页

作者： Yin-Xuan pei Chen-Guang Su Zheng Liao wei-wei Li Zi-Xiang Wang Jin-Long Liu Department of Hepatobiliary Surgery The Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina

BACKGROUND For resectable hepatocellular carcinoma(HCC),radical hepatectomy is commonly used as a curative ***,postoperative recurrence significantly diminishes the overall survival(OS)of HCC patients,especially with microva-scular invasion(MVi)as an independent high-risk factor for *** some studies suggest that postoperative adjuvant therapy may decrease the risk of recurrence following liver resection in HCC patients,the specific role of adju-vant therapies in those with MVi remains *** To conduct a network meta-analysis(NMA)to evaluate the efficacy of various adjuvant therapies and determine the optimal adjuvant *** A systematic literature search was conducted on PubMed,EMBASE,and Web of Science until April 6,*** comparing different adjuvant therapies or comparing adjuvant therapy with hepatectomy alone were *** ratios(HRs)with 95%confidence intervals were used to combine data on recurrence free survival and OS in both pairwise meta-analyses and *** Fourteen eligible trials(2268 patients)reporting five different therapies were *** terms of reducing the risk of recurrence,radiotherapy(RT)[HR=0.34(0.23,0.5);surface under the cumulative ranking curve(SUCRA)=97.7%]was found to be the most effective adjuvant therapy,followed by hepatic artery infusion chemotherapy[HR=0.52(0.35,0.76);SUCRA=65.1%].Regarding OS improvement,RT[HR:0.35(0.2,0.61);SUCRA=93.1%]demonstrated the highest effectiveness,followed by sorafenib[HR=0.48(0.32,0.69);SUCRA=70.9%].iNTRODUCTiON Hepatocellular carcinoma(HCC)is the sixth most common malignant tumor in the world and ranks third in terms of worldwide malignant tumor mortality rates in 2020[1].Curative treatments for HCC include ablation,radical hepatectomy,and liver ***,ablation is suitable only for early-stage HCC patients,who represent a small percentage of the overall HCC *** liver transplantation serves as the optimal tre

关键词： Hepatocellular carcinoma Adjuvant therapy Network meta-analysis Transarterial chemoembolization Hepatic artery infusion chemotherapy Radiotherapy Sorafenib

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identification,characterization,and verification of miR399 target gene in grape

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Horticultural Plant Journal 2024年第1期10卷 91-102页

作者： Maosong pei Hainan Liu Tonglu wei Huiying Jin Yihe Yu Mengting Ma Xiaomeng Song Rundong Dai Dalong Guo Henan Engineering Technology Research Center of Quality Regulation and Controlling of Horticultural Plants College of Horticulture and Plant ProtectionHenan University of Science and TechnologyLuoyangHenan 471023China

The microRNA miR399 plays an important role in phosphorus signal transduction pathways in ***,miR399 was shown to be closely associated with berry ripening in grape(Vitis vinifera).The objective of the present study was to elucidate the evolutionary characteristics of the miR399 gene family in grape and to verify the cleavage effect on the target *** miR399s were identified by miRNA sequencing and retrieval from the miRBase *** mature sequences and precursor sequences were subjected to phylogenetic analysis to reconstruct evolutionary trees,as well as secondary structure analysis of the precursor sequence,and prediction of target *** cisacting elements in the miR399 promoter were predicted and the cleavage effect of grape miR399b on its target genes was *** grape miR399 family comprised nine precursor sequences and nine mature *** precursor sequences formed a typical and stable stem—loop *** minimum folding free energy ranged from-55.70 kcal·mol^(-1)to-37.40 kcal·mol^(-1).Multiple sequence alignment revealed that the miR399 family was highly *** grape miR399 family was phylogenetically closely related to peach,apple,and citrus *** miR399s were predicted to target inorganic phosphate transporter 1—3,phospholipase D delta-like,and *** cleavage effect of grape miR399b on the target genes was verified by means of a dual-luciferase assay and 5’*** GUS staining showed that the promoter activity of miR399b was promoted by GA3treatment.

关键词： Grape miR399 Phosphorus metabolism Early ripening

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Potential clinical application of microRNAs in bladder cancer

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The Journal of Biomedical Research 2024年第04期 289-306页

作者： pei Wang Xiaowei wei Xiaojun Qu Yefei Zhu Laboratory Medicine Center the Second Affiliated Hospital of Nanjing Medical University School of Biological Science and Medical Engineering Southeast University

Bladder cancer(BC) is the tenth most prevalent malignancy globally, presenting significant clinical and societal challenges because of its high incidence, rapid progression, and frequent recurrence. Presently, cystoscopy and urine cytology serve as the established diagnostic methods for BC. However, their efficacy is limited by their invasive nature and low sensitivity. Therefore, the development of highly specific biomarkers and effective noninvasive detection strategies is imperative for achieving a precise and timely diagnosis of BC, as well as for facilitating an optimal tumor treatment and an improved prognosis. microRNAs(miRNAs), short noncoding RNA molecules spanning around 20–25 nucleotides, are implicated in the regulation of diverse carcinogenic *** altered miRNAs form robust functional regulatory networks that exert a notable influence on the tumorigenesis and progression of BC. investigations into aberrant miRNAs derived from blood, urine, or extracellular vesicles indicate their potential roles as diagnostic biomarkers and prognostic indicators in BC,enabling miRNAs to monitor the progression and predict the recurrence of the disease. Simultaneously, the investigation centered on miRNA as a potential therapeutic agent presents a novel approach for the treatment of BC. This review comprehensively analyzes biological roles of miRNAs in tumorigenesis and progression, and systematically summarizes their potential as diagnostic and prognostic biomarkers, as well as therapeutic targets for BC. Additionally, we evaluate the progress made in laboratory techniques within this field and discuss the prospects.

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The Active Compensation Technique for Large Reflector Antennas Based on Quadratic Curve Fitting

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Research in Astronomy and Astrophysics 2024年第7期24卷 226-234页

作者： Tian-Xiang Zheng Bin-Bin Xiang Han-wei Cui wei Wang pei-Yuan Lian Shang-Ming Lin Yang Zhang Jian-Ping Zhou Kai Li School of Mechanical Engineering Xinjiang UniversityUrumqi 830017China School of Mechano-Electronic Engineering Xidian UniversityXi’an 710017China Xi’an institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China

Active reflectors are often used to compensate the surface distortion caused by environmental factors that degrade the electromagnetic performance of large high-frequency reflector *** is crucial for maintaining high gain operation in antennas.A distortion compensation method for the active reflector of a large dual-reflector antenna is proposed.A relationship is established between the surface deformation and the optical path difference for the primary reflector by geometric ***,employing finite element analysis,a polynomial fitting approach is used to describe the impact of adjusting points on the reflector surface based on the coordinates of each *** standardizing the positions of various panels on the reflector,the fitting ns can be applied to the reflector panels of similar ***,based on the distribution characteristics of the primary reflector panels,the adjustment equation for the actuators is derived by the influence matrix *** can be used to determine the adjustment amount of actuators to reduce the rms of the optical path ***,the least squares method is employed to resolve the matrix *** example of a 110 m aperture dual-reflector antenna is carried out by finite element analysis and the proposed *** results show that the optical path difference is reduced significantly at various elevation cases,which indicates that the proposed method is effective.

关键词： Methods analytical-Methods numerical-Telescopes

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High-efficiency sodium storage of Co_(0.85)Se/WSe_(2) encapsulated in N-doped carbon polyhedron via vacancy and heterojunction engineering

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Carbon Energy 2024年第1期6卷 94-107页

作者： Ya Ru pei Hong Yu Zhou Ming Zhao Jian Chen Li Xin Ge wei Zhang Chun Cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchunChina Jilin Provincial international Cooperation Key Laboratory of High-Efficiency Clean Energy Materials Electron Microscopy CenterJilin UniversityChangchunChina

With the advantage of fast charge transfer,heterojunction engineering is identified as a viable method to reinforce the anodes'sodium storage ***,vacancies can effectively strengthen the Na+adsorption ability and provide extra active sites for Na+***,their synchronous engineering is rarely ***,a hybrid of Co_(0.85)Se/WSe_(2) heterostructure with Se vacancies and N-doped carbon polyhedron(CoWSe/NCP)has been fabricated for the first time via a hydrothermal and subsequent selenization *** aberration-corrected transmission electron microscopy confirms the phase interface of the Co_(0.85)Se/WSe_(2) heterostructure and the existence of Se *** functional theory simulations reveal the accelerated charge transfer and enhanced Na+adsorption ability,which are contributed by the Co_(0.85)Se/WSe_(2) heterostructure and Se vacancies,*** expected,the CoWSe/NCP anode in sodium-ion battery achieves outstanding rate capability(339.6 mAh g^(−1) at 20 A g^(−1)),outperforming almost all Co/W-based selenides.

关键词： Co_(0.85)Se/WSe_(2)heterostructure density functional theory simulations N-doped carbon polyhedron Se vacancies sodium-ion batteries

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Strong metal–support interaction boosts the electrocatalytic hydrogen evolution capability of Ru nanoparticles supported on titanium nitride

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Carbon Energy 2024年第1期6卷 245-254页

作者： Xin Wang Xiaoli Yang Guangxian pei Jifa Yang Junzhe Liu Fengwang Zhao Fayi Jin wei Jiang Haoxi Ben Lixue Zhang College of Chemistry and Chemical Engineering Collaborative Innovation Center for Hydrogen Energy Key Materials and Technologies of Shandong ProvinceQingdao UniversityQingdaoShandongChina State Key Laboratory of Bio-fibers and Eco-Textiles Qingdao UniversityQingdaoShandongChina Qingdao institute of Bioenergy and Bioprocess Technology Chinese Academy of ScienceQingdaoShandongChina

Ruthenium(Ru)has been regarded as one of the most promising alternatives to substitute Pt for catalyzing alkaline hydrogen evolution reaction(HER),owing to its inherent high activity and being the cheapest platinum-group ***,based on the idea of strong metal–support interaction(SMSi)regulation,Ru/TiN catalysts with different degrees of TiN overlayer over Ru nanoparticles were fabricated,which were applied to the alkaline electrolytic *** reveal that the TiN overlayer would gradually encapsulate the Ru nanoparticles and induce more electron transfer from Ru nanoparticles to TiN support by the Ru–N–Ti bond as the SMSi degree *** study shows that the exposed Ru–TiN interfaces greatly promote the H_(2) desorption ***,the Ru/TiN-300 with a moderate SMSi degree exhibits excellent HER performance,with an overpotential of 38 mV at 10 mA cm^(−2).Also,due to the encapsulation role of TiN overlayer on Ru nanoparticles,it displays super long-term stability with a very slight potential change after 24 *** study provides a deep insight into the influence of the SMSi effect between Ru and TiN on HER and offers a novel approach for preparing efficient and stable HER electrocatalysts through SMSi engineering.

关键词： electronic structure hydrogen evolution reaction ruthenium strong metal-support interaction titanium nitride

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Electrochemical converting ethanol to hydrogen and acetic acid for large scale green hydrogen production

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Nano Research 2024年第3期17卷 1542-1551页

作者： Yufeng Zhang wei Zhu Jinjie Fang Zhiyuan Xu Yanrong Xue Jiajing pei Rui Sui Xingdong Wang Xuejiang Zhang Zhongbin Zhuang State Key Lab of Organic-inorganic Composites and Beijing Advanced innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Laboratory of Advanced Functional Materials of Nanjing Nanjing Xiaozhuang UniversityNanjing 211171China Beijing Key Laboratory of Energy Environmental Catalysis Beijing University of Chemical TechnologyBeijing 100029China

Electrochemical coupling hydrogen evolution with biomass reforming reaction(named electrochemical hydrogen and chemical cogeneration(EHCC)),which realizes green hydrogen production and chemical upgrading simultaneously,is a promising method to build a carbon-neutral ***,we analyze the EHCC process by considering the market *** ethanol to acetic acid and hydrogen approach is the most feasible for large-scale hydrogen *** develop AuCu nanocatalysts,which can selectively oxidize ethanol to acetic acid(>97%)with high long-term *** isotopic and in-situ infrared experiments reveal that the promoted water dissociation step by alloying contributes to the enhanced activity of the partial oxidation reaction path.A flow-cell electrolyzer equipped with the AuCu anodic catalyst achieves the steady production of hydrogen and acetic acid simultaneously in both high selectivity(>90%),demonstrating the potential scalable application for green hydrogen production with low energy consumption and high profitability.

关键词： selective ethanol electrooxidation gold alloy catalyst electrochemical-coupled hydrogen production market assessment interfacial water activation

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Unveiling the secrets of diatom-mediated calcification:implications for the biological pump

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Science China Earth Sciences 2024年第9期67卷 2895-2909页

作者： Yiwen PAN Yifan Li Chen-Tung Arthur CHEN Zong-pei JiANG wei-Jun CAi Yunwen SHEN Zesheng DiNG Qixian CHEN Yanan Di wei FAN Chenba ZHU Ying CHEN Ocean College Zhejiang UniversityZhoushan 316021China Hainan institute of Zhejiang University Sanya 570203China Department of Oceanography Sun Yat-Sen UniversityGaoxiong 80424China School of Marine Science and Policy University of DelawareNewark DE 19716USA Carbon Neutral innovation Research Center Xiamen UniversityXiamen 361005China

Siliceous diatoms are one of the most prominent actors in the oceans,and they account for approximately 40%of the primary production and particulate organic carbon export *** is believed that changes in carbon flux caused by variations in diatom distribution can lead to significant climate *** the fundamental pathways of diatom-driven carbon sequestration have long been established,there are no reports of CaCO_(3) precipitation induced by marine diatom *** manuscript introduces novel details regarding the enhancement of aragonite precipitation during photosynthesis in Skeletonema costatum in both artificial and natural *** direct measurements of cell surfaces via a pH microelectrode and zeta potential analyzer,it was determined that the diatom-mediated promotion of CaCO_(3) precipitation is achieved through the creation of specific microenvironments with concentrated[CO_(3)^(2-)]and[Ca^(2+)]and/or the dehydrating effect of adsorbed Ca^(2+).Based on this mechanism,it is highly plausible that diatom-mediated calcification could occur in the oceans,an assertion that was supported by the significant deviation of total alkalinity(TA)from the conservative TA-salinity mixing line during a Skeletonema costatum bloom in the East China Sea and other similar *** newly discovered calcification pathway establishes a link between particulate inorganic and organic carbon flux and thus helps in the reassessment of marine carbon export fluxes and CO_(2) sequestration *** discovery may have important ramifications for assessing marine carbon cycling and predicting the potential effects of future ocean acidification.

关键词： Diatom bloom Skeletonema costatum Calcification Biological carbon pump Counter carbonate pump

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Molecular quantification of herbs(Herb-Q):a pyrosequencingbased approach and its application in Pinellia ternata

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Chinese Journal of Natural Medicines 2024年第7期22卷 663-672页

作者： pei Yifei LiU Ziyi YU Dade ZHANG Xiangyu SUN wei CHEN Xiaofang FENG Xue Li Xiwen institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Bijie institute of Traditional Chinese Medicine Bijie 551700China The Key Laboratory for Health industry of Bijie Bijie Medical CollegeBijie 551700China

Variations in herb dosage due to species adulteration and dosing inaccuracies can substantially affect clinical safety and *** species quantification remains challenging,as current methods often yield inconsistent *** study introduces a novel pyrosequencing-based technique,termed herb molecular quantification(Herb-Q),designed to precisely quantify herbal *** evaluated its effectiveness using Pinellia ternata and five of its ***,we assessed commonly used DNA barcodes with sequences from a public database,identifying two candidate regions,Maturase K(matK)and internal transcribed spacer 2(iTS2),for screening specific single nucleotide polymorphism(SNP)loci,allowing for species-specific *** loci were validated by amplifying and sequencing genomic material from collected *** validation studies showed that Herb-Q demonstrated excellent linearity,accuracy,repeatability,and detection *** established quantitative standard curves with high R^(2)values(>0.99)to enable precise species quantification,which were combined with external standards to provide clear and accurate visual quantification *** average bias in quantifying the tuber of *** was 2.38%,confirming that Herb-Q can accurately identify and quantify herbal product ***,the entire quantification process took less than 4 *** study presents a novel,rapid method for accurately quantifying species in herbal products and advances the application of DNA barcoding from species identification to quantitative detection.

关键词： Quantification Adulterant DNA barcodes Single nucleotide polymorphism

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Mice with type i interferon signaling deficiency are prone to epilepsy upon HSV-1 infection

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Virologica Sinica 2024年第2期39卷 251-263页

作者： wei Yang Chong-Yang Tang Dong-Ying Fan Yi-Song Wang pei-Gang Wang Jing An Guo-Ming Luan Beijing Key Laboratory of Epilepsy Sanbo Brain HospitalCapital Medical UniversityBeijing100093China Beijing institute for Brain Disorders Capital Medical UniversityBeijing100093China Department of Neurosurgery Epilepsy CenterSanbo Brain HospitalCapital Medical UniversityBeijing100093China Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Chinese institute for Brain Research Beijing102206China

Viral encephalitis continues to be a significant public health *** our previous study,we discovered a lower expression of antiviral factors,such as iFN-β,STiNG and iFi16,in the brain tissues of patients with Rasmussen's encephalitis(RE),a rare chronic neurological disorder often occurred in children,characterized by unihemispheric brain ***,a higher cumulative viral score of human herpes viruses(HHVs)was also found to have a significant positive correlation with the unihemispheric atrophy in *** i iFNs(iFN-i)signaling is essential for innate anti-infection response by binding to iFN-α/βreceptor(iFNAR).in this study,we infected WT mice and iFNAR-deficient A6 mice with herpes simplex virus 1(HSV-1)via periocular injection to investigate the relationship between iFN-i signaling and HHVs-induced brain *** all mice exhibited typical viral encephalitis lesions in their brains,HSV-induced epilepsy was only observed in A6 *** gene expression matrix,functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced ***,ten key genes with the highest scores were *** together,these findings indicate that intact iFN-i signaling can effectively limit HHVs induced neural symptoms and brain lesions,thereby confirming the positive correlation between iFN-i signaling repression and brain atrophy in RE and other HHVs encephalitis.

关键词： iFN-i signaling Human herpes viruses(HHVs) Rasmussen's encephalitis(RE)

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