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Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting Perineural Invasion in Pancreatic Cancer

Chinese Medical Journal 2016年第20期129卷 2460-2468页

作者： Zheng Lu Teng-Hui Dong pei-ren si Wei Shen Yi-Liang Bi Min Min Xin Chen Yan Liu Liver Cirrhosis Diagnosis and Therapy Center 302 Hospital of People's Liberation ArmyBeijing 100039China Department of Gastroenterology and Hepatology 307 Hospital of People's Liberation ArmyAcademy of Military Medical SciencesBeijing 100071China Department of Gastroenterology and Hepatology 107 Hospital of People's Liberation ArmyYantaiShandong 264002China Department of Bioengineering and Therapeutic Sciences University of CaliforniaSan FranciscoCA 94143-0912USA

Background：Perineural invasion （PNI） is a histopathological characteristic of pancreatic cancer （PanCa）.The aim of this study was to observe the treatment effect of continuous low-dose-rate （CLDR） irradiation to PNI and assess the PNI-related pain relief caused by iodine-125 （125I） seed ***：The in vitro PNI model established by co-culture with dorsal root ganglion （DRG） and cancer cells was interfered under 2 and 4 Gy of 125I seeds CLDR *** orthotopic models of PNI were established,and 125I seeds were implanted in *** PNI-related molecules were *** 30 patients with panCa,the pain relief was assessed using a visual analog scale （VAS）.Pain intensity was measured before and 1 week,2 weeks,and 1,3,and 6 months after 125I seed ***：The co-culture of DRG and PanCa cells could promote the growth of PanCa cells and DRG *** co-culture groups,the increased number of DRG neurites and pancreatic cells in radiation group was significantly *** orthotopic models,the PNI-positive rate in radiation and control group was 3/11 and 7/11;meanwhile,the degrees of PNI between radiation and control groups was significant difference （P 〈 0.05）.At week 2,the mean VAS pain score in patients decreased by 50% and significantly improved than the score at baseline （P 〈 0.05）.The pain scores were lower in all patients,and the pain-relieving effect was retained about 3 ***：The CLDR irradiation could inhibit PNI of PanCa with the value of further *** CLDR irradiation could do great favor in preventing local recurrence and alleviating pain.

关键词： Continuous Low-dose-rate Irradiation Pancreatic Cancer Perineural Invasion Radioactive Seeds

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色氨酸水溶液荧光强度的测定作为评价抗辐射药物模型的探试

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军事医学科学院院刊 1983年第6期 595-602页

作者：王培仁郑思新黄明欣军事医学科学院放射医学研究所

用哺乳动物评价抗辐射药物,可以反映在整体条件下化合物效价的最终结果,但实验常随动物本身及饲养条件等复杂因素的影响而波动。使用离体模型评价,可以作为整体试验的补充,并有助于从某种角度了解药物的作用机制。色氨酸水溶液经一定波... 详细信息

用哺乳动物评价抗辐射药物,可以反映在整体条件下化合物效价的最终结果,但实验常随动物本身及饲养条件等复杂因素的影响而波动。使用离体模型评价,可以作为整体试验的补充,并有助于从某种角度了解药物的作用机制。色氨酸水溶液经一定波长的紫外线激发

关键词：色氨酸辐射防护作用保护作用环化合物荧光强度

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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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Effects of different alloying elements M(M=Fe,Ni,Mn,si,Mo,Cu,Y)on Cr_(2)0_(3)with Cl:a first-principles study

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Journal of Iron and Steel Research International 2021年第5期28卷 613-620页

作者： Ya-nan Niu Nan Dong si Liu Jing Yang pei-de Han Yu-cheng Wu College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Shanxi Engineering Technology Research Center for Energy Materials and Analysis and Testing Taiyuan University of TechnologyTaiyuan 030024ShanxiChina

Using the first-principles methods,the effects of different alloying elements M(M=Fe,Ni,Mn,si,Mo,Cu,Y)on Cr_(2)0_(3)with Cl adsorption are *** results show that the layer distance of all doped models has been widened to different degrees with Cl *** Mo or Y is doped into the passive film,the difference of layer distance is reduced to a certain *** interaction between alloying elements and Cl is studied by calculating the adsorption height,bond population and electron density *** results show that Mo and Y can inhibit Cl erosion and improve the corrosion resistance of passive ***,we investigate the CrMoFe and CrMoY co-doped system with Cl *** calculations point out that when Mo and Y are doped together in the passive film,the corrosion resistance of the system is more prominent than that of CrMo,CrY and CrMoFe co-doping systems.

关键词： Density functional theory Cr_(2)0_(3) Doping Cl Austenitic stainless steel

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Influence of High-Pressure Nitrogenation on the Structural,Magnetic and Magnetocaloric Properties of La_(0.5)Pr_(0.5)Fe_(11.4)si_(1.6)

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Acta Metallurgica sinica(English Letters) 2015年第11期28卷 1382-1386页

作者： Nai-Kun Sun Zeng-Xin ren Jie Guo Sheng-Jie Du Ping-Zhan si School of Science Shenyang Ligong University College of Materials Science and Engineering China Jiliang University

Nitrogenation of La0.5Pr0.5Fe11.4si1.6 with a particle size of 100-150 μm was performed in a high-purity N2 atmosphere of 40 MPa. La0.5Pr0.5Fe11.4si1.6N0.3 nitrogenated at 480 ℃ exhibits an increase in the Curie temperature Tc from 187 to 195 K. Moreover, for a field change from 0 to 1.5 T, the maximum hysteresis loss at Tc is remarkably reduced from 53 to 3 J kg^-1 and a large magnetic-entropy change ASm of over 10 J kg^-1 K^-1 is maintained. For a La0.5Pr0.5- Fe11.4si1.6N1.2 sample, nitrogenated at 550 ℃, the XRD pattern clearly exhibits two 1：13 phases and, accordingly, the thermal magnetic curves exhibit two transitions, at 210 and at 295 K. The two transitions lead, for a field change of 5 T, to a ASm larger than 2 J kg^-1 K^-1 over a large temperature range from 200 to 310 K with a maximum value of 5.3 J kg^-1 K^-1 at 225 K. Upon further increase in the nitrogenation temperature to 650 ℃, the amount of the nitrogen- poor phase strongly decreases and a large amount of α-Fe precipitates, resulting in a large reduction in the MCE.

关键词： Metals and alloys Magnetocaloric effect Magnetic hysteresis

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Solid-State Diffusion Bonding of NbSS/Nb5si3 Composite Using Ni/Al and Ti/Al Nanolayers

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Acta Metallurgica sinica(English Letters) 2019年第9期32卷 1142-1150页

作者： Xin-Yu ren Hai-Shui ren Yong-Wang Kang Hua-Ping Xiong Chong pei Bo Chen Yao-Yong Cheng A.I.Ustinov Welding and Plastic Forming Division Beijing Institute of Aeronautical MaterialsBeijing 100095China Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing 100095China E.O.Paton Electric Welding Institute of NAS of Ukraine Kiev 03680Ukraine

Diffusion bonding of refractory Nb–si-based alloy was performed with Ni/Al and Ti/Al nanolayers under the condition of 1473 K/30 MPa/60 *** NbSS/Nb5si3 in situ composite with the nominal composition of Nb–22 Ti–16 si–3 Cr–3 Al–2 Hf was used as the parent *** joint microstructures were examined by using a scanning electron microscope equipped with an X-ray energy dispersive *** test was conducted for the bonded joints at room *** the joint bonded with Ni/Al multilayer,element diffusion occurred between the base metal and the nanolayer,with the reaction products of AlNb2+Ni3 Al,NiAl and AlNi2 Ti *** average shear strength was 182 *** using Ti/Al multilayer,the interface mainly consisted of TiAl,(Ti,Nb)Al and(Ti,Nb)2 Al phases,and the corresponding joints exhibited an increased strength of 228 *** this case,the fracture mainly took place in the TiAl phase and presented a typical brittle characteristic.

关键词： Nbss/Nb5si3 composite Diffusion bonding Nanolayer Shear strength

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High Fe‑Loading single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Redox-active nanoparticles for inflammatory bowel disease

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Nano Research 2021年第8期14卷 2535-2557页

作者： Qinjuan ren si Sun Xiao-Dong Zhang Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of SciencesTianjin UniversityTianjin 300350China Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China

Homeostasis of gut microbiota is extremely essential for maintaining nutrient metabolism and regulating immunological *** increasing evidence suggests that inflammatory bowel disease(IBD)is strongly associated with dysregulation of gut *** activated inflammation,excessive reactive oxygen species(ROS)and reactive nitrogen species(RNS)produced by inflammatory cells play a detrimental role in regulating IBD and gut ***/RNS cause damage to the surrounding tissues,including nutrient absorption disorders,intestinal dysmotility and barrier ***,ROS/RNS provide terminal electron receptors for anaerobic respiration and support the bloom of facultative anaerobes,eventually causing gut microbiota ***-active nanoparticles(NPs)with catalytic properties or enzyme-like activities can effectively scavenge ROS/RNS,and selectively target inflamed sites via ultrasmall size-mediated enhanced permeation and retention(EPR)effect,showing great potential to regulate IBD and maintain the homeostasis of gut *** addition,the widespread application of NPs in commercial products 1 has increased their accumulation in healthy organisms,and the biological effects on normal microbiota resulting from long-term exposure of NPs to gastrointestinal tract also need attention.

关键词： gut microbiota IBD ROS/RNS redox-active NPs

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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Isolated Toughness and k-Hamiltonian[a,b]-factors

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Acta Mathematicae Applicatae sinica 2020年第3期36卷 539-544页

作者： Zhi-ren SUN si-zhong ZHOU School of Mathematical Sciences Nanjing Normal UniversityNanjing 210046China School of Science Jiangsu University of Science and TechnologyMengxi Road 2Zhenjiang 212003China

Let a,b and k be nonnegative integers with a≥2 and b≥a(k+1)+2.A graph G is called a k-Hamiltonian graph if after deleting any k vertices of G the remaining graph of G has a Hamiltonian cycle.A graph G is said to have a k-Hamiltonian[a,b]-factor if after deleting any k vertices of G the remaining graph of G admits a Hamiltonian[a,b]-*** G is a k-Hamiltonian graph of order n with n≥a+k+*** this paper,it is proved that G contains a k-Hamiltonian[a,b]-factor ifδ(G)≥a+k andδ(G)≥I(G)≥a-1+(a(k+1))/(b-2).

关键词： isolated toughness k-Hamiltonian graph k-Hamiltonian[a b]-factor

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