Redox-active nanoparticles for inflammatory bowel disease

作     者：Qinjuan Ren Si Sun Xiao-Dong Zhang Qinjuan Ren;Si Sun;Xiao-Dong Zhang

作者机构：Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing TechnologySchool of SciencesTianjin UniversityTianjin 300350China Tianjin Key Laboratory of Brain Science and Neural EngineeringAcademy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2021年第14卷第8期

页      面：2535-2557页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.91859101,81971744,U1932107,and 81471786) the National Natural Science Foundation of Tianjin(No.19JCZDJC34000) the Innovation Foundation of Tianjin University 

主　　题：gut microbiota IBD ROS/RNS redox-active NPs 

摘      要：Homeostasis of gut microbiota is extremely essential for maintaining nutrient metabolism and regulating immunological *** increasing evidence suggests that inflammatory bowel disease(IBD)is strongly associated with dysregulation of gut *** activated inflammation,excessive reactive oxygen species(ROS)and reactive nitrogen species(RNS)produced by inflammatory cells play a detrimental role in regulating IBD and gut ***/RNS cause damage to the surrounding tissues,including nutrient absorption disorders,intestinal dysmotility and barrier ***,ROS/RNS provide terminal electron receptors for anaerobic respiration and support the bloom of facultative anaerobes,eventually causing gut microbiota ***-active nanoparticles(NPs)with catalytic properties or enzyme-like activities can effectively scavenge ROS/RNS,and selectively target inflamed sites via ultrasmall size-mediated enhanced permeation and retention(EPR)effect,showing great potential to regulate IBD and maintain the homeostasis of gut *** addition,the widespread application of NPs in commercial products 1 has increased their accumulation in healthy organisms,and the biological effects on normal microbiota resulting from long-term exposure of NPs to gastrointestinal tract also need attention.