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Application of rotational atherectomy in the drug-eluting stent era

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Journal of Geriatric Cardiology 2013年第3期10卷 231-216页

作者： Chun-Chi Chen I-Chang hsieh Department of Second Section of Cardiology Chang Gung Memorial Hospital Chang Gung University College of Medicine Linkou 5 Fuhsing St. Tao Yuan 333 Taiwan China

Rotational atherectomy (RA) was introduced in the interventional arena in 1988 as a dedicated device for calcified lesions. Due to the complexity of the technique, the development of alternative methods such as the cutting balloon procedure, and the high restenosis rate of subsequent bare metal stenting in long lesions, its use had later declined. However, with the increasing use of drug-eluting stents (DES) and the aggressive treatment of longer lesions, the number of procedure performed with RA has increased significantly again in recent years. In this article, we reviewed the application of RA in DES era.

关键词： Drug-eluting stents Lesions Rotational atherectomy

The regulatory pathways leading to stem-like cells underlie prostate cancer progression

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Asian Journal of Andrology 2019年第3期21卷 233-240页

作者： Chun-Jung Lin U-Ging Lo Jer-Tsong hsieh Department of Urology UT Southwestern Medical Center Dallas TX 75390 USA

Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Regardless of a favorable outcome of ADT, patients inevitably relapse to an end-stage castration-resistant prostate cancer (CRPC) leading to mortality. Therefore, revealing the mechanism and identifying cellular components driving aggressive PCa is critical for prognosis and therapeutic intervention. Cancer stem cell (CSC) phenotypes characterized as poor differentiation, cancer initiation with self-renewal capabilities, and therapeutic resistance are proposed to contribute to the onset of CRPC. In this review, we discuss the role of CSC in CRPC with the evidence of CSC phenotypes and the possible underlying mechanisms.

关键词： cancer stem cell castration-resistant prostate cancer neuroendocrine differentiation transdifferentiation

Detection of social group instability among captive rhesus macaques using joint network modeling

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Current Zoology 2015年第1期61卷 70-84页

作者： Brianne A. BEISNER Jian JIN hsieh FUSHING Brenda MCCOWAN Department of Population Health & Reproduction School of Veterinary Medicine UC Davis Davis CA 95616 USA California National Primate Research Center University of California Davis Davis CA 95616 USA Department of Statistics UC Davis Davis CA 95616 USA

Social stability in group-living animals is an emergent property which arises from the interaction amongst multiple behavioral networks. However, pinpointing when a social group is at risk of collapse is difficult. We used a joint network model- ing approach to examine the interdependencies between two behavioral networks, aggression and status signaling, from four sta- ble and three unstable groups of rhesus macaques in order to identify characteristic patterns of network interdependence in stable groups that are readily distinguishable from unstable groups. Our results showed that the most prominent source of aggres- sion-status network interdependence in stable social groups came from more frequent dyads than expected with opposite direc- tion status-aggression （i.e. A threatens B and B signals acceptance of subordinate status）. In contrast, unstable groups showed a decrease in opposite direction aggression-status dyads （but remained higher than expected） as well as more frequent than ex- pected dyads with bidirectional aggression. These results demonstrate that not only was the stable joint relationship between ag- gression and status networks readily distinguishable from unstable time points, social instability manifested in at least two differ- ent ways. In sum, our joint modeling approach may prove useful in quantifying and monitoring the complex social dynamics of any wild or captive social system, as all social systems are composed of multiple interconnected networks [Current Zoology 61 （1）： 70-84, 2015].

关键词： Nonhuman primates Network stability Social network analysis Dominance Aggression Status signaling

Xyloglucans of Monocotyledons Have Diverse Structures

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Molecular Plant 2009年第5期2卷 943-965页

作者： Yves S.Y. hsieh Philip J. Harris School of Biological Sciences The University of Auckland Private Bag 92019 Auckland New Zealand

Except in the Poaceae, little is known about the structures of the xyloglucans in the primary walls of monocotyledons. Xyloglucan structures in a range of monocotyledon species were examined. Wall preparations were isolated, extracted with 6 M sodium hydroxide, and the extracts treated with a xyloglucan-specific endo-（1→4）-β-glucanase preparation. The oligosaccharides released were analyzed by high-performance anion-exchange chromatography and by matrix-assisted laser-desorption ionization time-of-flight mass spectrometry. Oligosaccharide profiles of the non-commelinid monocotyledons were similar to those of most eudicotyledons, indicating the xyloglucans were fucogalactoxyloglucans, with a XXXG a core motif and the fucosylated units XXFG and XLFG. An exception was Lemna minor （Araceae）, which yielded no fucosylated oligosaccharides and had both XXXG and XXGn core motifs. Except for the Arecales （palms） and the Dasypogonaceae, which had fucogalactoxyloglucans, the xyloglucans of the commelinid monocotyledons were structurally different. The Zingiberales and Commelinales had xyloglucans with both XXGn and XXXG core motifs; small proportions of XXFG units, but no XLFG units, were present. In the Poales, the Poaceae had xyloglucans with a XXGn core motif and no fucosylated units. In the other Poales families, some had both XXXG and XXGn core motifs, others had only XXXG; XXFG units were present, but XLFG units were not.

关键词： Commelinid monocotyledons non-commelinid monocotyledons plant cell walls Poaceae xyloglucans xyloglucan-specific endo-(1→4)-β-glucanase.

Acupuncture and neuroregeneration in ischemic stroke

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Neural Regeneration Research 2018年第4期13卷 573-583页

作者： Qwang-Yuen Chang Yi-Wen Lin Ching-Liang hsieh department of family medicine lin shin hospitaltaichungtaiwanchina research center for chinese medicine and acupuncture china medical universitytaichungtaiwanchina graduate institute of acupuncture science college of chinese medicinechina medical universitytaichungtaiwanchina graduate institute of integrated medicine college of chinese medicinechina medical universitytaichungtaiwanchina department of chinese medicine china medical university hospitaltaichungtaiwanchina

Acupuncture is potentially beneficial for post-stroke rehabilitation and is considered a promising preventive strategy for *** pretreatment or treatment after ischemic stroke by using appropriate electroacupuncture parameters generates neuroprotective and neuroregenerative effects that increase cerebral blood flow,regulate oxidative stress,attenuate glutamate excitotoxicity,maintain bloodbrain barrier integrity,inhibit apoptosis,increase growth factor production,and induce cerebral ischemic tolerance.

关键词： acupuncture neuroprotection neuroregeneration

Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families

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World Journal of Gastroenterology 2021年第37期27卷 6262-6276页

作者： Ai-Ru hsieh Cathy S J Fann Hung-Chun Lin Jennifer Tai Sen-Yung hsieh Dar-In Tai Department of Statistics Tamkang UniversityNew Taipei City 25137Taiwan Institute of Biomedical Sciences Academia SinicaNankangTaipei 11529Taiwan Division of Hepatology Department of Gastroenterology and HepatologyChang Gung Memorial HospitalLinkou Medical CenterTaoyuan 33305Taiwan

BACKGROUND Genome-wide association studies from Asia indicate that HLA-DP and HLA-DQ loci are important in persistent hepatitis B virus(HBV)*** of the key elements for HBV-related carcinogenesis is persistent viral replication and *** To examine genetic and nongenetic factors with persistent HBV infection and viral load in families with hepatocellular carcinoma(HCC).METHODS The HCC families included 301 hepatitis B surface antigen(HBsAg)carriers and 424 noncarriers born before the nationwide vaccination program was initiated in *** HBV-related single nucleotide polymorphisms(SNPs)—rs477515,rs9272105,rs9276370,rs7756516,and rs9277535—were *** associated with persistent HBV infection and viral load were analyzed by a generalized estimating *** In the first-stage persistent HBV study,all SNPs except rs9272105 were associated with persistent infection.A significantly higher area under the reciprocal operating characteristic curve for nongenetic factors vs genetic factors(P<0.001)suggests that the former play a major role in persistent HBV *** the second-stage viral load study,we added 8 HBsAg carriers born after *** 309 HBsAg carriers were divided into low(n=162)and high viral load(n=147)groups with an HBV DNA cutoff of 105 cps/***,relationship to the index case,rs477515,rs9272105,and rs7756516 were associated with viral *** on the receiver operating characteristic curve analysis,genetic and nongenetic factors affected viral load equally in the HCC family cohort(P=0.3117).CONCLUSION In these east Asian adults,the mechanism of persistent HBV infection-related SNPs was a prolonged viral replication phase.

关键词： Generalized estimating equation Genetic polymorphism Genome-wide association study Hepatitis B surface antigen Hepatitis B virus Replication

Feasibility Study on Fabrication of Geopolymer Bricks by Wasted Grinding Wheel at Room Temperature

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Journal of Renewable Materials 2020年第12期8卷 1657-1670页

作者： Yi-Che hsieh Ta-Wui Cheng Chia-Ho Wu Department of Materials and Mineral Resources Engineering National Taipei University of TechnologyTaipei10608Taiwan Institute of Mineral Resources Engineering National Taipei University of TechnologyTaipei10608Taiwan

In this study,the feasibility of producing eco-friendly bricks by using geopolymer technology and a waste grinding wheel(WGW)from the grinding wheel industries was ***,in order to meet industrial needs,for instance,in Taiwan,approximately 500,000 grinding wheels are used *** is,a large number of“waste”grinding wheels are ***,few studies have been conducted on the use of WGWs as raw materials in geopolymer *** use of geopolymer technology to form bricks can avoid the utilization of clay and cement and even prevent the use of a high-temperature process in ***,it can decrease CO_(2) emission and energy consumption and thus,protect the *** this study,the following three major factors were considered:press-forming pressure(70 and 100 kgf/cm2),NaOH molar concentration(2 and 4M),and the ratio of binder fineaggregate(1:3,1:4,and 1:5).Under these conditions,the specimens were tested using the compressive strength test,water absorption test,microstructure analysis,a freezing–thawing test and toxicity characteristic leaching procedure *** optimal formulation was composed of 1:4 binder fine-aggregate ratio,4M NaOH concentration,and 100-kgf/cm2 ***,we used a WGW and achieved a compressive strength of 50.6 MPa after 28 days,which was greater than 32 MPa and conformed to the Grade A brick standard of National Standards of the Republic of China(13295).In conclusion,this brick fabrication method based on geopolymer technology was not only beneficial to the environment but also improved the efficiency of reutilizing WGW.

关键词： Geopolymer waste grinding wheel geopolymer bricks

Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity

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Cellular & Molecular Immunology 2021年第2期18卷 472-483页

作者： pei-Chi Chen Yu-Ting Shao Miao-Hsi hsieh Hui-Fang Kao Wen-Shuo Kuo Shih-Min Wang Shun-Hua Chen Lawrence Shih Hsin Wu Hui-Ju Tsai Jiu-Yao Wang Institute of Basic Medical Sciences College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Microbiology and Immunology College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Center for Allergy and Clinical Immunology Research College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Nursing National Tainan Junior College of NursingTainanTaiwanChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjingChina Department of Pediatrics National Cheng Kung University HospitalTainanTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Division of Biostatistics and Bioinformatics Institute of Population Health SciencesNational Health Research InstitutesZhunanTaiwanChina Department of Pediatrics National Cheng Kung University HospitalNo139Sheng-Li RoadTainan 70428 TaiwanChina

Virus-induced asthma is prevalent among children,but its underlying mechanisms are *** evidence indicates that early-life respiratory virus infection increases susceptibility to allergic ***,the relationship between systemic virus infections,such as enterovirus infection,and the ensuing effects on allergic asthma development is ***-life enterovirus infection was correlated with higher risks of allergic diseases in *** mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal *** marrow-derived macrophages(BMDMs)from recovered EV-A71-infected mice showed sustained innate immune memory(trained immunity)that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with *** transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naïve recipient mice,which was inhibited by 2-deoxy-D-glucose(2-DG)pretreatment,suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.

关键词： trained immunity allergy asthma

Limited water infusion decreases pain during minimally sedated colonoscopy

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World Journal of Gastroenterology 2011年第17期17卷 2236-2240页

作者： Yu-Hsi hsieh Hwai-Jeng Lin Kuo-Chih Tseng Division of Gastroenterology Department of MedicineBuddhist Dalin Tzu Chi General Hospital622 Chia-YiTaiwanChina Buddhist Tzu Chi University School of Medicine970 HwalienTaiwanChina Hwai-Jeng Lin Division of Gastroenterology and HepatologyDepartment of Internal MedicineTaipei Medical University Hospital110 TaipeiTaiwanChina Division of Gastroenterology and Hepatology Department of Internal MedicineTaipei Medical University Hospital110 TaipeiTaiwanChina School of Medicine Taipei Medical University110 TaipeiTaiwanChina

AIM:To investigate a limited water infusion method in ***:Consecutive patients undergoing minimally sedated colonoscopy were randomized to receive air insufflation(n = 89) or water infusion limited to the rectum,sigmoid colon and descending colon(n = 90).Completion rates,cecal intubation times,procedure times,need for abdominal compression,turning of patients and levels of discomfort were ***:Completion rates,total procedure times,need for abdominal compression,and turning of patients were similar between *** pain was experienced in the water group than in the air group(2.5 ± 2.5 vs 3.4 ± 2.8,mean ± SD,P = 0.021).The cecal intubation time was significantly longer in the water group than in the air group(6.4 ± 3.1 min vs 4.5 ± 2.4 min,P < 0.001).More water was infused in the water group(322 ± 80.9 mL vs 26.2 ± 39.4 mL,P < 0.001).CONCLUSION:Limited airless water infusion in the distal colon reduces patients' pain during colonoscopy.

关键词： Water Pain Colonoscopy Looping Intubation time