Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity
作者机构：Institute of Basic Medical SciencesCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Microbiology and ImmunologyCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Center for Allergy and Clinical Immunology ResearchCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of NursingNational Tainan Junior College of NursingTainanTaiwanChina School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjingChina Department of PediatricsNational Cheng Kung University HospitalTainanTaiwanChina Graduate Institute of Biomedical SciencesChina Medical UniversityTaichungTaiwanChina Division of Biostatistics and BioinformaticsInstitute of Population Health SciencesNational Health Research InstitutesZhunanTaiwanChina Department of PediatricsNational Cheng Kung University HospitalNo139Sheng-Li RoadTainan 70428 TaiwanChina
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2021年第18卷第2期
页 面：472-483页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This study was in part supported by the Centre of Allergy and Mucosal Immunity Headquarters of University Advancement at the National Cheng Kung University Ministry of Education Taiwan.H.J.T is supported in part by a grant from the National Health Research Institutes(PI:Tsai PH-101-PP-14 PH-101-SP-14 and PH-108-PP-08).
主 题：trained immunity allergy asthma
摘 要：Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonetheless,the relationship between systemic virus infections,such as enterovirus infection,and the ensuing effects on allergic asthma development is unknown.Early-life enterovirus infection was correlated with higher risks of allergic diseases in children.Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period.Bone marrow-derived macrophages(BMDMs)from recovered EV-A71-infected mice showed sustained innate immune memory(trained immunity)that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naïve recipient mice,which was inhibited by 2-deoxy-D-glucose(2-DG)pretreatment,suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.
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