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Chinese Journal of Natural Medicines 2022年第4期20卷 290-300页

作者： DU Bing-Xin LIN pei LIN jun School of Life Sciences and Health Engineering Jiangnan UniversityWuxi 214122China

Catechins have been proven to exert antitumor effects in different kinds of ***,the underlying mechanisms have not been completely clarified *** study aimed to assess the effects and mechanisms of(-)-epigallocatechin-3-gallate(EGCG)and(-)-epicatechin-3-gallate(ECG)on human melanoma skin A375 *** showed that EGCG and ECG inhibited the proliferation of A375 cells and ECG showed better inhibitory *** cytometry analysis had shown that EGCG and ECG induced apoptosis and led to cell cycle *** and ECG decreased Bcl-2 expression and upregulated Caspase-3 protein level,indicating the development of ***,EGCG and ECG could decreased mitochondrial membrane potential of A375 *** addition,the expression of Beclin-1,LC3 and Sirt3 were downregulated at protein levels,which known to be associated with *** autophagy was increased by rapamycin,the apoptotic trend was not change,indicating that apoptosis and autophagy are ***,EGCG and ECG treatments decreased phosphorylated-AMPK(p-AMPK)and increased the ratios of P-PI3K,p-AKT and p-mTOR in melanoma ***,EGCG and ECG induced apoptosis via mitochondrial signaling pathway,downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling *** indicated that EGCG and ECG may be utilized in human melanoma treatment.

关键词： EGCG ECG Apoptosis Autophagy PI3K/AKT/mTOR

A novel shape memory alloy actuated soft gripper imitated hand behavior

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Frontiers of Mechanical Engineering 2022年第4期17卷 261-272页

作者： Jie PAN Jingjun yu Xu pei School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China

The limited length shrinkage of shape memory alloy(SMA)wire seriously limits the motion range of SMA-based *** this paper,a new soft finger without silicone gel was designed based on pre bent SMA wire,and the finger was back to its original shape by heating SMA wire,rather than relying only on heat exchange with the *** imitating palm movement,a structure with adjustable spacing between fingers was made using SMA spring and rigid *** hook structure design at the fingertip can form self-locking to further improve the load capacity of *** the long thin rod model,the relationship of the initial pre bent angle on the bending angle and output force of the finger was *** stress-strain model of SMA spring was established for the selection of rigid *** grasping modes were proposed to adapt to the weight of the *** the test of the gripper,it was proved that the gripper had large bending amplitude,bending force,and response *** design provides a new idea for the lightweight design and convenient design of soft gripper based on SMA.

关键词： shape memory alloy(SMA) pre bent wire gripper grasping mode lightweight

Novel models for simulating maize growth based on thermal time and photothermal units: Applications under various mulching practices

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Journal of Integrative Agriculture 2023年第5期22卷 1381-1395页

作者： LIAO Zhen-qi ZHENG Jing FAN jun-liang pei Sheng-zhao DAI yu-long ZHANG Fu-cang LI Zhi-jun Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas Ministry of EducationNorthwest A&F UniversityYangling 712100P.R.China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041P.R.China

Maize (Zea mays L.) is one of the three major food crops and an important source of carbohydrates for maintaining food security around the *** height (H),stem diameter (SD),leaf area index (LAI) and dry matter (DM) are important growth parameters that influence maize ***,the combined effect of temperature and light on maize growth is rarely considered in crop growth *** maize growth models based on the modified logistic growth equation (Mlog) and the Mitscherlich growth equation (Mit) were proposed to simulate the H,SD,LAI and DM of maize under different mulching practices based on experimental data from 2015–*** the accumulative growing degree-days (AGDD),helio thermal units (HTU),photothermal units (PTU) or photoperiod thermal units (PPTU,first proposed here) was used as a single driving factor in the models;or AGDD was combined with either accumulative actual solar hours (ASS),accumulative photoperiod response (APR,first proposed here) or accumulative maximum possible sunshine hours (ADL) as the dual driving factors in the *** model performances were evaluated using seven statistical indicators and a global performance *** results showed that the three mulching practices significantly increased the maize growth rates and the maximum values of the growth curves compared with *** the four single factor-driven models,the overall performance of the Mlog_(PTU)Model was the best,followed by the Mlog_(AGDD)*** Mlog_(PPTU)Model was better than the Mlog_(AGDD)Model in simulating SD and *** the 10 models,the overall performance of the Mlog_(AGDD–APR)Model was the best,followed by the Mlog_(AGDD–ASS)***,the Mlog_(AGDD–APR)Model performed the best in simulating H and LAI,while the Mlog_(AGDD–ADL)and Mlog_(AGDD–ASS)models performed the best in simulating SD and DM,*** conclusion,the modified logistic growth equations with AGDD and either APR,ASS or ADL as the dual driving

关键词： thermal time accumulative growing degree-days helio thermal units photothermal units growth model

Variation of cyanobacteria with different environmental conditions in Nansi Lake,China

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Journal of Environmental Sciences 2012年第8期24卷 1394-1402页

作者： Chang Tian Haiyan pei Wenrong Hu jun Xie School of Environmental Science and Engineering Shandong UniversityJinan 250061China Shandong Provincial Engineering Center on Environmental Science and Technology Jinan 250061China Shandong Environmental Monitoring Central Station Jinan 250013China

Nansi Lake is located on the east line of the South-to-North Water Diversion Project in China. A comprehensive study was carried out to investigate the spatial and temporal distribution of cyanobacteria in the lake from june 2008 to May 2011 based on monthly sample monitoring from five stations. The effect of environmental factors on cyanobacterial abundance was also evaluated. The eyanobaeterial community contained 15 genera and 23 species. The cyanobacterial abundance of each monitoring station ranged from 0 to 1.53x 107 cells/L with an average of 1.45~ 106 cells/L, which accounted for 11.66% of the total phytoplankton abundance. The dominant species of cyanobacteria were Pseudanabaena （32.94%） and Merismopedia （19.85%）, not the bloom-forming algae such as Microcystis and Anabaena. In addition, the cyanobacterial community structure and water quality variables changed substantially over the survey period. Redundancy analysis （RDA） suggested that temperature and phosphorus were important environmental factors that affected cyanobacteria. Temperature was the most important factor affecting cyanobacterial abundance. The effect of phosphorus on cyanobacterial abundance was more notable in warm periods than in periods with low temperature.

关键词： cyanobacteria Nansi Lake cyanobacterial bloom South-to-North Water Diversion Project

NYFR output pulse radar signal TOA analysis using extended Fourier transform and its TOA estimation

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Journal of Systems Engineering and Electronics 2017年第2期28卷 212-223页

作者： Zhaoyang Qiu pei Wang jun Zhu Bin Tang School of Electronic Engineering University of Electronic Science and Technology of China Chengdu 611731 China

Nyquist folding receiver (NYFR) is a typical wideband analog-to-information architecture. Focusing on the non-cooperative receiving, the pulse radar signal intercepted by the NYFR in time domain is analyzed. The NYFR outputs under different input conditions are investigated based on the extended Fourier transform (EFT) and the sampling theorem. Combining with the characteristic of the NYFR output in time domain, a new time of arrival (TOA) estimation method based on the energy envelope and the wavelet transform is proposed. The proposed estimation method can be adapted for the non-cooperative situation. It has no requirement for prior information to determine the threshold and is not necessary to transform the signal into baseband. Simulation results prove the correctness of the NYFR output expressions and show the efficacy of the proposed estimation method. © 2017 Beijing Institute of Aerospace Information.

关键词： Fourier transforms Radar Time domain analysis Wavelet transforms

Cusp points and assembly changing motions in the PRR-PR-PRR planar parallel manipulator

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Frontiers of Mechanical Engineering 2023年第2期18卷 177-187页

作者： Chengwei SHEN Jingjun yu Xu pei School of Mechanical Engineering&Automation Beihang UniversityBeijing 100191China

Most parallel manipulators have multiple solutions to the direct kinematic *** ability to perform assembly changing motions has received the attention of a few *** points play an important role in the kinematic *** study investigates the cusp points and assembly changing motions in a two degrees of freedom planar parallel *** direct kinematic problem of the manipulator yields a quartic polynomial *** root in the equation determines the assembly configuration,and four solutions are obtained for a given set of actuated joint *** regarding the discriminant of the repeated roots of the quartic equation as an implicit function of two actuated joint coordinates,the direct kinematic singularity loci in the joint space are determined by the implicit *** points are then obtained by the intersection of a quadratic curve and a cubic *** assembly changing motions by encircling different cusp points are highlighted,for each pair of solutions with the same sign of the determinants of the direct Jacobian matrices.

关键词： planar parallel manipulator assembly changing motions cusp points quartic polynomial discriminant of repeated roots

Ranking important nodes in complex networks by simulated annealing

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Chinese Physics B 2017年第2期26卷 42-47页

作者： yu Sun pei-Yang Yao Lu-jun Wan Jian Shen yun Zhong Information and Navigation College Air Force Engineering University Xi'an 710077 China Air Traffic Control and Navigation College Air Force Engineering University Xi'an 710077 China

In this paper, based on simulated annealing a new method to rank important nodes in complex networks is ***, the concept of an importance sequence（IS） to describe the relative importance of nodes in complex networks is defined. Then, a measure used to evaluate the reasonability of an IS is designed. By comparing an IS and the measure of its reasonability to a state of complex networks and the energy of the state, respectively, the method finds the ground state of complex networks by simulated annealing. In other words, the method can construct a most reasonable IS. The results of experiments on real and artificial networks show that this ranking method not only is effective but also can be applied to different kinds of complex networks.

关键词： complex networks node importance ranking method simulated annealing

Nd:YAG water mist laser treatment for giant gestational gingival tumor: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1974-1979页

作者： Hong-yu Chen jun-Ji Xu Xiu-Lin Chang pei Wu Department of Stomatology Women and Children's Hospital Affiliated to Ningbo UniversityNingbo 315012Zhejiang ProvinceChina

BACKGROUND This case of gestational gingival tumor is huge and extremely rare in clinical *** the growth location of this gingival tumor is in the upper anterior tooth area,it seriously affects the pregnant woman's speech and food,causing great pain to the *** use of Nd:YGA water mist laser to remove the gingival tumor resulted in minimal intraoperative bleeding,minimal adverse reactions,and good postoperative healing,which is worthy of clinical promotion and *** SUMMARY The patient,a pregnant woman,reported a large lump in her mouth on the first day of postpartum *** on medical history and clinical examination,the diagnosis was diagnosed as gestational gingival *** pathological biopsy also confirmed this *** use of Nd:YAG water mist laser to remove the tumor resulted in minimal intraoperative bleeding,clear surgical field of view,short surgical time,and good postoperative *** In comparison to traditional surgery,Nd:YAG water mist laser surgery is minimally invasive,minimizes cell damage,reduces bleeding,ensures a clear field of vision,and virtually eliminates postoperative edema,carbonization,and the risk of cross *** has unique advantages in oral soft tissue surgery for pregnant ***,the clinical application of Nd:YAG water mist laser for the treatment of gestational gingival tumors is an ideal choice.

关键词： Gestational gingival tumor Nd:YAG water mist laser Granulomatous gingival tumor Minimally invasive dentistry Pregnancy related diseases Oral soft tissue surgery Case report

Enhanced piezoelectricity in 0.7BiFeO_(3)-0.3BaTiO_(3)lead-free ceramics:Distinct effect of poling engineering

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Journal of Materiomics 2023年第5期9卷 971-979页

作者： Aizhen Song yu-Cheng Tang Hezhang Li Ning Wang Lei Zhao jun pei Bo-Ping Zhang The Beijing Municipal Key Laboratory of New Energy Materials and Technologies School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China Department of Precision Instrument Tsinghua UniversityBeijing10084China Key Laboratory of High-precision Computation and Application of Quantum Field Theory of Hebei Province College of Physics Science and TechnologyHebei UniversityBaoding071002China

BiFeO_(3)-BaTiO_(3) based ceramics are considered to be the most promising lead-free piezoelectric ceramics due to their large piezoelectric response and high Curie *** the piezoelectric response of piezoelectric ceramics just appears after poling engineering,in this work,the domain evolution and microscopic piezoresponse were observed in-situ using piezoresponse force microscopy(PFM)and switching spectroscopy piezoresponse force microscopy(SS-PFM),which can effectively study the local switching characteristics of ferroelectric materials especially at the *** new domain nucleation preferentially forms at the boundary of the relative polarization region and expands laterally with the increase of bias voltage and *** maximum piezoresponse(Rs),remnant piezoresponse(Rrem),maximum displacement(Dmax)and negative displacement(Dneg)at 45 V and 120C reach 122,69,127 pm and 75 pm,*** to the distinct effect of poling engineering in full domain switching,the corresponding d33 at 50 kV/cm and 120C reaches a maximum of 205 pC/N,which is nearly twice as high as that at room *** the evolution of ferroelectric domains in the poling engineering of BiFeO_(3)-BaTiO_(3)ceramics provides an insight into the relationship between domain structure and piezoelectric response,which has implications for other piezoelectric ceramics as well.

关键词： 0.7BiFeO_(3)-0.3BaTiO_(3) Domain evolution Microscopic piezoresponse Poling engineering Piezoelectricity

Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： Li-hua Zhu yu-pei Liang Lian Yang Feng Zhu Li-jun Jia He-gen Li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis