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Comparison between the therapeutic effects of differentiated and undifferentiated Wharton’s jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes

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World Journal of Stem Cells 2020年第2期12卷 139-151页

作者： Chen-Yuan Hsiao Tien-Hua Chen Ben-Shian Huang Po-Han Chen Cheng-Hsi Su Jia-Fwu Shyu pei-jiun tsai Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114Taiwan Department of Surgery Landseed International HospitalTaoyuan 324Taiwan Institute of Anatomy and Cell Biology School of MedicineNational Yang Ming UniversityTaipei 112Taiwan Trauma Center Department of SurgeryVeterans General HospitalTaipei 112Taiwan Division of General Surgery Department of SurgeryVeterans General HospitalTaipei 112Taiwan Department of Obstetrics and Gynecology Veterans General HospitalTaipei 112Taiwan Department of Surgery Cheng Hsin General HospitalTaipei 112Taiwan Department of Biology and Anatomy National Defense Medical CenterTaipei 114Taiwan Department of Critical Care Medicine Veterans General HospitalTaipei 112Taiwan

BACKGROUND Despite the availability of current therapies,including oral antidiabetic drugs and insulin,for controlling the symptoms caused by high blood glucose,it is difficult to cure diabetes mellitus,especially type 1 diabetes *** Cell therapies using mesenchymal stem cells(MSCs)may be a promising ***,the therapeutic mechanisms by which MSCs exert their effects,such as whether they can differentiate into insulin-producing cells (IPCs) beforetransplantation, are *** this study, we used three types of differentiation media over 10 d to generateIPCs from human Wharton’s jelly MSCs (hWJ-MSCs). We further transplantedthe undifferentiated hWJ-MSCs and differentiated IPCs derived from them intothe portal vein of rats with streptozotocin-induced diabetes, and recorded thephysiological and pathological *** fluorescent staining and C-peptide enzyme-linked immunoassay, we wereable to successfully induce the differentiation of hWJ-MSCs into *** of both IPCs derived from hWJ-MSCs and undifferentiated hWJMSCshad the therapeutic effect of ameliorating blood glucose levels andimproving intraperitoneal glucose tolerance tests. The transplanted IPCs homedto the pancreas and functionally survived for at least 8 wk after transplantation,whereas the undifferentiated hWJ-MSCs were able to improve the insulitis andameliorate the serum inflammatory cytokine in streptozotocin-induced *** IPCs can significantly improve blood glucose levels in diabetic ratsdue to the continuous secretion of insulin by transplanted cells that survive in theislets of diabetic rats. Transplantation of undifferentiated hWJ-MSCs cansignificantly improve insulitis and re-balance the inflammatory condition indiabetic rats with only a slight improvement in blood glucose levels.

关键词： Human Wharton’s jelly mesenchymal stem cell Insulin-producing cells Diabetes mellitus Differentiation Regeneration therapy Anti-inflammatory

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Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1

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Translational Neurodegeneration 2019年第1期8卷 359-371页

作者： pei-jiun tsai Chang-Ching Yeh Wan-Jhen Huang Ming-Yuan Min Tzu-Hao Huang Tsui-Ling Ko pei-Yu Huang Tien-Hua Chen Sanford P.C.Hsu Bing-Wen Soong Yu-Show Fu Institute of Anatomy and Cell Biology School of MedicineNational Yang-Ming UniversityTaipeiTaiwanRepublic of China Trauma Center Department of SurgeryVeterans General HospitalTaipeiTaiwanRepublic of China Department of Critical Care Medicine Veterans General HospitalTaipeiTaiwanRepublic of China Department of Obstetrics and Gynecology Veterans General HospitalTaipeiTaiwanRepublic of China Institute of Clinical Medicine National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Obstetrics and Gynecology National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Life Science National Taiwan UniversityTaipeiTaiwanRepublic of China School of Medicine I-Shou UniversityKaohsiungTaiwanRepublic of China Institute of Physiology School of MedicineNational Yang-Ming UniversityTaipeiTaiwanRepublic of China Division of General Surgery Department of SurgeryVeterans General HospitalTaipeiTaiwanRepublic of China Department of Neurosurgery Neurological InstituteTaipei Veterans General HospitalTaipeiTaiwanRepublic of China School of Medicine National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Neurology Shuang Ho Hospitaland Taipei Neuroscience InstituteTaipei Medical UniversityTaipeiTaiwanRepublic of China Department of Neurology Taipei Veterans General HospitalTaipeiTaiwanRepublic of China Brain Research Center National Yang-Ming UniversityTaipeiTaiwanRepublic of China Department of Anatomy and Cell Biology School of MedicineNational Yang-Ming UniversityNo.155Sec.2Li-Nung StreetTaipei 112TaiwanRepublic of China

Background:Spinocerebellar ataxia type 1(SCA1)is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in ATXN1 gene resulting in an expansion of polyglutamine repeats in the ATXN1 ***,there has yet been any effective treatment so far for *** study investigated the feasibility of transplanting human umbilical mesenchymal stem cells(HUMSCs)into transgenic SCA1 mice containing an expanded uninterrupted allele with 82 repeats in the ATXN1-coding ***:106 human umbilical mesenchymal stem cells were transplanted into the cerebella at 1 month of ***:HUMSCs displayed significant ameliorating effects in SCA1 mice in terms of motor behaviors in balance beam test and open field test as compared with the untransplanted SCA1 *** transplantation effectively reduced the cerebellar atrophy,salvaged Purkinje cell death,and alleviated molecular layer *** studies showed higher amplitudes of compound motor action potentials as indicated by increasing neuronal-muscular response strength to stimuli after stem cell *** 5 months after transplantation,HUMSCs scattering in the mice cerebella remained viable and secreted cytokines without differentiating into neuronal or glia ***:Our findings provide hope for a new therapeutic direction for the treatment of SCA1.

关键词： Umbilical mesenchymal stem cells Cell transplantation SCA1

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Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

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Nano Research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing Joshua M.Little Haochen Yang tsai-Chun Chung Po-Yen Chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft ***,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality

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The ALMaQUEST Survey ⅩⅤ: The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics

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Science China(Physics,Mechanics & Astronomy) 2024年第9期Mechanics & Astronomy) .卷 178-200页

作者： Niankun Yu Zheng Zheng Chao-Wei tsai pei Zuo Sara L.Ellison David V.Stark Di Li Jingwen Wu Karen L.Masters Ting Xiao Yinghui Zheng Zongnan Li Kai Zhang Hongying Chen Shu Liu Sihan Jiao Fanyi Meng National Astronomical Observatories Chinese Academy of Sciences Key Laboratory of Radio Astronomy and Technology Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University School of Astronomy and Space Science University of Chinese Academy of Sciences Department of Physics & Astronomy University of Victoria Departments of Physics and Astronomy Haverford College Space Telescope Science Institute Zhejiang Laboratory New Cornerstone Science Laboratory School of Physics Zhejiang University

The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies,which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar *** compiled a sample of 94 nearby galaxies with observations of multi-phase gas contents by utilizing public HⅠ,CO,and optical IFU data from the Ma NGA survey together with new FAST HⅠ*** agreement with previous results,our sample shows that the global molecular-to-atomic gas ratio(Rmol≡log MH2/MHⅠ) is correlated with the global stellar mass surface density μ*with a Kendall's τ coefficient of 0.25 and p<10-3,less tightly but still correlated with stellar mass and NUV-r color,and not related to the specific star formation rate（sSFR）.The cold gas distribution and kinematics inferred from the HⅠand CO global profile asymmetry and shape do not significantly rely on *** to the availability of kpc-scale observations of MaNGA,we decompose galaxies into HⅡ,composite,and AGN-dominated regions by using the BPT *** increasing Rmol,the fraction of HⅡregions within 1.5 effective radius decreases slightly;the density distribution in the spatially resolved BPT diagram also changes significantly,suggesting changes in metallicity and ionization *** with high Rmoltend to have high oxygen abundance,both at one effective radius with a Kendall's τ coefficient of 0.37(p<10-3) and their central *** all parameters investigated here,the oxygen abundance at one effective radius has the strongest relation with global *** dependence of gas conversion on gas distribution and galaxy ionization states is *** contrast,the observed positive relation between oxygen abundance（μ*） and Rmolindicates that the gas conversion is efficient in regions of high metallicity（density）.

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The ALMaQUEST Survey XV: The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Niankun Yu Zheng Zheng Chao-Wei tsai pei Zuo Sara L.Ellison David V.Stark Di Li Jingwen Wu Karen L.Masters Ting Xiao Yinghui Zheng Zongnan Li Kai Zhang Hongying Chen Shu Liu Sihan Jiao Fanyi Meng School of Physics Zhejiang University National Astronomical Observatories Chinese Academy of Sciences Key Laboratory of Radio Astronomy and Technology Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University School of Astronomy and Space Science University of Chinese Academy of Sciences Department of Physics & Astronomy University of Victoria Departments of Physics and Astronomy Haverford College Space Telescope Science Institute Zhejiang Laboratory New Cornerstone Science Laboratory

The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies,which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar *** compiled a sample of 94 nearby galaxies with observations of multi-phase gas contents by utilizing public H i,CO,and optical IFU data from the Ma NGA survey together with new FAST H i *** agreement with previous results,our sample shows that the global molecular-to-atomic gas ratio Rmol=log MH2/MH1is correlated with the global stellar mass surface density μ*with a Kendall’sτcoefficient of 0.25and p<10-3,less tightly but still correlated with stellar mass and NUV-r color,and not related to the specific star formation rate （sSFR）.The cold gas distribution and kinematics inferred from the H i and CO global profile asymmetry and shape do not significantly rely on *** to the availability of kpc-scale observations of Ma NGA,we decompose galaxies into H ii,composite,and AGN-dominated regions by using the BPT *** increasing Rmol,the fraction of H ii regions within1.5 effective radius decreases slightly;the density distribution in the spatially resolved BPT diagram also changes significantly,suggesting changes in metallicity and ionization *** with high Rmoltend to have high oxygen abundance,both at one effective radius with a Kendall’sτcoefficient of 0.37 (p<10-3) and their central *** all parameters investigated here,the oxygen abundance at one effective radius has the strongest relation with global *** dependence of gas conversion on gas distribution and galaxy ionization states is *** contrast,the observed positive relation between oxygen abundance（μ*） and Rmolindicates that the gas conversion is efficient in regions of high metallicity （density）.

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星暴矮星系NGC 5253周围的中性氢气体分布

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中国科学院大学学报（中英文） 2024年第2期41卷 188-194页

作者：沃佳怡蔡肇伟左沛陈天禄西藏大学宇宙线教育部重点实验室拉萨850000 西藏大学理学院物理系拉萨850000 中国科学院国家天文台北京100101 中国科学院大学天文与空间科学学院北京101408 中国科学院FAST重点实验室北京100101 北京大学科维理天文与天体物理研究所北京100871

中性氢(HI)气体是恒星形成的基本物质,驱动着星系的演化。对于星暴矮星系NGC 5253,过去的研究利用射电干涉阵观测到的HI气体呈不对称分布,向东北方向延伸约7 kpc。这一延展结构可能表明NGC 5253与其附近的旋涡星系M 83之间存在动力学联... 详细信息

中性氢(HI)气体是恒星形成的基本物质,驱动着星系的演化。对于星暴矮星系NGC 5253,过去的研究利用射电干涉阵观测到的HI气体呈不对称分布,向东北方向延伸约7 kpc。这一延展结构可能表明NGC 5253与其附近的旋涡星系M 83之间存在动力学联系。为研究这两个星系之间可能存在的HI气体连接,从绿岸望远镜获得了射电L波段对NGC 5253周围的HI成图数据,探测到NGC 5253和M 83之间可能存在的7个HI气体云团。这些HI气体云团候选体主要分布在东北方向,由NGC 5253延展至距离超过60 kpc外。这些气体云团可能在触发矮星系NGC 5253剧烈的恒星形成活动中发挥重要作用。

关键词：星系相互作用恒星形成中性氢气体 NGC 5253

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快速射电暴在时间-能量双变量空间中表现为布朗运动

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Science Bulletin 2024年第8期69卷 1020-1026页

作者：张永坤李菂冯毅王培牛晨辉代实姚菊枚蔡肇伟 National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key Laboratory of Radio Astronomy and Technolgoy Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China New Cornerstone Science Laboratory Shenzhen 518054China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Science Western Sydney UniversityPenrith NSW 2751Australia Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China

The origin of fast radio bursts(FRBs),the brightest cosmic explosion in radio bands,remains *** introduce here a novel method for a comprehensive analysis of active FRBs’behaviors in the timeenergy ***"Pincus Index"and"Maximum Lyapunov Exponent",we were able to quantify the randomness and chaoticity,respectively,of the bursting events and put FRBs in the context of common transient physical phenomena,such as pulsar,earthquakes,and solar *** the bivariate timeenergy domain,repeated FRB bursts’behaviors deviate significantly(more random,less chaotic)from pulsars,earthquakes,and solar *** waiting times between FRB bursts and the corresponding energy changes exhibit no correlation and remain unpredictable,suggesting that the emission of FRBs does not exhibit the time and energy clustering observed in seismic *** pronounced stochasticity may arise from a singular source with high entropy or the combination of diverse emission mechanisms/***,our methodology serves as a pragmatic tool for illustrating the congruities and distinctions among diverse physical processes.

关键词： Fast radio burst Earthquake Stochastic Chaos

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A Novel Control Algorithm for Interaction Between Surface Waves and A Permeable Floating Structure

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China Ocean Engineering 2016年第2期30卷 161-176页

作者： pei-Wei tsai A.ALSAEDI T.HAYAT Cheng-Wu CHEN College of information Science and Engineering Fujian University of TechnologyFuzhou 350118China Fujian Provincial Key Laboratory of Big Data Mining and Applications(Fujian University of Technology) Fuzhou 350118China Nonlinear Analysis and Applied Mathematics(NAAM)Research Group King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics Quaid-I-Azam UniversityIslamabad 44000Pakistan Department of Maritime Information and Technology National Kaohsiung Marine UniversityKaohsiung 80543China Faculty of Engineering King Abdulaziz UniversityJeddah 21589Saudi Arabia

An analytical solution is undertaken to describe the wave-induced flow field and the surge motion of a permeable platform structure with fuzzy controllers in an oceanic *** the design procedure of the controller,a parallel distributed compensation（PDC） scheme is utilized to construct a global fuzzy logic controller by blending all local state feedback controllers.A stability analysis is carried out for a real structure system by using Lyapunov *** corresponding boundary value problems are then incorporated into scattering and radiation *** are analytically solved,based on separation of variables,to obtain series solutions in terms of the harmonic incident wave motion and surge *** dependence of the wave-induced flow field and its resonant frequency on wave characteristics and structure properties including platform width,thickness and mass has been thus drawn with a parametric *** which mathematical models are applied for the wave-induced displacement of the surge motion.A nonlinearly inverted pendulum system is employed to demonstrate that the controller tuned by swarm intelligence method can not only stabilize the nonlinear system,but has the robustness against external disturbance.

关键词： fuzzy Lyapunov function Takagi?Sugeno form swarm intelligence algorithm

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Anti-hepatitis C virus therapy in chronic kidney disease patients improves long-term renal and patient survivals

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World Journal of Clinical Cases 2019年第11期7卷 1270-1281页

作者： Yi-Chun Chen Chung-Yi Li Shiang-jiun tsai Yen-Chun Chen Division of Nephrology Department of Internal Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi County 622 Taiwan School of Medicine Tzu Chi University Hualien 970 Taiwan Department and Graduate Institute of Public Health College of Medicine National Cheng Kung University Tainan 701 Taiwan Department of Public Health College of Public Health China Medical University Taichung 404 Taiwan Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi County 622 Taiwan Division of Hepato-Gastroenterology Department of Internal Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi County 622 Taiwan

BACKGROUND Hepatitis C virus (HCV) infection is a documented risk factor for chronic kidney disease (CKD) and progression to end-stage renal disease (ESRD). However, to date there are no reports on the long-term hard endpoints (ESRD and death) of anti-HCV therapy [interferon-based therapy (IBT) or new direct-acting antivirals] in CKD patients. Direct-acting antivirals are not available in Taiwan’s singlepayer national health insurance database currently released for research. Therefore, we hypothesized that a retrospective analysis of the long-term outcomes of IBT in CKD patients will serve as a proxy for direct-acting antivirals to increase our understanding of progression to ESRD following HCV infection. AIM To evaluate the long-term outcomes (ESRD and death) of anti-HCV therapy, especially IBT, in HCV-infected patients with stage 1-5 CKD. METHODS We analyzed 93894 Taiwan Residents adults diagnosed with CKD and without HBV infection. Of these, 4.9% were infected with HCV. Of the 4582 HCV-infected CKD patients, 482 (10.5%) received IBT (treated cohort). They were matched 1:4 with 1928 untreated HCV-infected CKD patients (untreated cohort) by propensity scores and year, which further matched 1:2 by propensity scores with 3856 CKD patients without HCV infection (uninfected cohort). All participants were followed until the occurrence of ESRD, death, or the end of 2012. The association between HCV infection, IBT use, and risks of ESRD and death was analyzed using competing risk analysis. RESULTS Taking the uninfected cohort as a reference, the adjusted hazard ratios for ESRD, after adjusting for competing mortality, were 0.34 (0.14-0.84, P = 0.019) and 1.28 (1.03-1.60, P = 0.029) in the treated and untreated cohorts, respectively. The treated cohort had a 29%(0.54-0.92, P = 0.011) decrease in mortality compared to the untreated cohort, in which the mortality was 31%(1.18-1.45, P < 0.001) higher than in the uninfected cohort. The reduced risks of ESRD (0.14, 0.03–0.58,

关键词： Hepatitis C virus Chronic kidney disease End-stage renal disease Antihepatitis C virus therapy Cohort study

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Nationwide cohort study suggests that nucleos(t)ide analogue therapy decreases dialysis risk in Taiwan Residents chronic kidney disease patients acquiring hepatitis B virus infection

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World Journal of Gastroenterology 2018年第8期24卷 917-928页

作者： Yi-Chun Chen Chung-Yi Li Shiang-jiun tsai Yen-Chun Chen Department of Internal Medicine Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi County 622Taiwan School of Medicine Tzu Chi UniversityHualien 970Taiwan Department and Graduate Institute of Public Health College of MedicineNational Cheng Hung UniversityTainan 701Taiwan Department of Public Health College of Public HealthChina Medical UniversityTaichung 404Taiwan Department of Medical Research Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi County 622Taiwan Division of Hepato-Gastroenterology Department of Internal MedicineDalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi County 622Taiwan

AIM To investigate the risk of end-stage renal disease(ESRD) in hepatitis B virus(HBV)-infected patients with chronic kidney disease(CKD) with and without nucleos(t)ide analogue(NA) *** This nationwide cohort study included 103444 Taiwan Residents CKD adults without hepatitis C virus infection from the Taiwan Longitudinal Health Insurance Database 2005 between 1997 and 2012. We identified 2916 CKD patients who acquired HBV infection and did not receive NAs(untreated cohort), and they were propensitymatched 1:4 with 11664 uninfected counterparts. We also identified 442 CKD patients who acquired HBV infection and received NAs(treated cohort), and they were propensity-matched 1:3 with 1326 untreated counterparts. The association between HBV infection, NA use, and ESRD was analyzed using competing risk *** Multivariable Cox regression analysis showed a 1.67-fold higher risk(P < 0.0001) of ESRD in the untreated cohort(16-year cumulative incidence, 10.1%) than in the matched uninfected cohort(16-year cumulative incidence, 6.6%), which was independent of cirrhosis or diabetes. The treated cohort(16-year cumulative incidence, 2.2%) had an 87% lower ESRD risk(P < 0.0001) compared with the matched untreated cohort(16-year cumulative incidence, 11.9%). The number needed to treat for one fewer ESRD after NA use at 12 years was 12. Multivariable stratified analyses verified these associations in all *** This study suggests that untreated HBV infection and NA therapy are associated with increased and decreased risk of ESRD, respectively, in CKD patients. Identification of HBV status and targeted monitoring for ESRD development are important in CKD patients living in HBV-endemic areas.

关键词： hepatitis B virus chronic kidney disease end-stage renal disease nucleos(t)ide analogue cohort study

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