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Single-cell RNA sequencing to understand host-virus interactions

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Virologica Sinica 2024年第1期39卷 1-8页

作者： jia-Tong Chang li-Bo liu pei-Gang Wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Single-cell RNA sequencing(scRNA-seq)has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell *** review summarizes the existing scRNA-seq technologies together with their strengths and *** applications of scRNA-seq in various virological studies are discussed in depth,which broaden the understanding of the immune atlas,host-virus interactions,and immune ***-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

关键词： Single-cell RNA sequencing(scRNA-seq) Host-virus interaction COVID-19 Flavivirus

Slow magnetic relaxation and photoluminescence behaviors of dilanthanide complexes bearing N_(8)O_(2)donor macrocyclic ligand

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Journal of Rare Earths 2024年第7期42卷 1298-1303,I0004页

作者： pei-Yu liao Yu-Quan Qi Zhen li jian-Hua jia Ming-liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-Sen UniversityGuangzhou510006China

On account of the complicated magnetic exchange interactions between lanthanide ions,binuclear lanthanide complexes have broad application prospect in the field of single-molecule ***,it is necessary to develop reasonable bridging ligands to manipulate the directional assembly of binuclear lanthanide ***,we selected the macrocyclic ligand L^(N_(8)O_(2))to build up two new dilanthanide complexes[Ln_(2)(LN_(8)O_(2))(OpyO)_(2)(H_(2)O)2](NO_(3))_(2)(1-Ln,Ln=Dy,Tb;LN_(8)O_(2)=hexamethyl-tetraaza-dioxe-dipyrazolacycloicosaphane-2,9,12,19-tetraene;OpyOH=2-pyridinol-1-oxide).Dynamic magnetic studies show that 1-Dy exhibits slow relaxation behavior under a 1 kOe applied *** fitting analysis of relaxation times gives the effective energy barrier of 38.2 cm^(−1),and reveals that the slow magnetic relaxation behavior is dominated by the Orbach and Raman ***-resolution luminescence emission spectrum indicates the energy gap of 36.8 cm^(−1)between the ground state and the first excited state,consistent with the magnetic measurement results.1-Tb exhibits brilliant characteristic green light emission under UV light *** absolute quantum yield of 1-Tb is 44.8%,and its first-order fitted decay lifetime is 779.21μs at room *** study provides the way for directional construction of high-performance molecular materials with magnetic and optical dual-function.

关键词： Dilanthanide complexes Single-molecule magnets Macrocyclic ligand Photoluminescence behavior Rare earths

Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： li-hua Zhu Yu-pei liang lian Yang Feng Zhu li-jun jia He-gen li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis

Predicting Credit Bond Default with Deep Learning: Evidence from China

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Journal of Social Computing 2024年第1期5卷 36-45页

作者： Ning Zhang Wenhe li Haoxiang Chen Binshu jia pei Deng School of Information Central University of Finance and EconomicsBeijing 100081China SDIC Taikang Trust Co. Ltd.Beijing 100034China

China’s credit bond market has rapidly expanded in recent ***,since 2014,the number of credit bond defaults has been increasing rapidly,posing enormous potential risks to the stability of the financial *** study proposed a deep learning approach to predict credit bond defaults in the Chinese market.A convolutional neural network(CNN)was selected as the classification model and to reduce the extreme imbalance between defaulted and non-defaulted bonds,and a generative adversarial network(GAN)was used as the oversampling *** on 31 financial and 20 non-financial indicators,we collected Wind data on all credit bonds issued and matured or defaulted from 2014 to *** experimental results showed that our GAN+CNN approach had superior predictive performance with an area under the curve(AUC)of 0.9157 and precision of 0.8871 compared to previous research and other commonly used classification models-including the logistic regression,support vector machine,and fully connected neural network models-and oversampling techniques-including the synthetic minority oversampling technique(SMOTE)and Borderline SMOTE *** one-year predictions,indicators of solvency,capital structure,and fundamental properties of bonds are proved to be the most important indicators.

关键词： credit bond default prediction convolutional neural network imbalanced data processing generative adversarial network

Large isolated fibrous tumors in the upper esophagus: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 543-549页

作者： jia-jia Yu Huan-Shuang pei Yu Meng Department of Anesthesiology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Solitary fibrous tumors(SFT)are rare spindle cell tumors that are usually benign.A total of 10 cases of SFTs in the upper esophagus have ever been ***,we report the anesthetic management of a patient with a large isolated fibrous tumor of the upper esophagus compressing the tracheal *** also provide a literature review of the current *** SUMMARY We report the case of a 49 year old male with“cough aggravation and wheezing after exercise”,who underwent esophagectomy for a large isolated fibrous tumor compressing the tracheal membrane in the upper *** advise the use of a single-lumen tube with a blocker in patients with difficult airways to reduce the incidence of airway injury and fibrinoscopy at all stages of the perioperative period to guide airway *** case study is the first report of the anesthetic management of a large,isolated fibrous tumor compressing the tracheal membrane in the upper *** This rare case emphasizes the importance of perioperative management of anesthesia in patients with large isolated fibrous tumors of the upper esophagus that compress the tracheal *** use of blocker reduce the incidence of airway injury and fibrinoscopy at the perioperative period to guide airway mana-gement.

关键词： Upper esophagus Isolated fibrous tumor Tracheal membrane Peak airway pressure Case report

Perspective on powder technology for all-solid-state batteries:How to pair sulfide electrolyte with high-voltage cathode

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Particuology 2024年第3期86卷 55-66页

作者： jiangkui Hu Shijie Yang Yingying pei Xilong Wang Yulong liao Shuai li Aolong Yue jia-Qi Huang Hong Yuan School of Materials Science&Engineering Beijing Institute of TechnologyBeijing100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China

Sulfide solid electrolytes(SEs)have attracted ever-increasing attention due to their superior roomtemperature ionic conductivity(~10^(-2) S cm^(-1)).Additionally,the integration of sulfide SEs and highvoltage cathodes is promising to achieve higher energy ***,the incompatible interfaces between sulfide SEs and high-voltage cathodes have been one of the key factors limiting their ***,this review presents a critical summarization of the interfacial issues in all-solid-state lithium batteries based on sulfide SEs and high-voltage cathodes and proposes strategies to stabilize the electrolyte/cathode ***,the future research direction of electrolyte/cathode interfaces and application prospects of powder technology in sulfide-based ASSLBs were also discussed.

关键词： Sulfide solid electrolytes High-voltage cathodes Electrode/electrolyte interfaces All-solid-state lithium batteries

Uniqueness Problem for the Backward Differential Equation of a Continuous-State Branching Process

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1825-1836页

作者： pei Sen li Zeng Hu li School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100872P.R.China School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China

The distributional properties of a multi-dimensional continuous-state branching process are determined by its cumulant semigroup,which is defined by the backward differential *** provide a proof of the assertion of Rhyzhov and Skorokhod(Theory ***.,1970)on the uniqueness of the solutions to the equation,which is based on a characterization of the process as the pathwise unique solution to a system of stochastic equations.

关键词： Continuous-state branching process multi-dimensional backward differential equation stochastic equation generator

Comparison of corrosion mechanisms of 510L low alloy steel treated by ACS and EPS techniques under various service environments

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Journal of Iron and Steel Research International 2024年第2期31卷 501-518页

作者： Bao-sheng liu Peng-fei Xu Shao-hua Zhang Yan-rui li li-ming Mou jia-li li Yue-zhong Zhang pei-mao Fu Fa-cai Shi College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina College of Chemical and Biological Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina Technical Center Taiyuan Iron and Steel(Group)Co.Ltd.Taiyuan030003ShanxiChina

The corrosion mechanism of 510L low alloy steel treated by acid-cleaned surface(ACS)and eco-pickled surface(EPS)techniques in three simulated solutions(S0:atmospheric environment;S1:soil environment;S2:industrial environment)and the influence of interaction between different corrosive anions on corrosion were *** results show that the total corrosion rates of samples in three simulated solutions were in order of S2>S0>S1,which is simultaneously correlated with initial corrosion dissolution processes as well as after the formation of corrosion ***3−will inhibit the initial corrosion owing to the formation of films,whereas HSO3−will accelerate the dissolutions of the matrix based on the synergistic action of HSO3−and Cl−.On the other hand,there is no significant difference in corrosion rates between the samples treated by ACS and EPS *** EPS technique that is safe,reusable and environmentally friendly can be further widely used in future work.

关键词： Corrosion mechanism Low alloy steel Simulated solution Surface technique Immersion time

Two-dimensional ballistic transistors for advanced-node integrated circuits

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National Science Review 2024年第3期11卷 9-10页

作者： jia li Xidong Duan Hunan Provincial Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University

As the feature size of metal-oxide-semiconductor-field-effect-transistors(MOSFETs) in integrated circuits(ICs)is reduced to sub-10-nm, the traditional channel materials are plagued by enhanced scattering and short-cha... 详细信息

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