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Effects of marker density and minor allele frequency on genomic prediction for growth traits in Chinese Simmental beef cattle

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Journal of Integrative Agriculture 2017年第4期16卷 911-920页

作者： ZHU Bo ZHANG Jing-jing NIU Hong GUAN Long GUO Peng XU Ling-yang CHEN Yan ZHANG lu-pei GAO Hui-jiang GAO Xue LI Jun-ya Laboratory of Molecular Biology and Bovine Breeding Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China

Genomic selection has been demonstrated as a powerful technology to revolutionize animal breeding. However, marker density and minor allele frequency can affect the predictive ability of genomic estimated breeding values （GEBVs）. To investigate the impact of marker density and minor allele frequency on predictive ability, we estimated GEBVs by constructing the different subsets of single nucleotide polymorphisms （SNPs） based on varying markers densities and minor allele frequency （MAF） for average daily gain （ADG）, live weight （LW） and carcass weight （CW） in 1 059 Chinese Simmental beef cattle. Two strategies were proposed for SNP selection to construct different marker densities： 1） select evenly-spaced SNPs （Strategy 1 ）, and 2） select SNPs with large effects estimated from BayesB （Strategy 2）. Furthermore, predictive ability was assessed in terms of the correlation between predicted genomic values and corrected phenotypes from 10-fold cross-validation. Predictive ability for ADG, LW and CW using autosomal SNPs were 0.13＋0.002, 0.21＋0.003 and 0.25＋0.003, respectively. In our study, the predictive ability increased dramatically as more SNPs were included in analysis until 200K for Strategy 1. Under Strategy 2, we found the predictive ability slightly increased when marker densities increased from 5K to 20K, which indicated the predictive ability of 20K （3% of 770K） SNPs with large effects was equal to the predictive ability of using all SNPs. For different MAF bins, we obtained the highest predictive ability for three traits with MAF bin 0.01-0.1. Our result suggested that designing a low-density chip by selecting low frequency markers with large SNP effects sizes should be helpful for commercial application in Chinese Simmental cattle.

关键词： genomic prediction cross-validation Chinese Simmental beef cattle marker density minor allele frequency (MAF)

Design optimization of plastic scintillators with wavelength-shifting fibers and silicon photomultiplier readouts in the top veto tracker of the JUNO-TAO experiment

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Nuclear Science and Techniques 2023年第7期34卷 99-112页

作者： Guang luo Y.K.Hor pei-Zhi lu Zhi-Min Wang Ru-Hui Li Min Li Yi-Chen Li Liang Zhan Wei Wang Yue-Huan Wei Yu Chen Xiang Xiao Feng-Peng An School of Physics Sun Yat-sen UniversityGuangzhou 510275China Institute of High Energy Physics Beijing 100049Chin a 3 University of Chinese Academy of Sciences Beijing 100049China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

Plastic scintillators(PSs)embedded with wavelength-shifting fibers are widely used in high-energy particle physics,such as in muon taggers,as well as in medical physics and other *** this study,a simulation package was built to evaluate the effects of the diameter and layout of optical fibers on the light yield with different *** optimal optical configuration was designed based on simulations and validated using two PS prototypes under certain experimental condi-tions.A top veto tracker(TVT)for the JUNO-TAO experiment,comprising four layers of 160 strips of PS,was designed and *** threshold was evaluated when the muon tagging efficiency of a PS strip was>99%.The efficiency of three layer out of four layer of TVT is>99%,even with a tagging efficiency of a single strip as low as 97%,using a threshold of 10 photoelectrons and assuming a 40%silicon PM photon detection efficiency.

关键词： Plastic scintillator WLS fiber Light yield Optical transmission performance Muon tagging efficiency JUNO-TAO

Wave-induced flow and its influence on ridge erosion and channel deposition in Lanshayang channel of radial sand ridges

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Journal of Hydrodynamics 2014年第6期26卷 882-893页

作者：徐卓张玮陆培东安翔陈可峰 College of Harbor Coastal and Off-shore Engineering Hohai University Nanjing Hydraulic Research Institute China Communication Planning and Design Institute for Water Transportation LTD

Very limited modeling studies were available of the wave-induced current under the complex hydrodynamic conditions in the South Yellow Sea Radial Sand Ridge area（SYSRSR）. Partly it is due to the difficulties in estimating the influence of the waveinduced current in this area. In this study, a coupled 3-D storm-surge-wave model is built. In this model, the time-dependent varying Collins coefficient with the water level method（TCL） are used. The wave-flow environment in the Lanshayang Channel（LSYC） during the ＂Winnie＂ typhoon is successfully represented by this model. According to the modelling results, at a high water level（HWL）, the wave-induced current similar to the long-shore current will emerge in the shallow area of the ridges, and has two different motion trends correlated with the morphological characteristics of the ridges. The wave-induced current velocity could be as strong as 1 m/s, which is at the same magnitude as the tidal current. This result is verified by the bathymetric changes in the LSYC during the ＂Matsa＂ typhoon. Thus, the wave-induced current may be one of the driven force of the ridge erosion and channel deposition in the SYSRSR. These conclusions will help to further study the mechanism of the ridge erosion and channel deposition in the SYSRSR.

关键词： typhoon wave radiation stress wave-induced current South Yellow Sea Radial Sand Ridges ridges erosion and cha-nnel deposition

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面向复杂产品的数字化装配系统体系结构

计算机集成制造系统 2013年第11期19卷 2757-2764页

作者：蔡敏卢佩陶俐言杭州电子科技大学管理学院工业工程与管理研究所浙江杭州310018

为了有效支持复杂产品的数字化装配设计功能,分析了数字化装配系统中产品装配建模、装配序列规划、装配路径规划和装配分析等功能模块;提出了数字化装配系统的功能模型,在产品装配建模模块,为了提高装配过程中的精确度与准确度,考虑了... 详细信息

为了有效支持复杂产品的数字化装配设计功能,分析了数字化装配系统中产品装配建模、装配序列规划、装配路径规划和装配分析等功能模块;提出了数字化装配系统的功能模型,在产品装配建模模块,为了提高装配过程中的精确度与准确度,考虑了装配公差建模,提出含公差建模的数字化产品装配模型;为了降低复杂产品装配成本,缩短了装配时间,提高了装配质量,基于复杂产品装配系统的开发需求,提出了基于面向服务架构的开放式、可重构、可重用、可扩展的集成化数字化装配系统体系结构。

关键词：数字化装配体系结构功能结构图复杂产品装配模型面向服务架构

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用IDL实现基于CT图像的三维表面重建

仪器仪表学报 2006年第Z3期27卷 2293-2294,2312页

作者：陈宁卢佩石东天津科技大学电子信息与自动化学院天津300222

利用计算机断层(CT)图像进行人体组织三维重建,在医学、人体科学等领域拥有非常广阔的应用前景。IDL是近年来被广泛应用于医学图像处理的交互式数据语言。本文结合一组CT图像,介绍了一种用IDL语言实现CT图像形态学边缘检测、轮廓提取和... 详细信息

利用计算机断层(CT)图像进行人体组织三维重建,在医学、人体科学等领域拥有非常广阔的应用前景。IDL是近年来被广泛应用于医学图像处理的交互式数据语言。本文结合一组CT图像,介绍了一种用IDL语言实现CT图像形态学边缘检测、轮廓提取和三维表面重建的方法。并采用IDL中事件驱动的程序结构,设计了三维可视化程序。

关键词：计算机断层(CT) 交互式数据语言表面重建形态学

Comparison of the personality and other psychological factors of students with internet addiction who do and do not have associated social dysfunction

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上海精神医学 2015年第1期27卷 36-41页

作者： Qiang CHEN Xing QUAN Huimin lu pei FEI Ming LI GuangjiPsychiatricHospital

BACKGROUND:There is ongoing controversy about whether or not internet addiction should be considered a non-substance behavioral addiction (like gambling disorder) and, if so, what diagnostic criteria should be used to define the condition. Current criteria for internet addiction give equal diagnostic weight to the physiological symptoms and the social consequences of internet addiction.;OBJECTIVE:Assess the psychological correlates of social dysfunction among individuals with internet addiction.;METHODS:A total of 133 students who sought treatment at the Guangji Psychiatric Hospital from July 2011 to December 2013 for psychological problems related to excessive internet use and who currently met Young criteria for internet addiction were identified; 31 of the 38 students who meet rigorous criteria for concurrent internet-related social dysfunction and a random sample of 44 of the 95 students without concurrent social dysfunction completed a battery of psychosocial measures: seven supplementary scales of the Minnesota Multiphasic Personality Inventory (MMPI), the Egna Minnen av Barndoms Uppfostran perceived parenting scale, the Perceived Social Support Scale, the Trait Coping Style Questionnaire, and the Symptom Checklist 90.;RESULTS:Compared to persons with internet addiction without accompanying social dysfunction, those with social dysfunction had higher levels of interpersonal sensitivity, hostility, and paranoia; lower levels of social responsibility, anxiety, self-control, and family social support; and they were more likely to employ negative coping strategies. There were however, no differences in perceived parenting styles between the two groups.;CONCluSIONS:A relatively small proportion of individuals who meet the physiological markers of internet addiction simultaneously report significant internet-related social dysfunction. There are several psychosocial measures that distinguish persons with internet addiction who do or do not have concurrent social dys

关键词：社会责任网络成瘾功能障碍心理因素学生症状自评量表个性关联

Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography

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Chinese Journal of Chemistry 1991年第3期9卷 231-236页

作者： ZOU,Han-Fa ZHANG,Yu-Kui lu,pei-Chang Dalian Chromatographic R & D Center of China Dalian Institute of Chemical Physics,Academia Sinica,Dalian 116011 Dalian Chromatographic R & D Center of China Dalian Institute of Chemical Physics Academia Sinica Dalian 116011

In this paper,the concept of reversed-or normal-phase chiral stationary phase liquid chromatography has been put forward according to the polar strength of mobile and stationary phases. The statistical model developed in HPLC has been used to investigate the separation mechanism of D-and L-enantiomer in chiral stationary phase liquid *** has been observed that the variation of capacity factor of enantiomers with mobile phase composition in both reversed-phase and normal-phase chiral stationary phase liquid chromatography can be described by the fundamental elution equation lnk'=a+blnC_b+cC_*** effect of mobile phase composition on the selec- tivity of enantiomers D and L in normal-phase chiral stationary phase liquid chromatography cam be described by the equation lnα=⊿a+⊿blnC_b,but in reversed-phase chiral stationary phase liquid chromatography the selectivity is almost independant of the mobile phase composition.

关键词： Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography

Trichosanthin inhibits T cell activation by interfering with the recruitment of ZAP-70 to CD3 ζchain

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Cell Research 1998年第1期8卷 33-39页

作者： HONG JIAN SAI LI FU ZHONG YI SHEN pei HUA lu KUANG YEN CHOU (Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai China) Shanghai Institute of Immunology Shanghai Second Medical University Shanghai China

Plant protein Trichosanthin (Tk) has been shown in our previous experiments to suppress antigenic response of T cells. Here we explored its inhibitory mechanisms on the proliferation of human Jurkat leukemia T cell triggered by anti-CD3 McAb. By examination of tyrosine phosphorylation of cell lysate, we were able to show that Tk could interfere with the PTK-related activity in the TCR/CD3initiated signal transduction in addition to blocking the phosphorylation of PKC. As shown in our experiment,the expression intensity of ZAP-70, a kind of protein tyrosine kinase, was not changed but its phosphorylation could be inhibited. When physical link between CD3(chain and ZAP-70 was further examined by using coimmunoprecipitation after pluse-treatment of the cell line with Tk, the anti-CD3 McAb-induced recruitment of ZAP70 to CD3 ζ chain was observed to be blocked in some extent. This may account for, at least in part, how Trichosanthin was able to inhibit the TCR-triggered T cell proliferation.

关键词： Trichosanthin TCR signaling PTK tyrosine phosphorylation

Orientation dependence in high harmonics of ZnO with polarization corrections to counteract the birefringent effect

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Chinese Physics B 2021年第7期30卷 269-273页

作者： Yin-Fu Zhang Teng-Fei Huang Jia-Peng Li Ke Yang Liang Li Xiao-Song Zhu Peng-Fei Lan pei-Xiang lu School of Physics and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205China CAS Center for Excellence in Ultraintense Laser Science Shanghai 201800China

We investigate the influence of the birefringence on the high-order harmonics in an a-cut Zn O crystal with midinfrared laser *** high harmonics exhibit strong dependence on the alignment of the crystal with respect to the laser *** introduce the Jones calculus to counteract the birefringent effect and obtain the harmonics with polarization corrections in Zn *** show that the birefringent effect plays an important role in the orientation dependence of HHG.

关键词： high-order harmonics birefringent effect Jones calculus