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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.Blackwell peggy M.Cawthon Paul M.Coen Steven R.Cummings giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.goodpaster Stephen B.Kritchevsky Theresa Mau Frederico g.S.Toledo Anne B.Newman Nancy W.glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn Actigraph gT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of Actigraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(pght activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in Actigraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.

关键词： Aging Exercise Mitochondria

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The Level of Expression of Thioredoxin is Linked to Fundamental Properties and Applications of Wheat Seeds

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Molecular Plant 2009年第3期2卷 430-441页

作者： Yong-Chun Li Jiang-Ping Ren Myeong-Je Cho Su-Mei Zhou Yong-Bum Kim Hong-Xiang guo Joshua H. Wong Hong-Bin Niu Hyun-Kyung Kim Susumu Morigasaki peggy g. Lemaux Oscar L. Frick Jun Yin Bob B. Buchanan National Engineering Research Centre for Wheat Henan Agricultural University Zhengzhou 450002 China Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720 USA Department of Pediatrics School of Medicine University of California San Francisco CA 94143 USA

Work with cereals （barley and wheat） and a legume （Medicago truncatula） has established thioredoxin h （Trx h） as a central regulatory protein of seeds. Trx h acts by reducing disulfide （S-S） groups of diverse seed proteins （storage proteins, enzymes, and enzyme inhibitors）, thereby facilitating germination. Early in vitro protein studies were complemented with experiments in which barley seeds with Trx h overexpressed in the endosperm showed accelerated germination and early or enhanced expression of associated enzymes （α-amylase and pullulanase）. The current study extends the transgenic work to wheat. Two approaches were followed to alter the expression of Trx h genes in the endosperm：（1） a hordein promoter and its protein body targeting sequence led to overexpression of Trx hS, and （2） an antisense construct of Trx h9 resulted in cytosolic underexpression of that gene （Arabidopsis designation）. Underexpression of Trx h9 led to effects opposite to those observed for overexpression Trx h5 in barley--retardation of germination and delayed or reduced expression of associated enzymes. Similar enzyme changes were observed in developing seeds. The wheat lines with underexpressed Trx showed delayed preharvest sprouting when grown in the greenhouse or field without a decrease in final yield. Wheat with overexpressed Trx h5 showed changes commensurate with earlier in vitro work： increased solubility of disulfide proteins and lower aUergenicity of the gliadin fraction. The results are further evidence that the level of Trx h in cereal endosperm determines fundamental properties as well as potential applications of the seed.

关键词： metabolic regulation molecular physiology seed biology preharvest sprouting seed germination thioredoxin h wheat allergenicity.

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Efficacy and tolerability of chitin-glucan combined with simethicone(gASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec Pauline Le Roy peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean Michel godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage Pauline Bayart Michael genin Christel Rousseaux Veronique Maquet Salvatore Modica Pierre Desreumaux Caroline Valibouze Department of gastroenterology Hôpital privéLe BoisLille 59000France Department of gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKgROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week gASTRAP^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of gASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,Pg[8.0±1.7 vs 4.7±2.9,Pglobal symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

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冠状动脉性心脏病患者收缩压和舒张压变化与心肌梗死及脑卒中的关系

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中华高血压杂志 2014年第11期22卷 1056-1056页

作者：赵狄练桂丽 Paolo V gianpaolo R Fabio A Bruno T giuseppe M Janice P peggy g Peter S Koon T Salim Y

冠状动脉性心脏病（冠心病）患者过高及过低的血压均可能与不良的预后有关,即J形曲线现象。血压较基线的变化与其脑卒中和心肌梗死风险的关系仍不清楚。在替米沙坦单用及与雷米普利联用全球终点试验的25 620例随机患者中,入选19 102例... 详细信息

冠状动脉性心脏病（冠心病）患者过高及过低的血压均可能与不良的预后有关,即J形曲线现象。血压较基线的变化与其脑卒中和心肌梗死风险的关系仍不清楚。在替米沙坦单用及与雷米普利联用全球终点试验的25 620例随机患者中,入选19 102例冠心病患者进行该研究。入选时血压为141/82 mm Hg（1mm Hg=0.133 kPa）,随访期间血压平均降低7/6mm Hg。在校正一些潜在影响因素后,血压较基线降低34/21mm Hg与脑卒中风险降低有关,

关键词：冠状动脉性心脏病心脏病患者心肌梗死脑卒中舒张压变化收缩压冠心病患者血压平

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Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

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Natural Products and Bioprospecting 2016年第1期6卷 31-39页

作者： Qingxi Su peggy J.Brodie Yixi Liu James S.Miller Naina M.Andrianjafy Rabodo Antsiferana Vincent E.Rasamison David g.I.Kingston Department of Chemistry Virginia Tech Center for Drug DiscoveryM/C 0212Virginia TechBlacksburg VA24061USA Missouri Botanical garden P.O.Box 299St.LouisMO 63166-0299USA Missouri Botanical garden B.P 3391101 AntananarivoMadagascar Centre National d’Application des Recherches Pharmaceutiques B.P 702101 AntananarivoMadagascar

Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill.(Cardiopteridaceae)led to the isolation of ethyl esters of three new triterpenoid saponins(1–3)and the known sesquiterpenoid cinnamosmolide(4).The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass *** 1,2,and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8,10.2 and 2.0 lM,respectively.

关键词： Antiproliferative activity Triterpenoid saponins Leptaulus citroides(Cardiopteridacea)

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The relevance of serum albumin among elderly patients with acute decompensated heart failure

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Journal of geriatric Cardiology 2019年第7期16卷 522-528页

作者： Tuoyo O Mene-Afejuku Ela-Anamaria Moisa Adedoyin Akinlonu Carissa Dumancas Shushan Veranyan Jose A Perez peggy Salazar Shobhana Chaudhari gerald Pekler Savi Mushiyev Ferdinand Visco Department of Medicine New York Medical College Metropolitan Hospital Center

Objective To assess the prognostic utility of serum albumin among elderly patients admitted for acute decompensated heart failure(ADHF)in terms of all-cause mortality and also to identify the predictors of *** Retrospective cohort study of 119 elderly patients admitted for *** patients were defined as patients over the age of 65 *** patients were followed up for approximately 11 *** with advanced renal failure,liver disease not due to HF,cancer and other causes of low life expectancy were *** was defined as serum albumin≤2.9 g/*** The study was made up of 65 females and 54 males with age ranging from 65 to 96 *** the 119 elderly patients with ADHF,there were 26 deaths.A significantly higher proportion of patients in the mortality group had an admission serum albumin level of≤2.9 g/dL than those surviving(P=0.011).After Cox’s logistic regression,low albumin(P=0.016),elevated direct bilirubin(P=0.03),age greater than 85(P=0.008),lack of use of beta blockers(P=0.0001)and left ventricular ejection fraction less than 35%(P=0.005)increased the risk of *** serum creatinine(P=0.0357)was the only predictor of hypoalbuminemia following multiple linear *** Hypoalbuminemia may be an unrecognized marker of death in elderly patients with ADHF.

关键词： Albumin Heart Failure Mortality The elderly

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Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis(Baker)***

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Natural Products and Bioprospecting 2016年第5期6卷 261-265页

作者： Vincent E.Rasamison peggy J.Brodie Emilio F.Merino Maria B.Cassera Michel A.Ratsimbason Stephan Rakotonandrasana Andriamalala Rakotondrafara Elie Rafidinarivo David g.I.Kingston Harinantenaina L.Rakotondraibe Centre National d’Application de Recherches Pharmaceutiques B.P.702101 AntananarivoMadagascar Department of Chemistry and the Virginia Tech Center for Drug Discovery M/C 0212Virginia TechBlacksburgVA 24061USA Department of Biochemistry and the Virginia Tech Center for Drug Discovery M/C 0308Virginia TechBlacksburgVA 24061USA Institut Superieur de Technologie B.P.8122101 AntananarivoMadagascar Division of Medicinal Chemistry and Pharmacognosy College of PharmacyThe Ohio State UniversityColumbusOH 43210USA

Melicope madagascariensis(Rutaceae)is an endemic plant species of Madagascar that was first classified as a member of the genus Euodia J.R.&***(Rutaceae)under the scientific name Euodia madagascariensis *** on morphological characteristics,Thomas gordon Hartley taxonomically revised *** Baker to be ***(Baker)*** studies have long been used to help the identification and confirmation of taxonomical classification of plant species and *** to find more evidences to support the taxonomical revision performed on ***,we carried out phytochemical investigation of two samples of the *** of the ethanol extracts prepared from two stem bark samples of ***(Baker)*** led to the isolation of seven known furoquinoline alkaloids 1–7 and two known methoxyflavones 8 and *** presence of furoquinoline alkaloids and methoxyflavones in the title species is in agreement with its taxonomic transfer from Euodia to *** evaluation of the isolated compounds showed that 6-methoxy-7-hydroxydictamnine(heliparvifoline,3)showed weak antimalarial activity(IC_(50)=35μM)against the chloroquine-resistant strain Dd2 of Plasmodium ***(4)displayed moderate cytotoxicity with IC_(50)value of 1.5 lM against HT-29 colon cancer cell line whereas 3,5-dihydroxy-30,40,7-trimethoxyflavone(9)was weakly active in the same assay(IC_(50)=13.9μM).

关键词： Chemotaxonomy Furoquinoline alkaloids Methoxyflavones Antimalarial activity Cytotoxicity Melicope madagascariensis(Rutaceae)

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genome-wide SNP genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut

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Molecular Plant 2017年第2期10卷 309-322页

作者： Josh Clevenger Ye Chu Carolina Chavarro gaurav Agarwal David J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin Vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas g. Isleib C. Corley Holbrook Scott A. Jackson Rajeev K. Varshney peggy Ozias-Akins Department of Horticulture and Institute of Plant Breeding Genetics & Genomics The University of Georgia 2356 Rainwater Road Tifton GA 31793 USA Center for Applied genetic Technologies and Institute of Plant Breeding Genetics & Genomics The University of Georgia Athens GA 30602 USA International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Hyderabad 502324 India University of Brasilia Institute of Biological Sciences Campus Darcy Ribeiro 70910-900 Brasilia DF Brazil Embrapa genetic Resources and Biotechnology 70770-917 Brasflia DF Brazil eUSDA-ARS PGRCU Griffin GA 30223 USA Agricultural Research Organization Plant Sciences Institute 7528809 Rishon LeZion Israel Department of Plant and Soil Science Texas Tech University Lubbock TX 79409-2122 USA Department of Crop and Soil Sciences North Carolina State University Box 7629 Raleigh NC 28695-7629 USA USDA-ARS Tifton GA 31793. USA

Peanut （Arachis hypogaea; 2n = 4x = 40） is a nutritious food and a good source of vitamins, minerals, and healthy fats. Expansion of genetic and genomic resources for genetic enhancement of cultivated peanut has gained momentum from the sequenced genomes of the diploid ancestors of cultivated peanut. To facil- itate high-throughput genotyping of Arachis species, 20 genotypes were re-sequenced and genome-wide single nucleotide poiymorphisms （SNPs） were selected to develop a large-scale SNP genotyping array. For flexibility in genotyping applications, SNPs polymorphic between tetraploid and diploid species were included for use in cultivated and interspecific populations. A set of 384 accessions was used to test the array resulting in 54 564 markers that produced high-quality polymorphic clusters between diploid species, 47 116 polymorphic markers between cultivated and interspecific hybrids, and 15 897 polymorphic markers within A. hypogaea germplasm. An additional 1193 markers were identified that illuminated genomic re- gions exhibiting tetrasomic recombination. Furthermore, a set of elite cultivars that make up the pedigree of US runner germplasm were genotyped and used to identify genomic regions that have undergone pos- itive selection. These observations provide key insights on the inclusion of new genetic diversity in culti- vated peanut and will inform the development of high-resolution mapping populations. Due to its efficiency, scope, and flexibility, the newly developed SNP array will be very useful for further genetic and breeding applications in Arachis.

关键词： single nucleotide polymorphism groundnut Arachis hypogaea

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儿童围术期晶体和胶体液的管理：我们从哪里来又如何到这里？

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麻醉与镇痛 2011年第6期7卷 1-15页

作者： Ann g. Bailey, MD peggy P. McNaull, MD Edmund Jooste, MBCHB, DA Jay B. Tuchman, MD Departments of Anesthesiology Children＇s Hospital of Pittsburgh of UPMC Pittsburgh Pennsylvania Departments of Pediatrics University of North CarolinaChapel Hill North CarolinaChildren＇s Hospital of Pittsburgh of UPMC Pittsburgh Pennsylvania Departments ofDepartment of Anesthesiology Children＇s Hospital of Pittsburgh of UPMC Pittsburgh Pennsylvania

自从Holliday和Segar在50多年前发表了一篇关于住院儿童补液的成分与比例的标志性文章（Pediarics1957；19：823—32）以来，临床大部分围术期的补液治疗都以此为参考。但是现今对于儿科手术患者来说，糖、电解质以及血管内扩容的需要... 详细信息

自从Holliday和Segar在50多年前发表了一篇关于住院儿童补液的成分与比例的标志性文章（Pediarics1957；19：823—32）以来，临床大部分围术期的补液治疗都以此为参考。但是现今对于儿科手术患者来说，糖、电解质以及血管内扩容的需要量都与原先的描述大不一样了。因此，使用传统的Holliday和Segar推荐的低张补液可能会导致一些并发症，如术后患者出现高血糖和低钠血症。对于术后补液选择等张还是低张液体有着很大的争议。我们讨论了儿童围术期补液治疗的由来，对目前围术期患儿晶体治疗以及胶体应用的最新观念予以综述。

关键词：住院儿童围术期胶体液晶体补液治疗管理术后患者儿科手术

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上海26万妇女乳房自我检查随机试验

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中华肿瘤杂志 2005年第6期27卷 350-354页

作者：高道利 David BThomas Roberta M Ray 王文婉 Charlene J Allison 陈范良 peggy Porter 胡永伟赵关林潘雷达李雯瑾武春园 Zakia Coriaty Ilonka Evans 林明纲 Helge Stalsberg Steven gself 复旦大学中山医院分部肿瘤流行病学研究室上海200052

目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30～64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后... 详细信息

目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30～64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后的4年中,使用BSE录像带进行二次强化教育,并定期进行BSE指导和在医务人员监察下进行BSE操作。本研究进行5年,全部活动均被记录。队列人群随访到2000年7月,乳腺癌患者的生存状况随访到2001年12月。统计分析采用Kaplan-Meier方法、Logrank检验以及Cox模型。结果指导组检出乳腺癌864例,其中死于乳腺癌133例;对照组检出乳腺癌896例,其中死于乳腺癌130例。两组乳腺癌病例的肿块大小、TNM分期和累积死亡率的差异均无统计学意义(P均>0.05)。但是指导组比对照组有较多和较小的纤维腺瘤被检出(P<0.01)。结论对人群开展BSE教育和指导,未能降低人群的乳腺癌死亡率;接受BSE教育的妇女比没有接受教育的妇女可检出较多的和较小的良性乳房肿块。

关键词：上海妇女乳房自我检查随机试验乳腺癌流行病学

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