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Effects of a Plantago ovata-based herbal compound in prevention and treatment of oral mucositis in patients with breast cancer receiving chemotherapy: A double-blind, randomized, controlled crossover trial

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Journal of Integrative Medicine 2020年第3期18卷 214-221页

作者： Fatemeh Sadat Hasheminasab Seyed Mehdi Hashemi Azizallah Dehghan Fariba Sharififar Mohammad Setayesh pegah sasanpour Mojtaba Tasbandi Mahboobeh Raeiszadeh Herbal and Traditional Medicines Research Center Kerman University of Medical SciencesKerman ***Iran Department of Traditional Medicine School of Traditional MedicineKerman University of Medical SciencesKerman ***Iran Clinical Immunology Research Center Ali-ebne Abitaleb HospitalZahedan University of Medical SciencesZahedan ***Iran Noncommunicable Diseases Research Center Fasa University of Medical SciencesFasa ***Iran Medical School Zahedan University of Medical SciencesZahedan ***Iran Department of Traditional Pharmacy School of Traditional MedicineKerman University of Medical SciencesKerman ***Iran

Background: Oral mucositis(OM) is one of the most common complications of mucotoxic cancer therapy.Mucositis induces clinically significant pain, increases the risk of infections and affects the patients’ quality of life.Objective: This study investigated the effects of an herbal preparation from Plantago ovata hydrocolloid in the prevention and treatment of OM, in breast cancer patients undergoing chemotherapy with a regimen including adriamycin.Design, setting, participants, and interventions: This research was a double-blind, randomized, controlled crossover trial. The herbal compound consisted of a mixture of 500 mg of P. ovate husk in 30 m L water plus three drops of vinegar per dose, which was used as a mouthwash. Phytochemical and physicochemical tests of the compound were also performed. Twenty-eight patients who developed mucositis during the chemotherapy screening cycle were randomized to the herbal compound(n = 14) and placebo(n = 14) groups. They received herbal compound or placebo three times per day during their next chemotherapy cycle(cycle 1 of treatment). Patients were crossed over during cycle 2 of treatment and received the alternative therapy. An oral care protocol was prescribed to all patients in cycles 1 and 2 of the treatment.Main outcome measures: The patients were visited at baseline, the end of the first and second weeks of the screening cycle, and the end of the first and second weeks of each of two treatment cycles. The degree of mucositis was used as the main treatment outcome. Other indexes, such as the severity of pain, xerostomia grade and the quality of life were also measured.Results: Compared with the placebo, the herbal compound significantly reduced the degree of mucositis,the severity of pain and the xerostomia grade;it also improved the patients’ quality of life(P < 0.05).Comparison between the screening cycle and placebo treatment group showed that the oral care protocol had a significant effect in the reduction of OM(P < 0.05).Conclusion: The oral care protocol and the he

关键词： Persian medicine Oral mucositis Plantago ovate Breast cancer Chemotherapy

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