Effects of a Plantago ovata-based herbal compound in prevention and treatment of oral mucositis in patients with breast cancer receiving chemotherapy: A double-blind, randomized, controlled crossover trial

作     者：Fatemeh Sadat Hasheminasab Seyed Mehdi Hashemi Azizallah Dehghan Fariba Sharififar Mohammad Setayesh Pegah Sasanpour Mojtaba Tasbandi Mahboobeh Raeiszadeh Fatemeh Sadat Hasheminasab;Seyed Mehdi Hashemi;Azizallah Dehghan;Fariba Sharififar;Mohammad Setayesh;Pegah Sasanpour;Mojtaba Tasbandi;Mahboobeh Raeiszadeh

作者机构：Herbal and Traditional Medicines Research CenterKerman University of Medical SciencesKerman ***Iran Department of Traditional MedicineSchool of Traditional MedicineKerman University of Medical SciencesKerman ***Iran Clinical Immunology Research CenterAli-ebne Abitaleb HospitalZahedan University of Medical SciencesZahedan ***Iran Noncommunicable Diseases Research CenterFasa University of Medical SciencesFasa ***Iran Medical SchoolZahedan University of Medical SciencesZahedan ***Iran Department of Traditional PharmacySchool of Traditional MedicineKerman University of Medical SciencesKerman ***Iran 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2020年第18卷第3期

页      面：214-221页

核心收录：

学科分类：1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：a part of a Ph.D.thesis(NO.97000143),conducted by Fatemeh Sadat Hasheminasab supported by Kerman University of Medical Sciences,Kerman,Iran 

主　　题：Persian medicine Oral mucositis Plantago ovate Breast cancer Chemotherapy 

摘      要：Background: Oral mucositis(OM) is one of the most common complications of mucotoxic cancer *** induces clinically significant pain, increases the risk of infections and affects the patients’ quality of ***: This study investigated the effects of an herbal preparation from Plantago ovata hydrocolloid in the prevention and treatment of OM, in breast cancer patients undergoing chemotherapy with a regimen including ***, setting, participants, and interventions: This research was a double-blind, randomized, controlled crossover trial. The herbal compound consisted of a mixture of 500 mg of P. ovate husk in 30 m L water plus three drops of vinegar per dose, which was used as a mouthwash. Phytochemical and physicochemical tests of the compound were also performed. Twenty-eight patients who developed mucositis during the chemotherapy screening cycle were randomized to the herbal compound(n = 14) and placebo(n = 14) groups. They received herbal compound or placebo three times per day during their next chemotherapy cycle(cycle 1 of treatment). Patients were crossed over during cycle 2 of treatment and received the alternative therapy. An oral care protocol was prescribed to all patients in cycles 1 and 2 of the *** outcome measures: The patients were visited at baseline, the end of the first and second weeks of the screening cycle, and the end of the first and second weeks of each of two treatment cycles. The degree of mucositis was used as the main treatment outcome. Other indexes, such as the severity of pain, xerostomia grade and the quality of life were also ***: Compared with the placebo, the herbal compound significantly reduced the degree of mucositis,the severity of pain and the xerostomia grade;it also improved the patients’ quality of life(P 0.05).Comparison between the screening cycle and placebo treatment group showed that the oral care protocol had a significant effect in the reduction of OM(P 0.0