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Immunotherapy in biliary tract cancers:Current evidence and future perspectives

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1446-1455页

作者： pedro Luiz Serrano Uson Junior Raphael LC Araujo Center for Personalized Medicine Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Universidade Federal de São PauloSão Paulo 04039-002Brazil Department of Oncology Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil

Bile duct tumors are comprised of tumors that originate from both intrahepatic and extrahepatic bile ducts and gallbladder *** are aggressive tumors and chemotherapy is still the main treatment for advanced-stage disease and most of these cases have a poor overall *** are aimed at treatments with better outcomes and less toxicity which makes immunotherapy an area of significant *** Food and Drug Administration approvals of immune checkpoint inhibitors(ICI)for agnostic tumors based on biomarkers such as microsatellite instability-high and tumor mutation burden-high are important steps in the treatment of patients with advanced bile duct *** limited responses with isolated checkpoint inhibitors in later lines of systemic treatment in advanced disease,drug combination strategies have been demonstrating encouraging results to enhance ICI efficacy.

关键词： Biliary tract cancer Cholangiocarcinoma Anti-programmed cell death protein-1 Anti-programmed death ligand-1 Microsatellite instability high Tumor mutational burden high

Multi-Objective Particle Swarm Optimization(MOPSO) for a Distributed Energy System Integrated with Energy Storage

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Journal of Thermal Science 2019年第6期28卷 1221-1235页

作者： ZHANG Jian CHO Heejin MAGO pedro J. ZHANG Hongguang YANG Fubin Mechanical Engineering Department Mississippi State UniversityMississippi StateMS39762USA College of Environmental and Energy Engineering Beijing University of TechnologyBeijing 100124China

Distributed energy systems are considered as a promising technology for sustainable development and have become a popular research topic in the areas of building energy systems. This work presents a case study of optimizing an integrated distributed energy system consisting of combined heat and power(CHP), photovoltaics(PV), and electric and/or thermal energy storage for a hospital and large hotel buildings located in Texas and California. First, simulation models for all subsystems, which are developed individually, are integrated together according to a control strategy designed to satisfy both the electric and thermal energy requirements of a building. Subsequently, a multi-objective particle swarm optimization(MOPSO) is employed to obtain an optimal design of each subsystem. The objectives of the optimization are to minimize the simple payback period(PBP) and maximize the reduction of carbon dioxide emissions(RCDE). Finally, the energy performance for the selected building types and locations are analyzed after the optimization. Results indicate that the proposed optimization method could be applied to determine an optimal design of distributed energy systems, which reaches a trade-off between the economic and environmental performance for different buildings. With the presented distributed energy system, a peak shaving in electricity of about 300 kW and a reduction in boiler fuel consumption of 610 kW could be attained for the hospital building located in California for a winter day. For the summer and transition seasons, electricity peak shaving of 800 kW and 600 kW could be achieved, respectively.

关键词： multi-objective particle swarm optimization distributed energy system payback period carbon dioxide emission

Emerging patterns in the construction of Sejima’s,Sanaa’s and Nishizawa’s domestic spaces,from 1987 to 2010

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Frontiers of Architectural Research 2022年第3期11卷 375-401页

作者： pedro Garcia Martinez Francisco Javier Maroto Ramos Universidad Politecnica de Cartagena Escuela Tecnica Superior de Arquitectura y Tecnologfa de EdificationCartagena30201Spain Universidad Politecnica de Madrid Escuela Tecnica Superior de Arquitectura de MadridMadrid28040Spain

Sejima and Nishizawa have developed their work without explicitly referencing a theoretical ***,they have stated that their housing projects describe their"architectural biography."This study presents the hypothesis that systermic theories had infu-enced their housing projects at a spatial and constructive *** the aim of testing it,the research produces four lines of ***,we observe that the word system is prominently current in a signifcant sample of their published *** describe how architects like Tomi-naga,Ito,Taki,and Shinohara,who infuenced Sejima when she was still a student,discussed this concept inspired by Christopher Alexander's *** second line brings together all the couple's single-family housing projects published between 1987 and 2010 for the first time in a single document,as well as an original graphic-constructive reconstruction of the most outstanding ***,we unveil the emergence of four constructive patterns by applying these theories to the graphic material ***,we summarize the results in dia-grams,showing the frequency,intensity,and continuity of the identified patterns in the four phases throughout the studied *** the hypothesis facilitates further research relate their domestic work and their other types of projects.

关键词： Architecture House Pattern Sejima Nishizawa SANAA

Topological Minors in Bipartite Graphs

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Acta Mathematica Sinica,English Series 2011年第11期27卷 2085-2100页

作者： Camino BALBUENA Martin CERA pedro GARCIA-VAZQUEZ Juan Carlos VALENZUELA Departament de Matematica Aplicada III Universitat Politecnica de Catalunya C/ Jordi Girona 1-3 （ Edifici C2 Despatx 302） 08034 Barcelona Spain Departamento de Matemdtica Aplicada I Universidad de SeviUa EUIT Agrlcola Ctra. Utrera Kin. 1 41013 Sevilla Spain Departamento de Matemdtica Aplicada I Universidad de Sevilla ETS Arquitectura Avda. Reina Mercedes 2 41012 Sevilla Spain Departamento de Matemdticas Universidad de Cddiz EPS Algeciras Avda. Ramdn Puyol s/n 11202 Algeciras Spain

For a bipartite graph G on m and n vertices, respectively, in its vertices classes, and for integers s andt such that 2≤ s ≤ t, 0≤ m-s ≤ n-t, andre＋n≤ 2s＋t-1, we prove that if G has at least mn- （2（m - s）＋ n - t） edges then it contains a subdivision of the complete bipartite K（s,t） with s vertices in the m-class and t vertices in the n-class. Furthermore, we characterize the corresponding extremal bipartite graphs with mn- （2（m - s）＋ n - t ＋ 1） edges for this topological Turan type problem.

关键词： Bipartite graphs extremal graph theory topological minor

Epistatic interactions between pterin and carotenoid genes modulate intra-morph color variation in a lizard

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Integrative Zoology 2022年第1期17卷 44-53页

作者： Prem AGUILAR pedro ANDRADE Guillem PÉREZ I DE LANUZA CIBIO/InBIO Centro de Investigação em Biodiversidade e Recursos Genéticos da Universidade do PortoPortoPortugal Ethology Lab Institut Cavanilles de Biodiversitat i Biologia EvolutivaUniversitat de ValènciaValènciaSpain

Color polymorphisms have become a major topic in evolutionary biology and substantial efforts have been devoted to the understanding of the mechanisms responsible for originating such colorful ***-morph continuous variation,on the other hand,has been neglected in most of the ***,we combine spectrophotometric/visual modeling and genetic data to study the mechanisms promoting continuous variation within categorical color morphs of Podarcis *** results suggest that intra-morph variability in the pterin-based orange morph is greater compared to white and yellow *** also show that continuous variation within the orange morph is partially discriminable by *** results indicate that allelic variants at the BCO2 locus(responsible for deposition of yellow carotenoids)contribute to generate continuous variation in orange ***,other intrinsic and/or extrinsic mechanisms,such as body size,might be involved,opening a new avenue for future research on the drivers of continuous variation within-morphs.

关键词： BCO2 color polymorphism continuous variation lizard Podarcis muralis

Potential role of noise to improve intracortical microstimulation in tactile neuroprostheses

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Neural Regeneration Research 2021年第8期16卷 1533-1534页

作者： pedro Mabil Nayeli Huidobro Amira Flores Elias Manjarrez Laboratory of Integrative Neurophysiology Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaCPMéxico

The intracortical microstimulation(ICMS) from 40 to 100 μA is useful to elicit tactile sensations,which could be employed in neuroprostheses to control the robotic arms' ***,this electrical current applied for prolonged periods of time could damage the neuronal ***,there is a necessity to create new strategies for the practical use of ICMS in a safe intensity range for potential clinical applications in tetraplegic *** we describe crucial studies supporting the use of electrical and optical noise to guarantee a safe ICMS delivered through brain-machine interface technologies.

关键词： guarantee supporting sensation

New Dinosaur Tracks from the Lower Barremian of Portugal (Areia do Mastro Formation, Cape Espichel)

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Journal of Geoscience and Environment Protection 2021年第1期9卷 84-96页

作者： Silvério D. Figueiredo Carlos neto de Carvalho pedro P. Cunha Ismar de Sousa Carvalho Instituto Politécnico de Tomar CGeo-UC Unidade Departamental de Arqueologia Conserva&ccedil ã o e Restauro e Património Quinta do Contador-Estrada da Serra Tomar Portugal Serviç o de Geologia do Município de Idanha-a-Nova Geopark Naturtejo Mundial da UNESCO Avenida Joaquim Mor&atilde o Idanha-a-Nova IDL Instituto Dom Luiz Faculdade de Ciências da Universidade de Lisboa Campo Grande Lisboa Universidade de Coimbra MARE Dep. Ciências da Terra R. Sílvio Lima Coimbra Portugal Universidade Federal do Rio de Janeiro Instituto de Geociências CCMN Cidade Universitária Ilha do Fund&atilde o Rio de Janeiro Brasil

We present a new tracksite with multiple dinosaur tracks from the lowermost Barremian (Lower Cretaceous) of the Cape Espichel (Sesimbra, Portugal). The tracks are localized on three beds on the top carbonate beds of the Areia do Mastro Formation. Those bioclastic, nodular limestones were deposited in a very shallow subtidal-intertidal, restricted lagoon environment. The track surfaces are very dinoturbated, with a substantial number of tracks. Several tracks assign to sauropods, ornithopods and theropods dinosaurs were recorded. Due to heavy bioturbation and the preservation conditions, it is not possible to define trackways;some preliminary work done on the tracks could disclose some behaviours of their producers. Several species of carnivore and herbivore dinosaurs crossed that large area at different times. Herbivores may have used the lagoon margin as passage between feeding spots, while carnivores frequented the area to hunt in groups or individually.

关键词： Trampled Surface Dinosaurs Locomotion Behavior Lower Cretaceous Cape Espichel Portugal Iberia

PIEZO1 channels in cutaneous free nerve endings:novel insights into itch-scratch-mechanisms

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Signal Transduction and Targeted Therapy 2023年第2期8卷 319-320页

作者： Manuel pedro Pereira Henning Wiegmann Sonja Ständer Department of Dermatology and Center for Chronic Pruritus University Hospital Münster48149MünsterGermany

A recent study published in Nature by Hill et al.1 identified mechano-sensitive PIEZO1 ion channels in pruriceptive ***,PIEZO1 is involved in acute itch transmission and in mechanical alloknesis in chronic pruritus(CP... 详细信息

关键词： ZO1 insight scratch

Applying chemical engineering concepts to non-thermal plasma reactors

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Plasma Science and Technology 2018年第6期20卷 161-171页

作者： pedro AFFONSO NOBREGA Alain GAUNAND VANDad ROHANI Fran?ois CAUNEAU Laurent FULCHERI MINES ParisTech PSL Research UniversityPERSEE-Centre for ProcessesRenewable Energy and Energy Systems MINES ParisTech PSL Research UniversityCTP-Centre for Thermodynamics of p Processes

Process scale-up remains a considerable challenge for environmental applications of non-thermal *** the impact of reactor hydrodynamics in the performance of the process is a key step to overcome this *** this work,we apply chemical engineering concepts to analyse the impact that different non-thermal plasma reactor configurations and regimes,such as laminar or plug flow,may have on the reactor *** do this in the particular context of the removal of pollutants by non-thermal plasmas,for which a simplified model is *** generalise this model to different reactor configurations and,under certain hypotheses,we show that a reactor in the laminar regime may have a behaviour significantly different from one in the plug flow regime,often assumed in the non-thermal plasma *** the other hand,we show that a packed-bed reactor behaves very similarly to one in the plug flow *** those results,the reader will find in this work a quick introduction to chemical reaction engineering concepts.

关键词： non-thermal plasma chemical engineering dielectric barrier discharge(DBD) corona discharge plug flow reactor volatile organic compounds