检索结果-南通市图书馆

Can epigenetic and inflammatory biomarkers identify clinically aggressive prostate cancer?

World Journal of Clinical Oncology 2020年第2期11卷 43-52页

作者： pedro bargao santos Hitendra Patel Rui Henrique Ana Felix Department of Urology Prof.Doutor Fernando Fonseca HospitalAmadora 2720-276Portugal Department of Urology University Hospital North NorwayTromsø9019Norway Department of Urology St George’s University HospitalsTootingLondon SW170QTUnited Kingdom Departments of Pathology and Cancer Biology and Epigenetics Group-Research Center Portuguese Oncology Institute of PortoPorto 4200-072Portugal Department of Pathology and Molecular Immunology Institute of Biomedical Sciences Abel SalazarUniversity of PortoPorto 4099-002Portugal Department of Pathology Portuguese Oncology Institute of LisbonLisbon 1099-023Portugal Department of Pathology NOVA Medical SchoolLisbon 1169-056Portugal

Prostate cancer(PCa)is a highly prevalent malignancy and constitutes a major cause of cancer-related morbidity and *** emerges through the acquisition of genetic and epigenetic *** modifications include DNA methylation,histone modifications and micro RNA *** generate heritable transformations in the expression of genes but do not change the DNA *** in DNA methylation(hypo and hypermethylation)are the most characterized in *** lead to genomic instability and inadequate gene *** and minor-specific modifications in chromatin recasting are involved in PCa,with signs suggesting a dysfunction of enzymes modified by *** RNA deregulation also contributes to the initiation of PCa,including involvement in androgen receptor signalization and *** influence of inflammation on prostate tumor carcinogenesis is currently much better *** discoveries about microbial species resident in the urinary tract suggest that these are the initiators of chronic inflammation,promoting prostate inflammatory atrophy and eventually leading to *** characterization of the relationship between the urinary microbiome and prostatic chronic inflammation will be crucial to develop plans for the prevention of *** prevalent nature of epigenetic and inflammatory alterations may provide potential biomarkers for PCa diagnosis,treatment decisions,evaluation of prognosis and posttreatment surveillance.

关键词： Prostate cancer Epigenetics DNA methylation Histone modifications Micro RNAs Inflammation Initiation and progression Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring spatial relationships between stream channel features,water depths and flow velocities during flash floods using HEC-GeoRAS and Geographic Information Systems

引用

Journal of Geographical Sciences 2022年第4期32卷 757-782页

作者： Miguel LEAL Eusébio REIS pedro Pinto santos Centre of Geographical Studies and Associated Laboratory TERRA Institute of Geography and Spatial PlanningUniversidade de Lisboa1600-276 LisbonPortugal Forest Research Centre and Associated Laboratory TERRA School of AgricultureUniversidade de LisboaTapada da Ajuda1349-017 LisbonPortugal

Water depths and flow velocities decisively influence the damage caused by flash *** Information System(GIS)is a powerful and useful tool,allowing the spatial analysis of results obtained by hydraulic modelling,namely from the HEC-RAS/HEC-GeoRAS *** GIS spatial analysis performed in this study seeks to explain and quantify the spatial relationships between the stream channel features and flow components during flash flood *** these relationships are generically known,there are few studies exploring this subject in different geographic contexts.A 1D hydraulic model was applied in a small watershed in Portugal,providing good results in the definition of floodable areas,water depths and longitudinal *** direct relationship was found between water depths and velocities in the floodable areas;however,negative strong correlations were found between the two flow components along the stream *** slope,channel and flood width,and roughness prove to be highly relevant on the longitudinal variations of water depths and velocities and on the location of maximum *** peak discharges and return periods(R;)can change the relationships between water depths and velocities at the same *** can be improved with more accurate elevation data for stream channels and floodplains.

关键词： flash floods water depth flow velocity geographic information systems(GIS) spatial analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Seamless and non-repetitive 4D texture variation synthesis and real-time rendering for measured optical material behavior

引用

Computational Visual Media 2019年第2期5卷 161-170页

作者： Martin Ritz Simon Breitfelder pedro santos Arjan Kuijper Dieter W. Fellner Fraunhofer IGD Darmstadt64283Germany TU Darmstadt Darmstadt64289Germany TU Graz Graz8010Austria

We show how to overcome the single weakness of an existing fully automatic system for acquisition of spatially varying optical material behavior of real object surfaces. While the expression of spatially varying material behavior with spherical dependence on incoming light as a 4D texture(an ABTF material model) allows flexible mapping onto arbitrary 3D geometry, with photo-realistic rendering and interaction in real time,this very method of texture-like representation exposes it to common problems of texturing, striking in two disadvantages. Firstly, non-seamless textures create visible artifacts at boundaries. Secondly, even a perfectly seamless texture causes repetition artifacts due to their organised placement in large numbers over a 3D surface. We have solved both problems through our novel texture synthesis method that generates a set of seamless texture variations randomly distributed over the surface at shading time. When compared to regular 2D textures, the inter-dimensional coherence of the 4D ABTF material model poses entirely new challenges to texture synthesis, which includes maintaining the consistency of material behavior throughout the 4D space spanned by the spatial image domain and the angular illumination hemisphere. In addition, we tackle the increased memory consumption caused by the numerous variations through a fitting scheme specifically designed to reconstruct the most prominent effects captured in the material model.

关键词： optical material behavior reflectance modeling 4D texture synthesis texturing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Static-based early-damage detection using symbolic data analysis and unsupervised learning methods

引用

Frontiers of Structural and Civil Engineering 2015年第1期9卷 1-16页

作者： Joao pedro santos Christian CREMONA Andre D. ORCESI Paulo SILVEIRA Luis CALADO Department of Structures Av. Brasil 101 Lisbon 1700-066 Portugal Technical Center for Bridge Engineering CEREMA B.P. 214 Provins Cedex 77487 France Materials and Structures Department IFSTTAR University Paris-Est 14-20 Boulevard Newton Champs sur Marne Marne la Vallee Cedex2 F-77447 France Department of Civil Engineering Technical University Lisbon Avenida Rovisco Pais Lisbon 1096 Portugal

A large amount of researches and studies have been recently performed by applying statistical and machine learning techniques for vibration-based damage detection. However, the global character inherent to the limited number of modal properties issued from operational modal analysis may be not appropriate for early-damage, which has generally a local character. The present paper aims at detecting this type of damage by using static SHM data and by assuming that early-damage produces dead load redistribution. To achieve this objective a data driven strategy is proposed, consisting of the combination of advanced statistical and machine learning methods such as principal component analysis, symbolic data analysis and cluster analysis. From this analysis it was observed that, under the noise levels measured on site, the proposed strategy is able to automatically detect stiffness reduction in stay cables reaching at least 1%.

关键词： structural health monitoring early-damage detection principal component analysis symbolic data symbolic dissimilarity measures cluster analysis numerical model damage simulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Approach to Measuring Spatiotemporal Changes in Social Vulnerability at the Local Level in Portugal

引用

International Journal of Disaster Risk Science 2022年第6期13卷 842-861页

作者： pedro Pinto santos JoséLuís Zêzere Susana Pereira Jorge Rocha Alexandre Oliveira Tavares Centre for Geographical Studies Institute of Geography and Spatial PlanningTERRAUniversity of Lisbon(CEG-IGOT-ULisboa)1600-276 LisboaLAPortugal Centre for Social Studies Earth Science DepartmentScience and Technology FacultyUniversity of Coimbra(CES/DCT-FCT-UCoimbra)3000-995 CoimbraPortugal

Social vulnerability,as one of the risk components,partially explains the magnitude of the impacts observed after a *** this study,a spatiotemporally comparable assessment of social vulnerability and its drivers was conducted in Portugal,at the civil parish level,for three census *** first challenging step consisted of the selection of meaningful and consistent variables over *** were normalized using the Adjusted Mazziotta-Pareto Index(AMPI)to obtain comparable adimensional-normalized values.A joint principal component analysis(PCA)was applied,resulting in a robust set of variables,interpretable from the point of view of their self-grouping around vulnerability drivers.A separate PCA for each census was also conducted,which proved to be useful in analyzing changes in the composition and type of drivers,although only the joint PCA allows the monitoring of spatiotemporal changes in social vulnerability scores and drivers from 1991 to 2011.A general improvement in social vulnerability was observed for *** two main drivers are the economic condition(PC1),and aging and depopulation(PC2).The remaining drivers highlighted are uprooting and internal mobility,and daily *** data proved their value in the territorial,social,and demographic characterization of the country,to support medium-and long-term disaster risk reduction measures.

关键词： AMPI normalization Portugal Social vulnerability Spatiotemporal changes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructural characterization and mechanical behavior analysis of 7075-T6 aluminum subjected to simulated lightning strikes

引用

Chinese Journal of Aeronautics 2021年第12期34卷 39-50页

作者： Luis Henrique santos Weslei Patrick Teodosio SOUSA Sara Silva Ferreira DE DAFE pedro Americo Magalhaes JUNIOR Department of Mechanical Engineering Pontificia Universidade Catolica de Minas GeraisBelo Horizonte 30535-901Brazil

Aircrafts damages caused by lightning strikes have been known since the early days of ***,the physical effects on the aircraft structure are still being *** work seeks to evaluate the lightning strike effects in the aluminum alloy *** were submitted to lightning strike simulation in laboratory and the damages evaluated through characterization *** and profilometry tests have shown material loss to 0.272 mm depth in the damaged *** addition,it was detected the material accumulation occurrence in the damage vicinity of the *** the damage,it was found a region where metallurgical changes were *** tensile and microhardness tests results have shown reduction in the percentage elongation and hardness increasing in the material affected by *** results are corroborated by the X-Ray Diffraction(XRD)and Rietveld Method(red line)that indicated an increasing in dislocation density and micro-deformation in the material *** microscopy results have shown the presence of microcracks on the normal and cross-section surface of the samples *** Energy Dispersive X-Ray Spectroscopy(EDXS)and Electron Backscattered Diffraction Test(EBSD)found coarse intermetallic phases and precipitates compounds with dimensions greater than 1 lm in *** were responsible for nucleation of the microcracks that propagate along the material grain boundaries.

关键词： Aircraft structure Characterization techniques Lightning strikes Precipitates Microcracks

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boosting energy-storage capability in carbon-based supercapacitors using low-temperature water-in-salt electrolytes

引用

Journal of Energy Chemistry 2022年第7期31卷 521-530,I0013页

作者： Joao pedro A.santos Manuel J.Pinzón érick A.santos Rafael Vicentini Cesar J.B.Pagan Leonardo M.Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Department of Semiconductors Instruments and PhotonicsSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Laboratory of Fundamental and Applied Electrochemistry Department of ChemistryFederal University of Jequitinhonha e Mucuri’s ValleyMinas Gerais 39100-000Brazil

Supercapacitors(SCs) are high-power energy storage devices with ultra-fast charge/discharge *** using concentrated aqueous-based electrolytes can work at low temperatures due to their intrinsic properties, such as higher freezing point depression(FPD) and robustness. Besides the traditional organic-and aqueous-based(salt-in-water) electrolytes used in SCs, water-in-salt(WISE) sodium perchlorate electrolytes offer high FPD, non-flammability, and low-toxicity conditions, allowing the fabrication of safer, environmentally friendly, and more robust devices. For the first time, this work reports a comprehensive study regarding WISE system’s charge-storage capabilities and physicochemical properties under low-temperature conditions(T < 0 ℃) using mesoporous carbon-based electrodes. The effect of temperature reduction on the electrolyte viscosity and electrical properties was investigated using different techniques and the in-situ(or operando) Raman spectroscopy under dynamic polarization *** cell voltage, equivalent series resistance, and specific capacitance were investigated as a function of the temperature. The cell voltage(U) increased ~ 50%, while the specific capacitance decreased ~20%when the temperature was reduced from 25 ℃ to -10 ℃. As a result, the maximum specific energy(E = CU^(2)/2) increased ~ 100%. Therefore, low-temperature WISEs are promising candidates to improve the energy-storage characteristics in SCs.

关键词： Carbon supercapacitors Water-in-salt electrolytes Low-temperature charge-storage Specific energy improvement at low temperatures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis

引用

Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 96-101页

作者： Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos pedro González-santos pedro Valdivielso Division of Internal Medicine Hospital Universitario "Virgen de la Victoria" Division of Gastroenterology Hospital Universitario "Virgen de la Victoria" CIMES Department of Medicine & Dermatology University of Malaga Division of Laboratory Hospital Universitario "Virgen de la Victoria"

BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an *** study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe ***:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum *** APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being *** patients’ progression,etiological diagnosis,hospital stay and clinical and radiological severity were all ***:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) *** with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes *** usually consumed alcohol or consumed it excessively on the days before ***,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption.

关键词： acute pancreatitis hypertriglyceridemia apolipoprotein E alcohol biliary lithiasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sustainable living neighbourhoods:Measuring public space quality and walking environment in Lisbon

引用

Geography and Sustainability 2022年第4期3卷 289-298页

作者： Teresa santos Filipa Ramalhete Rui pedro Julião Nuno Pires Soares Interdisciplinary Centre of Social Sciences(CICS.NOVA) Faculty of Social Sciences and Humanities(NOVA FCSH)Universidade NOVA de LisboaAv.de Berna26 CLisboa 1069-061Portugal Studies Centre on Architecture City and Territory(CEACT)Universidade Autónoma de LisboaRua Fernando Assis Pacheco207Lisboa 1350-300Portugal

Obesity and global warming are two major challengesthat affect communities’health and quality of *** good walking environments,with appropriate pedestrian infrastructure,green areas and access to commercial retail and transport hubs favour liveable,healthy,and sustainable *** Lisbon City Hall has implemented an intervention program in the public space as a strategy to improve environmental quality and mitigate the effects of climate *** program“A square in each neighbourhood”intends not only to reinforce the economic base of Lisbon,namely tourism,restaurants,commerce,and creative activities but also to promote physical activity and improve the quality of living of all *** studying the impact of the public space quality on the walking environment,Campolide,a typical Lisbon neighbourhood,Portugal,which includes one of the requalified squares,was selected.A two-step methodology based on spatial modelling is *** the first step,the public space quality was evaluated based on a set of 13 urban quality ***,intended for the street level,were collected from open data platforms and complemented with a field ***,through spatial analysis,these attributes were used to build the Pedestrian Environment Quality Indicator and the Priority Intervention *** these indicators,walking-friendly streets were mapped and the most critical sites that require priority intervention were identified to prepare for the requalification planning *** street with the highest quality in the study area according to the dimensions evaluated-connectivity,convenience,comfort,cleanliness,and conviviality-has a great offer of trees,bus stops,commercial establishments,commercial diversity,crossings,paper bins/eco points and *** the opposite side of the rank,the street with the lowest quality has no trees or green areas,transport stops,benches and tables,or commercial *** urban quality indicators constitu

关键词： Public space Walking environment Spatial modelling Urban quality indicators Geographic Information Systems

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PED Flex with Shield Technology:a feasible alternative for fusiform MCA aneurysms

引用

Stroke & Vascular Neurology 2018年第3期3卷 185-188页

作者： Guilherme J.Agnoletto pedro Aguilar-Salinas Roberta santos Eric Sauvageau Ricardo A.Hanel Lyerly Neurosurgery Baptist Neurological InstituteJacksonvilleFLUSA

BACKGROUND The advent of flow diverters(FDs)has changed the scope of endovascular treatment options for intracranial aneurysms(IAs).FDs can effectively treat complex aneurysms in which both microsurgical and conventional endovascular options are less than ideal.12 The Pipeline Flex Embolization Device(PED;Medtronic,Irvine,California,USA)has been available in the USA for several years demon-strating positive *** recently,the PED Flex with enhanced delivery features has been introduced,and although decreased,thromboembolic complications are still a potential risk.3 In light of this,a new surface modification was applied to the PED Flex known as Shield Technology consisting of a phosphorylcholine layer covalently bound to its metal braids potentially reducing its thrombogenicity.4 Herein,we report our initial experience using the PED Flex with Shield Technology in the treatment of an unruptured fusiform aneurysm located in the middle cerebral artery(MCA)using dual-an-tiplatelet therapy.

关键词： Flex PED MCA treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：