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Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis

Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 96-101页

作者： Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos pedro González-Santos pedro valdivielso Division of Internal Medicine Hospital Universitario "Virgen de la Victoria" Division of Gastroenterology Hospital Universitario "Virgen de la Victoria" CIMES Department of Medicine & Dermatology University of Malaga Division of Laboratory Hospital Universitario "Virgen de la Victoria"

BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an *** study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe ***:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum *** APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being *** patients’ progression,etiological diagnosis,hospital stay and clinical and radiological severity were all ***:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) *** with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes *** usually consumed alcohol or consumed it excessively on the days before ***,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption.

关键词： acute pancreatitis hypertriglyceridemia apolipoprotein E alcohol biliary lithiasis

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Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?

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World Journal of Diabetes 2014年第5期5卷 577-585页

作者： pedro valdivielso José Ramírez-Bollero Carmen Pérez-López UGC de Medicina Interna Hospital "Virgen de la Victoria" de Málaga y Departamento de Medicina y Dermatología Universidad de Málaga

Peripheral arterial disease, manifested as intermittent claudication or critical ischaemia, or identified by an ankle/brachial index < 0.9, is present in at least one in every four patients with type 2 diabetes *** reasons exist for peripheral arterial disease indiabetes. In addition to hyperglycaemia, smoking and hypertension, the dyslipidaemia that accompanies type2 diabetes and is characterised by increased triglyceride levels and reduced high-density lipoprotein cholesterol concentrations also seems to contribute to this association. Recent years have witnessed an increased interest in postprandial lipidaemia, as a result of various prospective studies showing that non-fasting triglycerides predict the onset of arteriosclerotic cardiovascular disease better than fasting measurements do. Additionally,the use of certain specific postprandial particle markers,such as apolipoprotein B-48, makes it easier and more simple to approach the postprandial phenomenon. Despite this, only a few studies have evaluated the role of postprandial triglycerides in the development of peripheral arterial disease and type 2 diabetes. The purpose of this review is to examine the epidemiology and risk factors of peripheral arterial disease in type 2 diabetes, focusing on the role of postprandial triglycerides and particles.

关键词： Peripheral arterial disease Type 2 diabetes Postprandial lipidaemia Apolipoprotein B-48 Anklebrachial index Non-fasting triglycerides

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