检索结果-南通市图书馆

Electronics technology fundamentals

引用

2002年

作者： paynter Robert T.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Defining the Mitochondrial Stress Response in Arabidopsis thaliana

引用

Molecular Plant 2009年第6期2卷 1310-1324页

作者： Olivier Van Aken Botao Zhang Chris Carrie Vindya Uggalla Ellen paynter Estelle Giraud James Whelan ARC Centre of Excellence in Plant Energy Biology MCS Building M316 University of Western Australia 35 Stirling Highway Crawley 6009 Western AustraliaAustralia

To obtain a global overview of how mitochondria respond to stress, we aimed to define the plant mitochondrial stress response （MSR）. By combining a set of 1196 Arabidopsis thaliana genes that putatively encode mitochondrial proteins with 16 microarray experiments on stress-related conditions, 45 nuclear encoded genes were defined as widely stress-responsive. Using green fluorescent protein （GFP） fusion assays, the mitochondrial targeting of a large number of these proteins was tested, confirming in total 26 proteins as mitochondrially targeted. Several of these proteins were observed to be dual targeted to mitochondria and plastids, including the small heat shock proteins sHSP23.5 and sHSP23.6. In addition to the well defined stress components of mitochondria, such as alternative oxidases, nicotinamide adenine dinudeotide （NAD（P）H） dehydrogenases, and heat shock proteins, a variety of other proteins, many with unknown function, were identified. The mitochondrial carrier protein family was over-represented in the stress-responsive genes, suggesting that stress induces altered needs for metabolite transport across the mitochondrial inner membrane. Although the genes encoding many of these proteins contain common cis-acting regulatory elements, it was apparent that a number of distinct regulatory processes or signals likely triggered the MSR. Therefore, these genes provide new model systems to study mitochondrial retrograde regulation, in addition to the widely used alternative oxidase model. Additionally, as changes in proteins responsive to stress did not correlate well with changes at a transcript level, it suggests that post-transcriptional mechanisms also play an important role in defining the MSR.

关键词： Mitochondrial Stress Response (MSR) Arabidopsis thaliana

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Likelihood-based estimation and prediction for a measles outbreak in Samoa

引用

Infectious Disease Modelling 2023年第1期8卷 212-227页

作者： David Wu Helen Petousis-Harris Janine paynter Vinod Suresh Oliver J.Maclaren Department of Engineering Science University of AucklandGraftonAuckland1010New Zealand Department of General Practice and Primary Health Care University of AucklandGraftonAuckland1023New Zealand Auckland Bioengineering Institute University of AucklandGraftonAuckland1010New Zealand

Prediction of the progression of an infectious disease outbreak is important for planning and coordinating a *** equations are often used to model an epidemic outbreak's behaviour but are challenging to ***,these models can suffer from misspecification,which biases predictions and parameter *** models can help with misspecification but are even more expensive to simulate and perform inference ***,we develop an explicitly likelihood-based variation of the generalised profiling method as a tool for prediction and inference under model *** approach allows us to carry out identifiability analysis and uncertainty quantification using profile likelihood-based methods without the need for *** provide justification for this approach by introducing a new interpretation of the model approximation component as a stochastic *** preserves the rationale for using profiling rather than integration to remove nuisance parameters while also providing a link back to stochastic *** applied an initial version of this method during an outbreak of measles in Samoa in 2019e2020 and found that it achieved relatively fast,accurate *** we present the most recent version of our method and its application to this measles outbreak,along with additional validation.

关键词： Generalised profiling Likelihood-based inference Profile likelihood Parameter estimation Bootstrap Measles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

证据合成文献检索策略的发展:结合文本挖掘工具和客观方法的利弊

引用

英国医学杂志中文版 2022年第12期25卷 732-734页

作者： Gaelen P Adam Robin paynter 奚梓玮(译) 高旭(译) Center for Evidence Synthesis in Health Brown University School of Public HealthProvidenceRhode IslandUSA Scientific Resource Center AHRQ Effective Health Care ProgramPortlandOregonUSA 北京大学公共卫生学院

系统综述和相关的证据综合产物(如,快速综述、证据图和范围综述)是循证医学的基础,为各级卫生保健提供信息,从医患决策到国家政策的制定1。然而,系统综述面临的一个持续性的挑战是医学研究的期刊文章和其他相关报告(例如,临床试验记录... 详细信息

系统综述和相关的证据综合产物(如,快速综述、证据图和范围综述)是循证医学的基础,为各级卫生保健提供信息,从医患决策到国家政策的制定1。然而,系统综述面临的一个持续性的挑战是医学研究的期刊文章和其他相关报告(例如,临床试验记录、会议摘要和预印本)呈指数型增长。从2017年以来仅PubMed每年就增加了100多万条新记录2。因此,迫切需要使系统综述的信息检索过程效率更高。

关键词：文献检索预印本卫生保健提供系统综述信息检索过程效率证据合成循证医学

来源：

维普期刊数据库评论