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Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

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Journal of Pharmaceutical Analysis 2021年第3期11卷 364-373页

作者： Monika Zielinska Ewa Chmielewska Tomasz Buchwald Adam Voelkel pawełKafarski Poznan University of Technology Institute of Chemical Technology and EngineeringUl.Berdychowo 460-965PoznanPoland Wrocław University of Science and Technology Faculty of ChemistryDepartment of Bioorganic ChemistryWybrzeze Wyspia_nskiego 2750-370WrocławPoland Poznan University of Technology Institute of Materials Research and Quantum EngineeringPiotrowo 360-965PoznanPoland

There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite(HA), this study used three forms of ceramic materials,two of which are bone-stimulating materials, to assess the suitability of new active substances with antiresorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA(a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction(MINE) device(a polymer inert skeleton), respectively, were used. The affinity of risedronate(a standard compound) and sixteen aminomethylenebisphosphonates(new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorptionedesorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability.

关键词： Monolithic column Polymer composites Bisphosphonates Hydroxyapatite coatings Hydroxyapatite composite

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Mitochondrial transport of catalytic RNAs and targeting of the organellar transcriptome in human cells

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Journal of Molecular Cell Biology 2023年第8期15卷 40-53页

作者： pawełGłodowicz Konrad Kuczynski Romain Val AndréDietrich Katarzyna Rolle Department of Molecular Neurooncology Institute of Bioorganic ChemistryPolish Academy of Sciencesul.Z.Noskowskiego 12/1461-704 PoznanPoland Institute of Plant Molecular Biology French National Center for Scientific Research(CNRS)and University of Strasbourg12 rue du Général Zimmer67084 StrasbourgFrance

Mutations in the small genome present in mitochondria often result in severe *** genetic strategies have been explored,aiming to rescue such mutations.A number of these strategies were based on the capacity of human mitochondria to import RNAs from the cytosol and designed to repress the replication of the mutated genomes or to provide the organelles with wild-type versions of mutant ***,the mutant RNAs present in mitochondria turned out to be an obstacle to therapy and little attention has been devoted so far to their ***,we present the development of a strategy to knockdown mitochondrial RNAs in human cells using the transfer RNA-like structure of Brome mosaic virus or Tobacco mosaic virus as a shuttle to drive trans-cleaving ribozymes into the organelles in human cell *** obtained a specific knockdown of the targeted mitochondrial ATP6 mRNA,followed by a deep drop in ATP6 protein and a functional impairment of the oxidative phosphorylation *** strategy provides a powerful approach to eliminate mutant organellar transcripts and to analyse the control and communication of the human organellar genetic system.

关键词： human cells mitochondria ribozyme RNA trafficking transcriptome manipulation tRNA-like structure

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SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1117-1134页

作者： Katarzyna Wozniczka pawełKonieczynski Alina Plenis Tomasz Ba˛czek Anna Roszkowska Department of Pharmaceutical Chemistry Medical University of GdanskGdanskPoland Department of Analytical Chemistry Medical University of GdanskGdanskPoland

The endocannabinoid system(ECS),particularly its signaling pathways and ligands,has garnered considerable interest in recent *** with clinical work investigating the ECS’functions,including its role in the development of neurological and inflammatory conditions,much research has focused on developing analytical protocols enabling the precise monitoring of the levels and metabolism of the most potent ECS ligands:exogenous phytocannabinoids(PCs)and endogenous cannabinoids(endocannabinoids,ECs).Solid-phase microextraction(SPME)is an advanced,non-exhaustive sample-preparation technique that facilitates the precise and efficient isolation of trace amounts of analytes,thus making it appealing for the analysis of PCs and ECs in complex matrices of plant and animal/human *** this paper,we review recent forensic medicine and toxicological studies wherein SPME has been applied to monitor levels of PCs and ECs in complex matrices,determine their effects on organism physiology,and assess their role in the development of several diseases.

关键词： Phytocannabinoids Endocannabinoids Solid-phase microextraction Plant material Biological matrix

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Effect of geopolitical risk and economic uncertainty indices on renewable energy

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Geoscience Frontiers 2024年第3期15卷 237-247页

作者： Xin Zhao Kamel Si Mohammed Yaohui Wang paweł Stępień Grzegorz Mentel School of Statistics and Applied Mathematics Anhui University of Finance and EconomicsBengbuPR China Faculty of Economics and Management University Ain Temouchent Belhadj BouchaibAlgeria School of Urban and Regional Science Institute of Finance and Economics ResearchShanghai University of Finance and EconomicShanghaiPR China Institute of Economics and Finance University of SzczecinPoland Department of Quantitative Methods Faculty of ManagementRzeszow University of TechnologyRzeszow 35-959Poland

In this study,the relationships between five renewable energy sub-sectors markets and the geopolitical risk(GPR)and economic uncertainty indices(EUI)were examined using daily data from March 30,2012,to April 1,*** cross mapping results show that the renewable energy indices have definite relationships with the GPR and *** renewable energy indices show differences in response directions,speed and trends for a standard information difference impulse from the GPR and the EUI.A positive dynamic conditional correlation between renewable energies and EUI was observed in the first and second waves of the COVID-19 *** contrast,there was a relatively decreased effect for two risk indices during the Russia-Ukraine conflict of February-March *** results show that renewable energy may act as a time-varying hedge against economic uncertainty and GPR owing to its safehaven properties at various ***,building more secure and reliable renewable energy systems can help countries to increase their energy independence,which protects them against the risks of political and economic uncertainty.

关键词： Renewable energy Uncertainty indices Impulse response Safe-haven

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Phase Separation in PCDTBT:PCBM Blends:from Flory-Huggins Interaction Parameters to Ternary Phase Diagrams

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Chinese Journal of Polymer Science 2020年第9期38卷 1025-1033,I0009页

作者： Monika Biernat pawel Dabczynski pawel Biernat Jakub Rysz Jagiellonian University Faculty of Physics Astronomy and Applied Computer Science ul.lojasiewicza 1130-348 KrakówPoland Mathematisches Institut Rheinische Friedrich-Wilhelms-Universitat BonnEndenicher Allee 6053115 BonnGermany

The substantial increase in the efficiency of organic solar cells achieved in recent years would not have been possible without work on the synthesis of new materials and understanding the relationship between the morphology and performance of organic photovoltaic *** structure of solvent-cast active layers is a result of phase separation in mixtures of donor and acceptor *** a large extent,this process depends on the interactions between the components of the ***,we present a systematic analysis of the morphology of poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4',7'-di-2-thienyl-2',1',3'-benzothiadiazole)](PCDTBT)and[6,6]-phenyl-C71-butyric acid methyl ester(PC70BM)films in terms of the ternary phase *** interaction parameters between PCDTBT and four different solvents,namely chloroform,chlorobenzene,o-dichlorobenzene,and toluene,were estimated based on swelling *** on these values,ternary phase diagrams of PCDTBT:PC70BM in different solvents were *** morphology of spin-coated films with different blend ratios cast from different solvents is discussed in terms of the obtained phase diagrams.

关键词： PCDTBT Ternary phase diagrams Interaction parameter Swelling

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CDP-choline to promote remyelination in multiple sclerosis:the need for a clinical trial

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Neural Regeneration Research 2023年第12期18卷 2599-2605页

作者： Viktoria Gudi pawełGrieb Ralf ALinker Thomas Skripuletz Department of Neurology Hannover Medical SchoolHannoverGermany Department of Experimental Pharmacology Mossakowski Medical Research InstitutePolish Academy of SciencesWarsawPoland Department of Neurology University Hospital RegensburgRegensburgGermany

Multiple sclerosis is a multifactorial chronic inflammatory disease of the central nervous system that leads to demyelination and neuronal cell death,resulting in functional *** is the natural repair process of demyelination,but it is often incomplete or fails in multiple *** therapies reduce the inflammatory state and prevent clinical ***,therapeutic approaches to increase myelin repair in humans are not yet *** substance cytidine-5′-diphosphocholine,CDP-choline,is ubiquitously present in eukaryotic cells and plays a crucial role in the synthesis of cellular *** properties have been shown in various animal models of diseases of the central nervous *** have already shown that the compound CDPcholine improves myelin regeneration in two animal models of multiple ***,the results from the animal models have not yet been studied in patients with multiple *** this review,we summarise the beneficial effects of CDP-choline on biolipid metabolism and turnover with regard to inflammatory and regenerative *** also explain changes in phospholipid and sphingolipid homeostasis in multiple sclerosis and suggest a possible therapeutic link to CDP-choline.

关键词： astrocytes CDP-choline cuprizone microglia multiple sclerosis oligodendrocytes

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Short neuropeptide F in integrated insect physiology

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 389-409页

作者： Marcin CHOLEWINSKI Szymon CHOWANSKI Jan LUBAWY Arkadiusz URBANSKI Karolina WALKOWIAK-NOWICKA paweł MARCINIAK Department of Animal Physiology and Developmental Biology Adam Mickiewicz UniversityPoznan 61-614Poland

The short neuropeptide F(sNPF)family of peptides is a multifunctional group of neurohormones involved in the regulation of various physiological processes in *** have been found in a broad spectrum of species,but the number of isoforms in the precursor molecule varies from one to *** receptor for sNPF(sNPFR),which belongs to the G protein-coupled receptor family,has been characterized in various insect orders and was shown to be an ortholog of the mammalian prolactin-releasing peptide receptor(PrPR).The sNPF signaling pathway interacts with other neurohormones such as insulin-like peptides,SIFamide,and pigment-dispersing factors(PDFs)to regulate various *** main physiological function of sNPF seems to be involved in the regulation of feeding,but the observed effects are *** is also connected with the regulation of foraging behavior and the olfactory *** influence of sNPF on feeding and thus energy metabolism may also indirectly affect other vital processes,such as reproduction and *** addition,these neurohormones are involved in the regulation of locomotor activity and circadian rhythm in *** review summarizes the current state of knowledge about the sNPF system in insects.

关键词： Insect neuropeptide Invertebrate neurobiology Short neuropeptide F(sNPF) Feeding Neurohormone

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Comparison of the standard Euler-Euler and hybrid Euler-Lagrange approaches for modeling particle transport in a pilot-scale circulating fluidized bed

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Particuology 2014年第4期12卷 129-137页

作者： Wojciech P.Adamczyk Adam Klimanek Ryszard A.Biaecki Gabriel Wecel pawe Kozolub Tomasz Czakiert Institute of Thermal Technology Silesian University of Technology44-100 GliwiceKonarskiego 22Poland Institute of Advanced Energy Technologies Czestochowa University of TechnologyCzestochowaPoland

Particle transport phenomena in small-scale circulating fiuidized beds （CFB） can be simulated using the Euler-Euler, discrete element method, and Euler-Lagrange approaches. In this work, a hybrid Euler-Lagrange model known as the dense discrete phase model （DDPM）, which has common roots with the multiphase particle-in-cell model, was applied in simulating particle transport within a mid-sized experimental CFB facility. Implementation of the DDPM into the commercial ANSYS Fluent CFD package is relatively young in comparison with the granular Eulerian model. For that reason, validation of the DDPM approach against experimental data is still required and is addressed in this paper. Additional difficulties encountered in modeling fluidization processes are connected with long calculation times. To reduce times, the complete boiler models are simplified to include just the combustion chamber. Such simplifications introduce errors in the predicted solid distribution in the boiler. To investigate the conse- quences of model reduction, simulations were made using the simplified and complete pilot geometries and compared with experimental data. All simulations were performed using the ANSYSFLUENT 14.0 package. A set of user defined functions were used in the hybrid DDPM and Euler-Euler approaches to recirculate solid particles.

关键词： Particle Multiphase flow CFD Particulate processes CFB Fluidized bed

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Numerical modeling of blast-induced rock fragmentation in deep mining with 3D and 2D FEM method approaches

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第11期16卷 4532-4553页

作者： MichałKucewicz MazurkiewiczŁukasz pawełBaranowski Jerzy Małachowski Krzysztof Fuławka Piotr Mertuszka Marcin Szumny Military University of Technology Faculty of Mechanical EngineeringInstitute of Mechanics and Computational Engineering2 Gen.S.Kaliskiego Street00-908WarsawPoland KGHM CUPRUM Ltd. Research and Development Center2-8 Sikorskiego Street53-659WrocławPoland

To optimize the excavation of rock using underground blasting techniques,a reliable and simplified approach for modeling rock fragmentation is *** paper presents a multistep experimentalnumerical methodology for simplifying the three-dimensional(3D)to two-dimensional(2D)quasiplane-strain problem and reducing computational costs by more than ***,in situ tests were conducted involving single-hole and free-face blasting of a dolomite rock mass in a 1050-m-deep *** results were validated by laser *** craters were then compared with four analytical models to calculate the radius of the crushing ***,a full 3D model for single-hole blasting was prepared and validated by simulating the crack length and the radius of the crushing *** on the stable crack propagation zones observed in the 3D model and experiments,a 2D model was *** properties of the high explosive(HE)were slightly reduced to match the shape and number of radial cracks and crushing zone radius between the 3D and 2D *** final methodology was used to reproduce various cut-hole blasting scenarios and observe the effects of residual cracks in the rock mass on further *** presence of preexisting cracks was found to be crucial for fragmentation,particularly when the borehole was situated near a free rock ***,an optimization study was performed to determine the possibility of losing rock continuity at different positions within the well in relation to the free rock face.

关键词： Dolomite rock Two-dimensional(2D)rock modeling Rock fragmentation Cut-hole blasting

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Comments on "Structural,Optical,and Electrical Properties of Zn-Doped CdO Thin Films Fabricated by a Simplified Spray Pyrolysis Technique'' by *** and *** Published in Acta ***.(***.) 28(1),64–71(2015)

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Acta Metallurgica Sinica(English Letters) 2018年第9期31卷 1006-1006页

作者： pawe? E.Tomaszewski Institute of Low Temperature and Structure Research Polish Academy of Science

The commented paper [1] presents the results on structural, optical, and electrical properties of Zn-doped CdO thin films. Unfortunately, there are several mistakes and errors not found by any of referees. It is necessary to show these mistakes or misleading statements to avoid their use in the future papers by authors and other peoples.

关键词： Cd Comments on Engl.Lett Structural,Optical,and Electrical Properties of Zn-Doped CdO Thin Films Fabricated by a Simplified Spray Pyrolysis Technique by K.Usharani and A.R.Balu Published in Acta Metall.Sin Zn

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