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Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase

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World Journal of Gastroenterology 2013年第8期19卷 1210-1218页

作者： Dong Chuan Zuo Seok Choi pawan kumar Shahi Man Yoo Kim Chan Guk Park Young Dae Kim Jun Lee In Yeoup Chang Insuk So Jae Yeoul Jun Department of Physiology College of MedicineChosun UniversityGwangju 501-759South Korea Department of Internal Medicine College of MedicineChosun UniversityGwangju 501-759South Korea Department of Anatomy College of MedicineChosun UniversityGwangju 501-759South Korea Department of Physiology and Biophysics College of MedicineSeoul National UniversitySeoul 56-1South Korea

AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small ***:For this study,primary culture of ICCs was prepared from the small intestine of the *** was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp *** was used to examine the expression of the proteins in ***:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) ***-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ***(antioxidant agent) had no action on LPS-induced action in *** actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not ***:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions.

关键词： Interstitial cells of Cajal Lipopolysaccharide Mitogen-activated protein kinases Nuclear factor kB Small intestine

A Unified Decision-Making Technique for Analysing Treatments in Pandemic Context

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Computers, Materials & Continua 2022年第11期73卷 2591-2618页

作者： Fawaz Alsolami Abdullah Saad Al-Malaise Alghamdi Asif Irshad Khan Yoosef B.Abushark Abdulmohsen Almalawi Farrukh Saleem Alka agrawal Rajeev kumar Raees Ahmad Khan Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknow226025Uttar PradeshIndia Department of Computer Science and Engineering Babu Banarasi Das UniversityLucknow226028India

The COVID-19 pandemic has triggered a global humanitarian disaster that has never been seen *** experts,on the other hand,are undecided on the most valuable treatments of therapy because people ill with this infection exhibit a wide range of illness indications at different phases of ***,this project aims to undertake an experimental investigation to determine which treatments for COVID-19 disease is the most effective and *** research analysis is based on vast data gathered from professionals and research journals,making this study a comprehensive *** solve this challenging task,the researchers used the HF AHPTOPSIS Methodology,which is a well-known and highly effective MultiCriteria Decision Making(MCDM)*** technique assesses the many treatment options identified through various research papers and guidelines proposed by various countries,based on the recommendations of medical practitioners and *** review process begins with a ranking of different treatments based on their effectiveness using the HF-AHP approach and then evaluates the results in five different hospitals chosen by the authors as *** also perform robustness analysis to validate the conclusions of our *** a result,we obtained highly corroborative results that can be used as a *** results suggest that convalescent plasma has the greatest rank and priority in terms of effectiveness and demand,implying that convalescent plasma is the most effective treatment for SARS-CoV-2 in our *** also has the lowest priority in the estimation.

关键词： AHP-TOPSIS hesitant fuzzy sets SARS-CoV-2 healthcare sector preventive drugs

Intuitionistic Neuro-Fuzzy Optimization in the Management of Medical Diagnosis

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Applied Mathematics 2021年第11期12卷 993-1020页

作者： Nivedita Seema agrawal Dhanpal Singh Mukesh kumar Sharma Department of Mathematics S. S. V. (P. G.) College Hapur India Department of Mathematics Keshav Mahavidyalaya University of Delhi New Delhi India Department of Mathematics Chaudhary Charan Singh University Meerut India

Diabetes has become a major concern nowadays and its complications are affecting various organs of a diabetic patient. Therefore, a multi-dimensional technique including all parameters is required to detect the cause, its proper diagnostic procedure and its prevention. In this present work, a technique has been introduced that seeks to build an implementation for the intelligence system based on neural networks. Moreover, it has been described that how the proposed technique can be used to determine the membership together with the non-membership functions in the intuitionistic environment. The dataset has been obtained from Pima Indians Diabetes Database (PIDD). In this work, a complete diagnostic procedure of diabetes has been introduced with seven layered structural frameworks of an Intuitionistic Neuro Sugeno Fuzzy System (INSFS). The first layer is the input, in which six factors have been taken as an input variable. Subsequently, a neural network framework has been developed by constructing IFN for all the six input variables, and then this input has been fuzzified by using triangular intuitionistic fuzzy numbers. In this work, we have introduced a novel optimization technique for the parameters involved in the INSFS. Moreover, an inference system has also been framed for the neural network known as INFS. The results have also been given in the form of tables, which describe each concluding factor.

关键词： Intuitionistic Fuzzy Set Neural Network Neuro-Fuzzy System Intuitionistic Neuro-Fuzzy System Optimization Medical Diagnosis

Blunt traumatic superior gluteal artery pseudoaneurysm presenting as gluteal hematoma without bony injury： A rare case report

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Chinese Journal of Traumatology 2016年第4期19卷 244-246页

作者： Annu Babu Amit Gupta pawan Sharma Piyush Ranjan Atin kumar Department of Surgery Jai Prakash Narayan Apex Trauma Centre All India Institute of Medical Sciences New Delhi India

Blunt traumatic injuries to the superior gluteal artery are rare in clinic. A majority of injuries present as aneurysms following penetrating trauma, fracture pelvis or posterior dislocation of the hip joint. We reported a rare case of superior gluteal artery pseudoaneurysm following blunt trauma presenting as large expanding right gluteal hematoma without any bony injury. The gluteal hematoma was suspected clinically, confirmed by ultrasound and the arterial injury was diagnosed by CT angiography that revealed a large right gluteal hematoma with a focal contrast leakage forming a pseudoaneurysm within the hematoma. Pseudoaneurysm arose from the superior gluteal branch of right internal iliac artery, which was successfully angioembolized. The patient was discharged on day 4 of hospitalization with resolving gluteal hematoma. This report highlighted the importance of considering an arterial injury following blunt trauma to the buttocks with subsequent painful swelling. Acknowledgment of this rare injury pattern was necessary to facilitate rapid diagnosis and appropriate treatment.

关键词： Angioembolization Gluteal hematoma Pseudoaneurysm Superior gluteal artery

Impact Assessment of COVID-19 Pandemic Through Machine Learning Models

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Computers, Materials & Continua 2021年第9期68卷 2895-2912页

作者： Fawaz Jaber Alsolami Abdullah Saad Al-Malaise ALGhamdi Asif Irshad Khan Yoosef B.Abushark Abdulmohsen Almalawi Farrukh Saleem Alka agrawal Rajeev kumar Raees Ahmad Khan Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknow226025India Department of Computer Application Shri Ramswaroop Memorial UniversityBarabanki225003India

Ever since its outbreak in the Wuhan city of China,COVID-19 pandemic has engulfed more than 211 countries in the world,leaving a trail of unprecedented *** more debilitating than the infection itself,were the restrictions like lockdowns and quarantine measures taken to contain the spread of *** enforced alienation affected both the mental and social condition of people *** interactions and congregations are not only integral part of work life but also form the basis of human ***,COVID-19 brought all such communication to a grinding *** interactions have failed to enthuse the fervor that one enjoys in face-to-face *** pandemic has shoved the entire planet into an unstable *** main focus and aim of the proposed study is to assess the impact of the pandemic on different aspects of the society in Saudi *** achieve this objective,the study analyzes two perspectives:the early approach,and the late approach of COVID-19 and the consequent effects on different aspects of the *** used a Machine Learning based framework for the prediction of the impact of COVID-19 on the key aspects of *** of this research study indicate that financial resources were the worst *** countries are facing economic upheavals due to the pandemic and COVID-19 has had a considerable impact on the lives as well as the livelihoods of *** the damage is not irretrievable and the world’s societies can emerge out of this setback through concerted efforts in all facets of life.

关键词： Coronavirus social impact safety COVID-19 monitoring machine learning framework fuzzy AHP-TOPSIS

A Mobile Ad-Hoc Routing Algorithm with Comparative Study of Earlier Proposed Algorithms

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International Journal of Communications, Network and System Sciences 2010年第3期3卷 289-293页

作者： kumar Verma pawan Gupta Tarun Rakesh Nitin Nitin Nitin 不详

A mobile ad-hoc network is an autonomous collection of mobile nodes that communicate over bandwidth constrained wireless links. Due to nodal mobility, the network topology may change rapidly and unpredictably over time. The routing protocols meant for wired network cannot be used for mobile ad-hoc network because of mobility of network. A number of routing protocols like Destination-Sequenced Distance-Vector (DSDV), Ad-Hoc On-Demand Distance Vector (AODV), Dynamic Source Routing (DSR), and Temporally Ordered Routing Algorithm have been implemented. The ad-hoc routing protocols can be divided into two classes;Table-Driven and On-Demand. This paper examines two routing protocols for mobile ad-hoc networks—the Destination Sequenced Distance Vector (DSDV), the table-driven protocol and the Ad-Hoc On- Demand Distance Vector routing (AODV), an on-demand protocol and propose an algorithm that facilitates efficient routing of the packet and failure recovery

关键词： AODV DSDV Relative Performance

Feasibility and oncological outcomes of laparoscopic rectal resection following neo-adjuvant chemo-radiotherapy: A systematic review

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World Journal of Surgical Procedures 2015年第1期5卷 147-154页

作者： pawan kumar Dhruva Rao Manojkumar S Nair Puthucode N Haray Department of Colorectal Surgery Prince Charles Hospital University of South Wales

AIM: To study the feasibility and oncological outcomesfollowing laparoscopic total mesorectal excision(LTME) in patients who have received Neo-adjuvant long course chemo-radiotherapy(LCRT). METHODS: A protocol driven systematic review of published literature was undertaken to assess the feasibility and oncological outcomes following LTME in patients receiving LCRT. The feasibility was assessed using peri-operative outcomes and short term results. The oncological outcomes were assessed using local recurrence, disease free survival and overall ***: Only 8 studies-1 randomized controlled trial, 4 Case Matched/Controlled Studies and 3 Case Series were identified matching the search criteria. The conversion rate was low(1.2% to 28.1%), anastomotic leak rates were similar to open total mesorectal excision(0%-4.1% vs 0%-8.3%). Only 3 studies reported on local recurrence rates(5.2%-7.6%) at median 34 mo follow-up. A single study described disease free survival and overall survival at 3 years as 78.8% and 92.1% respectively. CONCLUSION: LTME following LCRT is feasible in experienced hands, with acceptable short term surgical outcomes and with the usual benefits associated with minimally invasive procedures. The long term oncological outcomes of LTME after LCRT appear to be comparable to open procedures but need further investigation.

关键词： Laparoscopic total mesorectal excision Rectal adenocarcinoma Feasibility Outcomes Neoadjuvant chemo-radiotherapy

Application of monorail fixator for femoral gap nonunion

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Chinese Journal of Traumatology 2014年第4期17卷 239-241页

作者： Hemendra kumar agrawal Ashish Jaiman Vipin Khatkar Vinod kumar Sharma Central Institute of Orthopedics VMMC & Safdarjung Hospital New Delhi 110029 India

Difficult femoral nonunion takes account of infective nonunion and aseptic gap *** length discrepancy and nonunion need to be tackled *** Ilizarov ring fixator is in vogue but it has some *** overcome these,monorail fixator is an effective *** good results can be obtained if we can get a perfect anatomical alignment and good regeneration.

关键词： Femur Ilizarov technique External fixators

Integrating Blockchain Technology into Healthcare Through an Intelligent Computing Technique

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Computers, Materials & Continua 2022年第2期70卷 2835-2860页

作者： Asif Irshad Khan Abdullah Saad Al-Malaise ALGhamdi Fawaz Jaber Alsolami Yoosef B.Abushark Abdulmohsen Almalawi Abdullah Marish Ali Alka agrawal Rajeev kumar Raees Ahmad Khan Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknow226025Uttar PradeshIndia Department of Computer Applications Shri Ramswaroop Memorial UniversityBarabanki225003Uttar PradeshIndia

The blockchain technology plays a significant role in the present era of information *** the last few years,this technology has been used effectively in several *** has already made significant differences in human life,as well as is intended to have noticeable impact in many other domains in the forthcoming *** rapid growth in blockchain technology has created numerous new possibilities for use,especially for healthcare *** digital healthcare services require highly effective security methodologies that can integrate data security with the availablemanagement *** test and understand this goal of security management in Saudi Arabian perspective,the authors performed a numerical analysis and simulation through a multi criteria decision making approach in this *** authors adopted the fuzzy Analytical Hierarchy Process(AHP)for evaluating the effectiveness and then applied the fuzzy Technique forOrder of Preference by Similarity to Ideal Solution(TOPSIS)technique to simulate the validation of *** eliciting highly corroborative and conclusive results,the study referred to a real time project of diabetes patients’management application of Kingdom of Saudi Arabia(KSA).The results discussed in this paper are scientifically proven and validated through various analysis *** the present study can be a credible basis for other similar endeavours being undertaken in the domain of blockchain research.

关键词： Blockchain technology data management fuzzy logic AHP TOPSIS