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The pursuit of transplantation tolerance:new mechanistic insights

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Cellular & Molecular Immunology 2019年第4期16卷 324-333页

作者： pawan K.gupta Christine M.McIntosh Anita S.Chong Maria-Luisa Alegre Department of Medicine The University of ChicagoChicagoIL 60637USA Department of Surgery The University of ChicagoChicagoIL 60637USA

Donor-specific transplantation tolerance that enables weaning from immunosuppressive drugs but retains immune competence to non-graft antigens has been a lasting pursuit since the discovery of neonatal *** recently,efforts have been devoted not only to understanding how transplantation tolerance can be induced but also the mechanisms necessary to maintain it as well as how inflammatory exposure challenges its *** review focuses on recent advances regarding key peripheral mechanisms of T cell tolerance,with the underlying hypothesis that a combination of several of these mechanisms may afford a more robust and durable tolerance and that a better understanding of these individual pathways may permit longitudinal tracking of tolerance following clinical transplantation to serve as *** review may enable a personalized assessment of the degree of tolerance in individual patients and the opportunity to strengthen the robustness of peripheral tolerance.

关键词： tolerance TCR avidity Treg T cell dysfunction

Knowledge and practice skills on home-based urinary catheter care among parents of under-five children with urinary catheter

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Journal of Integrative Nursing 2024年第1期6卷 29-34页

作者： Kurvatteppa HALEMANI Sanjay DHIRAAJ Basant KUMAR Saadhat HUSSAN Premalata Prerna pawan Priyanshi Raviraj gupta College of Nursing All India Institute of Medical SciencesRaebareliUttar PradeshIndia Department of Anesthesiology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknowUttar PradeshIndia Department of Pediatric Surgery Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknowUttar PradeshIndia

Objectives:The objectives of this study were to assess the knowledge and practice skills on home-based urinary catheter care among parents of under-five children with urinary *** and Methods:This cross-sectional study was conducted from June 1,2021,to September 11,2021,in a tertiary hospital in north *** sampling was used to select 50 *** instruments were employed for data collection after fulfilling sample criteria;for baseline information demographic tool,knowledge questionnaires,and a practice *** were analyzed using descriptive and inferential ***:On assessment of 50 participants,the majority of parents aged above 30 years(74%).Most of the participants were male(82%),graduated(38%),and working in the private sector(58%).Similarly,two-thirds of participants were residing in a nuclear family(64%)with a single child 32(64%)and family income<5000 rupees per month(60%).The mean score of knowledge was 1.94±0.81 and that of practice skills was 1.98±0.85 on home-based *** analysis showed that knowledge of parents was significantly associated with qualification(β:1.821,P=0.002).Similarly,association of practice skills of parents with gender(β:1.235,P=0.050)and qualification(β:1.889,P=0.00)was ***:The general findings of our study showed that parents’education and occupation played a significant role in a child’s *** education and catheter care skills positively affect the child and reduce readmission rates.

关键词： Home-based care knowledge parents practice urinary catheter

Therapeutic Approach for Hair Growth and Regeneration Using Bioactive Formulation Containing Mesenchymal Stromal Cell-Derived Conditioned Medium

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 182-208页

作者： pawan Kumar gupta Samatha Bhat Suresh Kannan Raviraja N. Seetharam Udaykumar Kolkundkar Stempeutics Research Pvt. Ltd. 3rd Floor Manipal Hospitals Whitefield Pvt. Ltd. Bengaluru India Stempeutics Research Pvt. Ltd. 4th Floor Shirdi Sai Baba Cancer Hospital Manipal India

Background and Aims: Androgenetic alopecia (AGA) is a common form of hair loss in both men and women. Despite its high prevalence and associated patient morbidity, the approved therapeutic options are limited to finasteride and minoxidil. The present study is aimed at assessing the efficacy of hair serum formulation, Trichosera®containing Bone marrow-derived mesenchymal stromal cells conditioned media as an active ingredient, for hair fall control and hair regrowth in healthy Indian human volunteers. Methods: The product was made using a 20% concentration of 10X Conditioned Media along with excipients. The final product was tested for physicochemical parameters, biomarkers, total protein content and microbial limits as per our in-house specifications. Results: The primary irritation patch test showed that the product is non-irritant and dermatologically safe. A clinical study on 40 subjects was conducted to evaluate the effectiveness of the bioactive formulation in hair fall control and hair regrowth in healthy volunteers. Phototrichogram measurement showed hair density and hair growth rate increased significantly by 11.54% and 18.66% at week 24. Hair tensile strength also increased significantly by 41.10% at 12 weeks follow-up. Hair pull test, to see a reduction in pulled hair and comb’s test to show a decrease in hair fall significantly improved from week 4 onwards. There were no significant adverse events in response to the product application. Conclusion: It is concluded that the hair serum product is completely safe on direct application to the scalp and showed significant improvement in the hair growth rate, hair density, scalp condition and reduction in hair fall. .

关键词： Trichosera® Bone Marrow Derived Mesenchymal Stromal Cells Conditioned Media Hair Fall Hair Regrowth Human Volunteer Study

Evaluation of the Secretome Profile and Functional Characteristics of Human Bone Marrow Mesenchymal Stromal Cells-Derived Conditioned Medium Suggest Potential for Skin Rejuvenation

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 99-117页

作者： Sudha Balasubramanian Charan Thej Ankita Walvekar Priyanka Swamynathan pawan K. gupta Raviraja N. Seetharam Anish S. Majumdar Stempeutics Research Pvt. Ltd. Bangalore India Manipal University Manipal India

Background/Purpose: Multipotent bone marrow-derived mesenchymal stromal cells (BMMSC) have been shown to possess the potential for tissue regeneration. The application of mesenchymal stromal cells (MSC)-derived growth factors and cytokines (GF/CKs) has been implicated for the repair and regeneration of the damaged skin that occurs due to aging and exposure to environmental stress factors. Methods: We have used both qualitative and quantitative measurements of the GF/CKs from the conditioned medium (CM) of a pooled population of BMMSC by antibody array analysis as well as by enzyme-linked immunosorbent assay (ELISA). Furthermore, the CM was also used in a variety of in vitro biological assays to measure its protective properties in human skin fibroblasts. Results: We have characterized the secretome of BMMSC by analyzing the composition of the CM using a forty-one growth factor array system. Thirteen of these GF/CK/extra cellular matrix (ECM)/ matrix metalloproteinases (MMP)-inhibitors in the CM were quantified owing to their involvement in skin repair cascade. In addition, we report that the BMMSC-CM was also able to protect dermal fibroblasts against tert-Butyl hydro peroxide (tbOH) induced oxidative stress and ultra violet B (UV-B) radiation induced cell damage. Conclusion: Based on the data presented here, we propose that BMMSC-derived CM may have the potential to promote health and rejuvenation of the aging skin.

关键词： Bone Marrow-Derived MSC Conditioned Medium Secretome Oxidative Stress UV-B Damage

A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 118-132页

作者： Mukta Sachdev Anoop Chullikana Raviraja N. Seetharam Rachana Shilpakar R. Sapna Keerthi Velugotla Ritambhara Anish S. Majumdar pawan Kumar gupta Manipal Hospital Bangalore India MS Skin Centre Bangalore India Stempeutics Research Pvt. Ltd. Bangalore India

Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bone-marrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV - VI of Norwood Scale for a duration of 90 days. Parameters—fine lines, wrinkles, crow’s feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 - 30 days. Product was safe and well tolerated as per the dermatologist and subjects’ self-assessment.

关键词： Cytokines Conditioned Media Crow’s Feet Anti-Ageing

QTL analysis for some quantitative traits in bread wheat

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第11期8卷 807-814页

作者： PUSHPENDRA Kumar gupta HARINDRA Singh Balyan pawan Laxminarayan Kulwal NEERAJ Kumar AJAY Kumar REYAZUL Rouf Mir AMITA Mohan JITENDRA Kumar Molecular Biology Laboratory Department of Genetics and Plant BreedingChaudhary Charan Singh UniversityMeerut 250 004India

Quantitative trait loci (QTL) analysis was conducted in bread wheat for 14 important traits utilizing data from four different mapping populations involving different approaches of QTL analysis. Analysis for grain protein content (GPC) sug- gested that the major part of genetic variation for this trait is due to environmental interactions. In contrast, pre-harvest sprouting tolerance (PHST) was controlled mainly by main effect QTL (M-QTL) with very little genetic variation due to environmental interactions; a major QTL for PHST was detected on chromosome arm 3AL. For grain weight, one QTL each was detected on chromosome arms 1AS, 2BS and 7AS. QTL for 4 growth related traits taken together detected by different methods ranged from 37 to 40; nine QTL that were detected by single-locus as well as two-locus analyses were all M-QTL. Similarly, single-locus and two-locus QTL analyses for seven yield and yield contributing traits in two populations respectively allowed detection of 25 and 50 QTL by composite interval mapping (CIM), 16 and 25 QTL by multiple-trait composite interval mapping (MCIM) and 38 and 37 QTL by two-locus analyses. These studies should prove useful in QTL cloning and wheat improvement through marker aided selection.

关键词： Quantitative trait loci (QTL) analysis Grain quality traits Grain protein content Pre-harvest sprouting tolerance(PHST) Grain weight Mapping populations Bread wheat

Blunt traumatic superior gluteal artery pseudoaneurysm presenting as gluteal hematoma without bony injury： A rare case report

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Chinese Journal of Traumatology 2016年第4期19卷 244-246页

作者： Annu Babu Amit gupta pawan Sharma Piyush Ranjan Atin Kumar Department of Surgery Jai Prakash Narayan Apex Trauma Centre All India Institute of Medical Sciences New Delhi India

Blunt traumatic injuries to the superior gluteal artery are rare in clinic. A majority of injuries present as aneurysms following penetrating trauma, fracture pelvis or posterior dislocation of the hip joint. We reported a rare case of superior gluteal artery pseudoaneurysm following blunt trauma presenting as large expanding right gluteal hematoma without any bony injury. The gluteal hematoma was suspected clinically, confirmed by ultrasound and the arterial injury was diagnosed by CT angiography that revealed a large right gluteal hematoma with a focal contrast leakage forming a pseudoaneurysm within the hematoma. Pseudoaneurysm arose from the superior gluteal branch of right internal iliac artery, which was successfully angioembolized. The patient was discharged on day 4 of hospitalization with resolving gluteal hematoma. This report highlighted the importance of considering an arterial injury following blunt trauma to the buttocks with subsequent painful swelling. Acknowledgment of this rare injury pattern was necessary to facilitate rapid diagnosis and appropriate treatment.

关键词： Angioembolization Gluteal hematoma Pseudoaneurysm Superior gluteal artery

A Mobile Ad-Hoc Routing Algorithm with Comparative Study of Earlier Proposed Algorithms

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International Journal of Communications, Network and System Sciences 2010年第3期3卷 289-293页

作者： Kumar Verma pawan gupta Tarun Rakesh Nitin Nitin Nitin 不详

A mobile ad-hoc network is an autonomous collection of mobile nodes that communicate over bandwidth constrained wireless links. Due to nodal mobility, the network topology may change rapidly and unpredictably over time. The routing protocols meant for wired network cannot be used for mobile ad-hoc network because of mobility of network. A number of routing protocols like Destination-Sequenced Distance-Vector (DSDV), Ad-Hoc On-Demand Distance Vector (AODV), Dynamic Source Routing (DSR), and Temporally Ordered Routing Algorithm have been implemented. The ad-hoc routing protocols can be divided into two classes;Table-Driven and On-Demand. This paper examines two routing protocols for mobile ad-hoc networks—the Destination Sequenced Distance Vector (DSDV), the table-driven protocol and the Ad-Hoc On- Demand Distance Vector routing (AODV), an on-demand protocol and propose an algorithm that facilitates efficient routing of the packet and failure recovery

关键词： AODV DSDV Relative Performance