检索结果-南通市图书馆

Botulinum toxin type A for treating chronic low back pain:A double blinded randomized control study

World Journal of Methodology 2024年第3期14卷 119-125页

作者： Mantu Jain Shahnawaz Khan paulson varghese Sujit Kumar Tripathy Manaswini Mangaraj Department of Orthopaedics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Biochemistry All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia

BACKGROUND Low back pain(LBP)is a prevalent issue that orthopedic surgeons frequently address in the outpatient *** can arise from various causes,with stiffness in the paraspinal muscles being a notable *** administration of Botulinum toxin type A(BoNT-A)has been found to alleviate back pain by relaxing these stiff *** BoNT-A is approved for use in numerous conditions,a limited number of randomized clinical trials(RCTs)validate its efficacy specifically for treating *** To study the safety and the efficacy of BoNT-A in minimizing pain and improving functional outcomes in patients of chronic LBP(CLBP).METHODS In this RCT,adults aged 18-60 years with mechanical LBP persisting for at least six months were *** were allocated to either the Drug group,receiving 200 Ipsen Units(2 mL)of BoNT-A,or the Control group,which received a 2 mL *** a 2-month follow-up period,both groups were assessed using the Visual Analog Scale(VAS)for pain intensity and the Oswestry Disability Index(ODI)for disability at the start and conclusion of the study.A decrease in pain by 50%was deemed clinically *** The study followed 40 patients for two months,with 20 in each group.A clinically significant reduction in pain was observed in 36 *** was a statistically significant decrease in both VAS and ODI scores in the groups at the end of two ***,when comparing the mean score changes,only the reduction in ODI scores(15 in the placebo group vs 16.5 in the drug group,clinically insignificant)was statistically significant(P=0.012),whereas the change in mean VAS scores was not significant(P=0.45).CONCLUSION The study concludes that BoNT-A does not offer a short-term advantage over placebo in reducing pain or improving LBP scores in CLBP patients.

关键词： Botulinum toxin type A Chronic low back pain Randomized control study Double-blinded Pain management Therapeutic efficacy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Perioperative mortality and morbidity of hip fractures among COVID-19 infected and non-infected patients: A systematic review and meta-analysis

引用

Chinese Journal of Traumatology 2023年第3期26卷 162-173页

作者： Sujit Kumar Tripathy paulson varghese Sibasish Panigrahi Bijnya Birajita Panda Anand Srinivasan Ramesh Kumar Sen Department of Orthopedics All India Institute of Medical SciencesBhubaneswar751019India Department of Ophthalmology Srirama Chandra Bhanja Medical College and HospitalCuttack753007India Department of Pharmacology All India Institute of Medical SciencesBhubaneswar751019India Department of Orthopaedics Max HospitalMohali160055India

Purpose:Hip fractures among elderly patients are surgical *** COVID-19 pandemic time,many such patients could not be operated at early time because of the limitation of the medical resources,the risk of infection and redirection of medical attention to a severe infective health ***:A search of electronic databases(PubMed,Medline,CINAHL,EMBASE and the Cochrane Central Register of Controlled Trials)with the keywords"COVID","COVID-19","SARS-COV-2","Corona","pandemic","hip fracture","trochanteric fracture"and"neck femur fracture"revealed 64 studies evaluating treatment of hip fracture in elderly patients during COVID-19 pandemic *** 30-day mortality rate,inpatient mortality rate,critical care/special care need,readmission rate and complications rate in both groups were *** were analyzed using Review Manager(RevMan)***:After screening,7 studies were identified that described the mortality and morbidity in hip fractures in both COVID-19 infected(COVID-19+)and non-infected(COVID-19-)*** were significantly increased risks of 30-day mortality(32.23%COVID-19+deathvs.8.85%COVID-19-death)and inpatient mortality(29.33%vs.2.62%)among COVID-19+patients with odds ratio(OR)of 4.84(95%CI:3.13-7.47,p<0.001)and 15.12(95%CI:6.12-37.37,p<0.001),*** COVID-19+patients needed more critical care admission(OR=5.08,95%CI:1.49-17.30,p<0.009)and they remain admitted for a longer time in hospital(mean difference=3.6,95% CI:1.74-5.45,p<0.001);but there was no difference in readmission rate between these 2 *** risks of overall complications(OR=17.22),development of pneumonia(OR=22.25),and acute respiratory distress syndrome/acute respiratory failure(OR=32.96)were significantly high among COVID-19+patients compared to ***:There are increased risks of the 30-day mortality,inpatient mortality and critical care admission among hip fracture patients who are COVID-19+.The chances of developing pn

关键词： Hip fracture Femur neck fracture Mortality COVID-19 Pandemic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Limb length discrepancy after total knee arthroplasty: A systematic review and meta-analysis

引用

World Journal of Clinical Cases 2021年第2期9卷 357-371页

作者： Sujit Kumar Tripathy Siddharth Satyakam Pradhan paulson varghese Prabhudev Prasad Purudappa Sandeep Velagada Tarun Goyal Bijnya Birajita Panda Jagadeesh Vanyambadi Department of Orthopaedics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Orthopedics VA Boston Health careBostonMassachusetts 02130United States Department of Orthopaedics All India Institute of Medical SciencesBathinda 209201India Department of Ophthalmology SCB Medical CollegeCuttack 751019India Department of Orthopaedics Salford Royal NHS Foundation TrustSalford M68HDUnited Kingdom

BACKGROUND Limb length discrepancy(LLD)after total knee arthroplasty(TKA)has been considered as one of the reasons for the unsatisfactory ***,there is no consensus about the extent of LLD that can be considered as clinically *** To evaluate the incidence of radiographic LLD and its impact on functional outcome following *** All randomized-controlled trial and observational studies on LLD in TKA,published till 22nd June 2020,were systematically searched and *** primary outcome was“limb lengthening or LLD after TKA”.The secondary outcomes included“assessment of LLD in varus/valgus deformity”and“impact of LLD on the functional outcome”.RESULTS Of 45 retrieved studies,qualitative and quantitative assessment of data was performed from eight studies and six studies,*** studies(n=1551)reported the average limb lengthening of 5.98 *** LLD after TKA was ranging from 0.4±10 mm to 15.3±2.88 *** incidence of postoperative radiographic LLD was reported in 44%to 83.3%of *** was no difference in the preoperative and postoperative LLD(MD-1.23;95%CI:-3.72,1.27;P=0.34).Pooled data of two studies(n=219)revealed significant limb lengthening in valgus deformity than varus(MD-2.69;95%CI:-5.11,0.27;P=0.03).The pooled data of three studies(n=611)showed significantly worse functional outcome in patients with LLD of≥10 mm compared to<10 mm(standard MD 0.58;95%CI:0.06,1.10;P=0.03).CONCLUSION Limb lengthening after TKA is common,and it is significantly more in valgus than varus *** LLD(≥10 mm)is associated with suboptimal functional outcome.

关键词： Arthroplasty Knee Replacement Limb length Joint diseases Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thirty-day mortality of patients with hip fracture during COVID-19 pandemic and pre-pandemic periods:A systematic review and metaanalysis

引用

World Journal of Orthopedics 2021年第1期12卷 35-50页

作者： Sujit Kumar Tripathy paulson varghese Sibasish Panigrahi Bijnya Birajita Panda Sandeep Velagada Samrat Smrutiranjan Sahoo Monappa A Naik Sharath K Rao Department of Orthopedics All India Institute of Medical SciencesBhubaneswar 751019India Department of Orthopedics All India Institute of Medical SciencesBhubaneswarBhubaneswar 751019India Department of Ophthalmology SCB Medical CollegeCuttack 753007India Department of Orthopedics All India Institute of Medical SciencesNagpur 441108India Department of Orthopedics Kasturba Medical CollegeManipal Academy of Higher EducationManipalUdupiKarnataka 576104India Department of Orthopedics Kasturba Medical CollegeManipal Academy of Higher EducationManipalUdupiKarnatakaManipal 576104India

BACKGROUND Timely intervention in hip fracture is essential to decrease the risks of perioperative morbidity and ***,limitations of the resources,risk of disease transmission and redirection of medical attention to a more severe infective health problem during coronavirus disease 2019(COVID-19)pandemic period have affected the quality of care even in a surgical *** To compare the 30-d mortality rate and complications of hip fracture patients treated during COVID-19 pandemic and pre-pandemic *** The search of electronic databases on 1st August 2020 revealed 45 studies related to mortality of hip fracture during the COVID-19 pandemic and pre-pandemic *** careful screening,eight studies were eligible for quantitative and qualitative analysis of *** The pooled data of eight studies(n=1586)revealed no significant difference in 30-d mortality rate between the hip fracture patients treated during the pandemic and pre-pandemic periods[9.63%vs 6.33%;odds ratio(OR),0.62;95%CI,0.33,1.17;P=0.14].Even the 30-d mortality rate was not different between COVID-19 non-infected patients who were treated during the pandemic time,and all hip fracture patients treated during the pre-pandemic period(OR,1.03;95%CI,0.61,1.75;P=0.91).A significant difference in mortality rate was observed between COVID-19 positive and COVID-19 negative patients(OR,6.99;95%CI,3.45,14.16;P<0.00001).There was no difference in the duration of hospital stay(OR,-1.52,95%CI,-3.85,0.81;P=0.20),overall complications(OR,1.62;P=0.15)and incidence of pulmonary complications(OR,1.46;P=0.38)in these two-time ***,the preoperative morbidity was more severe,and there was less use of general anesthesia during the pandemic *** There was no difference in 30-d mortality rate between hip fracture patients treated during the pandemic and pre-pandemic ***,the mortality risk was higher in COVID-19 positive patients compared to COVID-19 negativ

关键词： Hip fracture Femur neck fracture Trochanter fracture Mortality Pandemic COVID-19

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：