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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： paulo ricardo prado nunes Pamela Castro-e-Souza Anselmo Alves de Oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva Carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to ***:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass Lipid profile Menopause Strength training

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Animal modeling in bone research—Should we follow the White Rabbit?

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Animal Models and Experimental Medicine 2019年第3期2卷 162-168页

作者： Aline Schafrum Macedo Caroline Cezaretti Feitosa Fernando Yoiti Kitamura Kawamoto paulo Vinicius Tertuliano Marinho Isis dos Santos Dal‐Bo Bianca Fiuza Monteiro Leonardo prado Thales Bregadioli Gabriel Antonio Covino Diamante Cassio ricardo Auada Ferrigno Department of Veterinary Surgery School of Veterinary Medicine and Animal SciencesUniversity of Sao PauloUSPSao PauloSPBrazil Department of Veterinary Surgery School of Agricultural and Veterinarian SciencesSao Paulo State UniversityUNESPJaboticabalSPBrazil Department of Veterinary Surgery Federal Institute of EducationScienceand Technology of Southern Minas GeraisIFSULDEMINASMuzambinhoMGBrazil

Animal models are live subjects applied to translational *** provide insights into human diseases and enhance biomedical *** development has favored the pace of human social development over ***'s society is more aware of animal welfare than past *** general public has marked objections to animal research and many species are falling into *** search for an ideal methodology to replace animal use is on,but animal modeling still holds great importance to human *** research,in particular,has unmet requirements that in vitro technologies cannot fully *** novel models remains necessary and rabbits are gaining in popularity as potential bone *** aim here is to provide a broad overview of animal modeling and its ethical implications,followed by a narrower focus on bone research and the role rabbits are playing in the current scenario.

关键词： animal experimentation bone density Lagomorpha translational medical research

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The burden of prolonged sedentary behavior imposed by uberization

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Sports Medicine and Health Science 2023年第2期5卷 159-163页

作者： Thalles Guilarducci Costa Vinnycius nunes de Oliveira Douglas Assis Teles Santos ricardo Borges Viana Marilia Santos Andrade Rodrigo Luiz Vancini Katja Weiss Beat Knechtle Claudio Andre Barbosa de Lira Laboratório de Avaliação do Movimento Humano Faculdade de Educação Física e DançaUniversidade Federal de GoiásGoiâniaBrazil Colegiado de Educação Física Universidade do Estado da BahiaCampus XTeixeira de FreitasBahiaBrazil Instituto de Educação Física e Esportes Universidade Federal do CearáFortalezaBrazil Departamento de Fisiologia Universidade Federal de São PauloSão PauloBrazil Centro de Educação Física e Desportos Universidade Federal do Espírito SantoVitóriaBrazil Institute of Primary Care University of Zurich8006ZurichSwitzerland Medbase St.Gallen Am Vadianplatz 9000St.GallenSwitzerland

Mobility applications are rapidly growing in cities worldwide due to their convenience and low *** applications drivers experience vast flexibility in work hours,often work longer than in fixed-hours jobs,and can constantly transport passengers in their vehicles for up to 12 h;after this,they must go offline for eight consecutive hours before driving ***,drivers have found an easy way around this limitation by switching to other apps and continuing *** burden of prolonged work can increase sedentary behavior among mobility applications *** behavior is any waking activity in which the individual expends 1.5 metabolic equivalents(METs)or less while sitting or *** behavior can increase the risk of detrimental effects on *** this opinion article,we aim to discuss the possible effects of the burden of prolonged work on the sedentary behavior of mobility applications drivers and propose possible strategies to face this concerning situation.

关键词： Mobility application Drivers Health outcomes Sedentary lifestyle Quality of life

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Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats

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Animal Models and Experimental Medicine 2019年第1期2卷 51-57页

作者： Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia Maria Napolitano Goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi Mariah Acioli Righeti Vitória ricardo Karina Fittipaldi Bombonato-prado Simone Cecílio Hallak Regalo Selma Siessere Department of Morphology Physiology and Basic PathologySchool of Dentistry of Ribeirao PretoUSP-University of Sao Paulo Faculty of Health and Medical Sciences School of Veterinary MedicineUniversity of Surrey

Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions.

关键词： bone low-level laser therapy osteocytes osteoporosis

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Artificial Neural Network for Websites Classification with Phishing Characteristics

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Social Networking 2018年第2期7卷 97-109页

作者： ricardo Pinto Ferreira Andréa Martiniano Domingos Napolitano Marcio Romero Dacyr Dante De Oliveira Gatto Edquel Bueno prado Farias Renato José Sassi Graduate Program in Informaticsand Knowledge Management Universidade Nove de Julho S&atilde o paulo Brazil

Several threats are propagated by malicious websites largely classified as phishing. Its function is important information for users with the purpose of criminal practice. In summary, phishing is a technique used on the Internet by criminals for online fraud. The Artificial Neural Networks (ANN) are computational models inspired by the structure of the brain and aim to simu-late human behavior, such as learning, association, generalization and ab-straction when subjected to training. In this paper, an ANN Multilayer Per-ceptron (MLP) type was applied for websites classification with phishing cha-racteristics. The results obtained encourage the application of an ANN-MLP in the classification of websites with phishing characteristics.

关键词： Artificial Intelligence Artificial Neural Network Pattern Recognition Phishing Characteristics Social Engineering

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The Cumulative Effects of Sewage Sludge Compost on Raphanus sativus L: Growth and Soil Properties

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Green and Sustainable Chemistry 2016年第1期6卷 1-10页

作者： Vanessa N. Lima ricardo V. Trótski O. Silva Patrícia nunes paulo H. da Silva Kyriale Morant Rosileide F. S. Andrade Aline E. Nascimento Galba M. Campos-Takaki Arminda Saconi Messias Development of Environmental Processes Catholic University of Pernambuco Recife PE Brazil Chemical Engineering Course Catholic University of Pernambuco Recife PE Brazil Nucleus of Research in Environmental Sciences and Biotechnology Catholic University of Pernambuco Recife PE Brazil

The main goal of this research study was to establish the physicochemical characteristics of sewage sludge, and the nutrients needed to enhance the properties of soil with a view to exploiting were potential for agriculture. The example used was the cultivation of radish (Raphanus sativus). The findings are intended as a contribution towards making agriculture sustainable. This study was carried out to assess the response of radish (Raphanus sativus L.) to doses of sewage sludge applied in medium texture soils, and the socioeconomic contributions that such cultivation of radish would make. Levels of 0.25 and 75 ton/ha of sewage sludge plus the equivalent dose of 25 ton/ha of sewage sludge vermin compost by California Red were used after making a randomized experimental design with three replicates. 30 days after sowing radish seeds, the following data were collected: the number of leaves per plant (NLP);plant height (PH in cm);root diameter (RD) and tubercle production (TP ton/ha). In addition, the pH, EC-electric conductivity (EC), and soil organic matter (SOM) were determined. Statistical analysis showed that 25 and 50 tons/ha gave the best results for the parameters assessed. The estimated increase in family mean income from selling radish crops fertilized with sewage sludge is around 17%.

关键词： Sewage Sludge Productivity Soil Solid Waste Raphanus sativus L.

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Candidate genes for male and female reproductive traits in Canchim beef cattle

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Journal of Animal Science and Biotechnology 2018年第1期9卷 59-68页

作者： Marcos Eli Buzanskas Daniela do Amaral Grossi ricardo Vieira Ventura Flavio Schramm Schenkel Tatiane Cristina Seleguim Chud Nedenia Bonvino Stafuzza Luciana Diniz Rola Sarah Laguna Conceio Meirelles Fabiana Barichello Mokry Maurício de Alvarenga Mudadu Roberto Hiroshi Higa Marcos Vinícius Gualberto Barbosa da Silva Maurício Mello de Alencar Luciana Correia de Almeida Regitano Danísio prado Munari Departamento de Zootecnia Universidade Federal da Paraíba(UFPB)AreiaParailba 58397-000Brazil Fast Genetics SaskatoonSK S7K 2K6Canada Beef Improvement Opportunities(BIO) GuelphON N1K 1ESCanada Department of Animal and Poultry Science University of GuelphCentre for Genetic Improvement of Livestock(CGIL)GuelphON N1G 2W1Canada Departamento de Ciencias Exatas Faculdade de Ci6ncias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Departamento de Zootecnia Nucleo de Pesquisa e Conservacao de CervMeosFaculdade de Ciencias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Department of Animal Science Federal University/of Lavras(UFLA)LavrasMinas Gerais 37200 000Brazil Department of Genetics and Evolution Federa University of Sao Carlos(UFSCar)Sao CarlosSao Paulo 13565-905Brazil Embrapa Agricultural Informatics Campinas55o Paulo 13083 886Brazil Embrapa Dairy Cattle Juiz de ForaMinas Gerais 36038 330Brazil Embrapa Southeast Livestock Sao CarlosSao Paulo 13560 970Brazil

Background： Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 ***： Associated SNPs were observed for scrotal circumference at 420 d of age（435 SNPs）, followed by scrotal circumference at 210 d of age（12 SNPs）, age at first calving（six SNPs）, and age at second calving（four SNPs）. We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and ***： Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless,the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, al relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.

关键词： Animal breeding Composite breed Genome-wide association Genomic data Single nucleotide polymorphism

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B-1 cells modulate the murine macrophage response to Leishmania major infection

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World Journal of Biological Chemistry 2017年第2期8卷 151-162页

作者： Angelica F Arcanjo Marise P nunes Elias B Silva-Junior Monique Leandro Juliana Dutra Barbosa da Rocha Alexandre Morrot Debora Decote-ricardo Celio Geraldo Freire-de-Lima Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Instituto Oswaldo Cruz FIOCRUZ Instituto de Microbiologia paulo de Góes Universidade Federal do Rio de Janeiro Instituto de Veterinária Universidade Federal Rural do Rio de Janeiro

AIM To investigate the modulatory effect of B-1 cells on murine peritoneal macrophages infected with Leishmania major(L. major) in *** Peritoneal macrophages obtained from BALB/c andBALB/c XID mice were infected with L. major and cultured in the presence or absence of B-1 cells obtained from wild-type BALB/c mice. Intracellular amastigotes were counted, and interleukin-10(IL-10) production was quantified in the cellular supernatants using an enzymelinked immunosorbent assay. The levels of the lipid mediator prostaglandin E2(PGE2) were determined using a PGE2 enzyme immunoassay kit(Cayman Chemical, Ann Arbor, MI), and the number of lipid bodies was quantified in the cytoplasm of infected macrophages in the presence and absence of B-1 cells. Culturing the cells with selective PGE2-neutralizing drugs inhibited PGE2 production and confirmed the role of this lipid mediator in IL-10 production. In contrast, we demonstrated that B-1 cells derived from IL-10 KO mice did not favor the intracellular growth of L. *** We report that B-1 cells promote the growth of L. major amastigotes inside peritoneal murine macrophages. We demonstrated that the modulatory effect was independent of physical contact between the cells, suggesting that soluble factor(s) were released into the cultures. We demonstrated in our co-culture system that B-1 cells trigger IL-10 production by L. major-infected macrophages. Furthermore, the increased secretion of IL-10 was attributed to the presence of the lipid mediator PGE2 in supernatants of L. major-infected macrophages. The presence of B-1 cells also favors the production of lipid bodies by infected macrophages. In contrast, we failed to obtain the same effect on parasite replication inside L. major-infected macrophages when the B-1 cells were isolated from IL-10 knockout mice. CONCLUSION Our results show that elevated levels of PGE2 and IL-10 produced by B-1 cells increase L. major growth, as indicated by the number of parasites

关键词： Leishmania major Macrophages B-1 cells Interleukin-10 Prostaglandin E2 Infection

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