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Communicating with the non-dominant hemisphere:Implications for neurological rehabilitation

Neural Regeneration Research 2013年第13期8卷 1236-1246页

作者： Fabricio ferreira de Oliveira Sheilla de Medeiros Correia Marin paulo henrique ferreira bertolucci Department of Neurology and Neurosurgery Escola Paulista de Medicina Federal University of So Paulo (UNIFESP) So Paulo SP

Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia.

关键词： neural regeneration reviews linguistics aphasia language speech non-dominant hemisphere disability evaluation prognosis cerebrum function grants-supported paper neuroregeneration

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Free amino acid content in trunk,branches and branchlets of Araucaria angustifolia(Araucariaceae)

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Journal of Forestry Research 2018年第6期29卷 1489-1496页

作者： Crizane Hackbarth Patricia Soffiatti Fla′vio Zanette Eny Iochevet Segal Floh Amanda ferreira Macedo henrique Aparecido Laureano Departamento de Fitotecnia e Fitossanitarismo Federal University of Parana(UFPR)Rua dos Funcionarios1540JuveveCuritibaPR 81531-990Brazil Departamento de Botanica Federal University of Parana(UFPR)Av.Cel.Francisco H.dos Santos100Jardim das AmericasCuritibaPR 81531-980Brazil Instituto de Biociencias University of Sao PauloRua do Matao277Sao PauloSP 05508-090Brazil Departamento de Estatstica Federal University of Parana(UFPR)Av.Cel.Francisco H.dos Santos100Jardim das AmericasCuritibaPR 81531-980Brazil

Araucaria angustifolia(Bertol.) O. Kuntze exhibits dimorphism in its stem structure, where the trunk is orthotropic and branches and branchlets(primary and secondary branches) are plagiotropic. These stems exhibit different behavior when used for vegetative propagation,and only segments of trunk can form a complete plant. The physiological and biochemical mechanisms that characterize these stems are still little known. The aim of this study was to describe the free amino acid profiles in trunks,branches, and branchlets of A. angustifolia. Segments of 5 cm in length were excised from young individuals below the stem apex. The needles were removed and samples were frozen and lyophilized. The determinations were made by high-performance liquid chromatography, and the results were expressed as lg/g fresh weight(FW). The trunks and branches had the highest content of total amino acids, which were 112.23 ± 20.57 lg/g FW and 111.97 ± 27.78 lg/g FW, respectively. The amino acids—glutamine, aspartate and c-aminobutyric acid and tyrosine—were noticeably higher in the three types of *** the trunk, a higher amount of asparagine and tryptophan,was also detected. Glutamic acid and glutamine were found in higher quantities in the branches. The branchlets had very low total amino acid content (30.79 ± 4.19 lg/g FW), wherein asparagine is the only amino acid not detected. Thus, it was observed that the profile of the free amino acid differs among trunks, branches, and branchlets in A. angustifolia, indicating that they perform different functions.

关键词： Brazilian pine Physiological mechanisms Stem’s dimorphism Free amino acids

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Study of tumor necrosis factor receptor in the inflammatory bowel disease

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World Journal of Gastroenterology 2023年第18期29卷 2733-2746页

作者： Roberta Figueiroa Souza Marcos Antônio ferreira Caetano henrique Inhauser Riceti Magalhães Patricia Castelucci Department of Anatomy Institute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000Brazil Department of Surgery School of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 05508-270Brazil

Ulcerative colitis(UC)and Crohn’s disease(CD)are part of Inflammatory Bowel Diseases(IBD)and have pathophysiological processes such as bowel necrosis and enteric neurons and enteric glial *** addition,the main inflammatory mediator is related to the tumor necrosis factor-alpha(TNF-α).TNF-αis a mediator of the intestinal inflammatory processes,thus being one of the main cytokines involved in the pathogenesis of IBD,however,its levels,when measured,are present in the serum of patients with *** addition,TNF-αplays an important role in promoting inflammation,such as the production of interleukins(IL),for instance IL-1βand *** are two receptors for TNF as following:The tumor necrosis factor 1 receptor(TNFR1);and the tumor necrosis factor 2 receptor(TNFR2).They are involved in the pathogenesis of IBD and their receptors have been detected in IBD and their expression is correlated with disease *** soluble TNF form binds to the TNFR1 receptor with,and its activation results in a signaling cascade effects such as apoptosis,cell proliferation and cytokine *** contrast,the transmembrane TNF form can bind both to TNFR1 and *** studies have suggested that TNF-αis one of the main pro-inflammatory cytokines involved in the pathogenesis of IBD,since TNF levels are present in the serum of both patients with UC and *** and subcutaneous biologics targeting TNF-αhave revolutionized the treatment of IBD,thus becoming the best available agents to induce and maintain IBD *** application of antibodies aimed at neutralizing TNF-αin patients with IBD that induce a satisfactory clinical response in up to 60%of patients,and also induced long-term maintenance of disease remission in most *** has been suggested that anti-TNF-αagents inactivate the pro-inflammatory cytokine TNF-αby direct neutralization,i.e.,resulting in suppression of ***,anti-TNF-αantibodies perform more complex functions than a simple block

关键词： Tumor necrosis factor 1 receptor Tumor necrosis factor 2 receptor Inflammatory bowel diseases Enteric nervous system tumor necrosis factor-alpha

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Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma

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World Journal of Gastroenterology 2006年第38期12卷 6207-6211页

作者： Danielle Queiroz Calcagno Mariana ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki paulo Pimentel Assumpcao Mario henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano Human Cytogenetics and Toxicological Genetics Laboratory Department of BiologyCenter of Biological SciencesFederal University of ParáBelémPABrazil Genetics Division Department of Morphology Federal University of Sao PauloSao PauloSPBrazil Department of Pathology and Surgery Service Federal University of ParáBelémPABrazil Joao de Barros Barreto University Hospital Federal University of ParáBelémPABrazil Molecular Genetics Laboratory Department of Pathology Medical SchoolFederal University of CearáFortalezaCEBrazil

AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways.

关键词： Chromosome 8 aneuploidy C-MYC amplification Immunostaining Gastric adenocarcinoma

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Direct Electrochemical Determination of Glyphosate Herbicide Using a Screen-Printed Carbon Electrode Modified with Carbon Black and Niobium Nanoparticles

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Journal of Analysis and Testing 2023年第4期7卷 425-434页

作者： Julia Oliveira Fernandes Cassiano Augusto Rolim Bernardino Juliana dos Santos Fernandes Claudio Fernando Mahler Bernardo ferreira Braz Luiz henrique Carpenter dos Santos Rodrigo JoséCorrêa Ricardo Erthal Santelli Braulio Soares Archanjo Emerson Schwingel Ribeiro Fernando henrique Cincotto Departament of Analytical Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Departament of Civil Engineering COPPEFederal University of Rio de JaneiroRio de Janeiro 21941-598Brazil National Institute of Science&Technology of Bioanalytics(INCTBio) CampinasSão Paulo 13083-862Brazil Departament of Inorganic Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Unesp National Institute of Alternative Technologies for DetectionToxicological Assessment and Removal of Micropollutants and Radioactives(INCT-DATREM)AraraquaraSão Paulo 14800-060Brazil National Institute of Metrology Quality and TechnologyInmetroAv.Nossa Senhora das Graças50XerémDuque de Caxias 25250-020Brazil

Glyphosate is a herbicide that has been widely used worldwide and is used in agricultural areas to control weeds and unwanted *** sensors developed from different nanomaterials have high efficiency,excellent cost-benefit,and fast analysis time for detecting traces of environmental *** study aimed to produce an electrochemical sensor with disposable screen-printed electrodes based on carbon black modified with niobium nanoparticles to determine glyphosate in aqueous *** morphology,structure and electrochemical performance of the sensor were characterized by scanning electron microscopy,energy-dispersive X-ray spectroscopy,X-ray diffraction and cyclic *** pulse voltammetry in BR buffer solution at pH 5.0 allowed the generation of a method to quantify glyphosate concentration in a linear range of 5.90-172.30μmol/L(1.00-29.13μg/mL),with a limit of detection calculated at 3.07μmol/L(0.52μg/mL).The method efficiently quantified glyphosate in real water samples and showed no interference from K^(+),Na^(+),Ca^(2+),Mg^(2+)ions or thiamethoxam,imidacloprid and carbendazim pesticides.

关键词： Glyphosate Electrochemical sensor Carbon black Niobium nanoparticles

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Peroxisome proliferator-activated receptor-alpha activation and dipeptidyl peptidase-4 inhibition target dysbiosis to treat fatty liver in obese mice

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World Journal of Gastroenterology 2022年第17期28卷 1814-1829页

作者： Flavia Maria Silva-Veiga Carolline Santos Miranda Isabela Macedo Lopes Vasques-Monteiro henrique Souza-Tavares Fabiane ferreira Martins Julio Beltrame Daleprane Vanessa Souza-Mello Department of Anatomy Institute of BiologyState University of Rio de JaneiroLaboratory of MorphometryMetabolism and Cardiovascular DiseasesRio de Janeiro 20551-030Brazil Department of Clinical and Toxicology Analysis State University of Rio de JaneiroNutrition InstituteState University of Rio de JaneiroNutrition InstituteUniversity of Sao PauloRio de Janeiro 20551-030Brazil

BACKGROUND Obesity and comorbidities onset encompass gut dysbiosis,altered intestinal permeability,and *** that target gut dysbiosis can cope with obesity and nonalcoholic fatty liver disease(NAFLD)*** proliferator-activated receptor(PPAR)-alpha activation and dipeptidyl-peptidase-4(DPP-4)inhibition alleviate NAFLD,but the mechanism may involve gut microbiota modulation and merits further *** To address the effects of PPAR-alpha activation and DPP-4 inhibition(isolated or combined)upon the gut-liver axis,emphasizing inflammatory pathways in NAFLD management in high-fat-fed C57BL/6J *** Male C57BL/6J mice were fed a control diet(C,10%of energy as lipids)or a highfat diet(HFD,50%of energy as lipids)for 12 wk,when treatments started,forming the groups:C,HF,HFA(HFD+PPAR-alpha agonist WY14643,2.5 mg/kg body mass),HFL(HFD+DPP-4 inhibitor linagliptin,15 mg/kg body mass),and HFC(HFD+the combination of WY14643 and linagliptin).RESULTS The HFD was obesogenic compared to the C *** treatments elicited significant body mass loss,and the HFC group showed similar body mass to the C *** treatments tackled oral glucose intolerance and raised plasma glucagon-like peptide-1 *** metabolic benefits restored Bacteroidetes/Firmicutes ratio,resulting in increased goblet cells per area of the large intestine and reduced lipopolysaccharides concentrations in treated *** the gene level,treated groups showed higher intestinal Mucin 2,Occludin,and Zo-1 expression than the HFD *** reduced endotoxemia suppressed inflammasome and macrophage gene expression in the liver of treated *** observations complied with the mitigation of liver steatosis and reduced hepatic triacylglycerol,reassuring the role of the proposed treatments on NAFLD *** PPAR alpha activation and DPP-4 inhibition(isolated or combined)tackled NAFLD in dietinduced obese mice by restoration of gut-liver axis

关键词： Nonalcoholic fatty liver disease High-fat diet Peroxisome proliferator-activated receptor-alpha Dipeptidyl-peptidase-4-inhibitor Dysbiosis Inflammation

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Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis

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World Journal of Gastroenterology 2023年第22期29卷 3440-3468页

作者： henrique Inhauser Riceti Magalhães Felipe Alexandre Machado Roberta Figueiroa Souza Marcos Antônio ferreira Caetano Vanessa Ribeiro Figliuolo Robson Coutinho-Silva Patricia Castelucci Department of Surgery School of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 05508-270Brazil Department of Anatomy University of São PauloSão Paulo 05508-000Brazil Biophysics Institute Carlos Chagas Filho Federal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

BACKGROUND The literature indicates that the enteric nervous system is affected in inflammatory bowel diseases(IBDs)and that the P2X7 receptor triggers neuronal ***,the mechanism by which enteric neurons are lost in IBDs is *** To study the role of the caspase-3 and nuclear factor kappa B(NF-κB)pathways in myenteric neurons in a P2X7 receptor knockout(KO)mouse model of *** Forty male wild-type(WT)C57BL/6 and P2X7 receptor KO mice were euthanized 24 h or 4 d after colitis induction by 2,4,6-trinitrobenzene sulfonic acid(colitis group).Mice in the sham groups were injected with *** mice were divided into eight groups(n=5):The WT sham 24 h and 4 d groups,the WT colitis 24 h and 4 d groups,the KO sham 24 h and 4 d groups,and the KO colitis 24 h and 4 d *** disease activity index(DAI)was analyzed,the distal colon was collected for immunohistochemistry analyses,and immunofluorescence was performed to identify neurons immunoreactive(ir)for calretinin,P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,and total NF-κ*** analyzed the number of calretinin-ir and P2X7 receptor-ir neurons per ganglion,the neuronal profile area(μm^(2)),and corrected total cell fluorescence(CTCF).RESULTS Cells double labeled for calretinin and P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,or total NF-κB were observed in the WT colitis 24 h and 4 d *** number of calretinin-ir neurons per ganglion was decreased in the WT colitis 24 h and 4 d groups compared to the WT sham 24 h and 4 d groups,respectively(2.10±0.13 vs 3.33±0.17,P<0.001;2.92±0.12 vs 3.70±0.11,P<0.05),but was not significantly different between the KO *** calretinin-ir neuronal profile area was increased in the WT colitis 24 h group compared to the WT sham 24 h group(312.60±7.85 vs 278.41±6.65,P<0.05),and the nuclear profile area was decreased in the WT colitis 4 d group compared to the WT sham 4 d group(104.63±2.49 vs 117.41±1.14,P<0.01).The number of

关键词： Cell death Enteric nervous system Gastroenterology Inflammatory bowel diseases P2X7 receptor Purinergic signaling

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Modeled Surface Observations for Spatial Analysis of Landscape Dynamics

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Journal of Geographic Information System 2013年第4期5卷 409-417页

作者： Manoel do Couto Fernandes Tata Lacale Canal dos Santos Pedro henrique ferreira Coura paulo Marcio Leal de Menezes Alan Jose Salomao Graca Department of Geography Federal University of Rio de JaneiroRio de JaneiroBrazil

Landscape dynamics is a geoecological characteristic that defines changes in a landscape spatial structure and function during an established time scale. In this kind of analysis, geoprocessing is an essential tool, because it combines several technologies that help in this work. However, the majority of landscape dynamic investigations do not consider the dimensionality of the data and the information to be used, which is projected not measured from modeled (real) surface observations, and presents underestimated results, mainly in irregular relief landscapes. Considering that, this paper intends to assess the difference between observations on modeled and planimetric surfaces on the interpretation of landscape dynamics. The study was conducted in the massif of Tijuca, Rio de Janeiro (Brazil) using land use and soil cover maps of different times and a digital elevation models (DEM) generated based on a triangular irregular. The results show an increase of dynamic areas values when observations were carried out on modeled surface, as well as the deforestation rate (17.57% or 0.13 km2/year). This survey showed higher values in comparison with observations on planimetric surface, characterizing more realistic interpretations of how the structural elements and analyses made from these are structured in the landscape.

关键词： DEM Modeled Surface Landscape Change

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Cultivation of Perennial Herbaceous Legumes in Weed Management in Coffee Plantation on the Cerrado

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Journal of Agricultural Science and Technology(B) 2013年第6期3卷 420-428页

作者： Julio Cesar Freitas Santos Aquiles Junior da Cunha Francisco Affonso ferreira Ricardo henrique Silva Santos Ney Sussumu Sakiyama paulo Cesar de Lima Brazilian Agricultural Research Corporation-Embrapa Brasilia Distrito Federal 70770-901 Brazil Agronomy Academical Center of the Cerrado-Patroclnio Patroclnio Minas Gerais 38740-000 Brazil Department of Crop Science Universidade Federal de Vigosa Vicosa Minas Gerais 36571-000 Brazil Minas Gerais Agricultural Research Corporation-Epamig Vigosa Minas Gerais 36571-000 Brazil

The aim of this study was to evaluate the cultivation of perennial herbaceous legumes on weed control and yield of the coffee crop in the Cerrado. The experimental design was a randomized complete block with four replications. The 10 treatments tested in factorial 4 × 2 ＋ 2, were four legumes： forage peanut （Arachis pintoi）, hybrid Java （Macrotyloma axillare）, perennial soybean （Neonotonia wightii） and wild ground nut （Calopogonium mucunoides）; two forms in the interrows of coffee plants with two and three rows of legumes spaced by 0.50 m and 0.25 m, respectively; and two additional treatments consisted of hand weeding with hoe and chemical control with glyphosate. The hybrid Java and wild ground nut in the first year and the hybrid Java and perennial soybean in the second year, all followed by forage peanut, promoted lower density and biomass of the weeds. The wild ground nut in the first year and forage peanut in the second year showed higher soil cover. The hybrid Java had its highest biomass production in two years, and wild ground nut being higher in the first year. The cultivation of perennial herbaceous legumes promoted weed control without interfering in the productivity of the coffee crop.

关键词： Legumes intercropping soil cover weed control coffee crop weed management.

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Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

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Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz henrique Medeiros Geraldo Tania Cristina Leite de Sampaio Spohr Rackele ferreira do Amaral Anna Carolina Carvalho da Fonseca Celina Garcia Fabio de Almeida Mendes Catarina Freitas Marcos Fabio dosSantos Flavia Regina Souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro paulo Niemeyer-Secretaria de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

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