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In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds

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Bio-Design and Manufacturing 2024年第5期7卷 651-669页

作者： Yanhao hou Weiguang Wang paulo Bartolo school of Engineering Faculty of Science and EngineeringThe University of ManchesterManchesterUK singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingaporeSingapore

Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the *** to the intrinsic limitations of PCL,carbon nanomaterials are often investigated to reinforce the PCL *** several studies that have been conducted on carbon nanomaterials,such as graphene(G)and graphene oxide(GO),certain challenges remain in terms of the precise design of the biological and nonbiological properties of the *** paper addresses this limitation by investigating both the nonbiological(element composition,surface,degradation,and thermal and mechanical properties)and biological characteristics of carbon nanomaterial-reinforced PCL scaffolds for bone tissue engineering *** showed that the incorporation of G and GO increased surface properties(reduced modulus and wettability),material crystallinity,crystallization temperature,and degradation ***,the variations in compressive modulus,strength,surface hardness,and cell metabolic activity strongly depended on the type of ***,a series of phenomenological models were developed based on experimental results to describe the variations of scaffold’s weight,fiber diameter,porosity,and mechanical properties as functions of degradation time and carbon nanomaterial *** results presented in this paper enable the design of three-dimensional(3D)bone scaffolds with tuned properties by adjusting the type and concentration of different functional fillers.

关键词： Additive manufacturing Bone tissue engineering Carbon nanomaterial Graphene Graphene oxide scaffold

Evaluation of large language models for the classification of medical device software

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Bio-Design and Manufacturing 2024年第5期7卷 819-822页

作者： Yu han Aaron Ceross Florence Bourgeois paulo savaget Jeroen h.M.Bergmann Department of Engineering science University of OxfordOld Road CampusOxford OX37QDUK harvard-MIT Center for Regulatory science Harvard Medical SchoolBostonMAUSA Computational health Informatics Program(ChIP) Boston Children’s HospitalBostonMAUSA Department of Technology and Innovation The University of Southern DenmarkOdenseDenmark

Amidst the rapidly expanding integration of large language models(LLMs)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

Temporal and spatial differences in human activities performed in Urban Green spaces of Vilnius(Lithuania)

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Geography and sustainability 2024年第2期5卷 302-317页

作者： Luís Valença Pinto Carla sofia santos Ferreira paulo Pereira Research Centre for Natural Resources Environment and society(CERNAs) Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Polytechnic Institute of Coimbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urban green spaces(UGs)are relevant to city well-being,as recognized by the United Nations’sustainable Development Goals(sDGs).however,few studies have studied the temporal use of *** work assessed the seasonal,weekly,and daily use of three urban green spaces(Vingis Park,Bernardino Garden,and Jomantas Park)in Vilnius(Lithuania).The study is based on an on-site observation-based survey,which recorded users’characteristics,activities,and weather conditions during summer and *** results showed that UGs’s seasonal,weekly,and daily use differed according to park and users’*** with a higher diversity of facilities had a high seasonal difference in the number of observed *** numbers were higher in the summer for activities with children,social activities,sports,and water activities than in the *** Park had the lowest variability in user *** variables were linked to changes in users’*** precipitation and lower temperature were associated with reducing the number of users and the diversity of registered *** of the stationary activities were observed during *** diversity of the observed activities was associated with the available facilities rather than the park *** distribution of stationary activities was spatially correlated with facility/equipment(benches,playgrounds,sports,and fitness equipment)and proximity to water *** results of this study are relevant for UGs design,planning,and management.

关键词： Urban parks seasonal differences Temporal use Time of day spatial distribution of UGs users

Investigation and optimization of high-valent Ta-doped srFeO_(3-δ)as air electrode for intermediate-temperature solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2102-2109页

作者： shanshan Jiang hao Qiu shaohua Xu Xiaomin Xu Jingjing Jiang Beibei Xiao paulo sérgio Barros Juliao) Chao su Daifen Chen Wei Zhou school of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China WA school of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerth WA6102Australia Institute of Analysis and Testing Beijing Academy of Science and TechnologyBeijing 100089China state Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

To explore highly active and thermomechanical stable air electrodes for intermediate-temperature solid oxide fuel cells(ITsOFCs),10mol%Ta5+doped in the B site of strontium ferrite perovskite oxide(srTa_(0.1)Fe_(0.9)O_(3-δ),sTF)is investigated and *** effects of Ta^(5+)doping on structure,transition metal reduction,oxygen nonstoichiometry,thermal expansion,and electrical performance are evaluated *** 10mol%Ta^(5+)doping,the thermal expansion coefficient(TEC)decreased from 34.1×10^(-6)(srFeO_(3-δ))to 14.6×10^(-6) K^(-1)(sTF),which is near the TEC of electrolyte(13.3×10^(-6) K^(-1) for sm_(0.2)Ce_(0.8)O_(1.9),sDC),indicates excellent thermomechanical *** 550-750℃,sTF shows superior oxygen vacancy concentrations(0.262 to 0.331),which is critical in the oxygen-reduction reaction(ORR).Oxygen temperature-programmed desorption(O_(2)-TPD)indicated the thermal reduction onset temperature of iron ion is around 420℃,which matched well with the inflection points on the thermos-gravimetric analysis and electrical conductivity *** 600℃,the sTF electrode shows area-specific resistance(AsR)of 0.152Ω·cm^(2) and peak power density(PPD)of 749 mW·cm^(-2).ORR activity of sTF was further improved by introducing 30wt%sm_(0.2)Ce_(0.8)O_(1.9)(sDC)powder,sTF+sDC composite cathode achieving outstanding AsR value of 0.115Ω·cm2 at 600℃,even comparable with benchmark cobalt-containing cathode,Ba_(0.5)sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)(BsCF).Distribution of relaxation time(DRT)analysis revealed that the oxygen surface exchange and bulk diffusion were improved by forming a composite *** 650℃,sTF+sDC composite cathode achieving an outstanding PPD of 1117 mW·cm^(-2).The excellent results suggest that sTF and sTF+sDC are promising air electrodes for IT-sOFCs.

关键词： strontium ferrite-based perovskite Ta doping composite cathode intermediate-temperature solid oxide fuel cells

Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第3期22卷 235-244页

作者： Miguel Faria Mónica Teixeira Maria João Pinto paulo sargento Núcleo de Investigação em Ciências e Tecnologias da saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica são João de Deus 1700-048 LisboaPortugal REQUIMTE/LAQV(Rede de Química e Tecnologia/Laboratório Associado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal hospital sOERAD 2560-312 Torres VedrasPortugal Centro de Estudos Avançados em Direito“Francisco suarez ”1749-024 LisboaPortugal

Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in *** is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological ***:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer *** strategy:six electronic databases(PubMed,EBsCO,Cochrane Library,scielo,b-On and scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022using Mesh terms such as“acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analgesia,”“oncological pain,”and“cancer pain.”Inclusion criteria:studies included were randomized controlled trials(RCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual *** extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was *** primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain *** outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic *** were expressed as standardized mean difference(sMD)with 95%confidence interval(CI).Results:sixteen RCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of *** was more effective in reducing pain than no treatment(sMD=–0.90,95%CI[–1.68,–0.12]),sham acupuncture(sMD=–1.10,95%CI[–1.59,–0.61])or usual care(sMD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with *** some limitations due to the low quality and small sample size of some included st

关键词： Acupuncture Cancer pain Meta-analysis systematic review

Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye school of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore school of Pharmacy and Biomedical sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

Annual variation of adult survival of a south-temperate house Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： Gustavo J.Fernandez Mariana E.Carro paulo E.Llambías Grupo de Investigacion en Ecofisiología de Fauna silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of house Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern house Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJs Density-dependence survival Troglodytes aedon bonariae

Accuracy Enhancement of the Folin-Ciocalteu Method for Propolis

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American Journal of Analytical Chemistry 2024年第8期15卷 253-267页

作者： Rosilene s. N. Paganotti paulo J. s. Barbeira Instituto Federal de Educao Cincia e Tecnologia de Minas GeraisCampus Formiga Formiga MG Brazil Departamento de Qumica Instituto de Cincias Exatas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil

This study presents an optimization of the Folin-Ciocalteu spectrophotometric method for the determination of total phenol content. Multivariate optimization using factorial planning 22 with a central point and central composite planning was constructed to evaluate the influence of variables in the process and maximize radiation absorption with minimal radiation scattering caused by solid formation. X-ray fluorescence and X-ray diffraction spectrometry were used to evaluate the chemical composition of solids formed and nephelometric and spectrophotometric studies were also used to evaluate whether the type, origin, dilution and dry extract contents of commercial propolis extracts would significantly influence the increase in radiation scattering and absorption. The optimized methodology added several advantages, such as reduction of reagents, time analysis, and higher accuracy.

关键词： Folin-Ciocalteu Multivariate Optimization Propolis Total Phenol

Benchmarks for Pirá2.0,a Reading Comprehension Dataset about the Ocean,the Brazilian Coast,and Climate Change

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Data Intelligence 2024年第1期6卷 29-63页

作者： paulo Pirozelli Marcos M.José Igor silveira Flávio Nakasato sarajane M.Peres Anarosa A.F.Brandão Anna h.R.Costa Fabio G.Cozman Universidade de são paulo Ringgold standard Institution-Instituto de Estudos Avançados Av.370 São Paulo 05508-900Brazil Universidade de são paulo Ringgold standard Institution-Instituto de Matemática e Estatística Av.370 São Paulo 05508-900Brazil Universidade de são paulo Rua Cayowaá876 apto 141SÃO PAULO 05018-001Brazil Universidade de são paulo Ringgold standard Institution Escola Politécnica Av.370São Paulo 05508-900Brazil.

Piráis a reading comprehension dataset focused on the ocean,the Brazilian coast,and climate change,built from a collection of scientific abstracts and reports on these *** dataset represents a versatile language resource,particularly useful for testing the ability of current machine learning models to acquire expert scientific *** its potential,a detailed set of baselines has not yet been developed for Pirá.By creating these baselines,researchers can more easily utilize Piráas a resource for testing machine learning models across a wide range of question answering *** this paper,we define six benchmarks over the Pirádataset,covering closed generative question answering,machine reading comprehension,information retrieval,open question answering,answer triggering,and multiple choice question *** part of this effort,we have also produced a curated version of the original dataset,where we fixed a number of grammar issues,repetitions,and other ***,the dataset has been extended in several new directions,so as to face the aforementioned benchmarks:translation of supporting texts from English into Portuguese,classification labels for answerability,automatic paraphrases of questions and answers,and multiple choice *** results described in this paper provide several points of reference for researchers interested in exploring the challenges provided by the Pirádataset.

关键词： Natural language processing Question answering Benchmarks Language resource DomainOriented dataset scientific knowledge text dataset