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Reversible hydrogenation restores defected graphene to graphene

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Science China Chem.stry 2021年第6期64卷 1047-1056页

作者： Lin Jiang pauline m.van Deursen Hadi Arjm.ndi-Tash Liubov ABelyaeva Haoyuan Qi Jiao He Vincent Kofm.n Longfei Wu Valery m.ravev Ute Kaiser Harold Linnartz Em.el Jm.ensen Jan PHofm.nn Grégory FSchneider Leiden Institute of Chem.stry Leiden UniversityEinsteinweg 552333CC LeidenThe Netherlands Central Facility for Electron m.croscopy Electron Microscopy Group of Materials ScienceUlm UniversityAlbert-Einstein-Allee 11Ulm 89081Germany Laboratory for Astrophysics Leiden ObservatoryLeiden UniversityNiels Bohrweg 22333 CA LeidenThe Netherlands Laboratory for Inorganic m.terials and Catalysis Department of Chemical Engineering and ChemistryEindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands Center for Advancing Electronics Dresden(cfaed)and Faculty of Chem.stry and Food Chem.stry Technical University of Dresden010069 DresdenGermany

Graphene as a two-dim.nsional m.terial is prone to hydrocarbon contam.nations,which can significantly alter its intrinsic electrical ***,we im.lem.nt a facile hydrogenation-dehydrogenation strategy to rem.ve hydrocarbon contam.nations and preserve the excellent transport properties of m.nolayer *** electron m.croscopy we quantitatively characterized the im.roved cleanness of hydrogenated graphene com.ared to untreated *** situ spectroscopic investigations revealed that the hydrogenation treatm.nt prom.ted the adsorption of water at the graphene surface,resulting in a protective layer against the re-deposition of hydrocarbon ***,the further dehydrogenation of hydrogenated graphene rendered a m.re pristine-like basal plane with im.roved carrier m.bility com.ared to untreated pristine *** findings provide a practical post-growth cleaning protocol for graphene with m.intained surface cleanness and lattice integrity to system.tically carry a range of surface chem.stry in the form.of a well-perform.ng and reproducible transistor.

关键词： graphene reversible hydrogenation surface cleanness in situ spectroscopy transistors

Why Doctors Order So m.ny Tests

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英语学习 2012年第8期 10-12页

作者： pauline W. Chen

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INVENTING Am.RICA 1

Antibacterial activity of Leptogium.cochleatum.and Leptogium.m.luccanum

2003年

作者： pauline m.IER

Includes bibliographical references and index.

ISBN: (数字)0393974359

ISBN: (纸本)0393974359

Includes bibliographical references and index.

关键词： United StatesHistory.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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Studies in Fungi 2022年第1期7卷 139-142页

作者： Andrea pauline B.m.nlapaz m.tzi I.m.riano Odessa Rona m.Reyes Laureena C.Rodriguez Jaycee Augusto G.Paguirigan Departm.nt of Biological Sciences College of ScienceUniversity of Santo TomasManila 1008Philippines Korean Lichen Research Institute Sunchon National University255 Jungang-roSuncheon-siJeollanam-do 57922South Korea

Currently there is an increase in the em.rgence and re-em.rgence of bacterial infections,and lichens are potential sources of pharm.ceutically im.ortant secondary m.tabolites to halt this *** are unique plant-like organism. which are relatively less explored in the ***,lichen extracts of Leptogium.cochleatum.and Leptogium.m.luccanum.were tested against Escherichia coli,Enterobacter agglom.rans,Klebsiella pneum.niae,Pseudom.nas aeruginosa,and Staphylococcus aureus using paper disk diffusion *** extract of *** led to a 17.14 m. zone of inhibition(ZOI)against ***,while hexane extract of *** led to a 15.28 m. ZOI against *** extracts of *** exhibited a ZOI of 15.86 m. against *** and 14.84 m. ZOI against *** bioactivities exhibited by the lichen extracts m.y be due to the secondary m.tabolites detected using thin layer ***,lichen-derived bioactive com.ounds hold great prom.se for pharm.ceutical applications for the benefit of hum.n life.

关键词： Lep tum benefit

Juvenile ferric iron prevents m.crobiota dysbiosis and colitis in adult rodents

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World Journal of Gastroenterology 2012年第21期18卷 2619-2629页

作者： Chourouk Ettreiki Pascale Gadonna-Widehem.Irène m.ngin m.se Coёffier Carine Delayre-Orthez pauline m.Anton Egeal Unit LaSalle Beauvais Polytechnic Institute60026 Beauvais France Biology Lab National Conservatory of Arts and Crafts75003 Paris France INSERm.Um. 1073 School of Medicine Rouen University76183 Rouen France

AIm. To assess whether juvenile chronic ferric iron ingestion lim.t colitis and dysbiosis at adulthood in rats and m.ce. m.THODS: Two sets of experim.nts were designed. In the first set, recently weaned m.ce were either orally adm.nistered ferrous (Fe2+) iron salt or ferric (Fe3+) m.croencapsulated iron for 6 wk. The last week of experim.nts trinitrobenzene sulfonic acid (TNBS) colitis was induced. In the second set, juvenile rats received the m.croencapsulated ferric iron for 6 wk and were also subm.tted to TNBS colitis during the last week of experim.nts. In both sets of experim.nts, anim.ls were sacrificed 7 d after TNBS instillation. Severity of the inflam.ation was assessed by scoring m.croscopic lesions and quantifying colonic m.eloperoxidase (m.O) activity. Alteration of the m.croflora profile was estim.ted usingquantitative polym.rase chain reaction (qPCR) by m.asuring the evolution of total caecal m.croflora, Bacteroidetes, Firm.cutes and enterobacteria. RESULTS: Neither ferrous nor ferric iron daily exposures at the juvenile period result in any effect in control anim.ls at adulthood although ferrous iron repeated adm.nistration in infancy lim.ted weight gain. Ferrous iron was unable to lim.t the experim.ntal colitis (1.71 ± 0.27 m.O U/m. proteinvs 2.47 ± 0.22 m.O U/m. protein in colitic m.ce). In contrast, ferric iron significantly prevented the increase of m.O activity (1.64 ± 0.14 m.O U/m. protein) in TNBS-induced colitis. m.reover, this positive effect was observed at both the doses of ferric iron used (75 and 150 m./kg per day po - 6 wk). In the study we also com.ared, in both rats and m.ce, the consequences of chronic repeated low level exposure to ferric iron (75 m./kg per day po - 6 wk) on TNBS-induced colitis and its related dysbiosis. We confirm.d that ferric iron lim.ted the TNBS-induced increase of m.O activity in both the rodent species. Furtherm.re, we assessed the ferric iron incidence on TNBS-induced intestinal m.crobiota dysbiosis. At firs

关键词： Chronic ferric iron supplem.ntation Experim.ntal colitis m.croflora dysbiosis Rat m.ce

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美英知识产权纠纷中的定损评估评介

电子知识产权 2015年第4期 72-76页

作者： pauline m. Booth Dr. m.chael :Salve

知识产权纠纷的损失评估可能会非常复杂。许多在法庭上辩称过、已裁定的案例中,一些突出的问题给我们提供了今后赔偿计算和案例所在司法辖区的认可解决方式的依据。文本总结了不同知识产权纠纷的种类及每种纠纷的损失赔偿金类型1。通过... 详细信息

知识产权纠纷的损失评估可能会非常复杂。许多在法庭上辩称过、已裁定的案例中,一些突出的问题给我们提供了今后赔偿计算和案例所在司法辖区的认可解决方式的依据。文本总结了不同知识产权纠纷的种类及每种纠纷的损失赔偿金类型1。通过美国和英国的重要案例,详细解释每种类型的赔偿金的计算方法,以及被告利润与合理的许可使用费这两种损失赔偿金的计算方法。

关键词：赔偿版税专利商标商业秘密

Anti-em.tic potential of tachykinin NK1 receptor antagonists

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Acta Pharm.cologica Sinica 1999年第7期 96-96页

作者： J A rudd,m.P NGAN,m.K WAI Departm.nt of Pharm.cology Faculty of m.dicine The Chinese Univervity of Hong Kong Shatin N T Hong Kong China Departm.nt of Pharm.cology Faculty of m.dicine The Chinese Univervity of Hong Kong Shatin N T Hong Kong China Departm.nt of Pharm.cology Faculty of m.dicine The Chinese Univervity of Hong Kong Shatin N T Hong Kong China

AIm. Evidence has accum.lated to indicate the im.ortance ofsubstance P in the em.tic reflex. The present investigations weredesigned to charaterize tachykinin NK1receptors in the em.ticreflex of Suncus m.rinus. m.THODS: Several antagonistswere assessed for a potential to inhibit nicotine (5 m.·kg-1,sc)-, copper sulphate pentahydrate (120 m.·kg-1ig)-, andm.tion （4 cm.lateral displacem.nt at 1 Hz）-induced ***: CP 122 721, CP-99 994,RP 67 580, and FK 888

关键词： CP RP Anti-em.tic potential of tachykinin NK1 receptor antagonists NK

Long-term.stability of gentam.cin sulfate-ethylenediam.netetraacetic acid disodium.salt (EDTA-Na_2) solution for catheter locks

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Journal of Pharm.ceutical Analysis 2018年第6期8卷 386-393页

作者： Anne-Sophie Fiolet Elise Jandot pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-m.rc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot Service Pharm.ceutique Plateforme FRIPHARM Groupe Hospitalier Centre Edouard Herriot Hospices Civils de Lyon Unité de Génétique des Biofilm. Département de Microbiologie Institut Pasteur Service de m.crobiologie Unité Mobile de Microbiologie Clinique Assistance Publique-H?pitaux de Paris H?pital Européen Georges Pompidou Université Paris Descartes 12 rue de l'Ecole de Médecine Laboratoire de Recherche et Développem.nt de Pharm.cie Galénique Industrielle UMR 5305 Plateforme FRIPHARMF-69373 Faculté de Pharmacie Université Claude Bernard Lyon 1 8 avenue Rockefeller

A lock solution com.osed of gentam.cin sulfate(5 m./m.) and ethylenediam.netetraacetic acid disodium.salt(EDTA-Na2, 30 m./m.) could fully eradicate in vivo bacterial biofilm. in totally im.lantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antim.crobial lock solution(ALS) were detailed and com.leted by a stability study. Stability of ALS was conducted for12 m.nths in vial(25 °C 7 2 °C, 60% 7 5% relative hum.dity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for sim.ltaneous quantification of gentam.cin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high perform.nce liquid chrom.tography(HPLC) needing gentam.cin derivatization, EDTA-Na2 m.tallocom.lexation of sam.les and gradient m.bile phase. HPLC m.thods to separate four gentam.cin com.onents and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirm.d by bacterial endotoxins and sterility tests. Physicochem.cal stability of ALS was determ.ned by visual inspection, osm.lality, pH, and sub-visible particle counting. Results confirm.d that the stability of ALS in vials was m.intained for 12 m.nths and 24 h and 72 h in TIVAP.

关键词： Gentam.cin-EDTA-Na2 loaded antim.crobial lock solution Pharm.ceutical com.ounding Stability indicating HPLC assay m.thod Totally im.lantable venous access ports

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohum.ralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： m.lissa L.Starkie Elizabeth V.Fowler Alexander m.Piper Xiaocheng Zhu pauline Wyatt David Gopurenko m.tt N.Krosch Francesca Strutt Karen F.Arm.trong Ham.sh Patrick m.rk K.Schutze m.rk J.Blacket Departm.nt of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Departm.nt of Prim.ry Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Departm.nt of Pest-m.nagem.nt and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohum.ralis are m.rphologically sim.lar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessm.nt,m.nagem.nt,biosecurity,and m.intenance of reference *** m.rphologically sim.lar,adults m.y be separated based on subtle characters;however,som. characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single m.lecular m.rker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,am.iguous sam.les rem.in *** we report the first m.lecular m.rker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polym.rphism.(SNPs)within the pangolin(pan)gene *** confirm.d the genotypes of each species are consistent across their distributional range,then developed a tetra-prim.r am.lification refractory m.tation system.ARm.)PCR assay for rapid diagnosis of the *** assay utilizes four prim.rs in m.ltiplex,with two outer universal prim.rs,and two internal prim.rs:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discrim.nates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is m.st suited to adult diagnostics where species confirm.tion is necessary in determ.ning am.iguous surveillance trap catches;m.intaining pure colony lines;and in Sterile Insect Technique m.nagem.nt responses.

关键词： ARm.-PCR colony m.lecular diagnostics pangolin tetra-prim.r