Anti-emetic potential of tachykinin NK1 receptor antagonists

作     者：J A RUDD,M P NGAN,M K WAI 

作者机构：Department of Pharmacology Faculty of Medicine The Chinese Univervity of Hong Kong Shatin N T Hong Kong China Department of Pharmacology Faculty of Medicine The Chinese Univervity of Hong Kong Shatin N T Hong Kong China Department of Pharmacology Faculty of Medicine The Chinese Univervity of Hong Kong Shatin N T Hong Kong China 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：1999年第7期

页      面：96-96页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：CP RP Anti-emetic potential of tachykinin NK1 receptor antagonists NK 

摘      要：AIM: Evidence has accumulated to indicate the importance ofsubstance P in the emetic reflex. The present investigations weredesigned to charaterize tachykinin NK1receptors in the emeticreflex of Suncus murinus. METHODS: Several antagonistswere assessed for a potential to inhibit nicotine (5 mg·kg-1,sc)-, copper sulphate pentahydrate (120 mg·kg-1ig)-, andmotion （4 cm lateral displacement at 1 Hz）-induced ***: CP 122 721, CP-99 994,RP 67 580, and FK 888