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Correlating the global increase in type 1 diabetes incidence across age groups with national economic prosperity: A systematic review

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World Journal of Diabetes 2019年第12期10卷 560-580页

作者： Natalia Gomez-Lopera Nicolas Pineda-Trujillo paula Andrea Diaz-Valencia Grupo Mapeo Genetico Departamento de PediatríaFacultad de MedicinaUniversidad de AntioquiaMedellín 050010470Colombia Epidemiology Group.School of Public Health.Universidad de Antioquia Medellín 050010470Colombia

BACKGROUND The global epidemiology of type 1 diabetes(T1D)is not yet well known,as no precise data are available from many countries.T1D is,however,characterized by an important variation in incidences among countries and a dramatic increase of these incidences during the last decades,predominantly in younger *** the United States and Europe,the increase has been associated with the gross domestic product(GDP)per *** our previous systematic review,geographical variation of incidence was correlated with socio-economic *** To investigate variation in the incidence of T1D in age categories and search to what extent these variations correlated with the GDP per *** A systematic review was performed to retrieve information about the global incidence of T1D among those younger than 14 years of *** study was carried out according to the PRISMA *** the analysis,the incidence was organized in the periods:1975-1999 and *** searched the incidence of T1D in the age-groups 0-4,5-9 and *** compared the incidences in countries for which information was available for the two *** obtained the GDP from the World *** analysed the relationship between the incidence of T1D with the GDP in countries reporting data at the national *** We retrieved information for 84 out of 194 countries around the *** found a wide geographic variation in the incidence of T1D and a worldwide increase during the two *** largest contribution to this increase was observed in the youngest group of children with T1D,with a relative increase of almost double when comparing the two periods(P value=2.5×e-5).Twenty-six countries had information on the incidence of T1D at the national level for the two *** was a positive correlation between GDP and the incidence of T1D in both periods(Spearman correlation=0.52 from 1975-1999 and Spearman correlation=0.53 from 2000-2017).CONCLUSION The incidence increase was

关键词： Type 1 diabetes Incidence Children Age categories Gross domestic product per capita

Agmatine as a novel candidate for rapid-onset antidepressant response

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World Journal of Psychiatry 2021年第11期11卷 981-996页

作者： Ana paula Valverde Anderson Camargo Ana Lúcia S Rodrigues Department of Biochemistry Campus UniversitárioCenter for Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSC 88040900Brazil

Major depressive disorder(MDD)is a disabling and highly prevalent mood disorder as well as a common cause of *** stress,inflammation,and intestinal dysbiosis have all been shown to play crucial roles in the pathophysiology of *** conventional antidepressants are widely used in the clinic,they can take weeks to months to produce therapeutic *** discovery that ketamine promotes fast and sustaining antidepressant responses is one of the most important breakthroughs in the pharmacotherapy of ***,the adverse psychomimetic/dissociative and neurotoxic effects of ketamine discourage its chronic ***,agmatine,an endogenous glutamatergic modulator,has been postulated to elicit fast behavioral and synaptogenic effects by stimulating the mechanistic target of rapamycin complex 1 signaling pathway,similar to ***,recent evidence has demonstrated that the modulation of the NLR family pyrin domain containing 3 inflammasome and gut microbiota,which have been shown to play a crucial role in the pathophysiology of MDD,may also participate in the antidepressant-like effects of both ketamine and *** review seeks to provide evidence about the mechanisms that may underlie the fast antidepressant-like responses of agmatine in preclinical *** the anti-inflammatory properties of agmatine,it may also be further investigated as a useful compound for the management of MDD associated with a pro-inflammatory ***,the fast antidepressant-like response of agmatine noted in animal models should be investigated in clinical studies.

关键词： Agmatine Fast-acting antidepressants Ketamine Major depressive disorder Microbiota-gut-brain axis Neuroinflammation

Comparative stability analyses of traditional and selective room-and-pillar mining techniques for sub-horizontal tungsten veins

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 1-8页

作者： Vidal Felix Navarro Torres Carlos Dinis da Gama Matilde Costa e Silva paula Falcao Neves Qiang Xie Mining and Geo-resources Engineering Department of IST Technical University of Lisbon 1049-001 Portugal Faculty of Civil Engineering Chongqing University Chongqing 400045 China

The stability and productivity concerning a modification on the traditional room and pillar for a new selective technique at the Portuguese Panasqueira Mine have been *** traditional room-and-pillar stoping uses 5.0-m wide rooms with 3.0 m×3.0 m pillars,while the selective room-and-pillar mining technique consists in stoping with rooms of 4.0 m wide and pillars of 4 m×4 m with a subsequent selective cutting of the quartz veins at the mid pillar of approximately 0.5 m high,to obtain a pillar section with an area of 3.0 m×3.0 *** stability and productivity analyses indicate that the selective technique obtains smaller average pillar safety factor,more rock mass displacement,more extraction and selectivity ratios,and ore grade improvement,compared with the traditional *** results show that the selective technique is also more *** proposed selective room-and-pillar mining technique is applicable to any sub-horizontal narrow quartz veins with wolfram,gold,*** as the famous La Rinconada gold mine in the Peruvian Andes.

关键词： mines and mining tungsten deposits productivity stability stoping

Structured PDMS Chambers for Enhanced Human Neuronal Cell Activity on MEA Platforms

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Journal of Bionic Engineering 2012年第1期9卷 1-10页

作者： Joose Kreutzer Laura Yla-Outinen paula Karna Tiina Kaarela Jarno Mikkonen Heli Skottman Susanna Narkilahti Pasi KaUio Department of Automation Science and Engineering Tampere University of Technology Korkeakoulunkatu 3 33720 Tampere Finland BioMediTech Biokatu 10 33520 Tampere Finland NeuroGroup Institute of Biomedical Technology University of Tampere Biokatu 12 33520 Tampere Finland The Science Center of Pirkanmaa Hospital District Biokatu 12 33521 Tampere Finland Department of Psychology University of Jyvdskyld Ylistonmgientie 33 40500 Jyvdskyla Finland

Structured poly（dimethylsiloxane）（PDMS） chambers were designed and fabricated to enhance the signaling of human Embryonic Stem Cell （hESC） - derived neuronal networks on Microelectrode Array （MEA） platforms. The structured PDMS chambers enable cell seeding on restricted areas and thus, reduce the amount of needed coating materials and cells. In addition, the neuronal cells formed spontaneously active networks faster in the structured PDMS chambers than that in control chambers. In the PDMS chambers, the neuronal networks were more active and able to develop their signaling into organized signal trains faster than control cultures. The PDMS chamber design enables much more repeatable analysis and rapid growth of functional neuronal network in vitro. Moreover, due to its easy and cheap fabrication process, new configurations can be easily fabricated based on investigator requirements.

关键词： cell culturing electrical activity human embryonic stem cells microelectrode array poly(dimethylsiloxane)

Prediction of sorption enhanced steam methane reforming products from machine learning based soft-sensor models

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Energy and AI 2020年第2期2卷 157-166页

作者： paula Nkulikiyinka Yongliang Yan Fatih Gülec Vasilije Manovic Peter T.Clough Energy and Power Theme School of WaterEnergy and EnvironmentCranfield UniversityCranfieldBedfordshireMK430ALUK Advanced Materials Research Group Faculty of EngineeringUniversity of NottinghamNottinghamNG72RDUK

Carbon dioxide-abated hydrogen can be synthesised via various processes,one of which is sorption enhanced steam methane reforming(SE-SMR),which produces separated streams of high purity H_(2) and CO_(2).Properties of hydrogen and the sorbent material hinder the ability to rapidly upscale SE-SMR,therefore the use of artificial intelligence models is useful in order to assist scale *** of a data driven soft-sensor model over ther-modynamic simulations,is the ability to obtain real time information dependent on actual process *** this study,two soft sensor models have been developed and used to predict and estimate variables that would otherwise be difficult direct *** artificial neural networks and the random forest models were devel-oped as soft sensor prediction *** were shown to provide good predictions for gas concentrations in the reformer and regenerator reactors of the SE-SMR process using temperature,pressure,steam to carbon ratio and sorbent to carbon ratio as input process *** models were very accurate with high R^(2) values,all above 98%.However,the random forest model was more precise in the predictions,with consistently higher R^(2) values and lower mean absolute error(0.002-0.014)compared to the neural network model(0.005-0.024).

关键词： Machine learning Artificial neural network Soft sensor Sorption enhanced steam methane reforming Calcium looping

Combining European Earth Observation products with Dynamic Global Vegetation Models for estimating Essential Biodiversity Variables

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International Journal of Digital Earth 2020年第2期13卷 262-277页

作者： Mateus Dantas de paula Marta Gómez Giménez Aidin Niamir Martin Thurner Thomas Hickler Biodiversity and Climate Research Centre(BiK-F) Senckenberg Gesellschaft für NaturforschungFrankfurt am MainGermany Department of Ecological Modelling UFZ—Helmholtz Centre for Environmental Research LeipzigGermany

Global,fast and accessible monitoring of biodiversity is one of the main pillars of the efforts undertaken in order to revert it *** Group on Earth Observations Biodiversity Observation Network(GEO-BON)provided an expert-based definition of the biological properties that should be monitored,the Essential Biodiversity Variables(EBVs).Initiatives to provide indicators for EBVs rely on global,freely available remote sensing(RS)products in combination with empirical models and field data,and are invaluable for decision *** this study,we provide alternatives for the expansion and improvement of the EBV indicators,by suggesting current and future data from the European Space Agencýs COPERNICUS and explore the potential of RS-integrated Dynamic Global Vegetation Models(DGVMs)for the estimation of *** review found that mainly due to the inclusion of the Sentinel constellation,Copernicus products have similar or superior potential for EBV indicator estimation in relation to their NASA *** simulate the ecosystem level EBVs(ecosystem function and structure),and when integrated with remote sensing data have great potential to not only offer improved estimation of current states but to provide projection of ecosystem *** suggest that focus on producing EBV relevant outputs should be a priority within the research community,to support biodiversity preservation efforts.

关键词： Dynamic Global Vegetation Modelling remote sensing ecosystem dynamics Copernicus Programme Essential Biodiversity Variables

Low-ionization galaxies and evolution in a pilot survey up to z=1

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Research in Astronomy and Astrophysics 2011年第3期11卷 245-270页

作者： Edmond Giraud Qiu-Sheng Gu Jorge Melnick Hernan Quintana Fernando Selman Ignacio Toledo paula Zelaya LPTA Universit6 Montpellier 2 - CNRS/IN2P3 34095 Montpellier France edmond.giraud@ lpta. in2p3.fr Department of Astronomy Nanjing University Nanjing 210093 China European Southern Observatory /klonso de Cbrdova 3107 Santiago Chile Department of Astronomy and Astrophysics R Universidad Catolica de Chile Casilla 306Santiago Chile

We present galactic spectroscopic data from a pencil beam of 10.75×7.5 centered on the X-ray cluster RXJ0054.0–2823 at z=*** study the spectral evolution of galaxies from z=1 down to the cluster redshift in a magnitude-limited sample at R≤23,for which the statistical properties of the sample are well *** divide emission-line galaxies into star-forming galaxies,Low Ionization Nuclear Emission line Regions（LINERs） ,and Seyferts by using emission-line ratios of[OII],Hβ,and[OIII],and derive stellar fractions from population synthesis models. We focus our analysis on absorption and low-ionization *** absorption-line galaxies,we recover the well-known result that these galaxies have had no detectable evolution since z～0.6-0.7,but we also find that in the range z=0.65-1,at least 50% of the stars in bright absorption systems are younger than 2.5 *** absorption-line galaxies in the cluster at z=0.29 also had significant star formation during the previous 2-3 Gyr,but their brighter counterparts seem to be only composed of old *** z～0.8,our dynamically young cluster had a truncated *** result seems to be consistent with a scenario where the final assembly of E/S0 took place at *** the volume-limited range 0.35≤z≤0.65,we find that 23% of the early-type galaxies have LINER-like spectra with Hβin absorption and have a significant component of A *** vast majority of LINERs in our sample have significant populations of young and intermediate-aged stars and are thus not related to AGNs,but to the population of‘retired galaxies’recently identified by Cid Fernandes et *** the Sloan Digital Sky Survey（SDSS） .Early-type LINERs with various fractions of A stars and E＋A galaxies appear to play an important role in the formation of the red sequence.

关键词： cosmology:observations—galaxies:evolution—large scale structures —evolution—RX J0054.0–2823

The best of both worlds:mastering nerve regeneration combining biological and nanotechnological tools

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Neural Regeneration Research 2023年第3期18卷 556-557页

作者： paula A.Soto Marcela B.Fernández van Raap C.Patricia Setton-Avruj Departamento de Química Biológica Cátedra de Química Biológica PatológicaUniversidad de Buenos AiresFacultad de Farmacia y BioquímicaInstituto de Química y Fisicoquímica Biológicas(IQUIFIB)Universidad de Buenos AiresBuenos AiresArgentina Departamento de Física Universidad Nacional de La Plata(UNLP)Facultad de Ciencias ExactasLa PlataArgentinaLaboratorio de BiotecnologíaUniversidad ORT UruguayMontevideoUruguay

Over the last decade,remarkable developments in nanotechnology have powered medical research,unveiling new approaches for the solution of public health issues such as the treatment of traumatic peripheral neuropathies.

关键词： traumatic technological treatment

Changes in microhabitat, but not allelopathy, affect plant establishment after Acacia dealbata invasion

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Journal of Plant Ecology 2017年第4期10卷 610-617页

作者： paula Lorenzo Jonatan Rodríguez Luís González Susana Rodríguez-Echeverría Centre for Functional Ecology(CFE) Department of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal Facultade de Bioloxía Departamento de Bioloxía Vexetal e Ciencia do SoloUniversidade de VigoAs Lagoas-Marcosende s/n36310PontevedraSpain

Aims The tree legume Acacia dealbata Link is an aggressive Australian invader that severely affects abiotic and biotic compartments of eco-systems *** invasive species outcompetes native plant communities through direct competition,changes in microhabitat and soil properties under the canopy and the release of allelopathic ***,these effects are usually studied separately and under controlled *** objective of this study was to evaluate the combined effect of these modifications exerted by *** on the establishment of native and invasive species in the *** A full factorial experiment was performed in order to test the com-bined effect of microhabitat,soil type and allelopathy on the establish-ment of the invasive *** and three native species in the field(North-West Spain).We sowed seeds of native or invasive species in pots with different soil type(soil collected under *** or Pinus pinaster),allelopathy status(soil treated or untreated with activated car-bon)and microhabitat(under the canopy of *** or ***).The number and total biomass of established plants were evaluated after 8 *** abiotic properties were determined in all *** Findings The establishment of native and invasive species was signifi-cantly affected by the microhabitat,with a higher number of seedlings under the native forest(***).The establishment of *** seedlings was also significantly promoted by its own soil.A negligible effect of allelopathy was detected on the establishment and growth of both invasive and native *** conclude that(i)the main factor affecting seedling establish-ment was microhabitat rather than changes in soil properties or allelopathy,(ii)soil modifications by *** promote the establishment of its own seedlings,contributing to the progress of invasion and(iii)allelochemicals released by *** do not seem to play a key role for the establishment of native

关键词： plant invasion microhabitat soil changes allelopathy plant establishment