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Acta Pharmacologica Sinica 2006年第11期27卷 1509-1514页

作者： Wei-jia KONG~(2,4,5)Hua-mao CHENG~(2,4)paul van CAUWENBERGE~3 2 Department of Otorhinolaryngology,Union Hospital of Tongji Medical College,Huazhong Science and Technology University,Wuhan 430030,China 3 Department of Otorhinolaryngology,Ghent University Hospital,De Pintelaan 185,9000 Gent,Belgium Department of Otorhinolaryngology Union Hospital of Tongji Medical College Huazhong Science and Technology University Wuhan China Department of Otorhinolaryngology Ghent University Hospital Gent Belgium

Aim:To explore the cell specific existence of α9 AChR in the vestibular type Ⅱ haircells(VHC Ⅱ)of ***:To detect the expression of α9 AChR messengerRNA(mRNA)in the vestibular endorgans and single VHC Ⅱ of rats by using thereverse transcription polymerase chain reaction(RT-PCR)technique and the singlecell RT-PCR technique,***:It was shown that α9 AChR mRNAwas detected in the vestibular *** using single-cell RT-PCR,mRNAencoding α9 AChR was also detected in the VHC Ⅱ of the *** analysisof the PCR products confirmed identity to corresponding cDNA sequence in thepredicted ***:We established a method which could effectivelydetect the cell specific expression of mRNA in an individual *** dataconfirm that α9 AChR mRNA is expressed in the VHC Ⅱ of rats and indicates thatα9 AChR may function as a mediator of efferent cholinergic signaling in mamma-lian VHC.

关键词： hair cells vestibule rats nicotinic acetylcholine receptor single cell reverse transcriptase polymerase chain reaction

GC-MS法测定Calophyllum inophyllum L.中的红厚壳素(英文)

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中国天然药物 2011年第6期9卷 429-434页

作者： Ha Minh Hien paul WS Heng Nguyen van Thi Nguyen Khac Quynh Cu Vo Thi Bach Hue Institute of Drug Quality Control-Ho Chi Minh City Ho Chi Minh CityVietnam Department of Pharmacy Faculty of ScienceGEA-NUS Pharmaceutical Processing Research LaboratoryNational University of Sin-gaporeSingapore Faculty of Pharmacy University of Medicine and PharmacyHo Chi Minh CityVietnam

AIM:To establish a GC-MS method for the determination of calophyllolide in Calophyllum inophyllum *** its application in quality control of natural ***:Methanolic extract from Calophyllum inophyllum *** *** was isolated,purified and then identified to serve as a chemical marker for development and validation a GC-MS method according to ICH guideline and *** established method was proved to be useful in quality control with the aid of Principle Component Analysis (PCA),a multivariate data analysis ***:The proposed method was selective against mass spectral deconvoluting software *** linear range was from 3.125-50 μg·*** RSD of intra-and inter-day precision variations were less than 3% and the mean recovery was (101.22±1.98)% (RSD=1.95%).PCA was used to indicate a differentiation of batches in production as well as proving that calophyllolide has influence on the discrimination of extracts from different ***:The proposed capillary gas chromatography/mass spectrometric method for the determination of calophyllolide obtained from resin of Calophyllum inophyllum *** oil showed its suitability,simplicity,rapidity and precision,and it can be used for chemical *** is the first time such a technique was reported in *** multivariate data analysis technique was employed to provide an extensive but inclusive method for quality control of the extracts,to ensure consistency for batch to batch of extracts to be used for product development.

关键词： Calophyllum inophyllum Calophyllolide GC-MS Validation

Effect of Metal Contamination on Characteristics of Ultra-Thin Gate Oxide

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Journal of Semiconductors 2004年第5期25卷 502-507页

作者：王刘坤 Twan Bearda Karine Kenis Sophia Arnauts Patrick van Doorne 陈寿面 paul Mertens Marc Heyns 上海集成电路研发中心上海201203 Interuniversity Microe lectronics Center

The purpose of this work relates to study on the characteristics of ultra thin gate oxide (2 5nm thickness) and the effect of metal Al,Zr,and Ta contamination on *** controlled metallic contamination experiments are carried out by depositing a few ppm contaminated metal and low pH solutions on the *** maximum metal surface concentration is controlled at about 10 12 cm -2 level in order to simulate metal contamination during ultra clean processing.A ramped current stress for intrinsic charge to breakdown measurements with gate injection mode is used to examine the characteristics of these ultra thin gate oxides and the effect of metal contamination on *** is the first time to investigate the influence of metal Zr and Ta contamination on 2 5nm ultra thin gate *** is demonstrated that there is little effect of Al contamination on GOI,while Zr contamination is the most detrimental to GOI,and early breakdown has happened to wafers contaminated by Ta.

关键词： gate oxide integrity metal contamination charge to breakdown ramped current stress MOS capacitor

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富蕴断裂:低应变速率条件下断层滑动习性

地震地质 2012年第4期34卷 606-617页

作者：徐锡伟孙鑫喆谭锡斌李康于贵华 Marie Etchebes Yann Klinger paul Tapponnier J.van Der Woerd 中国地震局地质研究所活动构造与火山重点实验室北京100029 Tectonics Institut de Physique du Globe de ParisSorbone Paris CitéCNRS Earth Observatory of Singapore Singapore Institut de Physique du Globe StrasbourgFrance

富蕴断裂是阿尔泰地区低应变速率条件下的典型右旋走滑断层之一。野外考察和3个观测点的3D陆地LiDAR扫描DEM影像断错地貌恢复、重建,结合高分辨率卫星影像解译等进一步证实,1931年富蕴地震同震右旋走滑位移平均值为(6.3±1.2)m,且沿富... 详细信息

富蕴断裂是阿尔泰地区低应变速率条件下的典型右旋走滑断层之一。野外考察和3个观测点的3D陆地LiDAR扫描DEM影像断错地貌恢复、重建,结合高分辨率卫星影像解译等进一步证实,1931年富蕴地震同震右旋走滑位移平均值为(6.3±1.2)m,且沿富蕴断裂向南北两端缓慢、平稳衰减,中部同震位移最大值为(6.7±0.5)m,而不是前人给出的10～14m;包含2～5次地震的同震累积位移值为1931年富蕴地震相同地点同震位移的整数倍,表明富蕴断裂大地震复发服从特征地震模型。2个观测点多级地貌面宇宙成因核素(10Be)系统测年数据,进一步限定富蕴断裂晚更新世以来的右旋走滑速率为(0.76±0.24)mm/a,大地震复发间隔(9700±3300)a。低滑动速率和长周期特征地震复发模型可能为板块间相互作用产生的远程应变效应的基本特征。

关键词：富蕴断裂同震右旋走滑位移特征地震复发模型阿尔泰地区

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质量、病人安全和风险管理一体化

中国卫生产业 2006年第4期3卷 88-89页

作者： paul van Ostenberg 沈健（编译） JCI国际总经理不详

医疗服务体系正发生三个重要的变化：风险管理（risk management）、质量管理（quality management）和病人安全（patient safety）。三种变化的源头各不相同。风险管理起源于20世纪中叶的保险行业，随着病人权利意识的提高和这种权利... 详细信息

医疗服务体系正发生三个重要的变化：风险管理（risk management）、质量管理（quality management）和病人安全（patient safety）。三种变化的源头各不相同。风险管理起源于20世纪中叶的保险行业，随着病人权利意识的提高和这种权利遭受侵害时的法律诉讼，十多年后进入卫生行业。质量管理起源于二战时期的制造业，深受Edwards Demings关于全面质量管理（TQM）教育的影响。几十年后，这种概念才在卫生行业扎根。由于1999年美国医学研究院（Institute of Medicine）的报告，题为：是人，肯定会犯错：建立一个更安全的医疗体系，2004年WHO成立了病人安全世界联盟，病人安全飞跃式地进入医疗卫生前沿。

关键词：全面质量管理病人安全风险管理管理一体化医疗服务体系权利意识卫生行业保险行业 20世纪法律诉讼

The role of ultrasonic bat detectors in improving inventory and monitoring surveys in Vietnamese karst bat assemblages

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Current Zoology 2009年第5期55卷 327-341页

作者： Neil M.FUREY Iain J.MACKIE paul A.RACEY School of Biological Sciences University of AberdeenAberdeen

Bats account for 30% of mammal diversity in SE Asia and are potential bioindicators of wider biodiversity impacts resulting from habitat loss and climate change. As existing sampling techniques in the region typically fail to record bats that habitually fly in open areas and at higher altitudes, current inventory efforts are less than comprehensive. Acoustic sampling with bat detectors may help to overcome these limitations for insectivorous bats, but has yet to be tested in mainland SE Asia. To do so, we sampled bats while simultaneously recording the echolocation calls of insectivorous species commuting and foraging in a variety of karst habitats in north Vietnam. Monitoring of cave-dwelling bats was also undertaken. Discriminant function analysis of 367 echolocation calls produced by 30 insectivorous species showed that acoustic identification was feasible by correctly classifying 89. 1% of calls. In all habitats, acoustic sampling and capture methods recorded significantly more species each night than capture methods alone. Capture methods consequently failed to record 29% （ten spp. of aerial insectivores） of the bat fauna in commuting and foraging habitats and 11% （two spp. ） of that in our cave sample. Only four of these species were subsequently captured following significantly greater sampling effort. This strongly suggests that acoustic methods are indispensable for maximizing bat inventory completeness in SE Asia. As accurate inventories and monitoring are essential for effective species conservation, we recommend the inclusion of acoustic sampling in future studies of bat assemblages across the region [ Current Zoology 55 （5）： 327 - 341, 2009].

关键词： Bats Echolocation Inventory completeness Karst Vietnam

Feeding Biochar to Cows:An Innovative Solution for Improving Soil Fertility and Farm Productivity

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Pedosphere 2015年第5期25卷 666-679页

作者： Stephen JOSEPH Doug POW Kathy DAWSON David R.G.MITCHELL Aditya RAWAL James HOOK Sarasadat TAHERYMOOSAVI Lukas van ZWIETEN Joshua RUST Scott DONNE paul MUNROE Ben PACE Ellen GRABER Torsten THOMAS Shaun NIELSEN Jun YE Yun LIN PAN Genxing LI Lianqing Zakaria M.SOLAIMAN Discipline of Chemistry University of Newcastle School of Materials Science and Engineering University of New South Wales Electron Microscopy Center AIIMUniversity of Wollongong Institute of Resources Ecosystem and Environment of AgricultureNanjing Agricultural University Marron Brook Farm Warren Catchments Council 52 Bath StManjimup 6258 (Australia) Mark Wainwright Analytical Centre University of New South Wales Wollongbar Primary Industries Institute NSW Department of Primary Industries Institute of Soil Water and Environmental SciencesThe Volcani CenterAgricultural Research Organization Centre for Marine Bio-Innovation School of Biotechnology and Biomolecular SciencesThe University of New South Wales Soil Biology and Molecular Ecology Group School of Earth and Environment (M087)The University of Western Australia

Addition of biochar produced through thermal decomposition of biomass has been seen as a strategy to improve soils and to sequester carbon （C）, but wide scale implementation of the technology requires to devise innovative profitable solutions. To develop biochar utilisation with an integrated system approach, an innovative program was implemented in 2012 on a 53-ha farm in Western Australia to determine the costs and benefits of integrating biochar with animal husbandry and improvement of pastures. Biochar was mixed with molasses and fed directly to cows. The dung-biochar mixture was incorporated into the soft profile by dung beetles. We studied the changes in soil properties over 3 years. Biochar extracted from fresh dung and from the soil to a depth of 40 cm was characterised. A preliminary financial analysis of the costs and benefits of this integrated approach was also undertaken. The preliminary investigation results suggested that this strategy was effective in improving soil properties and increasing returns to the farmer. It was also concluded that the biochar adsorbed nutrients from the cow＇s gut and from the dung. Dung beetles could transport this nutrient-rich biochar into the soil profile. There was little evidence that the recalcitrant component of the biochar was reduced through reactions inside the gut or on/in the soil. Further research is required to quantify the long-term impact of integrating biochar and dung beetles into the rearing of cows.

关键词： animal husbandry biochar C sequestration dung beetles financial benefit pasture

Iron and Zinc Serum Levels in Young Adult Cameroonians after Supplementation in Poor Vitamin A and Controlled Diets

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Journal of Food Science and Engineering 2014年第4期4卷 184-195页

作者： Kana Sop Marie Modestin Gouado Inocent Schweigert Florian van Camp John Oberleas Donald AmvamZollo paul Henri Tetanye Ekoe Department of Biochemistry Faculty of Science University of Douala Douala 24157 Cameroon Institute of Nutritional Science University of Potsdam Potsdam 114-115 D-14558 Germany Department of Food Safety and Food Quality University of Gent Ghent 653 B-9000 Belgium Food and Nutrition University of Lubbok Lubbock 79423 USA Department of Biochemistry University of Ngaoundere Ngaoundere 454 Cameroon Department of Paediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundd Yaounde 2036 Cameroon

Iron, zinc and vitamin A deficiencies co-exist in Cameroon in all age groups. However, natural sources of vitamin A are available and could be used to meet the need of the whole population in association with iron and zinc supplementation. This study aims at assessing the serum levels of zinc and iron after 11 days of supplementation. The study enrolled 26 men 08-33 years）, distributed into five groups. From the first day, they were supplemented with 20 mg of zinc and iron, taken each alone, both either together or at two different times. The five last days, participants were put on free vitamin A diets. Serums were obtained at day l, day 5 and day 11 for Zn and Fe levels determination by atomic absorption spectrophotometry. The highest serum iron and zinc concentrations were observed in groups either supplemented with zinc or with iron given alone. In those two groups, serum Zn concentrations increased from 0.69 μg/mL ±0.02μg/mL to 0.95 μg/mL ± 0.13 μg/mL （group 2）, from 0.48 μg/mL ± 0.06 μg/mL to 0.97 μg/mL ± 0.11 μg/mL （group 3）; and serum Fe concentrations from 1.49 μg/mL ± 0.54 μg/mL to 3.49 μg/mL ± 1.01 μg/mL （group 2）; and from 1.42 μg/mL ± 0.45 μg/mL to 3.41 μg/mL ± 0.81 μg/mL （group 3）, respectively. Supplementation with Fe or Zn alone increased both Fe and Zn serum levels of participants. Serum levels of iron and zinc when given together or at different time were not significantly different. Further studies on a larger population are necessary to confirm that supplementation with zinc or with iron alone could raise both zinc and iron levels in serum simultaneously.

关键词： Supplementation iron zinc young-adults Cameroon.

阿尔金断裂带对青藏高原北部生长、隆升的制约

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地学前缘 2006年第4期13卷 59-79页

作者：李海兵杨经绥许志琴孙知明 paul TAPPONNIER Jerome van DER WOERD Anne-Sophie MERIAUX 中国地质科学院地质研究所国土资源部大陆动力学重点实验室中国地质科学院地质力学研究所地壳变形与作用重点实验室 Laboratoire de Tectonique Institut de Physique du Globe de Paris4 Place Jussieu75252 Paris Cedex 05France Institut de Physique du Globe de Strasbourg EOST 5 rue Ren Descartes 67084 Strasbourg Cedex France School of Geosciences Institute of GeographyDrummond Street EH8 9XPEdinburgh UK

大量的同位素年代学证据表明（古）阿尔金断裂带可能形成于三叠纪，后又经历了侏罗纪、白垩纪的强烈左旋走滑活动，自印度板块与欧亚大陆碰撞后阿尔金断裂再次活动。主要的走滑活动发生在：（1）245～220Ma；（2）180～140Ma；（3）120... 详细信息

大量的同位素年代学证据表明（古）阿尔金断裂带可能形成于三叠纪，后又经历了侏罗纪、白垩纪的强烈左旋走滑活动，自印度板块与欧亚大陆碰撞后阿尔金断裂再次活动。主要的走滑活动发生在：（1）245～220Ma；（2）180～140Ma；（3）120～100Ma；（4）90～80Ma；（5）60～45Ma（6）渐新世至中新世；（7）上新世至更新世以及（8）全新世。沿阿尔金断裂带，伴随左旋走滑活动形成一系列的逆冲断裂和正断裂，反映走滑过程中伴随隆升作用的存在，并且形成自北向南包括祁连山、大雪山、党河南山、柴北缘山、祁漫塔格山和昆仑山，表明阿尔金断裂带制约着青藏高原北部的生长和隆升。阿尔金断裂带东、西两端的白垩纪和新生代火山活动是断裂走滑活动的响应。

关键词：阿尔金断裂带逆冲断裂火山作用滑移速率青藏高原北部