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Food Science and Human Wellness 2024年

作者： Chi Chen Bowen Li Mengfan Ding Huizhen Li Jianxin Zhao R.paul Ross Catherine Stanton Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre， Moorepark National Engineering Research Center for Functional Food， Jiangnan University

Irritable bowel syndrome-diarrhea （IBS-D） is a prevalent functional bowel disease severely impairs the quality of life of patients. Visceral hypersensitivity （VH） is the main symptom of IBS-D. Probiotics have been found to effectively alleviate VH. In this study， neonatal maternal separation （NMS） was used to induce VH in 72 rats and investigated the effects of daily gavage of 3*109CFU of Lactobacillus and Bifidobacterium on alleviating the symptoms of IBS-D and behavioral interventions， as well as exploring potential mechanisms. The results demonstrated that Lactobacillus acidophilus and Bifidobacterium breve could alleviate the symptoms of IBS-D such as VH and increased frequency of bowel movements， as well as improving non-spatial memory in NMS rats. These effects were achieved by modulating the composition of gut microbiota and metabolites （including short-chain fatty acids， deoxycholic acid and adenosine）， and by regulating the expression of genes and proteins associated with the NGF/TrkA signaling pathway， tryptophan metabolism， and inflammatory factors in the hippocampus. This finding suggests that Lactobacillus acidophilus and Bifidobacterium breve have promising potential for the alleviation of IBS.

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Infant feces-derived Bifidobacterium breve CCFM1078 inhibits the occurrence of rheumatoid cachexia by IRS1/PI3K/Akt signaling pathway

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Chen Chi Guoxun Shi Xiaoming Liu Jianxin Zhao paul Ross Catherine Stanton Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Department of Rheumatology， Jiangnan University Medical Center International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre National Engineering Research Center for Functional Food， Jiangnan University

This study aimed to investigate the effects of infant feces-derived Bifidobacterium breve CCFM1078 on rheumatoid cachexia （RC）. Twenty-four female Wistar rats were assigned to three groups: CON group （normal saline by gavage）， CIA group （collagen-induced arthritis， normal saline by gavage）， and CCFM1078 group (collagen-induced arthritis， 3×109CFU/rat/day B breve CCFM1078 gavage). The results demonstrated that B. breve CCFM1078 not only improved skeletal muscle function in CIA rats， but also modulated the gut microbiota， skeletal muscle metabolism and hormone levels， reduced inflammation in the knee joint and skeletal muscles， decreased activity of the NF-κB inflammatory signaling pathway， enhanced the IRS1/PI3K/Akt signaling pathway， promoted skeletal muscle differentiation， and maintained skeletal muscle fiber diameter， consequently slowing down the progression of RC. These findings suggested that B. breve CCFM1078 may have a beneficial role as part of a dietary intervention for RC， enhancing overall therapeutic effects.

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A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale Jacob McCormick Craig Lynch paul A.Cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

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Prevalence of diabetic cheiroarthropathy and its association with macrovascular complications:A cross-sectional study

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Rheumatology & Autoimmunity 2024年第3期4卷 189-191页

作者： Athul paul Kothai Gnanamoorthy Gisha Sivan Janardanan S.Kumar Department of General Medicine SRM Medical College Hospital and Research Centre SRMISTKattankalathurTamilNaduIndia Division of Medical Research SRM Medical College Hospital and Research Centre SRMISTKattankalathurTamilNaduIndia

To the Editor,Diabetes mellitus(DM)patients have a higher incidence of musculoskeletal issues compared to those without *** diabetes-related complications increasing,early detection of musculoskeletal diseases is crucial for better quality of life and reduced *** joint mobility(LJM),also known as diabetic stiff hand or diabetic cheiroarthropathy(DCA),is an often overlooked complication of type 2 *** manifests as painless stiffness in hands,restricted joint movement,and tight *** in hand joints can spread to major joints like elbows and knees,severely impacting daily tasks and quality of *** examination aids in diagnosing LJM and related rheumatic conditions like scleroderma.

关键词： diabetic complications sectional

Evaluation of Procedural Pain in Neonates in Cameroon

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Open Journal of Pediatrics 2024年第3期14卷 568-578页

作者： Claude-Audrey Meguieze Rose Bidias Etouckey Georges Eric Nseme Koki Ndombo paul Olivier Pediatrics Department Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Morphologic Sciences Department Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon

Introduction: Acute pain associated with caregiving is a major cause of pain among neonates. Left untreated, it can lead to long-term neurosensory and psychoaffective consequences. In Cameroon, this subject has been scarcely explored, thus constituting an impediment to the management of care-induced pain. Objective: Assess procedural pain in neonates in Yaoundé. Material and Methods: We conducted a cross sectional study with prospective data collection over a period of eight months (October 2022 to May 2023) in three hospitals. We included neonates who were being cared for and were not crying prior to the onset of healthcare, whose parents consented to the study. Assessments were done using the DAN scale, which is specific to care-induced pain. Data was entered and analyzed using SPSS 23.0 software. Results: A total of 161 newborns were included. The hospital prevalence of care-induced pain in neonates was 85%. Neonatal sepsis was the main cause for admission (96.6%). The most common procedures were venous blood sampling (94.4%) and insertion of peripheral venous lines (93.8%). The pain intensity for these procedures was severe (83.9%). The most painful procedure was lumbar tap, followed by venous access procedures. Conclusion: Neonates in hospitals are subjected to many painful procedures. The pain experienced during these procedures is severe. The most nociceptive procedure is a lumbar puncture.

关键词： Assessment Procedural Pain Neonate Yaoundé Cameroon

Fatty Acid Composition of Hazelnut Kernel Oil from Coula edulis Collected in the Republic of Congo

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Food and Nutrition Sciences 2024年第4期15卷 290-297页

作者： Josiane Enzonga Yoca Jean paul Latran Ossoko Yves Okandza Michel Didace Mvoula Tsieri Laboratoire de Contrô le et Qualit&#233 des Aliments de l&#8217Ecole Nationale Sup&#233rieure d&#8217Agronomie et de Foresterie Universit&#233 Marien NGOUABI Brazzaville Congo Université Denis Sassou NGUESSO Brazzaville Congo

Coula edulis is non-timber forest product (NTFP) used in Africa for its hazelnuts, which contain edible seeds with a demonstrated nutritional potential. However, there have been very few scientific studies of this species in the Republic of Congo. Thus, the aim of the current study was therefore to determine the fatty acid composition of the oil extracted from Coula edulis hazelnut seeds collected at random in the Republic of Congo. The oil was extracted using the Soxhlet method and its fatty acid composition was determined by gas chromatography. The extracted oil from Coula edulis hazelnut kernels is rich in monounsaturated fatty acids (95.28%), particularly oleic acid (94.5%), which classifies it as an oleic oil and gives it interesting nutritional and therapeutic properties. On the other hand, saturated fatty acids (4.15%) and polyunsaturated fatty acids (0.35%) are not well represented. Its low poly-unsaturated fatty acid content makes it more stable when stored at room temperature.

关键词： Coula edulis Fatty Acids Oil Seeds Hazelnuts Republic of Congo NTFP

Investigation of Carbonation of Concrete Based on Crushed Sand and Admixtures

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Journal of Minerals and Materials Characterization and Engineering 2024年第5期12卷 247-264页

作者： Jacques Herve Koung à Bediang Emmanuel Elat Assoua Moukete paul Djomou Djonga Michel Mbessa Laboratory of Civil and Mechanical Engineering Department of Civil Engineering National Advanced School of Engineering of Yaounde 1 Yaounde Cameroon Laboratory of Mechanics and Materials of Civil Engineering Department of Civil Engineering CY Cergy Paris University Paris France Department of Textile and Leather Engineering National Advanced School of Engineering of Maroua Maroua Cameroon Department of Civil Engineering National Advanced School of Public Works National Advanced School of Engineering of Yaounde 1 Yaounde Cameroon

Carbonation is a natural aging process that occurs in all types of concrete. One of its primary implications is the acceleration of steel corrosion caused by the phenomena of depassivation. The goal of this research is to investigate the carbonation of quarry sand-based concrete. The concrete is made of 100% crushed sand 0/6.3, gravel 8/15, and 15/25 from the Arab Contractor quarry in Nomayos, Cameroon, with CEM II B-P 42.5 R from CIMENCAM (Cimenteries du Cameroun). The study employed two admixtures: one with a dual superplasticizing and reducing action (Sikamen) and another with a water-repellent effect (Sika liquid). Carbonation was performed on concrete samples at the following dates: 0, 7, 14, 28, 56, 90, 180 days, one year, and six months. Carbonated concrete (CC) and non-carbonated concrete (NCC) samples are compared in terms of their physical attributes and mineralogical characteristics. The results of this investigation reveal that after more than a year and six months of carbonation, porosity decreases and permeability increases. Despite the high fineness modulus of quarry sand, the compressive strength of quarry sand-based concrete is satisfactory. Carbonation depth is relatively high on some dates, exceeding the minimal cover value for concrete reinforcement. Sikament additive increases concrete compactness and durability while decreasing permeability. Sika water repellant mixes with the lime in cement to generate complimentary crystallizations that block the mortar’s capillaries, making it watertight.

关键词： Carbonation Concrete Crushed Sand Sikamant Water-Repellent

Uncovering the Challenges of Faecal Sludge Management in Benin’s Urban Hubs: The Cases of Abomey-Calavi and Natitingou

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Journal of Environmental Protection 2024年第7期15卷 767-780页

作者： Nikita Topanou Blaise Agbatchi Gouvidé Jean Gbaguidi Jacques Fatombi Fidèle paul Tchobo Kaba Laboratory of Chemical Research and Application (LaKReCA) Department of Chemistry Faculty of Science and Technology of Natitingou University of Abomey Natitingou Bnin Laboratory of Study and Research in Applied Chemistry Polytechnic School of Abomey-Calavi University of Abomey-Calavi (LERCA/EPAC/UAC) Cotonou Bnin

The issue of faecal sludge management in developing countries remains a significant challenge due to the indiscriminate discharge of sludge into the environment. This practice generates more environmental problems than it solves. This study aims to assess the management of household faecal sludge in the communes of Abomey-Calavi and Natitingou, Benin, in order to optimise the best storage conditions for subsequent more effective treatment. To this end, a sociological survey was conducted among households in Abomey-Calavi and Natitingou, as well as among manual emptiers. The results of our studies revealed that two types of latrines are used in households. 20.55% of households use traditional latrines, while 59.83% use ordinary latrines. 7.97% of households use both types of latrine. Moreover, the depth of the latrines varies from 2.5 m to 7 m in Abomey-Calavi and from 2.5 m to 8 m in Natitingou. Among households with a latrine, 28.26% empty their pit at least once, while 71.74% have never emptied it. The emptying cost varies between 35,000 FCFA and 90,000 FCFA. The mixing of faecal sludge with solid waste, including plastic materials, makes emptying difficult due to the obstruction of the vacuum pump. The results obtained will serve as a reliable database to facilitate decision-making in the context of faecal sludge management.

关键词： Management Faecal Sludge Valorization Benin

中国社会陌生人之间合作行为的变迁:基于社会困境研究的元分析(1999~2019)

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心理学报 2024年第9期56卷 1159-1175页

作者：苑明亮伍俊辉金淑娴林靓寇彧 paul A.M.Van Lange 安徽农业大学人文社会科学学院心理学系合肥230036 中国科学院心理研究所行为科学重点实验室北京100101 中国科学院大学心理学系北京100049 萨塞克斯大学心理学院英国布莱顿BN19RH 北京师范大学发展心理研究院应用实验心理北京市重点实验室心理学国家级实验教学示范中心(北京师范大学)北京100875 阿姆斯特丹自由大学脑与行为研究院实验与应用心理学系荷兰阿姆斯特丹1081BT

陌生人间的合作行为对于解决社会公共问题,应对世界百年未有之大变局意义重大。本研究采用横断历史元分析方法,基于1999~2019年间开展的254项使用社会困境范式测量我国陌生人间合作行为的研究(共302个合作率,29249名被试,平均年龄:18~28... 详细信息

陌生人间的合作行为对于解决社会公共问题,应对世界百年未有之大变局意义重大。本研究采用横断历史元分析方法,基于1999~2019年间开展的254项使用社会困境范式测量我国陌生人间合作行为的研究(共302个合作率,29249名被试,平均年龄:18~28岁),探讨了中国社会中合作行为的变迁及一些社会发展指标在其中的解释作用,并比较中美两国的合作行为变迁趋势。结果表明,中国人的合作行为水平随时间而上升,一些社会发展指标(人均国内生产总值、城市化率、高等教育水平、互联网普及率等)可能是其上升的社会变迁基础。中美两国合作行为表现出相似的上升趋势,但中国的在更短时间内有更大上升幅度。研究结果对提振民众信心具有重要意义。

关键词：合作行为社会资本社会困境横断历史元分析社会变迁

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4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

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Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei Kato Daisuke Nishizaki Hirotaka Miyashita Suzanna Lee Mary K.Nesline Sarabjot Pabla Jeffrey M.Conroy paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure