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Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural regeneration research 2025年第4期20卷 1101-1102页

作者： Hadley Osman paul Ashwood Department of Medical Microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(MIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with ASD by the age of 8 years,with ASD rates continuing to increase in prevalence in USA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural regeneration research 2025年第6期20卷 1709-1710页

作者： Martin-paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

Traumatic aortic rupture mimicking intramural hematoma of the entire thoracic aorta

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中华胸心血管外科杂志 2003年第4期 68-69页

作者： paul r. vogt , Joerg Babin-Ebell , Erwin P. Bauer Department for Cardiovascular Surgery University Hospital Giessen and the Kerckhoff Clinic Foundation Bad Nauheim Germany Department for Cardiovascular Surgery University Hospital Giessen and the Kerckhoff Clinic Foundation Bad Nauheim Germany Department for Cardiovascular Surgery University Hospital Giessen and the Kerckhoff Clinic Foundation Bad Nauheim Germany

抢救 1例因摩托车事故急诊入院男病人。X线胸片发现病人右气管旁外侧纹理和左纵隔影异常增宽 ,并扩展至主动脉弓水平。经食管心脏超声检查发现围绕主动脉根部和升主动脉的壁间水肿 ,延伸至主动脉弓和左横膈下水平的全程降主动脉 ;左锁... 详细信息

抢救 1例因摩托车事故急诊入院男病人。X线胸片发现病人右气管旁外侧纹理和左纵隔影异常增宽 ,并扩展至主动脉弓水平。经食管心脏超声检查发现围绕主动脉根部和升主动脉的壁间水肿 ,延伸至主动脉弓和左横膈下水平的全程降主动脉 ;左锁骨下动脉起始点远端降主动脉上端全层断裂。急诊手术行降主动脉上端端端吻合 ,终因心跳骤停未及手术死亡。尸检证实全程胸主动脉自破裂处向前和逆向延伸 ,引起双向主动脉夹层。

关键词：降主动脉主动脉降部主动脉弓主动脉结 Traumatic aortic rupture mimicking intramural hematoma of the entire thoracic aorta

Three‐terminal perovskite/integratedbackcontactsilicon tandem solar cells under low light intensity conditions

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Interdisciplinary Materials 2022年第1期1卷 148-156页

作者： Hiroyuki Kanda Valentin Dan Mihailetchi Marie-Estelle Gueunier-Farret Jean-paul Kleider Zakaria Djebbour Jose Alvarez Baranek Philippe Olindo Isabella Malte r.vogt rudi Santbergen Philip Schulz Fiala Peter Mohammad K.Nazeeruddin James P.Connolly Group for Molecular Engineering of Functional Materials Ecole Polytechnique Federale de LausanneValais WallisSionSwitzerland International Solar Energy research Center ISC-Konstanz E.V.KonstanzGermany Centrale Supelec CNRSLaboratoire de Genie Electrique et Electronique de ParisUniversite Paris-SaclayGif-sur-YvetteFrance CNrS Laboratoire de Genie Electrique et Electronique de ParisSorbonne UnibversiteParisFrance CNrS Institut Photovoltaique d'Île de France(IPVF)PalaiseauFrance Department EFESE EDF Lab Paris‐SaclayEDF R&DPalaiseauFrance Delft University of Technology(TU Delft) DelftThe Netherlands Photovoltaics and Thin-Film Electronics Laboratory Ecole Polytechnique Federale de LausanneNeuchatelSwitzerland

The current climate and energy crisis urgently needs solar cells with efficiencies above the 29% single junction efficiency ***/perovskite tandem solar cells are a solution,which is attracting much *** silicon/perovskite tandem cells in 2-terminal and 4-terminal configurations are well documented,the three-terminal concept is still in its *** has significant advantages under low light intensities as opposed to concentrated sunlight,which is the critical factor in designing tandem solar cells for low-cost terrestrial *** study pre-sents novel studies of the sub-cell performance of the first three-terminal perovskite/silicon selective band offset barrier tandem solar cells fabricated in an ongoing research *** study focuses on short circuit current and operating voltages of the subcells under light intensities of one sun and *** studies show that the perovskite bulk carrier lifetime is insensitive to illumination,while the silicon cell's lifetime decreases with decreasing light *** combination of perovskite and silicon in the 3T perovskite-silicon tandem therefore reduces the sensitivity of V_(OC) to light intensity and maintains a relatively higher V_(OC) down to low light intensities,whereas silicon single-junction cells show a marked *** technological advantage is proposed as a novel advantage of three-terminal perovkite/silicon solar cells for low light intensities of one sun or less.

关键词： low light intensity conditions perovskite solar cells tandem solar cells three-terminal perovskite/Si solar cells

Arthropod prey of imported fire ants （Hymenoptera： Formicidae） in Mississippi sweetpotato fields

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Insect Science 2013年第4期20卷 467-471页

作者： Tahir rashid Jian Chen James T. vogt paul J. McLeod Aicorn State University Extension~Research Demonstration Farm & Tech Transfer Center Mound Bayou Mississippi USDA ARS Bio- logical Control of Pests Research Unit Stoneville Mississippi USDA FS Inventory & Analysis Knoxville Tennessee Department of Entomology University of Arkansas Fayetteville Arkansas United States

The red imported fire ants, Solenopsis invicta （Buren）, are generally considered pests. They have also been viewed as beneficial predators feeding on other insect pests of various agroecosystems. This study documents the foraging habits of fire ants in a sweetpotato field in Mississippi. Fire ant foraging trails connecting outside colonies to a sweetpotato field were exposed and foraging ants moving out of the field toward the direction of the colony were collected along with the solid food particles they were carrying. The food material was classified as arthropod or plant in origin. The arthropod particles were identified to orders. Fire ant foragers carried more arthropods than plant material. Coleoptera and Homoptera were the most abundant groups preyed upon. These insect orders contain various economically important pests of sweetpotato. Other major hexapod groups included the orders Hemiptera, Diptera and Collembola. The quantity of foraged material varied over the season. No damage to sweetpotato roots could be attributed to fire ant feeding. Imported fire ant foraging may reduce the number of insect pests in sweetpotato fields.

关键词： foraging imported fire ant predation Solenops& invicta sweetpotato

Identification of habitat controls on northern red-legged frog populations: implications for habitat conservation on an urbanizing landscape in the Pacific Northwest

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Ecological Processes 2017年第1期6卷 463-475页

作者： Lauren A.Grand Marc P.Hayes Kristiina A.vogt Daniel J.vogt paul r.Yarnold Klaus O.richter Christopher D.Anderson Elissa C.Ostergaard Jo O.Wilhelm College of Forestry Oregon State University996 Jefferson StEugeneOR 97402USA. Science Division Habitat ProgramWashington Department of Fish and Wildlife(WDFW)600 Capitol Way NorthOlympiaWA 98501-1091USA. School of Environmental and Forest Sciences(SEFS) University of WashingtonBox 352100SeattleWA 98195-2100USA. Optimal Data Analysis LLC6348 N.Milwaukee Ave.#163ChicagoIL 60646USA. 11040104th Ave NE KirklandWA 98033-4423USA. District 12 King CountyWashington Department of Fish and Wildlife(WDFW)Region 416018 Mill Creek BlvdMill CreekWA 98012USA. King County Department of Natural resources and Parks(DNrP) Water and Land Resources Division(WLRD)King Street Center201 S Jackson St.Suite 600SeattleWA 98104USA.

Introduction: In the Pacific Northwest of North America, research addressing lentic-breeding amphibian populationvulnerability has emphasized aquatic habitats, frequently neglecting terrestrial habitats. Consequently, wetlandprotection and restoration often fails to preserve or restore adjacent uplands required by lentic-breeding *** to the juxtaposition and connectivity of uplands to wetlands could locally extirpate lentic-breedingamphibians. The objective of this research is to identify the relative importance of juxtaposed terrestrial and aquatichabitats in a lentic-breeding amphibian, the northern red-legged frog (rana aurora), by evaluating the relationshipbetween its occurrence and abundance with its aquatic and terrestrial habitats. To accomplish this, egg mass countswere used to quantify r. aurora populations in 30 stillwater habitats across an urbanization gradient. Using aGeographic Information System, seven descriptors of aquatic and surrounding terrestrial habitats were measured toevaluate their relationships to r. aurora occurrence and ***: rana aurora occurrence and breeding abundance both reflect the forested area around wetland breedingsites and forest connectivity to those sites. rana aurora breeding abundance also strongly reflects the percent offorested perimeter around wetland breeding sites. The forest habitat most important for r. aurora breeding abundanceseems to be > 200 m from the breeding wetlands. The American bullfrog presence and the two aquatic parametersmeasured, wetland area and vegetated area, were unrelated to r. aurora occurrence and breeding ***: Area and connectivity of juxtaposed forested terrestrial habitat may represent a basic control on r. aurorapresence and population size. Urban development policies should consider preservation and restoration of uplandforest habitats beyond current fixed-width buffers and wetland habitat area at landscape scales.

关键词： Northern red-legged frog Amphibian habitat rana aurora Land use Landscape planning Urban landscapes Amphibian population

Enhanced Trust Based Access Control for Multi-Cloud Environment

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Computers, Materials & Continua 2021年第12期69卷 3079-3093页

作者： N.r.rejin paul D.paul raj Technology PuduvoyalGummidipoondi601206India r M D Engineering College KavaraipettaiGummidipoondi601206India

Security is an essential part of the cloud *** ensuring the security of the data being communicated to and from the cloud server,a significant parameter called trust was ***-based security played a vital role in ensuring that the communication between cloud users and service providers remained unadulterated and *** most cloud-based data distribution environments,emphasis is placed on accepting trusted client users’requests,but the cloud servers’integrity is seldom *** paper designs a trust-based access control model based on user and server characteristics in a multi-cloud environment to address this *** proposed methodology consists of data encryption using Cyclic Shift Transposition Algorithm and trust-based access control *** this trust-based access control mechanism framework,trust values are assigned to cloud users using direct trust *** direct trust degree is estimated based on the following metrics:success and failure rate of interactions,service satisfaction index,and dishonesty *** addition to this,trust values are assigned to cloud servers based on the metrics:server load,service rejection rate,and service access *** role-Based Access control policy of each user is modified based on his trust *** the server fails to meet the minimum trust level,then another suitable server will be *** proposed system is found to outperform other existing systems in a multi-cloud environment.

关键词： Cloud computing trust access control cloud service provider cloud data user CSTA

Utilization of Pyrrolic Compounds as Indicators of Secondary Migration for Woodford Oils in the Anadarko Basin,Oklahoma,USA

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Journal of Earth Science 2024年第5期35卷 1499-1512页

作者： Mu Liu r.paul Philp Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Geosciences University of OklahomaNorman 73109United States

Migration pathways and distances of the oils in reservoir are thought to affect the distribution of pyrrolic compounds such as carbazole,its alkyl derivatives(alkylated carbazoles)and benzocarbazoles,although other factors,including maturity and depositional environments may also affect the distribution of these organic nitrogen *** this study,14 oil samples produced from conventional reservoirs in pauls Valley,south Oklahoma were investigated using organic geochemical *** sterane and hopane fingerprints suggest that most of the oils were sourced from the Devonian Woodford *** parameters consistently indicate that the maturity level of the studied samples are all of similar maturity(rc=~0.7%),suggesting the distribution of the organic nitrogen organic compounds is possibly reflecting variations in relative migration *** distribution of alkylcarbazoles revealed a preferential enrichment during migration,with the nitrogen-shielded alkylcarbazole tending to be enriched relative to the nitrogen-semi-shielded alkylcarbozoles particularly in oils produced close to the Arbuckle uplift to the ***,another family of pyrrolic compounds,benzocarbazoles,whose distributions also indicated that the pauls Valley Woodford oils came from deeper part of the Anadarko Basin as the benzo-[a]/([a]+[c])-carbazole ratios decrease *** more specific migration systems,although the pyrrolic compound indicators are potentially disturbed by the structural complexes,the general migration directions suggest that the studied oils in pauls Valley Hunton uplift were sourced from the deep basin area,and migrate upwards in porous sediments due to the *** study investigates the feasibility of using pyrrolic compounds to estimate relative migration distances and will aid in the interpretation of migration history by using the distribution of carbazole,alkylated carbazoles,benzocarbazoles isomers in the Anadarko and Ardmore Basin

关键词： carbazole migration oil Oklahoma biomarker organic geochemistry

A Survey of Language-Based Approaches to Cyber-Physical and Embedded System Development

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Tsinghua Science and Technology 2015年第2期20卷 130-141页

作者： paul Soulier Depeng Li John r. Williams University of Hawaii Massachusetts Institute of Technology(MIT)

As computers continue to advance, they are becoming more capable of sensing, interacting, and communicating with the physical and cyber world. Medical devices, electronic braking systems in automotive applications, and industrial control systems are examples of the many Cyber-Physical Systems （CPS） that utilize these computing capabilities. Given the potential consequences of software related failures in such systems, a high degree of safety, security, and reliability is often required. Programming languages are important tools used by programmers to develop CPS. They provide a programmer with the ability to transform designs into machine code. Of equal importance is their ability to detect and avoid programming mistakes. The development of CPS has predominantly been accomplished using the C programming language. Although C is a powerful language, it lacks features present in other languages that facilitate the development of reliable systems. This has prompted research into language-based alternatives for improving program quality through the use of programming languages. This paper presents an overview of the characteristics of embedded and cyber-physical systems and the associated requirements imposed on programming languages. This is followed by a survey of relevant research into language- based methods for creating safe, reliable, and robust software for CPS.

关键词： cyber-physical systems embedded systems programming languages type systems