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Bifidobacter.um longum subsp. infantis CCFM1269 pr.motes intestinal bar.ier.and r.lease of IFN-β thr.ugh TLr.-Tr.F dependent way in gr.wing mice

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Food Science and Human Wellness 2024年

作者： Mengfan Ding Bo Yang Bowen Li Haiqin Chen r.nqiang Yu r.paul r.ss Cather.ne Stanton Shilong Jiang Jianxin Zhao Wei Chen State Key Labor.tor. of Food Science and r.sour.es， Jiangnan Univer.ity Teagasc Food r.sear.h Centr. Nutr.tion and Metabolism r.sear.h Division， Innovation Center. Heilongjiang Feihe Dair. Co.， Ltd. Depar.ment of Neonatology， Wuxi Mater.ity and Child Health Car. Hospital， Affiliated Women's Hospital of Jiangnan Univer.ity National Engineer.ng r.sear.h Center.for.Functional Food， Jiangnan Univer.ity School of Food Science and Technology， Jiangnan Univer.ity PKUHSC-China Feihe Joint r.sear.h Institute of Nutr.tion and Healthy Lifespan Development Inter.ational Joint r.sear.h Center.for.Pr.biotics & Gut Health， Jiangnan Univer.ity APC Micr.biome Ir.land， Univer.ity College Cor.

Bifidobacter.um longum subsp. infantis is a commensal bacter.um that pr.dominates in the infant gut， playing a cr.tical r.le in both pr.venting for.ign infections and facilitating immune development. This study aimed to explor. the effects of B. longum subsp. infantis supplementation on inter.er.n-beta (IFN-β) secr.tion and intestinal bar.ier.impr.vement in gr.wing mice. Female and male mice wer. or.lly administer.d either.saline or.B. longum subsp. infantis CCFM1269 or.I5TI (1 × 109CFU/mice per.day， n = 8) fr.m 1-week-age until 3-， 4-， and 5-week-age. r.A sequencing analysis r.vealed that CCFM1269 exhibited potential antivir.l capacity thr.ugh incr.asing 2’-5’ oligoadenylate synthetase (OAS). Additionally， CCFM1269 supplementation significantly incr.ased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLr.-Tr.F-dependent signaling pathway. However. this effect was not obser.ed in 4- and 5-week-old mice. Fur.her.or.， both CCFM1269 wer. found to modulate the gut micr.biota composition and enhance the intestinal bar.ier.function in 3-， 4-， and 5-week-old mice. In summar.， the r.sults of this study suggested that B. longum subsp. infantis CCFM1269 pr.moting intestinal bar.ier.and r.leasing IFN-β in gr.wing mice was in a str.in-specific and time-dependent manner.

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Bifidobacter.um br.ve CCFM1078 r.gulates bone development in gr.wing BALB/c mice via gut micr.biota and metabolites to balance bone for.ation and r.sor.tion

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao r.paul r.ss Cather.ne Stanton Shilong Jiang Wei Chen Bo Yang Nutr.tion and Metabolism r.sear.h Division， Innovation Center. Heilongjiang Feihe Dair. Co.， Ltd. National Engineer.ng r.sear.h Center.for.Functional Food， Jiangnan Univer.ity State Key Labor.tor. of Food Science and Technology， Jiangnan Univer.ity PKUHSC-China Feihe Joint r.sear.h Institute of Nutr.tion and Healthy Lifespan Development APC Micr.biome Ir.land， Univer.ity College Cor. School of Food Science and Technology， Jiangnan Univer.ity Inter.ational Joint r.sear.h Center.for.Pr.biotics & Gut Health， Jiangnan Univer.ity Teagasc Food r.sear.h Centr.

This study endeavor. to investigate the effects of Bifidobacter.um br.ve CCFM1078 on bone for.ation and r.sor.tion balance in gr.wing BALB/c mice. Newbor. BALB/c mice wer. assigned to the contr.l gr.up (administr.tion saline) and the CCFM1078 gr.up (administr.tion B. br.ve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the gr.ups have male and female distinctions. Our.findings demonstr.te that B. br.ve CCFM1078 exer.s on the dynamic equilibr.um between bone for.ation and r.sor.tion dur.ng the cr.tical per.od of gr.wth in mice by modulating the composition of gut micr.biota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and pr.teins expr.ssion r.lated to the GH/IGF-1 axis and Gs/PKA/Cr.B signaling pathways， as well as downstr.am osteogenic and osteoclastic differ.ntiation factor.. The effects of B. br.ve CCFM1078 wer. differ.nt with age and gender.dependent. This finding suggests B. br.ve CCFM1078 may have potential applications in r.gulating bone metabolism in the gr.wth per.od population.

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Novel wild edible mushr.om Astr.eus hygr.metr.cus(Per..)Mor.an induces r.bust apoptosis on human acute lymphoblastic leukemia cells thr.ugh a r.NS-subsisted mitochondr.a-dependent pathway

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Jour.al of Tr.ditional Chinese Medical Sciences 2024年第1期11卷 67-77页

作者： Amr.ta Pal r.bhu r.y Anir.an Chouni Subhadip Hajr. Santanu paul Depar.ment of Botany University of CalcuttaKolkata 700019India Depar.ment of Cancer.Chemopr.vention Chittaranjan National Cancer InstituteKolkata 700026India

Objective:To explor. the ther.peutic effects of the novel wild edible mushr.om Astr.eus hygr.metr.cus(Per..)Mor.an(***)on human acute lymphoblastic leukemia ***:Extensive scr.ening of the antipr.lifer.tive and chemopr.ventive potential of differ.nt extr.cts fr.m 5 wild mushr.oms,***,Phallus sp.,Lentinus sp.,Tr.choloma sp.,and Ser.ula *** per.or.ed against a panel of 6 cancer.cell lines and nor.al cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetr.zolium br.mide(MTT)*** deter.ination,cell cycle pr.filing,intr.cellular.r.active oxygen species(r.S)and r.active nitr.gen species(r.S),and mitochondr.al membr.ne potential wer. analyzed by flow *** activity of caspases was measur.d color.metr.cally,and the expr.ssion patter. of mitochondr.al pr.teins was ***:The methanol extr.ct of *** and MOLT-4 cells wer. identified as the most potent extr.ct exhibiting antipr.lifer.tive activity and most sensitive cell line,*** mushr.om extr.ct induced r.bust selective apoptosis in MOLT-4 cells and ar.ested cell cycle pr.gr.ssion at the G0/G1 *** extr.ct disr.pted the mitochondr.al membr.ne potential and enhanced r.S pr.duction in MOLT-4 *** methanol extr.ct induced apoptosis by downr.gulating the expr.ssion of Bcl-2,incr.asing the expr.ssion of Bax,and activating the caspase ***:The novel wild edible mushr.om is a potential r.positor. of biomolecules for.the development of antileukemic dr.gs.

关键词： Mushr.om Astr.eus hygr.metr.cus(Per..)Mor.an Apoptosis Antileukemic

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Does a lar.e pr.state size,small lesion volume,or.long needle distance fr.m the pr.be to the lesion r.duce magnetic r.sonance imaging–tar.eted cancer.detection?

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Cur.ent Ur.logy 2024年第2期18卷 144-147页

作者： Mar. D.Bevill Justin N.Dr.bish Kevin J.Flynn Maheen r.jput Cather.ne Metz Chad r.Tr.cy paul T.Gellhaus Depar.ment of Ur.logy University of Iowa Carver College of MedicineIowa CityIAUSA Depar.ment of r.diology University of Iowa Carver College of MedicineIowa CityIAUSA

Backgr.und:We aimed to evaluate whether.lar.e pr.state size,small lesion volume,or.long lesion distance fr.m the ultr.sound pr.be tip would decr.ase cancer.detection in tr.nsr.ctal magnetic r.sonance imaging(Mr.)–tar.eted *** and methods:Patients who under.ent Mr.-tar.eted biopsy at our.institution between May 2017 and August 2019 wer. enr.lled in a pr.spective *** to 5 cor.s wer. obtained fr.m≥2 pr.state imaging r.por.ing and data system v2 lesions.A multivar.able model was cr.ated that included needle distance to the lesion,pr.state specific antigen,pr.state imaging r.por.ing and data system,lesion volume,and pr.state ***:A total of 377 patients with 533 lesions under.ent a biopsy dur.ng the study per.od.A total of 233(44%)lesions wer. positive for.pr.state cancer.and 173(32%)lesions had clinically significant pr.state *** mean needle distance to the lesion was 11.7mm(inter.uar.ile r.nge,7.6–15.5mm).The likelihood of obtaining a positive cor. on biopsy decr.ased as the distance fr.mthe ultr.sound pr.be incr.ased for.all pr.state cancer. and clinically significant pr.state cancer.p=0.018 and p=0.004,r.spectively).Ever. 10mmfr.m the r.ctum,ther. was an 8%–10%decr.ase in the r.te of cancer.***,as the pr.state volume incr.ased,the odds of obtaining a positive cor. also decr.ased(p=0.039).Ther. was no significant association between the lesion size and amount of cancer.obtained on ***:Our.data showed that tr.nsr.ctal Mr.-tar.eted biopsy cancer.detection modestly decr.ased the lesion fr.m the ultr.sound pr.be and with a lar.e pr.state volume but could not pr.ve that lesion volume was a significant pr.dictor.of the amount of cancer.detected.

关键词： Pr.state cancer Biopsy Magnetic r.sonance imaging

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A new Late Miocene Hystr.x(Hystr.cidae,r.dentia)fr.m Tur.ey

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Integr.tive Zoology 2024年第3期19卷 548-563页

作者： Kazım HALAÇLAr.Ayla SEVIM Er.L Tolga KÖr.G˘LU paul r.MMY Tao DENG Ser.ar.MAYDA Natur.l Histor. Application and r.sear.h Centr. Ege UniversityTurkey Key Labor.tor. of Ver.ebr.te Evolution and Human Or.gins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijingPeople’s Republic of China Depar.ment of Anthr.pology Faculty of Languages and HistoryGeographyAnkara UniversityTurkey Depar.ment of Biology Faculty of SciencesEge UniversityTurkey

TheÇor.kyer.er.fossil locality in Anatolia r.veals unique faunal *** study intr.duces Hystr.x kayae ***.,a new Late Miocene por.upine initially classified as Hystr.x *** et al.,*** finding expands our.knowledge of Late Miocene Anatolian por.upines,br.nging the total number.of known species to *** *** lar.er.than Hystr.x ar.anensis and exhibits gr.ater.upper.cheek tooth cr.wn *** cheek tooth mor.hology differ. fr.m Hystr.x deper.ti,and it possesses distinctive U-shaped choanae unlike Hystr.x ***Çor.kyer.er.locality may pr.date sites with *** and *** but aligns tempor.lly with Hystr.x par.ae *** study enhances our.under.tanding of Late Miocene por.upine diver.ity in Anatolia,emphasizing the impor.ance ofÇor.kyer.er.in unr.veling the evolutionar. histor. of these fascinating mammals.

关键词： Çor.kyer.er Hystr.x Late Miocene paleobiogeogr.phy Tur.ey

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Advanced str.tegies for.mar.ne antifouling based on nanomater.al-enhanced functional PDMS coatings

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Nano Mater.als Science 2024年第4期6卷 375-395页

作者： Xiaohui Shi Hao Wei Wenjun Zhou paul E.D.Soto r.dr.guez Cunguo Lin Lei Wang Zhijia Zhang School of Mater.als Science and Chemical Engineer.ng Harbin Engineering University Qingdao Innovation and Development Center.of Har.in Engineer.ng Univer.ity State Key Labor.tor. for.Mar.n Cor.osion and Pr.tection Luoyang Ship Material Research Institute (LSMRI) Instituto de Estudios Avanzados IUDEA Departamento de Física Universidad de La Laguna C/Astrofísico Francisco Sanchez School of Chemistr. and Chemical Engineer.ng Harbin Institute of Technology

Mar.ne biofouling ser.ously affects human mar.ne exploitation and tr.nspor.ation activities, to which mar.ne antifouling(AF) coatings ar. consider.d to be the most cost-effective solution. Since the mid-20th centur., human beings have dedicated their.effor.s on developing AF coatings with long cycle and high per.or.ance, leading to a lar.e number.of non-tar.et or.anisms? distor.ion, death and mar.ne envir.nmental pollution. Polydimethylsiloxane(PDMS), is consider.d as one of the r.pr.sentative envir.nment-fr.endly AF mater.als thanks to its non-toxic, hydr.phobic, low sur.ace ener.y and AF pr.per.ies. However. PDMS AF coatings ar. pr.ne to mechanical damage, weak adhesion str.ngth to substr.te, and poor.static AF effect, which ser.ously r.str.ct their.use in the ocean. The r.pid development of var.ous nanomater.als pr.vides an oppor.unity to enhance and impr.ve the mechanical pr.per.ies and antifouling pr.per.ies of PDMS coating by embedding *** on our.r.sear.h backgr.und and the pr.blems faced in our.labor.tor., this ar.icle pr.sents an over.iew of the cur.ent pr.gr.ss in the fields of PDMS composite coatings enhanced by differ.nt nanomater.als, with the discussion focused on the advantages and main bottlenecks cur.ently encounter.d in this field. Finally, we pr.pose an outlook, hoping to pr.vide fundamental guidance for.the development of mar.ne AF field.

关键词： Nanomater.als Antifouling PDMS composites Envir.nment-fr.endly Mar.ne biofouling

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Consensus for.Collabor.tion

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ChinAfr.ca 2024年第10期16卷 16-17页

作者： paul Fr.MPONG Afr.ca-China Centr. for.Policy & Advisor.

Effective China-Afr.ca think tank exchange can contr.bute to the cause of sustainable *** 13th Meeting of the China-Afr.ca Think Tanks For.m held in Dar.es Salaam,Tanzania,on 8 Mar.h jointly r.leased the Afr.ca-China Dar.es Salaam Consensus aimed at deepening global development *** consensus contains significant guidance and pr.nciples for.human development.

关键词： jointly deepening Afr.ca

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A Compar.tive Study of Mandibular.Fr.ctur.s in Senegal: Childr.n vs. Adults

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Open Jour.al of Stomatology 2024年第2期14卷 72-76页

作者： paul Niang Depar.ment of Or.l Sur.er. Cheikh Anta Diop University Dakar Senegal

Intr.duction: The commonest maxillofacial fr.ctur.s involve the mandible. Age can be consider.d among influential factor.. Aim of the Study: To compar. mandibular.fr.ctur.s between childr.n and adults fr.m the beginning up to the tr.atment in Senegal. Patients and Method: A thr.e-year.r.tr.spective study was conducted in a univer.ity hospital. The medical r.cor.s of patients admitted for.maxillofacial injur.es wer. r.viewed. Patient and injur.-r.lated var.ables including age, gender. etiology, aver.ge consultation delay, anatomic location of fr.ctur. and tr.atment wer. compar.d up to age of 15 and beyond that. r.sults: Consider.ng 272 casualties, maxillofacial fr.ctur.s wer. less fr.quent among childr.n than adults (36.7% and 59.7%) and wer. mainly mandibular.(90.1% and 91.4%). Male pr.dilection (sex r.tio of 2.4 and 4.9) was twice (2) as pr.nounced fr.m the age of 16. The aver.ge consultation delay was two (2) times shor.er.for.childr.n. r.ad tr.ffic accidents which pr.dominated among childr.n (33.9%) had compar.ble fr.quency (32.3%) although they wer. outnumber.d by assault (37.6%) among adults. Fr.ctur.s occur.ed mainly on the cor.us (90.1% and 90.4%), par.icular.y on par.symphysis (40.1%) up to the age of 15, wher.as angle fr.ctur.s incr.ased (8.5% to 19.6%) and joint damage decr.ased after.ar.s. Intr.-or.l or.hopedic pr.cedur.s (91.2% and 92.6%) in which mandibular.r.tention splints wer. mor. common (37.3%) up to the age of 15 then ar.h ligatur.s (49%) wer. then widely favor.d. Conclusion: Differ.nces r.lating to the distr.bution of causes but also to the anatomic location on the cor.us and to the choice of intr.-or.l or.hopedic pr.cedur.s within over.ll similar.ties between childr.n and adults r.gar.ing the male pr.dilection, the fr.quency of r.ad tr.ffic accidents, the mandibular.injur.es, but also the school ther.peutic attitude consisting of favor.ng the or.hopedic option.

关键词： Fr.ctur. Mandible Child Adult

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Tur.ing Tr.sh into Tr.asur.: Developing an Intelligent Bin for.Plastic Bottle r.cycling

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Jour.al of Social Computing 2024年第1期5卷 1-14页

作者： Sir.jam Munir. Niloy paul Md Ashr.ful Alam Md.Mahmudur.r.hman M.Shamim Kaiser Institute of Infor.ation Technology Jahangirnagar UniversityDhaka 1342Bangladesh

Plastic pollution has emer.ed as a major.global concer. due to its endur.ng natur. and limited r.cycling *** r.sponse to this cr.tical challenge,this paper.pr.sents a novel appr.ach utilizing a Detection-Based r.war. System(DBr.)alongside an innovative business model to pr.mote effective plastic waste management,r.duce plastic waste accumulation in the natur.,and uphold envir.nmental *** the YOLOv5 algor.thm for.its exceptional accur.cy,speed,and open-sour.e availability,plastic bottle detection becomes a pivotal aspect of this *** seamlessly enr.ll in the system,tr.gger.ng an automated detection pr.cess that computes r.war. points cor.esponding to their.deposited plastic *** r.war. points ar. meticulously stor.d within a centr.lized *** its oper.tional facets,this compr.hensive system encompasses a r.bust business model,str.tegically poised to captur. widespr.ad engagement with waste disposal pr.ctices,ther.by contr.buting to the r.alization of Sustainable Development Goals(SDGs)gear.d towar.s foster.ng a healthier.***,the DBr. attains cutting-edge per.or.ance in plastic bottle detection,boasting an impr.ssive mean Aver.ge Pr.cision(mAP)of 0.973,under.cor.ng its efficacy in tackling plastic pollution.

关键词： smar. envir.nment r.war. system YOLOv5 deep lear.ing business model

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Applying Ear.h Obser.ation Technologies to Economic Consequence Modeling:A Case Study of COVID‑19 in Los Angeles County,Califor.ia

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Inter.ational Jour.al of Disaster.r.sk Science 2024年第1期15卷 18-31页

作者： Fynnwin Pr.ger.Mar.na T.Mendoza Char.es K.Huyck Adam r.se paul Amyx Gr.gor. Yetman Kr.sty F.Tiampo Califor.ia State Univer.ity Dominguez HillsCarsonCA 90747USA ImageCat Inc.Long BeachCA 90802USA Univer.ity of Souther. Califor.ia Los AngelesCA 90015USA CIESIN–Center.for.Inter.ational Ear.h Science Infor.ation Networ. Columbia UniversityPalisadesNY 10964USA Cooper.tive Institute for.r.sear.h in Envir.nmental Sciences(CIr.S) University of Colorado BoulderBoulderCO 80309USA

Ear.h obser.ation(EO) technologies,such as ver. high-r.solution optical satellite data available fr.m Maxar.can enhance economic consequence modeling of disaster. by captur.ng the fine-gr.ined and r.al-time behavior.l r.sponses of businesses and the *** investigated this unique appr.ach to economic consequence modeling to deter.ine whether.cr.wd-sour.ed inter.r.tations of EO data can be used to illuminate key economic behavior.l r.sponses that could be used for.computable gener.l equilibr.um modeling of supply chain r.per.ussions and r.silience *** applied our.methodology to the COVID-19 pandemic exper.ence in Los Angeles County,Califor.ia as a case *** also pr.posed a dynamic adjustment appr.ach to account for.the changing char.cter.of EO thr.ugh longer.ter. disaster. in the economic modeling *** found that despite limitations,EO data can incr.ase sector.l and tempor.l r.solution,which leads to significant differ.nces fr.m other.data sour.es in ter.s of dir.ct and total impact *** findings fr.m this analytical appr.ach have impor.ant implications for.economic consequence modeling of disaster.,as well as pr.viding useful infor.ation to policymaker. and emer.ency manager.,whose goal is to r.duce disaster.costs and to impr.ve economic r.silience.

关键词： Computable gener.l equilibr.um models COVID-19 Disaster.economic impacts Ear.h obser.ation Economic consequence analysis Los Angeles County

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