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Hypoxia,vascular smooth muscles and endothelium

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Acta Pharmaceutica Sinica B 2013年第1期3卷 1-7页

作者： Calvin K.Chan paul m.vanhoutte Department of Pharmacology and Pharmacy University of Hong KongHong KongChina Department of BIN Fusion Technology Chonbuk National UniversityJeonjuSouth Korea

Hypoxia,or the lack of oxygen,has multiple impacts on the vascular *** major molecular sensors for hypoxia at the cellular level are hypoxia inducible factor and heme *** also acts on the vasculature directly conveying its damaging effects through disruption of the control of vascular tone,particularly in the coronary circulation,enhancement of inflammatory responses and activation of coagulation *** effects could be particularly detrimental under pathological conditions such as obstructive sleep apnea and other breathing disorders.

关键词： Coronary circulation Contractions Hypoxia Endothelium

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一氧化氮研究三十年:自优而劣（英文）

中国药理学与毒理学杂志 2016年第10期30卷 999-1000页

作者： paul m.vanhoutte State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina

In the last thirty years,it became over whelmingly apparent that the endothelium releases relaxing factors(EDRF),which diffuse to the underlying vascular smooth muscle cells and elicit endothelium-dependent *** best characterized EDRF is nitric oxide(NO)formed by endothelial NO synthase(e NOS).In the vascular smooth muscle cells,NO stimulates soluble guanylate cyclase which normally produces cyclic *** release by e NOS can be augmented by increases in shear stress or by activation of endothelial cell membrane receptors(*** response toα2-adrenergic agonists,serotonin,vasopressin,adenosine diphosphate and bradykinin).The ability of the endothelial cell to release NO can be up-regulated by estrogens,repeated increases in blood flow,exercise,diet(ω3-unsaturated fatty acids,polyphenols),and down-regulated by oxidative stress and increased presence of oxidized low density lipoproteins(LDL).The bioavailability of NO is curtailed by aging,smoking,environmental pollution or obesity and in hypertension and *** addition to lesser direct relaxation of the underlying vascular smooth muscle,a decreased release of NO also permits the production of vasoconstrictor prostanoids and/or *** endothelium-dependent relaxations can also be due to unresponsiveness of the vascular smooth muscle to ***,in coronary arteries,hypoxia and certain quinonescause acute augmentations of vasoconstrictor responses that depend on the presence of NO and the biased activation of soluble guanylate cyclase which produces cyclic ImP rather than cyclic *** hypoxia is implicated in exaggerated vasoconstrictions observed in coronary artery disease,the emerging role of this non-canonical cyclic nucleotide may help identifying novel therapeutic targets.

关键词： NOS GmP

Endothelium-dependent Contractions in Hypertension:When Prostacyclin Becomes Ugly

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Endothelium-dependent Contractions in Hypertension:When Pros...

第八届海峡两岸心血管科学研讨会

作者： paul m.vanhoutte Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong Department of BIN Fusion Technology Chonbuk National UniversityJeonjuKorea

＜正＞Endothelial cells modulate vascular tone by causing vasodilatation resulting from the release of nitric oxide（NO） and the generation of hyperpolarizing signals（EDHF）,but also can release endothelium - derived contracting factors（EDCF）,prostanoids derived from the metabolism of arachidonic *** over-production of EDCF contributes to the endothelial dysfunction which accompanies spontaneous[essential]hypertension. EDCF-release can be triggered by,agonists suh as acetylcholine,adenine nucleotides and calcium -ionophores which augment the intracellular calcium concentration in the endothelial *** increase in cytosolic calcium ions initiates the activation of the calcium-dependent phospholipase A2,cyclooxygenases and prostanoid *** arteries of spontaneously hypertensive rats（SHR） both cyclooxygenase-1 and prostacyclin synthase are over-expressed Their exaggerated activity leads to an abnormal production of prostanoids, mainly prostacyclin,which subsequently activate thromboxane - prostanoid（TP） receptors on the vascular smooth muscle cells which have lost the ability to relax in response to *** observation that inhibitors of cyclooxygenase nearly normalize the vasodilatation to acetylcholine in the forearm of essential hypertensive patients illustrates the role of EDCF in the endothelial dysfunction of hypertension.

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Endothelial dysfunction and coronary disease

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Endothelial dysfunction and coronary disease

中国药理学会第十次全国学术会议

作者： paul m.vanhoutte Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong Kong

The endothelium mediates relaxations(dilatations) of the underlying vascular smooth muscle *** endothelium -dependent relaxations are due to the release of non-prostanoid vasodilator *** best characterized endothelium...

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IUPHAR主席paul vanhoutte教授在开幕式上的致辞

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中国药理通讯 2006年第3期23卷 6-7页

作者： paul m.vanhoutte 国际药理学联合会主席

亲爱的同道们：我非常高兴在北京欢迎您。在这里，您将参加由中国药理学会（CNPHARS）和国际药理学联合会（IUPHAR）共同主办的“第十五届世界药理大会”。这次大会将从2006年7月2日开始，到7月7日结束。我们特别欢迎国际药理联合会会... 详细信息

亲爱的同道们：我非常高兴在北京欢迎您。在这里，您将参加由中国药理学会（CNPHARS）和国际药理学联合会（IUPHAR）共同主办的“第十五届世界药理大会”。这次大会将从2006年7月2日开始，到7月7日结束。我们特别欢迎国际药理联合会会员国的代表们，并正式代表他们感谢大会科学地组织了精彩的特邀报告、学术研讨会和专题会议。我们还高兴地看到，来自世界各地的参会者提交了大量的论文摘要，这些论文摘要组成了规模宏大的墙报展览。另外，大会还组织了特别活动用以展示那些极具潜力的年青药理学工作者的风采。勿庸置疑，中国，特别是北京，将为我们提供一个领略悠久文化和美好环境的独具特色的窗口。我相信，这一切将使得第十五届世界药理大会成为令我们难以忘怀的重要事件!

关键词： IUPHAR 主席 paul vanhoutte 教授开幕式中国药理学会

Flow,pressure and vascular responsiveness

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Flow,pressure and vascular responsiveness

11th International Vascular Neuroeffector mechanisms and Cardiovascular Pharmacology and medicine Symposia, Shanghai-Suzhou 2006

作者： Lasse E.Rasmussen paul m.vanhoutte Boye L.Jensen Ole Skott Physiology and Pharmacology University of Southern Denmark Winslowparken 21.3 Oefense C 5000 Denmark Physiology and Pharmacology University of Southern Denmark Winslowparken 21.3 Oefense C 5000 Denmark Physiology and Pharmacology University of Southern Denmark Winslowparken 21.3 Oefense C 5000 Denmark Physiology and Pharmacology University of Southern Denmark Winslowparken 21.3 Oefense C 5000 Denmark

Unidirectional endothelial shear stress is supposed to maintain a continuous release of nitric oxide.[1-3]. Consistent with this, low wall shear stress is associated with endothelial dysfunction in patients with peripheral artery disease or abdominal aortic aneurysm[4]. However in rabbit aorta perfused ex vivo [5] chronic shear stress does not stimulate eNOS. . Thus, the effect of flow on endothelial function in large vessels is unresolved. Therefore experiments were

关键词： Flow,pressure and vascular responsiveness

Prostanoid synthases and receptors in aorta of spontaneously hypertensive rat

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Prostanoid synthases and receptors in aorta of spontaneously...

11th International Vascular Neuroeffector mechanisms and Cardiovascular Pharmacology and medicine Symposia, Shanghai-Suzhou 2006

作者： Eva H.C.Tang George P.m.Leung Amy C.Y.Lo Sookja K.Chung Ricky Y.K.man paul m.vanhoutte Dept of Pharmacology University of HK Hong Kong Dept of Pharmacology University of HK Hong Kong Dept of Anatomy University of HK Hong Kong Dept of Anatomy University of HK Hong Kong Dept of Pharmacology University of HK Hong Kong Dept of Pharmacology University of HK Hong Kong

Expression pattern of prostanoid synthases on freshly isolated endpthelial cells and its respective receptors on smooth muscle cells of the thoracic aorta of eight-month old Wistar Kyoto rat (WKY) and spontaneously hypertensive rat (SHR) are assessed. Total RNA was isolated, converted into cDNA and used for quantitative real-time polymerase chain reaction (PCR) using SYBR green fluorescent dye to quantify the accumulation of double-stranded PCR

关键词： Prostanoid synthases and receptors in aorta of spontaneously hypertensive rat

Combining neural progenitor cell transplant and rehabilitation for enhanced recovery after cervical spinal cord injury

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Neural Regeneration Research 2024年第7期19卷 1433-1434页

作者： Camila m.Freria paul Lu Department of Neurosciences University of CaliforniaSan DiegoLa JollaCAUSA Veterans Administration San Diego Healthcare System San DiegoCAUSA

Efforts to promote recovery of function after human spinal cord injury(SCI) will likely require interventions to rgeting the corticospinal tract(CST) motor system:the most important pathway for voluntary motor control in *** system has historically been the most refractory to regenerative efforts after *** "nonregeneration" of the CST changed when robust regeneration of the CST into spared tissue was demonstrated by the inactivation of phosphatase and tensin homolog and delivery of inosine.

关键词： cervical progenitor injury

Pressurized environments directly influence friction and wear of dry steel contacts—Investigations in a novel high fluid pressure tribometer

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Friction 2024年第7期12卷 1599-1617页

作者： paul REICHLE Jakob BARZ Georg UmLAUF Günter E.m.TOVAR Institute of Interfacial Process Engineering and Plasma Technology(IGVP) University of StuttgartStuttgart 70569Germany Fraunhofer Institute for Interfacial Engineering and Biotechnology(IGB) Stuttgart 70569Germany

To reduce the usage of classical lubricants in deep drawing,a new tribological system based on volatile lubricants was ***,a volatile medium is injected under high pressure into the interstice between drawing tool and sheet *** on temperature and pressure,the temporary lubricant may exist in its gaseous or liquid *** this study,a novel high fluid pressure tribometer was designed to investigate the friction and wear of dry steel contacts under comparable conditions like in dry deep ***,a new ball-on-disc tribometer was designed and integrated into a high-pressure *** specifically investigate the effects of different environments(technical air,liquid and gaseous carbon dioxide,nitrogen,argon)at atmospheric and high pressure(0.1 mPa,6 mPa)on tribology,the specimens and all components were operating *** the experiments,the friction was measured *** show that the highest friction occurs in air and the lowest in carbon dioxide *** to the experiments,the wear of the specimens was assessed along with changes in surface chemistry related to tribochemical ***,the tribology of the dry sliding contacts is correlated to changes of the surface *** differences as well as similarities regarding the different fluid environments are *** the results show,the differences between the media used are most pronounced at elevated ***,this work gives clear indications on the suitability of volatile lubricants in dry friction or rather gas lubrication,especially for dry deep drawing.

关键词： dry friction and dry wear gas lubrication carbon dioxide tribo-layer dry metal forming