检索结果-南通市图书馆

Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2010年第1期4卷 59-66页

作者： Dai-Hai YU De-Pei LIU Lai-Yuan WANG Jing CHEN Cashell E.JAQUISH Dabeeru C.RAO James E.HIXSON Jian-Feng HUANG Chung-Shiuan CHEN Charles GU Ji-Chun CHEN Jie CAO Shu-Feng CHEN paul k.whelton Jiang HE Dong-Feng GU Department of Evidence-based Medicine and Population Genetics Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Chinese National Human Genome Center at Beijing Beijing 100176China Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLA 70112USA Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA National Heart Lungand Blood InstituteNational Institute of HealthBethesdaMD 20892USA Washington University in St.Louis School of Medicine St.LouisMO 63110USA University of Texas School of Public Health HoustonTX 77030USA Loyola University Medical Center MaywoodIL 60153USA

Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular ***,blood pressure(BP)responses to potassium supplementation vary among *** study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to *** conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north *** measurements were obtained at the end of each intervention period using a random-zero *** identiﬁed signiﬁcant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all Pker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A *** addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple *** and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A *** summary,our study identified novel associations between

关键词： blood pressure genetics polymorphism dietary potassium potassium sensitivity adducin 1 alpha(ADD1) guanine nucleotide binding protein beta polypeptide 3(GNB3)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国成年人体重与死亡率的关系

中华内分泌代谢杂志 2007年第4期23卷 294-300页

作者：顾东风 HE Jiang 段秀芳吴锡桂 kristi Reynolds CHEN Jing 黄广勇 CHEN Chung Shiuan paul k.whelton 陈纪春阜外心血管病医院卫生部心血管病防治研究中心中国医学科学院协和医科大学阜外心血管病医院卫生部心血管病防治研究中心北京100037 Tulane大学公共卫生学院

目的探讨中国成年人体重指数(BMI)与死亡率的关系。方法本项前瞻性队列研究包括全国40岁以上男性和女性共169 871人。1991年采用标准化方案进行基线调查获得体重和其它各项数据,1999年至2000年对该人群进行了全部死亡原因的随访,应答率9... 详细信息

目的探讨中国成年人体重指数(BMI)与死亡率的关系。方法本项前瞻性队列研究包括全国40岁以上男性和女性共169 871人。1991年采用标准化方案进行基线调查获得体重和其它各项数据,1999年至2000年对该人群进行了全部死亡原因的随访,应答率93.4%(n=158 666)。结果排除体重或身高缺失的数据后,共分析了154 736名成年人的资料。在调整年龄、性别、吸烟、饮酒、体力活动、文化程度、地域以及城乡等因素后,BMI与全因死亡率之间呈"U"型相关(pkg/m^2者为参照组,BMIkg/m^2组的全因死亡相对危险度分别为1.65(95%CI,1.54-1.77)、1.31(95%CI,1.***.1.41)、1.20(95%CI,1.11-1.29)、1.12(95%CI,1.04-1.21)、1.11(95%CI,1.03-1.20)、1.09(95%CI,1.***.1.19)、1.00(95%CI,0.92-1.08)、1.15(95%CI,1.***.1.24)和1.29(95%CI,,1.16-1.42)。即使排除了现在或曾经吸烟者、酗酒者、基线检查有慢性疾病者、基线调查后3年内死亡者,这种"U"型关系仍然存在。BMI与心血管疾病、癌症以及其它死因死亡率之间均有类似关系。结论中国成年人群低体重和肥胖都与死亡率的增加有关,建议在所有种族和民族中采用一个共同标准来定义超重和肥胖。

关键词：体重指数超重肥胖症全因死亡率前瞻性研究

在线全文

学校读者我要写书评

暂无评论

中国成年人主要死亡原因及其危险因素

中国慢性病预防与控制 2006年第3期14卷 149-154页

作者：顾东风 Jiang He 吴锡桂段秀芳姚崇华王家良 kristi Reynolds Chung-Shiuan Chen Michael J．klag paul k．whelton 中国医学科学院协和医科大学阜外心血管病医院卫生部心血管病防治研究中心北京100037 Tulane大学公共卫生学院美国新奥尔良首都医科大学附属安贞医院北京100029 四川大学华西医学院四川成都610041 美国JohnsHopkins大学医学院美国巴尔的摩

目的调查我国成人的主要死亡原因及其可改变的主要危险因素。方法前瞻性队列研究。该队列包括169871名≥40岁男女性有代表性样本,基线调查于1991年,于1999和2000年进行随访,随访率为93.4%。结果我国40～64岁人群中,恶性肿瘤、脑血管疾... 详细信息

目的调查我国成人的主要死亡原因及其可改变的主要危险因素。方法前瞻性队列研究。该队列包括169871名≥40岁男女性有代表性样本,基线调查于1991年,于1999和2000年进行随访,随访率为93.4%。结果我国40～64岁人群中,恶性肿瘤、脑血管疾病和心脏病死亡率分别为265.9/10万人.年、171.5/10万人.年和159.1/10万人.年,高于美国同年龄人群。高血压的全死因相对危险性和人群归因危险度(PAR)分别为1.48%(95%CI1.44～1.53),11.7%;与未患高血压的人群相比,高血压患者总死亡率高48%,若高血压得到有效控制,预计全人群的全死因死亡将下降11.7%。吸烟、缺乏体力活动分别为第2、3位主要死亡原因,吸烟、缺乏体力活动PAR分别是7.9%和6.8%。男性的前5位死因为恶性肿瘤、心脏病、脑血管疾病、意外伤害和传染病;女性前5位死因为心脏病、脑血管疾病、恶性肿瘤、肺炎、流感和传染性疾病。结论血管疾病和癌症是中国成年人死亡的主要原因。控制血压、戒烟、增加体力活动和改善营养等方法是降低中国成年人早死负担的重要策略。

关键词：队列研究慢性病人群归因危险度

中国人基因变异和体力活动的相互作用与血压相关

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志 2012年第2期20卷 198-198页

作者： May E.Montasser Lawrence C.Shimmin Charles Gu Tanika N.kelly Cashell E.Jaquish Treva Rice Dabeeru C.Rao paul k.whelton James E.Hixson 罗冬梅叶鹏

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体... 详细信息

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体力活动将3142名入选者进行分组（体力活动组与非体力活动组），应用广义估计方程分析收缩压和舒张压与血压调控通路中24个基因表型改变的关系[包括196单核苷酸多态性（single-nucleotide polymorphisms，SNP）]。

关键词：体力活动血压动态相互作用基因变异中国农村非遗传因素单核苷酸多态性广义估计方程

Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley Osman paul Ashwood Department of Medical Microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(MIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with ASD by the age of 8 years,with ASD rates continuing to increase in prevalence in USA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

Emerging insights into the function of very long chain fatty acids at cerebellar synapses

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1709-1710页

作者： Martin-paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

功函促进钼基异质结电催化剂的电子结构重整提升其析氢反应活性（英文）

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2025年第1期 189-198页

作者：陈想冯帅谢松苗亚萍高标张旭明黄莉李筠 paul k.Chu 彭祥 Hubei key Laboratory of Plasma Chemistry and Advanced Materials Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education School of Materials Science and Engineering Wuhan Institute of Technology School of Textile Science and Engineering Xi'an Polytechnic University The State key Laboratory of Refractories and Metallurgy Institute of Advanced Materials and Nanotechnology Wuhan University of Science and Technology Guizhou Wujiang Hydropower Development Co. Ltd. Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong

Mo基催化剂在电催化析氢反应（HER）中具有巨大应用潜力.然而,其活性位点的暴露不足、极强的氢吸附能力导致其催化性能未能充分体现.本文在碳布上构筑了Mo2N–MoSe2异质结（MNS）,以增强Mo基催化剂的HER活性.由于MNS中的Mo2N具有较低的...

Mo基催化剂在电催化析氢反应（HER）中具有巨大应用潜力.然而,其活性位点的暴露不足、极强的氢吸附能力导致其催化性能未能充分体现.本文在碳布上构筑了Mo2N–MoSe2异质结（MNS）,以增强Mo基催化剂的HER活性.由于MNS中的Mo2N具有较低的功函数,能够在异质界面产生内建电场,显著提高了其在HER中电荷转移效率.此外,MNS中原子之间的强电子相互作用优化了Mo位点的电子结构,降低了氢吸附能力,进一步增强了其本征催化活性.因此, MNS催化剂产生20 m A cm-2和1 A cm-2的析氢电流密度所需的过电位仅为65和210 mV, Tafel斜率仅为96 mV dec-1.此外, MNS在1 A cm-2电流密度下稳定运行240小时后,形貌、结构和性能均无明显变化.以上研究结果为工业大电流制氢所需的非贵金属基电催化剂的设计和合成提供了新思路.

关键词：

同方期刊数据库

Evolution of Nanocrystalline TiBCN Structure with Temperature and Mechanism

在线全文

学校读者我要写书评

暂无评论

稀有金属材料与工程 2012年第S1期41卷 341-343页

作者： paul k Chu Department of Physics and Materials Science City University of HongkongKowloon HongkongChina

Evolution of the TiB0.71C3.32N0.79 quaternary nanocomposite structure at 600,700,800,900,and 1000℃ is investigated by high-resolution transmission electron microscopy,X-ray diffraction,X-ray photoelectron spectrometry,and micro-hardness *** nc-Ti(C,N)nanocrystallites exhibit the(200)preferential orientation and the amorphous carbon(a-C)phase gradually transforms into the crystallite graphite phase as the temperature is *** 1000℃,the nc-Ti(C,N)nanocrystallites increase to a size of 13 nm but the microhardness diminishes to 18-19 *** corresponding mechanism is discussed.

关键词： nanocomposites structure TiBCN

Environmental threats to the Three Gorges Reservoir Region:Are mutagenic and genotoxic substances important?

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2015年第12期27卷 172-174页

作者： paul k.S.Lam State key Laboratory in Marine Pollution Department of Biology and ChemistryCity University of Hong Kong

The Three Gorges Dam project（TGDP）,with a total static investment of 95.46 billion RMB（US$10.97 billion）based on the 1993 price level,commenced in 1994 and was completed in *** creation of the Three Gorges Reservoir following the completion of the TGDP had brought about significant changes to the Three Gorges Reservoir Region（TGRR）,stretching from the town of Sandouping in Hubei Province to the Jiangjin District of Chongqing *** TGDP has led to progressive urbanization and industrialization of the TGRR,accompanied by increased shipping activities,greater

关键词： Three Gorges Dam Persistent organic pollutants Yangtze River Sediment Water