检索结果-南通市图书馆

Conversation Analysis and Social Action

在线全文

学校读者我要写书评

暂无评论

外国语 2013年第3期36卷 2-19页

作者： paul drew Loughborough University UK

Conversation analysis(CA) has come to be regarded as focusing primarily on turn-taking,on the way speakers design,hold and extend their turns at talk;how they select next speakers;how others know when it is their turn to speak;how orderly transition from one turn to the next is managed and how turns *** argument in this paper is that this research focus is waning,and that in its place a new direction is emerging(or perhaps reemerging) -the investigation of how social actions are conducted through *** research direction connects with an area that is quite familiar in linguistic pragmatics,that of speech act analysis(Austin,Searle).But CA's approach is quite distinctive,exploring as it does the systematic basis for the selection of one from among the alternative constructions or formats for doing certain *** is illustrated through recent studies of offering and requesting,with some further observations of negatively formatted interrogatives used to make *** studies show that speakers select between the alternative available forms on the basis of the sequential position in which the speaker is conducting that action.

关键词：英语学习学习方法阅读知识阅读材料

Investigation of cholecystokinin receptors in the human lower esophageal sphincter

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第21期20卷 6554-6559页

作者： Jun-Feng Liu Jian Zhang Xin-Bo Liu paul a drew Department of Thoracic Surgery Fourth HospitalHebei Medical University School of Nursing and Midwifery Flinders UniversityAdelaide 5001Australia

AIM: To compare the binding of cholecystokinin (CCK)-8 to CCK receptors in sling and clasp fibers of the human lower esophageal sphincter.

关键词： Cholecystokinins Cholecystokinins-A receptor Cholecystokinins-B receptor Radioligand binding Lower esophageal sphincter Sling fibers Clasp fibers

Methylation of TIMP3 in esophageal squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第2期14卷 203-210页

作者： Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson paul a drew Discipline of Surgery School of Medicine Faculty of Health Sciences TheUniversity of Adelaide Royal Adelaide Hospital South Australia5005 Australia Department of Thoracic Surgery Fourth Hospital of Hebei Medical University Shijiazhuang050011 Hebei Province China Division of Tissue Pathology Institute of Medical and Veterinary Science AdelaideSouth Australia 5000 Australia School of Nursing and Midwifery Flinders University Bedford Park South Australia 5042 Australia

AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in ***: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by ***: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just ***: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China.

关键词： Esophageal squamous cell carcinoma Immunohistochemistry Methylation TIMP3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

甲醛固定石蜡包埋组织中DNA的降解情况

中华病理学杂志 2004年第3期33卷 292-293页

作者：田子强刘俊峰王贵英 Eric Smith paul drew David Watson Glyn G Jamieson 河北医科大学第四医院胸外科石家庄050011 河北医科大学第四医院外科石家庄050011 Department of Surgery Royal Adelaide Hospitalthe University of Adelaide

为了对比国外甲醛固定石蜡包埋组织中DNA的保存质量与国内标本的差异,特设计实验如下。

关键词：甲醛固定石蜡包埋 DNA降解 DNA保存

Unique MR Findings in a Case Series of Two Symptomatic Patients with Peliosis Hepatis

在线全文

学校读者我要写书评

暂无评论

Open Journal of Radiology 2014年第1期4卷 79-84页

作者： drew Pierce Christopher S. Davis paul M. Bloomston Zarine K. Shah Department of Radiology Ohio State University Wexner Medical Center Columbus USA Department of Surgery Ohio State University Wexner Medical Center Columbus USA

Purpose: The aim of this report is to describe the unusual MR imaging characteristics observed in two patients with biopsy-proven peliosis hepatis. Imaging findings using gadoxetate disodium (Eovist) as the contrast agent in a patient with peliosis hepatis are presented for the first time. Methods: This is a retrospective review of the MRI findings in two patients reviewed independently by two specialized abdominal imaging radiologists. The radiological findings were correlated with clinical history and histopathology. Results: Peliosis hepatis is a rare clinical and radiological entity that is often a diagnostic dilemma due to its non-specific clinical characteristics. Unusual imaging characteristics in this rare entity make diagnosis even more challenging. Conclusions: Improved understanding of the imaging characteristics of peliosis hepatis may prevent unnecessary and potentially dangerous biopsies in select patients with peliosis hepatis. This requires a high index of suspicion for practicing radiologists due to the rarity of this disease.

关键词： Peliosis Hepatis Magnetic Resonance Imaging Hepatic lesions Liver Disease Gadoxetate Disodium

新的城市设计感知力:一种可为全球不断增长的人口提供空间的科学途径

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

景观设计学（中英文） 2016年第1期4卷 30-41页

作者：卡梅伦·巴瑞戴尔菲利普·恩奎斯特保罗·欧科纳德鲁·温斯利 SOM建筑设计事务所 Moriyama and Teshima景观规划事务所总裁

我们看到了一个不同的未来……据预测,到2050年时,地球上将有约97亿人口—大致占全球人口的66%—居住在城市。随着人口爆炸和飞速的人口城市化,设计在为人类提供优质的生活空间这一方面变得日益重要;同时,设计还需谨慎负责地利用全球资... 详细信息

我们看到了一个不同的未来……据预测,到2050年时,地球上将有约97亿人口—大致占全球人口的66%—居住在城市。随着人口爆炸和飞速的人口城市化,设计在为人类提供优质的生活空间这一方面变得日益重要;同时,设计还需谨慎负责地利用全球资源,以保持我们人类和地球家园的健康。未来的弹性城市一定是诞生于并从其环境中得到支持;反过来,如果我们人类想要以某一物种的身份在地球上蓬勃发展,那么我们便必须尊重、提升并保护供我们所有人类生存发展的自然生态系统。因此,我们必须探索一种新的城市设计感知力,这种感知力再度强调人类要服从于自然的力量,并迫使设计者、决策者和科学家对我们的选择进行重新评估—这些评估应更加基于需要消耗多少来自我们周遭环境的投入,并要求我们进行更为系统的思考,而非盲目追求好看。这种探索城市设计的新方式,使科学和生态得以决定城市形式,而非反过来由形式所决定。

关键词：可持续的都市主义科学技术生态城市设计生态系统

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

在线全文

学校读者我要写书评

暂无评论

Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin Hanna David Baron Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin Rajendra D. Badgaiyan Edward J. Modestino drew Edwards Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAS CANS Genetic Addiction Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

BA46基因转染树突状细胞治疗乳腺癌的研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华微生物学和免疫学杂志 2005年第7期25卷 574-577页

作者：尤长宣罗荣城苏瑾张军一廖旺军郑航 Yong Liu paul L Hermonat 广州南方医科大学附属南方医院肿瘤科广州南方医科大学附属南方医院呼吸科美国阿肯色大学医学院基因治疗中心

目的探讨以乳腺癌特异抗原BA46基因转导树突状细胞(DC)治疗乳腺癌的可行性。方法取健康人外周血,采用密度梯度离心的方法分离外周血单个核细胞(DC前体细胞),以AIM-V培养基于6孔板培养,贴壁5h,轻轻洗去悬浮细胞(T细胞,冻存备用),取贴壁细... 详细信息

目的探讨以乳腺癌特异抗原BA46基因转导树突状细胞(DC)治疗乳腺癌的可行性。方法取健康人外周血,采用密度梯度离心的方法分离外周血单个核细胞(DC前体细胞),以AIM-V培养基于6孔板培养,贴壁5h,轻轻洗去悬浮细胞(T细胞,冻存备用),取贴壁细胞,将细胞分为基因转染组及对照组,基因转染组感染携带BA46基因的重组腺相关病毒rAAV/BA46/Neo,对照组以293细胞冻融液刺激,两组细胞均采用重组人粒细胞巨噬细胞集落刺激因子(GM-CSF)、白细胞介素4(IL-4)、肿瘤坏死因子-α(TNF-α)诱导DC前体细胞成熟。第7天,收集悬浮细胞(DC),显微镜观察细胞形态,流式细胞仪分析DC的表面标志CD80、CD86、CD40的表达情况;另取该DC与T细胞按1∶20比例混合,含5%人血清蛋白的AIM-V为培养基,同时加入IL-2与GM-CSF,共育7d,诱导获得细胞毒性T淋巴细胞(CTL),取BA46阳性的乳腺癌细胞株Hs578T为靶细胞,采用51Cr释放法测量杀伤效率,同时以流式细胞仪检测CTL群体中CD8/CD4和CD8/CD56的比值。结果BA46基因转导的DC表面标志CD80、CD86、CD40的表达均明显高于对照组DC,所激活的T细胞对BA46阳性的乳腺癌细胞株Hs578T有很好的杀伤效果,此杀伤具有抗原特异性和MHC限制性,且该T细胞中CD8/CD4和CD8/CD56的比值均明显高于对照组(细胞裂解物冲击DC所激活的T细胞)。结论BA46基因转染成功制备DC,并诱导特异的CTL,为乳腺癌的DC基因转染疗法打下基础。

关键词：树突状细胞 BA46 基因转染乳腺癌乳腺癌细胞株细胞治疗重组人粒细胞巨噬细胞集落刺激因子肿瘤坏死因子-α(TNF-α) 细胞毒性T淋巴细胞外周血单个核细胞