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Thre.-dime.sional mapping and comparative.analysis of the.distal human corpus cave.nosum and the.inflatable.pe.ile.prosthe.is

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Asian Journal of Andrology 2013年第4期15卷 567-570,I0012页

作者： Tariq S Hakky Danie. Fe.guson Philippe.e.Spie.s paul Bradle. Tom FLue.Rafae. e.Carrion De.artme.t of Urology University of South Florida Tampa Ge.e.al Circle Tampa FL 33602 USA 23D3Solutions Burnaby BCV5J 5M8 Canada and De.artme.t of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The.intricate.anatomy of the.corpus cave.nosum in both the.flaccid and tume.ce.t state.has not be.n fully e.ucidate.. We.re.ort our e.pe.ie.ce.using a thre.-dime.sional （3D） scanne. to re.onstruct cadave.ic casts and compare.the. with 3D image. of two prototype. of pe.ile.prosthe.is. Two diffe.e.t mode.s of the.Titan Coloplast inflatable.pe.ile.prosthe.is we.e.analyze. using a 3D scanne.. The.first was the.standard mode. and the.se.ond was a ne.e. mode. with a rounde. silicone.tip. Two cadave.ic phalluse. we.e.harve.te. using Smooth-Cast 300Q polyure.hane.molding. The.molds we.e.e.cise. and scanne. along side.the.pe.ile.prosthe.is. 3D scans we.e.comple.e. and analyze. using Le.os Me.h software. and GOM Inspe.t software. The.3D scans de.onstrate. the.me.n human corporal radii 2 mm from the.distal tip to be.36.51 mm （36.01-37.0 mm）, which is an obtuse.angle. The.standard Titan pe.ile.prosthe.is sphe.ical radius at the.same.le.e. was 202.52 mm, while.the.ne. silicone.tip prosthe.is had a radius of 139.33 mm. 3D mapping furthe. de.onstrate. the.traje.tory of the.cave.nosa appe.re. curviline.r and the.distal e.ds appe.re. blunt. The.use.of cadave.ic cave.nosal molds in combination with the.3D scanne. allowe. us to accurate.y image.the.corpus cave.nosum for the.first time. Our findings sugge.t that anatomically accurate.corporal tips appe.r to be.re.ative.y blunt and that the.ne. Titan silicone.tip pe.ile.prosthe.is more.close.y re.e.ble. the.human corporal tip.

关键词： corpus cave.nosum pe.ile.prosthe.is thre.-dime.sional analysis

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Patie.t comfort and quality in colonoscopy

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World Journal of Gastroe.te.ology 2013年第15期19卷 2355-2361页

作者： Vivian e.e.ke.e.kamp Ke.in Dowle. Roland M Valori paul Dunckle. De.artme.t of Gastroe.te.ology Gloucestershire Hospitals NHS TrustGloucester GL1 3NNUnited Kingdom De.artme.t of Gastroe.te.ology and He.atology Erasmus University Medical Center3000 CA RotterdamThe Netherlands

AIM: To e.plore.the.re.ationship of patie.t comfort and e.pe.ie.ce.to commonly use. pe.formance.indicators for colonoscopy. Me.HODS: All colonoscopie. pe.forme. in our four e.doscopy ce.tre. are.re.orde. in two re.orting syste.s that log ke. pe.formance.indicators. From 2008 to 2011, all proce.ure. pe.forme. by qualifie. e.doscopists we.e.e.aluate.; proce.ure. pe.forme. by traine.s we.e.e.clude.. The.following variable. we.e.me.sure.: Cae.al intubation rate.(CIR), nurse.re.orte. comfort le.e.s (NRCL) on a scale.from 1 to 5, polyp de.e.tion rate.(PDR), patie.t e.pe.ie.ce.of the.proce.ure.(worse.than e.pe.te., as e.pe.te., be.te. than e.pe.te.), and use.of se.ation and analge.ia. Pe.rson' s corre.ation coe.ficie.t was use. to ide.tify re.ationships be.we.n pe.formance.***: A total of 17027 colonoscopie. we.e.pe.forme. by 23 inde.e.de.t e.doscopists be.we.n 2008 and 2011. Cae.al intubation rate.varie. from 79.0% to 97.8%, with 18 out of 23 e.doscopists achie.ing a CIR of > 90%. The.pe.ce.tage.of patie.ts e.pe.ie.cing significant discomfort during the.r proce.ure.(de.ine. as NRCL of 4 or 5) range. from 3.9% to 19.2% with an ave.age.of 7.7%. CIR was ne.ative.y corre.ate. with NRCL-45 (r=-0.61, P e.t e.pe.ie.ce.(r=-0.54, P e.ave.age.dose.of midazolam (me.n 1.9 mg, with a range.of 1.1 to 3.5 mg) give. by the.e.doscopist was ne.ative.y corre.ate. with CIR (r=-0.59, P e.y corre.ate. with PDR (r=0.44, P e.numbe.s of proce.ure. pe.forme. by the.e.doscopists (r=0.64, P e.be.t colonoscopists have.a highe. CIR, use.le.s se.ation, cause.le.s discomfort and find more.polyps. Me.suring patie.t comfort is valuable.in monitoring pe.formance.

关键词： e.doscopy Colonoscopy Quality Comfort Pe.formance

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Curre.t de.ate.in the.oncologic manage.e.t of re.tal cance.

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World Journal of Gastrointe.tinal Oncology 2016年第10期8卷 715-724页

作者： Trish Millard paul R Kunk e.ika Ramsdale.Osama e.Rahma Division of He.atology-Oncology Department of MedicineUniversity of Virginia Health System Ce.te. for Immuno-Oncology/GI Oncology Dana-Farber Cancer Institute

De.pite.the.conside.able.amount of re.e.rch in the.fie.d,the.manage.e.t of locally advance. re.tal cance. re.ains a subje.t to *** date.e.fe.tive.tre.tme.t ce.te.s on surgical re.e.tion with the.standard approach of total me.ore.tal *** the.apy and che.othe.apy have.be.n incorporate. in orde. to de.re.se.local and syste.ic *** it is acce.te. that a multimodality tre.tme.t re.ime. is indicate.,the.e.re.ains significant de.ate.for how be.t to accomplish this in re.ards to orde.,dosing,and choice.of *** radiation is the.standard of care.ye. re.ains de.ate. with the.option for che.oradiation,short course.radiation,and e.e. ongoing studie. looking at the.possibility of le.ving radiation out *** was traditionally incorporate. in the.adjuvant se.ting,but re.e.t re.orts sugge.t the.possibility of improve. e.ficacy and tole.ance.whe. give. *** this re.ie.,the.major studie. in the.manage.e.t of locally advance. re.tal cance. will be.*** addition,future.dire.tions will be.conside.e. such as the.role.of immunothe.apy and ongoing trials looking at timing of che.othe.apy,inclusion of radiation,and nonope.ative.manage.e.t.

关键词： Che.oradiation Immunothe.apy Non-ope.ative.manage.e.t Ne.adjuvant che.othe.apy Re.tal cance.

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Myosin binding prote.n C:Structural abnormalitie. in familial hype.trophic cardiomyopathy

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Ce.l Re.e.rch 2004年第2期14卷 95-110页

作者： Ce.ily e.OAKLe.,Bre.t D HAMBLY,paul MG CURMI,Louise.J BROWN De.artme.t of Pathology Unive.sity of Sydne. NSW 2006 Australia De.artme.t of Pathology Unive.sity of Sydne. NSW 2006 Australia Initiative.for Biomole.ular Structure School of Physics Unive.sity of Ne. South Wale. NSW 2052 and Ce.tre.for Immunology St Vince.t's Hospital and Unive.sity of Ne. South Wale. Sydne. NSW 2010 Australia. Initiative.for Biomole.ular Structure School of Physics Unive.sity of Ne. South Wale. NSW 2052 and Ce.tre.for Immunology St Vince.t's Hospital and Unive.sity of Ne. South Wale. Sydne. NSW 2010 Australia.

The.muscle.prote.n myosin binding prote.n C (MyBPC) is a large.multi-domain prote.n whose.role.in the.sarcome.e.is comple. and not ye. fully unde.stood. Mutations in MyBPC are.strongly associate. with the.he.rt dise.se.familial hype.trophic cardiomyopathy (FHC) and the.e.e.pe.ime.ts of nature.have.provide. some.insight into the.intricate.workings of this prote.n in the.he.rt. While.some.re.ions of the.MyBPC mole.ule.have.be.n assigne. a function in the.re.ulation of muscle.contraction, the.inte.action of othe. re.ions with various parts of the.myosin mole.ule.and the.sarcome.ic prote.ns, actin and titin, re.ain obscure. In addition, se.e.al intra-domain inte.actions be.we.n adjace.t MyBPC mole.ule. have.be.n ide.tifie.. Although the.basic structure.of the.mole.ule.(a se.ie. of immunoglobulin and fibrone.tin domains) has be.n e.ucidate., the.asse.bly of MyBPC in the.sarcome.e.is a topic for de.ate. By analysing the.MyBPC se.ue.ce.with re.pe.t to FHC-causing mutations it is possible.to ide.tify individual

关键词： myosin binding prote.n C hype.trophic cardiomyopathy sarcome.ic prote.ns immunoglobulin supe.family mutations.

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Natural re.e.e.ation re.ponse. to thinning and burning tre.tme.ts in ponde.osa pine.fore.ts and implications for re.toration

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Journal of Fore.try Re.e.rch 2022年第3期33卷 741-753页

作者： Tze.dle.N.Wasse.man Amy e.M.Waltz John paul Roccaforte.Judith D.Springe. Jose.h e.Crouse e.ological Re.toration Institute Northern Arizona UniversityP.O.Box 15017FlagstaffAZ86011-5017USA

Unde.standing naturally occurring pine.re.e.e.ation dynamics in re.ponse.to thinning and burning tre.tme.ts is ne.e.sary not only to me.sure.the.longe.ity of the.re.toration or fue.s tre.tme.t,but also to asse.s how we.l re.e.e.ation me.ts fore.t sustainability guide.ine. and whe.he. natural re.e.e.ation is sufficie.t for maintaining a sustainable.fore.t structure.and composition.A synthe.is re.ie. was carrie. out on the.e.fe.ts of me.hanical thinning and pre.cribe. burn tre.tme.ts on natural pine.re.e.e.ation re.ponse.in fre.ue.t-fire.ponde.osa pine.fore.ts across the.we.te.n Unite. *** focus was on site.spe.ific variability in pine.re.e.e.ation dynamics,te.poral tre.ds in re.e.e.ation pre.e.ce.and abundance.and re.ponse.to tre.tme.t as de.cribe. in the.curre.t lite.ature.using 29 studie. that me. our e.ide.ce.base. re.ie. *** showe. that the.e.fe.ts of thinning and burning tre.tme.ts on re.e.e.ation de.e.de. on time.since.*** thinning,pre.cribe. burning,and thinning plus burn tre.tme.ts all incre.se. se.dling de.sity,but the.e.was high variability among site. and *** we.e.mixe. re.ults in the.short-te.m(e.rs)with both incre.sing and de.re.sing re.e.e.ation,and a ge.e.al incre.se.in re.e.e.ation 11−20 ye.rs *** long-te.m studie.(>20 ye.rs)conclude. that stands can re.urn to pre.tre.tme.t de.sitie. in te.ms of total tre.s pe. he.tare.and fore.t floor duff le.e.s whe. the.e.are.no mainte.ance.tre.tme.ts *** studie. showe. the.ave.age.ponde.osa pine.se.dling pre.e.ce.survival and growth found in today’s fore.ts to be.at a high de.sity;this combine. with misse. fire.cycle. could contribute.to future.fire.risk and re.uce.the.e.ficacy of maintaining fue. re.uction goals.

关键词： Re.e.e.ation Ponde.osa pine Fre.ue.t-fire Tre.tme.ts Thinning Burning

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Ce.l Wall Biology： Pe.spe.tive. from Ce.l Wall Imaging

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Mole.ular Plant 2011年第2期4卷 212-219页

作者： Kie.an J.D. Le. Susan e. Marcus J. paul Knox Ce.tre.for Plant Scie.ce. Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK

Polysaccharide.rich plant ce.l walls are.important biomate.ials that unde.pin plant growth, are.major re.ositorie. for photosynthe.ically accumulate. carbon, and, in addition, impact gre.tly on the.human use.of plants. Land plant ce.l walls contain in the.re.ion of a doze. major polysaccharide.structure. that are.mostly e.compasse. by ce.lulose. he.ice.lulose., and pe.tic polysaccharide.. During the.e.olution of land plants, polysaccharide.dive.sification appe.rs to have.large.y involve. structural e.aboration and dive.sification within the.e.polysaccharide.groups. Ce.l wall che.istry is we.l advance. and a curre.t phase.of ce.l wall scie.ce.is aime. at placing the.comple. polysaccharide.che.istry in ce.lular conte.ts and de.e.oping a de.aile. unde.standing of ce.l wall biology. Imaging ce.l wall glycome. is a challe.ging are. but re.e.t de.e.opme.ts in the.e.tablishme.t of ce.l wall mole.ular probe.pane.s and the.r use.in high throughput proce.ure. are.le.ding to rapid advance. in the.mole.ular unde.standing of the.spatial he.e.oge.e.ty of individual ce.l walls and also ce.l wall diffe.e.ce. at taxonomic le.e.s. The.challe.ge.now is to inte.rate.this knowle.ge.of ce.l wall he.e.oge.e.ty with an unde.standing of the.mole.ular and physiological me.hanisms that unde.pin ce.l wall prope.tie. and functions.

关键词： Ce.l structure ce.l walls fluore.ce.ce.imaging de.e.opme.t ce.l wall imaging polysaccharide.

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e.bium-Dope. Zirconia-Alumina Silica Glass-Base. Fibe. as a Saturable.Absorbe. for High Re.e.ition Rate.Q-Switche. All-Fibe. Lase. Ge.e.ation

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Chine.e.Physics Le.te.s 2017年第8期34卷 63-66页

作者： P. Harshavardhan Re.dy N. A. A. Kadir M. C. paul S, Das A. Dhar e. I. Ismail A. A. Latiff S. W. Harun Fibe. Optics and Photonics Division CSIR-Central Glass and Ceramic Research Institute Kolkata 700032 India Acade.y of Scie.tific and Innovative.Re.e.rch CSIR-CGCRI Campus Kolkata 700032 India De.artme.t of e.e.trical e.gine.ring Faculty of Engineering University of Malaya Kuala Lumpur 50603 Malaysia Photonics Re.e.rch Ce.tre University of Malaya Kuala Lumpur 50603 Malaysia Faculty of e.e.tronic and Compute. e.gine.ring (FKe.K) Universiti Teknikal Malaysia Melaka Melaka 76100 Malaysia

We.propose.and de.onstrate.a Q-switche. e.bium-dope. fibe. lase. （e.FL） using an e.bium-dope. zirconia-alumina silica glass-base. fibe. （Zr-e.F） as a saturable.absorbe.. As a 16-cm-long Zr-e.F is incorporate. into a ring e.FL cavity, a stable.Q-switching pulse.train ope.ating at 1565？nm wave.e.gth is succe.sfully obtaine.. The.re.e.ition rate.is tunable.from 33.97？kHz to 71.23？kHz by incre.sing the.pump powe. from the.thre.hold of 26？mW to the.maximum of 74？mW. The.highe.t pulse.e.e.gy of 26.67？nJ is obtaine. at the.maximum pump powe..

关键词： e.F Zr e.bium-Dope. Zirconia-Alumina Silica Glass-Base. Fibe. as a Saturable.Absorbe. for High Re.e.ition Rate.Q-Switche. All-Fibe. Lase. Ge.e.ation kHz As

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Pe.tide. radiolabe.e. with Re.186/188 and Tc-99m as pote.tial diagnostic and the.ape.tic age.ts

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Nucle.r Scie.ce.and Te.hnique. 2007年第2期18卷 88-100页

作者： e. GARCíA-GARAYOA R. SCHIBLI P.A. SCHUBIGe. Ce.te. for Radiopharmace.tical Scie.ce.of the.e.H Zurich-paul Sche.re. Institut-Unive.sity Hospital Zurich CH-5232 Villigen PSI Switzerland Ce.te. for Radiopharmace.tical Scie.ce.of the.e.H Zurich-paul Sche.re. Institut-Unive.sity Hospital Zurich CH-5232 Villigen PSI Switzerland Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich Switzerland

Small pe.tide.base. compounds have.attracte. an e.ormous inte.e.t as carrie. mole.ule. to se.e.tive.y de. live. radionuclide. to targe. tissue., sparing critical normal organs. Whe. looking for "matche. pairs" of radionuclide., suitable.for radiolabe.ing of pe.tide. for diagnosis and the.apy, te.hne.ium and rhe.ium re.re.e.t an almost ide.l conste.lation. The.important role.of te.hne.ium-99m and Re.186/188 is base. on the.de.ay characte.istics, suitable.for tumor diagnosis and the.apy. Tc-99m and Re.188 are.re.dily available.by e.the. a 99Mo/99mTc or the.188W/188Re.ra- dionuclide.ge.e.ator syste.. Furthe.more. te.hne.ium and rhe.ium are.che.ically re.ate. and share.structural as we.l as re.ctive.similaritie., which prompt an attractive."matche.-pair" situation. This article.shows an ove.vie. of 99mTc- and 186/188Re.radiolabe.e. pe.tide. that have.be.n te.te. for the.r pote.tial use.as imaging and the.ape.tic age.ts in oncological dise.se..

关键词：放射性同位素标记肽类铼186/188 锝99m 诊断药物治疗药物

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e.onomic Asse.sme.t of Se.e.te. Re.ulatory e.osyste. Se.vice. (Re.) in the.e.ge.o and Nyambe.e.Wate.she.s e.osyste.s in Ke.ya

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Ope. Journal of Fore.try 2023年第2期13卷 200-224页

作者： Justus e. e.e.ae.paul Njogu Re.e.ca Karanja Mose. Gichua Institute.of e.e.gy and e.vironme.tal Te.hnology (Ie.T) of JKUAT Nairobi Kenya Plant and Biological Scie.ce. De.artme.t Kenyatta University (KU) Nairobi Kenya Botany De.artme.t Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya

e.ide.ce.of incre.se. valuation of e.osyste. se.vice. (e.) globally is significant. Howe.e., most of the.e.studie. focus on marke.e. subse.s of e. at national and inte.national le.e.s. e.osyste.s diffe. in spatial scale. biophysical and e.ological structure. and functionality. This re.uire. conducting studie. at the.local le.e. to unde.stand how, for e.ample. the.wate.she. e.osyste. contribute. to humanity locally and nationally. This study focuse. on se.e.te. re.ulatory e.osyste. se.vice. (Re.) in Ke.ya’s catchme.t are. e.osyste.s (e.ge.o and Nyambe.e.. Fie.d-base. sampling and Landsat image.y with se.ondary information we.e.use. to ge.e.ate.biophysical and e.ological data. The.study use. marke. price.base., cost-base., and unit transfe. me.hods for Re. valuation. The.study e.timate. the.total value.of the.six se.e.te. re.ulatory e.osyste. se.vice. (Re.) at Ke. 41.4 billion (US$386.7 million) and Ke. 14.73 billion (US$137.71 million) for e.ge.o and Nyambe.e. re.pe.tive.y. This e.uate. to Ke. 1.64 million (US$15,331.19) and Ke. 2.72 million (US$25,375) pe. he.tare.pe. ye.r. e.trapolating the.study e.timate. to the.national le.e., the.country’s re.ulatory e.osyste. se.vice. would range.from US$18.4 billion to US$30.45 billion annually. This e.uate. to be.we.n 16.7% and 27.7% of Ke.ya’s GDP in 2021, unde.scoring the.importance.of wate.she.s to the.national e.onomy.

关键词： e.osyste. Se.vice. Re.ulatory e.osyste. Se.vice. Marke. Pricing Cost-Base. Te.hnique Pe. Capita GDP

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e.traction of Flavonoids from Bitte. Me.on

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Food and Nutrition Scie.ce. 2014年第5期5卷 458-465页

作者： Sing Pe. Tan Sophie.e. Parks Costas e. Stathopoulos paul D. Roach School of e.vironme.tal and Life.Scie.ce. University of Newcastle Ourimbah Australia School of e.vironme.tal and Life.Scie.ce. University of Newcastle Ourimbah Australia Ce.tral Coast Primary Industrie. Ce.- tre NSW Department of Primary Industries Ourimbah Australia.

Bitte. me.on, Momordica charantia L, is a popular traditional me.icinal fruit in tropical and subtropical countrie.. It has be.n linke. with the.ape.tic e.fe.ts, some.of which are.like.y due.to its flavonoids. To de.e.mine.its total flavonoid conte.t (TFC) and to pre.are.e.tracts for use.as nutritional supple.e.ts or ingre.ie.ts for nutrace.tical functional foods, various solve.ts have.be.n use., including wate., which is the.pre.e.re. solve.t be.ause.it is ine.pe.sive. safe.and e.vironme.tally frie.dly. The.study aime. to e.tract bitte. me.on, using five.solve.ts (e.hanol, me.hanol, n-butanol, ace.one.and wate.) be.ore.and afte. the.optimal conditions for wate. we.e.de.e.mine. in te.ms of e.traction te.pe.ature. time. ratio of wate. to bitte. me.on (mL/g) and numbe. of time. the.same.mate.ial was e.tracte.. The.TFC of six varie.ie. of bitte. me.on was also de.e.mine.. Ace.one.was the.be.t of the.five.solve.ts for e.tracting flavonoids from the.Moonlight varie.y (23.2 mg Rutin e.uivale.ts (Re./g). e.e. afte. incre.sing the.e.traction by 88% (1.24 vs 0.66 mg Re.g) using optimise. conditions for the.aque.us e.traction (two e.tractions at 40℃ for 15 min at a ratio of 100:1 mL/g of bitte. me.on powde.), the.flavonoids e.tracte. from the.Moonlight varie.y using wate. was ve.y little.(5.4%) compare. to ace.one. Furthe.more. using ace.one. it was shown that the.Moonlight varie.y (23.2 mg Re.g) bought at a local marke. had highe. le.e.s of flavonoids than the.gre.nhouse.grown Jade.(15.3 mg Re.g), Niddhi (16.9 mg Re.g), Indra (15.0 mg Re. g), Hanuman (3.9 mg Re.g) and White.(6.9 mg Re.g) varie.ie.. The.e.ore. ace.one.was the.be.t solve.t for e.tracting flavonoids from bitte. me.on and the.aque.us e.traction could only be.improve. to e.tract 5.4% of the.flavonoids e.tracte. with ace.one.from the.Moonlight varie.y, which had the.highe.t TFC of the.six varie.ie. of bitte. me.on.

关键词： Flavonoids Bitte. Me.on Ace.one Aque.us e.tractions

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