Current debate in the oncologic management of rectal cancer
Current debate in the oncologic management of rectal cancer作者机构：Division of Hematology-OncologyDepartment of MedicineUniversity of Virginia Health System Center for Immuno-Oncology/GI OncologyDana-Farber Cancer Institute
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2016年第8卷第10期
页 面：715-724页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Chemoradiation Immunotherapy Non-operative management Neoadjuvant chemotherapy Rectal cancer
摘 要：Despite the considerable amount of research in the field,the management of locally advanced rectal cancer remains a subject to *** date,effective treatment centers on surgical resection with the standard approach of total mesorectal *** therapy and chemotherapy have been incorporated in order to decrease local and systemic *** it is accepted that a multimodality treatment regimen is indicated,there remains significant debate for how best to accomplish this in regards to order,dosing,and choice of *** radiation is the standard of care,yet remains debated with the option for chemoradiation,short course radiation,and even ongoing studies looking at the possibility of leaving radiation out *** was traditionally incorporated in the adjuvant setting,but recent reports suggest the possibility of improved efficacy and tolerance when given *** this review,the major studies in the management of locally advanced rectal cancer will be *** addition,future directions will be considered such as the role of immunotherapy and ongoing trials looking at timing of chemotherapy,inclusion of radiation,and nonoperative management.
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