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Effective depth-of-penetration range due to hardness variation for different lots of nominally identical target material

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Defence Technology（防务技术） 2016年第2期12卷 171-176页

作者： patrick FRUEH Andreas HEINE Karl Ernst WEBER matthias WICKERT fraunhofer EmI Eckerstrasse 479104 FreiburgGermany

The effect of small variations of target hardness on the depth of penetration for nominally identical target material has not been addressed systematically in publications yet and is often neglected. An investigation of this issue for laboratory-scale long rod projectiles penetrating into semi-infinite rolled-homogeneous-armor steel targets was conducted. The tungsten-heavy-alloy penetrators were of length 90 mm and diameter6 mm. Five lots of armor steel with a nominal hardness range of 280–330 BHN provided material for the targets. The pursued approach consisted of hardness testing of the targets, in total 17 ballistic experiments at velocities in between 1250 m/s and 1780 m/s and data analysis.A linear regression analysis of penetration vs. hardness shows that a target hardness increase within the given range of 280–330 BHN may result in a reduction of penetration depth of about 5.8 mm at constant velocity. This is equal to a change of-12% at an impact velocity of 1250 m/s. A multiple linear regression analysis included also the influence of yaw angle and impact velocity. It shows that small yaw angles and slight variations of impact velocities provide a smaller variation of the semi-infinite penetration depths than a variation of target hardness within a typical specification span of 50 BHN. For such a span a change in penetration of approximately-4.8 mm due to hardness variation is found, whereas 1°of yaw angle or-10 m/s of velocity variation gives a change of about-1.0 mm respectively-0.9 mm. For the given example, the overwhelming part of the variation is to be attributed to hardness effects – 4.8 mm out of 5.8 mm(83%). For nominally identical target material the target hardness thus influences the ballistic test results more severely than the typical scatter in impact conditions.

关键词：硬度变化渗透深度靶材料一元线性回归分析多元线性回归分析地段穿透深度冲击速度

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Azoximer bromide and hydroxyapatite:promising immune adjuvants in cancer

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Cancer Biology & medicine 2023年第12期20卷 1021-1034页

作者： Jean-François Rossi patrick Frayssinet maksim matciyak Nikolai Tupitsyn Institut du Cancer Avignon-Provence Sainte Catherine–Department of Hematology-BiotherapyAvignon 84918France University of montpellier UFR MédecineMontpellier 34090France HASTIm Inc. Rue de CauletToulouse 31300France Petrovax NPO Pharm Moscow 123112Russia Laboratory of Immunology of Hematopoiesis N.N.Blokhin Cancer Research Center(RCRC)Moscow 123112Russia

Immune adjuvants are immune modulators that have been developed in the context of infectious *** is currently a growing interest in immune adjuvants due to the development of immunotherapy against *** adjuvant mechanisms of action are focused on the initiation and amplification of the inflammatory response leading to the innate immune response,followed by the adaptive immune *** main activity lies in the support of antigen presentation and the maturation and functions of dendritic *** immune adjuvants are associated with a vaccine or incorporated into the new generation of m RNA *** immune adjuvants are used as ***(HA)ceramics and azoximer bromide(AZB)are overlooked molecules that were used in early clinical trials,which demonstrated clinical efficacy and excellent tolerance *** combined in an autologous vaccine was previously developed in the veterinary field for use in canine spontaneous ***,an original immune modulator derived from a class of heterochain aliphatic polyamines that is licensed in Russia,the Commonwealth of Independent States,and Slovakia for infectious and inflammatory diseases,is and now being developed for use in cancer with promising *** two immune adjuvants can be combined in various immunotherapy strategies.

关键词： Immune adjuvants cancer azoximer bromide hydroxyapatite Toll receptor agonists immunotherapy

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The effects of Spirulina on anemia and immune function in senior citizens

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Cellular & molecular Immunology 2011年第3期8卷 248-254页

作者： Carlo Selmi patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski m Eric Gershwin Division of Rheumatology Allergy and Clinical ImmunologyUniversity of California at DavisDavisCAUSA Department of medicine IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Department of Food Science and Technology University of California at DavisDavisCAUSA Cyanotech Kailua-KonaHIUSA

Anemia and immunological dysfunction(***)are commonly found in older subjects and nutritional approaches are sought to counteract these *** is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant *** hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of *** enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic *** took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the *** cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of *** study participants completed the entire study and the data obtained were *** the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both *** addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male *** women appeared to benefit more rapidly from Spirulina ***,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina *** may ameliorate anemia and immunosenescence in older *** encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.

关键词： functional food immunosenescence red blood cell IDO

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Climate Change Adaptation for People and Nature:A Case Study from the ***

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Advances in Climate Change Research 2012年第1期3卷 22-37页

作者： patrick D.mCCARTHY The Nature Conservancy Santa Fe 87501U.S.

In the ***,global climate change,acting in concert with extant stressors such as urbanization and over-allocation of water resources,is changing ecosystems in measureable and sometimes dramatic ***-first century projections indicate accelerating climate change and cascading ecological *** observed to date include large-scale forest dieback,large and severe wildfires,and changes in the flow regimes of rivers and streams with attendant changes to riparian and aquatic *** temperatures and changing precipitation patterns are pushing ecosystems across physiological and ecological thresholds,causing widespread mortality and,in some cases,major changes in composition,structure and *** changes have prompted action by the conservation community to reduce the adverse effects of climate *** Southwest Climate Change Initiative(SWCCI),a project led by The Nature Conservancy,works with local stakeholders in affected landscapes,reduces adverse impacts on ecological and social systems using scientific knowledge and practical *** Initiative has learned through practical experience that: 1) managers must embrace change and manage for resilience rather than resistance;2) strong local science-management partnerships are critical to effective adaptation planning and implementation;3) planners and managers must broaden the scope and accelerate the pace of conservation activities if ecosystem services are to be sustained;4) adaptation often does not require radically new or different management practices,rather,conservationists already have many of the tools they need;and 5) rapid documentation and widespread communication of methods and findings can build rapidly regional capacity for climate change *** experience suggests that adaptation efforts can be effective if they are focused at the local scale;employ learning networks;and engage in ecosystem-based adaptation:the sustainable management,conservation

关键词： climate change adaptation ecosystem-based adaptation ecological thresholds learning networks

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Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression

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Cellular & molecular Immunology 2022年第10期19卷 1130-1140页

作者： Tihong Shao patrick S.C.Leung Weici Zhang Koichi Tsuneyama William m.Ridgway Howard A.Young Zongwen Shuai Aftab A.Ansari m.Eric Gershwi Department of Rheumatology and Immunology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina Division of Rheumatology Allergyand Clinical ImmunologySchool of MedicineUniversity of CaliforniaDavisCAUSA Department of Pathology and Laboratory medicine Institute of Biomedical SciencesTokushima University Graduate SchoolTokushimaJapan Center for Cancer Research National Cancer Institute-FrederickFrederickMDUSA

The interferon(IFN)signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of *** have generated a unique murine model named ARE-Del,with chronic overexpression of IFNγ,by altering IFNγ***,these mice develop an immunologic and clinical profile similar to patients with primary biliary cholangitis,including high titers of autoantibodies and portal *** hypothesized that the downregulation of IFN signaling pathways with a JAK1/2 inhibitor would inhibit the development and progression of *** study this hypothesis,ARE-Del^(+/−)mice were treated with the JAK1/2 inhibitor ruxolitinib and serially *** inhibition resulted in a significant reduction in portal inflammation and bile duct damage,associated with a significant reduction in splenic and hepatic CD4^(+)T cells and CD8^(+)T ***,ruxolitinib inhibited the secretion of the proinflammatory cytokines IFNγand TNF from splenic CD4^(+)T ***,ruxolitinib treatment also decreased the frequencies of germinal center B(GC B)cells and T follicular helper(Tfh)cells and led to lower serological AmA *** note,liver and peritoneal macrophages were sharply decreased and polarized from m1 to m2 with a higher level of IRF4 expression after ruxolitinib ***,ruxolitinib inhibited the secretion of IL-6,TNF and mCP1 and the expression of STAT1 but promoted the expression of STAT6 in macrophages in vitro,indicating that m1 macrophage polarization to m2 occurred through activation of the STAT6-IRF4 *** data highlight the significance,both immunologically and clinically,of the JAK/STAT signaling pathway in autoimmune cholangitis.

关键词： Primary biliary cholangitis Autoimmunity Interferons Janus Kinase Inhibitors Ruxolitinib

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Nonlinear resonances phenomena in a modified Josephson junction model

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Chinese Physics B 2020年第12期29卷 162-173页

作者： Pernel Nguenang Sandrine Takam mabekou patrick Louodop Arthur Tsamouo Tsokeng martin Tchoffo Research Unit Condensed matter Electronics and Signal ProcessingThe University of DschangP.O.Box 67 DschangCameroon Unitède Recherche de mècanique et de modèlisation des Systemes Physiques(UR-2mSP) Facultèdes SciencesUniversitède DschangBP 69 DschangCameroun Sao Paulo State University(UNESP) Instituto de Fìsica TeóricaRua Dr.BentoTeobaldo Ferraz 271Bloco IIBarra Funda01140-070 Sao PauloBrazil

In this paper,the equivalent circuit of the non-autonomous Josephson junction(JJ)is presented and the effect of the proper frequency on the phaseφis *** also study nonlinear resonance phenomena in the oscillations of a modified Josephson junction(mJJ).These oscillations are probed through a system of nonlinear differential equations and the multiple time scale method is employed to investigate all different types of resonance that *** results of primary,superharmonic and subharmonic resonances are obtained *** show that the system exhibits hardening and softening behaviors,as well as hysteresis and amplitude hopping phenomena in primary and superharmonic resonances,and only the hysteresis phenomenon in subharmonic *** addition,the stabilities and the steady state solutions in each type of resonances are kindly *** number of equilibrium points that evolve with time and their stabilities are also ***,the equations of motion are numerically integrated to check the correctness of analytical *** further show that the dynamics of the mJJ is strongly influenced by its parameters.

关键词： nonlinear resonances hysteresis and jump phenomena modified Josephson junction

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Self-Dual Hadamard Bent Sequences

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Journal of Systems Science & Complexity 2023年第2期36卷 894-908页

作者： SHI minjia LI Yaya CHENG Wei CRNKOVIC Dean KROTOV Denis SOLépatrick Key Laboratory of Intelligent Computing Signal Processing Ministry of EducationSchool of Mathematical SciencesAnhui UniversityHefei 230601China State Key Laboratory of Information Security(Institute of Information Engineering) Chinese Academy of SciencesBeijing 100093China. LTCI Télécom ParisParis91120 PalaiseauFrance Secure-IC S.A.S. 104 Bd du Montparnasse75014 Paris Faculty of mathematics University of RijekaNovosibirsk 630090Russia Sobolev Institute of mathematics Novosibirsk 630090Russia Aix marseille Univ CNRSCentrale MarseilleI2MMarseilleFrance

A new notion of bent sequence related to Hadamard matrices was introduced recently,motivated by a security application(Solé,et al.,2021).The authors study the self-dual class in length at most *** authors use three competing methods of generation:Exhaustion,Linear Algebra and Gr?bner *** Hadamard matrices and Bush-type Hadamard matrices provide many *** authors conjecture that if v is an even perfect square,a self-dual bent sequence of length v always *** authors introduce the strong automorphism group of Hadamard matrices,which acts on their associated self-dual bent *** authors give an efficient algorithm to compute that group.

关键词： Bent sequences bush-type Hadamard matrices Hadanard matrices PUF functions regular Hadamard matrices

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WARA-PS:a research arena for public safety demonstrations and autonomous collaborative rescue robotics experimentation

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Autonomous Intelligent Systems 2021年第1期1卷 104-134页

作者： Olov Andersson patrick Doherty mårten Lager Jens-Olof Lindh Linnea Persson Elin A.Topp Jesper Tordenlid Bo Wahlberg Department of Computer and Information Science Linköping UniversityLinköpingSweden Saab Kockums MalmöSweden Division of Decision and Control Systems School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologyStockholmSweden Department of Computer Science Lund UniversityLundSweden Saab Combitech AB LinköpingSweden Division of Automatic Control Department of Electrical EngineeringLinköping UniversityLinköpingSweden

A research arena(WARA-PS)for sensing,data fusion,user interaction,planning and control of collaborative autonomous aerial and surface vehicles in public safety applications is *** objective is to demonstrate scientific discoveries and to generate new directions for future research on autonomous systems for societal *** enabler is a computational infrastructure with a core system architecture for industrial and academic *** includes a control and command system together with a framework for planning and executing tasks for unmanned surface vehicles and aerial *** motivating application for the demonstration is marine search and rescue operations.A state-of-art delegation framework for the mission planning together with three specific applications is also *** first one concerns model predictive control for cooperative rendezvous of autonomous unmanned aerial and surface *** second project is about learning to make safe real-time decisions under uncertainty for autonomous vehicles,and the third one is on robust terrain-aided navigation through sensor fusion and virtual reality tele-operation to support a GPS-free positioning system in marine *** research results have been experimentally evaluated and demonstrated to industry and public sector audiences at a marine test *** would be most difficult to do experiments on this large scale without the WARA-PS research ***,these demonstrator activities have resulted in effective research dissemination with high public visibility,business impact and new research collaborations between academia and industry.

关键词： Autonomous systems Intelligent system architectures Research demonstration arena Autonomous drones Autonomous marine vessels Public safety and security Collaborative robotics

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Lions, hyenas and mobs （oh my!）

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Current Zoology 2017年第3期63卷 313-322页

作者： Kenna D.S. LEHmANN Tracy m. mONTGOmERY Sarah m. mACLACHLAN Jenna m. PARKERC livia S. SPAGNUOLO Kelsey J. VANDEWETERING patrick S. BILLS Kay E. HOLEKAmP Department of Integrative Biology Michigan State University 288 Farm Lane Room 203 East Lansing MI 48824 USA Ecology Evolutionary Biology and Behavior Michigan State University 293 Farm Lane Room 103 East Lansing MI 48824 USA Department of Fish Wildlife and Conservation Biology Colorado State University 1474 Campus Delivery Fort Collins CO 80523 USA Conservation Ecology and Environmental Informatics School of Natural Resources and Environment University of Michigan 440 Church St. Ann Arbor MI 48109 USA Institute for Cyber Enabled Research Michigan State University Biomedical & Physical Sciences Building 567 Wilson Road Room 1440 East Lansing MI 48824 USA

Understanding the factors that facilitate the emergence of cooperation among organisms is central to the study of social evolution. Spotted hyenas Crocuta crocuta frequently cooperate to mob lions Panthera leo, approaching the lions as a tightknit group while vocalizing loudly in an attempt to overwhelm them and drive them away. Whereas cooperative mobbing behavior has been well documented in birds and some mammals, to our knowledge it has never been described during interactions between 2 apex predators. Using a 27-year dataset, we characterize lion-hyena encoun- ters, assess rates of mobbing behavior observed during these interactions, and inquire whether mobbing results in successful acquisition of food. Lions and hyenas interacted most often at fresh kills, especially as prey size and the number of hyenas present increased. Possession of food at the beginning of an interaction positively affected retention of that food by each predator species. The presence of male lions increased the probability of an interspecific interaction but decreased the likelihood of hyenas obtaining or retaining possession of the food. Hyena mobbing rates were highest at fresh kills, but lower when adult male lions were present. The occurrence of mobbing was predicted by an increase in the number of hyenas present. Whether or not mobbing resulted in acquisition of food from lions was predicted by an increase in the number of mobs formed by the hyenas present, suggesting that cooperation among hyenas enhances their fitness.

关键词： competition cooperation hyena lion mobbing sociality.

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Zinc deficiency in patients with chronic pancreatitis

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World Journal of Gastroenterology 2019年第5期25卷 600-607页

作者： miroslav Vujasinovic AleksANDra Hedstr?m patrick maisonneuve Roberto Valente Henrik von Horn J-matthias L?hr Stephan L Haas Department for Digestive Diseases Karolinska University Hospital Division of Epidemiology and Biostatistics IEO European Institute of Oncology IRCCS Department for Digestive Diseases Sapienza University of Rome Division of Clinical Chemistry Department of Molecular Medicine and Surgery Karolinska Institutet Karolinska University Hospital Department of Clinical Science Intervention and Technology (CLINTEC)Karolinska Institute

BACKGROUND Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis(CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency(PEI),which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting *** To investigate serum zinc levels in patients with CP of various *** Between October 2015 and march 2018, patients with a diagnosis of CP were identified and recruited from the Pancreatic Outpatient Clinic at the Karolinska University Hospital in Stockholm, Sweden. Demographic, clinical and laboratory data were analyzed. Etiology of CP was determined according to the mANNHEIm classification system into the following etiological subcategories:alcohol consumption, nicotine consumption, hereditary factors, efferent pancreatic duct factors and immunological factors. Pancreatic exocrine function was defined as normal(fecal elastase 1 > 200 μg/g), mildly reduced(100-200μg/g) and severely reduced(fecal elastase 1 mol/L) was present in 39(26.0%) of patients: 22 females and 17 males. In the group of patients with zinc deficiency, 76.7% of patients had an exocrine pancreatic insufficiency(FE-1 mpared to patients 0.002]. Smoking and number of packyears were additionally associated with low zinc levels. The risk of zinc deficiency in current smokers and smokers with ≥ 20 pack-years was approximately three times higher

关键词： Zinc Pancreas Pancreatic exocrine insufficiency Chronic pancreatitis malnutrition

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